Article
Biotechnology & Applied Microbiology
Dahae Lee, Jae Sik Yu, Rhim Ryoo, Jin-Chul Kim, Tae Su Jang, Ki Sung Kang, Ki Hyun Kim
Summary: The study analyzed the anticancer activity of pulveraven A from Pulveroboletus ravenelii, demonstrating its induction of apoptotic cell death in breast cancer cells via the extrinsic apoptotic signaling pathway.
JOURNAL OF ANTIBIOTICS
(2021)
Article
Multidisciplinary Sciences
Yujie Ren, An Wang, Bowen Zhang, Wenting Ji, Xiao-Xu Zhu, Jing Lou, Muhan Huang, Yang Qiu, Xi Zhou
Summary: UL36 encoded by human cytomegalovirus not only inhibits apoptosis but also suppresses immune signaling by targeting IRF3 directly. Although UL36-mediated inhibition of apoptosis enhances immune signaling, its immunosuppressive activity counterbalances this effect.
Article
Biochemistry & Molecular Biology
Collins Waguia Kontchou, Ian E. Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich, Georg Haecker
Summary: During infection of human cells, Chlamydia trachomatis inhibits apoptosis by blocking the activation of the effectors Bak and Bax, upregulating the anti-apoptotic protein Mcl-1, reducing Bax oligomerization and association with the outer mitochondrial membrane, and inhibiting conformational changes of Bak. The protective effect of Chlamydia infection on mitochondria is lost upon protease digestion, and it is dependent on the regulator VDAC2. The outer membrane protein OmpA of Chlamydia can associate with mitochondria and mimic the anti-apoptotic effect of infection.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Pharmacology & Pharmacy
Sisi Ling, Lijun Jin, Shizheng Li, Fangcheng Zhang, Qiong Xu, Mingke Liu, Xuke Chen, Xiaolin Liu, Jielei Gu, Shiming Liu, Ningning Liu, Wenchao Ou
Summary: Allium macrostemon saponin inhibits platelet activation induced by CD40L by affecting downstream proteins of the CD40 pathway, leading to TRAF2-associated ubiquitination degradation and an anti-thrombotic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Dong-Wook Kim, Hyun Young Kim, Seung Hyun Kim, Ki Sung Kang
Summary: This study evaluated the anticancer activities of Centipeda minima (CMX) extracts and brevilin A against human gastric cancer cells and identified key anticancer genes targeted by brevilin A. The findings suggest that CMX and brevilin A may be novel sources of herbal medicine effective for the treatment of gastric cancer.
Article
Immunology
Parimal Samir, David E. Place, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti
Summary: The study shows that innate immune signaling through the TLR-IKK complex axis can inhibit the assembly and promote disassembly of stress granules, revealing a regulatory mechanism for the dynamics of stress granule assembly-disassembly.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang, Xiaojiao Cheng, Wenhui Zhang, Baiwen Zhang, Cong Zhou, Shuiping Tu
Summary: UTD1, a novel microtubule stabilizing agent, has shown significant anti-tumor activity in colorectal cancer by inhibiting cell proliferation, inducing cell cycle arrest in G2/M phase, and triggering apoptosis. Additionally, UTD1 exhibits a stronger apoptosis-inducing effect in ABCB1 high-expression cells.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Andrew J. Haak, Benita Sjogren
Summary: This study validates the inhibitory effect of regulator of G protein signaling 2 (RGS2) on uveal melanoma (UM) cell growth and suggests that this effect is dependent on the association between RGS2 and G alpha(q).
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Yeqing Fang, Chengcheng Duan, Shaoyuan Chen, Zhenguo Liu, Bimei Jiang, Wen Ai, Lei Wang, Peiyi Xie, Hongcheng Fang
Summary: Tan-IIA exhibits protective effects on myocardial tissue in rats with myocardial infarction by reducing myocardial tissue apoptosis and improving cardiac function. Additionally, Tan-IIA inhibits myocardial cell apoptosis through multiple mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Jindi Zeng, Jiancheng Wu, Shuijiao Pang, Feifei Wang, Xin Yu, Shouhua Zhang, Junquan Zeng, Jinlong Yan, Jianping Lian
Summary: Brassicasterol exhibits anti-cancer activity against HBV-associated hepatocellular carcinoma (HBV + HCC) by downregulating the AKT pathway, and this activity is independent of HBV infection.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Oncology
Zhi-Gao Hu, Yu-Bing Chen, Mei Huang, Jiang-Bo Tu, Shu-Ju Tu, Yu-Juan Pan, Xue-Li Chen, Song-Qing He
Summary: This study identified Plasminogen (PLG) as a key gene in the progression of HBV-induced hepatocellular carcinoma (HCC), promoting HCC development by activating SRC and enhancing the Hippo signaling pathway in HBV-infected HCC cells. These findings suggest that PLG may serve as a potential prognostic biomarker and therapeutic target for HBV-induced HCC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Oncology
Nikita Lvanisenko, Kamil Seyrek, Laura K. Hillert-Richter, Corinna Koenig, Johannes Espe, Kakoli Bose, Inna N. Lavrik
Summary: This article discusses the role and regulatory mechanisms of cellular FLICE inhibitory protein (c-FLIP) in the extrinsic pathway of cancer networks. In addition to its key role in apoptosis, c-FLIP may regulate other cellular functions and serve as a therapeutic target for cancer treatment.
Article
Multidisciplinary Sciences
Liping Liu, Mengnan Chai, Youmei Huang, Jingang Qi, Wenhui Zhu, Xinpeng Xi, Fangqian Chen, Yuan Qin, Hanyang Cai
Summary: Inflorescence architecture is regulated by the inflorescence meristem and pedicel length. SDG2 genetically interacts with the SWR1-ER signaling pathways to influence inflorescence growth, potentially mediated by auxin. SWR1 and ER signaling are necessary for H2A.Z histone variant enrichment, while SDG2 regulates SDG2-mediated H3K4me3 histone modification at auxin-related genes and H2A.Z histone variant enrichment, affecting auxin hormone signaling pathways.
Article
Veterinary Sciences
Xufan Zhao, Yaqin Chen, Wenrui Zhang, Hui Zhang, Yilong Hu, Fengyu Yang, Yingying Zhang, Xu Song
Summary: Pseudorabies virus (PRV) infections have caused significant economic losses to the global pig industry and pose a potential zoonotic threat. The emergence of new mutants has reduced the efficacy of vaccination, highlighting the need for new control measures. In this study, dihydromyricetin (DMY) exhibited potent antiviral activity against PRV in vitro, ameliorating excessive inflammatory responses and inducing apoptosis of PRV-infected cells. These findings suggest that DMY could be a candidate drug for PRV treatment.
VETERINARY SCIENCES
(2023)
Article
Microbiology
Jingying Xie, Xiangrong Li, Shunyu Yang, Zhenfang Yan, Lei Chen, Yanmei Yang, Dianyu Li, Xiangbo Zhang, Ruofei Feng
Summary: DDX56 plays an important role in inhibiting the replication of pseudorabies virus (PRV). It inhibits PRV proliferation by up-regulating cGAS-STING-induced IFN-beta expression. In addition, DDX56 can promote cGAS expression and directly interact with it. These findings contribute to a better understanding of host factors controlling PRV replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Developmental Biology
Remi Logeay, Charles Geminard, Patrice Lassus, Miriam Rodriguez-Vazquez, Diala Kantar, Lisa Heron-Milhavet, Bettina Fischer, Sarah J. Bray, Jacques Colinge, Alexandre Djiane
Summary: This study investigates the activity changes of the Notch pathway in Drosophila wing disc epithelial growth according to the polarity status of cells. The results show that the scrib mutation affects the transcriptional output of the Notch pathway, but not the global distribution of the Notch-dedicated transcription factor. Furthermore, it is found that a group of transcription factors is required for Notch-dependent neoplasms. Additionally, the study highlights some specificities of Notch/schb, such as the role of PAR domain-containing basic leucine zipper transcription factors and Notch direct target genes in neoplastic growth.
Article
Medicine, Research & Experimental
Bachirou Tinto, Dramane Kania, Therese Samdapawinde Kagone, Amadou Dicko, Isidore Traore, Nathalie de Rekeneire, Brice Wilfried Bicaba, Herve Hien, Philippe Van de Perre, Yannick Simonin, Sara Salinas
Summary: Dengue fever diagnosis in West Africa is challenging due to similar clinical presentations with other diseases, making biological diagnosis the only alternative. However, resource-limited countries often lack high-quality equipment and trained personnel, leading to misdiagnosis of dengue fever as malaria and serious health consequences for patients.
M S-MEDECINE SCIENCES
(2022)
Article
Immunology
Marie-France Martin, Ghizlane Maarifi, Herve Abiven, Marine Seffals, Nicolas Mouchet, Cecile Beck, Charles Bodet, Nicolas Leveque, Nathalie J. Arhel, Fabien P. Blanchet, Yannick Simonin, Sebastien Nisole
Summary: Usutu virus (USUV) has a greater propensity to infect Langerhans cells (LCs) in human skin, facilitated by the LC-specific receptor langerin. LCs replicate USUV more efficiently and elicit a stronger innate immune response compared to West Nile virus (WNV).
EMERGING MICROBES & INFECTIONS
(2022)
Review
Immunology
Mathieu Blot, Olivier Disson, Alexandre Leclercq, Alexandra Moura, Helene Bracq-Dieye, Pierre Thouvenot, Guillaume Vales, Barbara Burroni, Audrey Lupo, Marc Lecuit, Caroline Charlier
Summary: The study found that Listeria-associated lymphadenitis is rare, but it is associated with a mortality rate as high as invasive listeriosis and is frequently diagnosed alongside neoplasia.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Microbiology
Jacqueline Butterworth, Damien Gregoire, Marion Peter, Armando Andres Roca Suarez, Guillaume Desandre, Yannick Simonin, Alessia Virzi, Amal Zine El Aabidine, Marine Guivarch, Jean-Christophe Andrau, Edouard Bertrand, Eric Assenat, Joachim Lupberger, Urszula Hibner
Summary: Chronic hepatitis C infection is associated with altered gene expression profiles, which increases the risk of hepatocellular carcinoma. A novel HCV target gene, GOLT1B, has been identified, and its expression is correlated with poor outcome in HCC.
Article
Virology
Orianne Constant, Jonathan Barthelemy, Anna Nagy, Sara Salinas, Yannick Simonin
Summary: The study shows that increased levels of inflammatory cytokines and neuronal factors in patients infected with West Nile virus (WNV) are associated with the development of severe neurological impairments. These biomarkers could play a crucial role in patient monitoring, improving care, and preventing undesirable outcomes.
Review
Immunology
Orianne Constant, Ghizlane Maarifi, Fabien P. Blanchet, Philippe van de Perre, Yannick Simonin, Sara Salinas
Summary: This review highlights the important contribution of dendritic cells in the development and consequences of viral brain infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Nicolas Collongues, Guillaume Becker, Valerie Jolivel, Estelle Ayme-Dietrich, Jerome de Seze, Fabien Biname, Christine Patte-Mensah, Laurent Monassier, Ayikoe Guy Mensah-Nyagan
Summary: Multiple sclerosis is a chronic inflammatory disease with no neuroprotective drugs available. Research has identified potential targets for protecting axons from degeneration, offering hope for patients.
NEUROLOGY AND THERAPY
(2022)
Article
Cell Biology
Lydie Carreres, Marion Mercey-Ressejac, Keerthi Kurma, Julien Ghelfi, Carole Fournier, Olivier Manches, Florent Chuffart, Sophie Rousseaux, Melanie Minoves, Thomas Decaens, Herve Lerat, Zuzana Macek Jilkova
Summary: This study investigated the impact of OSA-related chronic intermittent hypoxia on HCC progression using a HCC model. The study found that intermittent hypoxia further increased HCC cell proliferation, potentially contributing to an increased risk of HCC progression.
Article
Multidisciplinary Sciences
Richard Wheeler, Paulo Andre Dias Bastos, Olivier Disson, Aline Rifflet, Ilana Gabanyi, Julia Spielbauer, Marion Berard, Marc Lecuit, Ivo Gomperts Boneca
Summary: Peptidoglycan, the major component of bacterial cell walls, plays a crucial role in affecting physiological and behavioral changes in mammalian hosts. However, the mechanism and regulation of its translocation from the gut to host tissues have not been fully understood. This study investigated the absorption and dissemination of peptidoglycan across the intestine. The results showed that peptidoglycan has a preference for certain host organs, particularly the brain, when absorbed through the gut. The translocation of peptidoglycan is an active process regulated by the microbiota-induced parasympathetic pathway through muscarinic acetylcholine receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Anthony Lozano, Francois-Regis Souche, Carine Chavey, Valerie Dardalhon, Christel Ramirez, Serena Vegna, Guillaume Desandre, Anais Riviere, Amal Zine El Aabidine, Philippe Fort, Leila Akkari, Urszula Hibner, Damien Gregoire
Summary: Quantitative differences in signal transduction in tumor heterogeneity, particularly in the MAPK Erk pathway, have been understudied. The study used different dosages of an oncogenic form of Ras to model subclonal variations in MAPK signaling, revealing selection processes and vulnerability of hepatocellular carcinoma. Orthotopic allografts of Ras-transformed cells in immunocompromised mice led to aggressive tumor growth in primary and secondary locations. The immune tumor microenvironment and the role of strong MAPK signaling in primary liver tumors were also analyzed.
Article
Microbiology
Norvi Rigobert Bienvenu Massengo, Bachirou Tinto, Yannick Simonin
Summary: The One Health concept recognizes the interconnections between human, animal, and ecological health and aims to address the socio-health issues in Africa, particularly infectious diseases like arboviruses. This approach is vital in combating pathogens and ensuring the well-being of humans, animals, and the environment, considering the challenges faced by the African continent. Establishing guidelines and effective solutions through a One Health strategy is crucial in promoting healthy interactions and sustainable practices.
Editorial Material
Infectious Diseases
Yannick Simonin
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Bachirou Tinto, Justine Revel, Laurie Virolle, Baptiste Chenet, Florence Reboul Salze, Alix Ortega, Marielle Beltrame, Yannick Simonin
Summary: This study investigates the prevalence of SARS-CoV-2 in domestic animals (dogs and cats) and zoo animals in the south of France. The findings reveal the presence of SARS-CoV-2 antibodies not only in domestic dogs and cats but also in several mammals in zoos. These results highlight the importance of implementing surveillance measures, including serological studies, to identify and monitor cases of SARS-CoV-2 infection in animals.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Nikolaus Dietlein, Xi Wang, Jonas Metz, Olivier Disson, Fuwei Shang, Celine Beyersdoerffer, Esther Rodriguez Correa, Daniel B. Lipka, Yvonne Begus-Nahrmann, Robyn Laura Kosinsky, Steven A. Johnsen, Marc Lecuit, Thomas Hoefer, Hans-Reimer Rodewald
Summary: Emergency hematopoiesis is a response of the immune system aimed at enhancing protection from infection. Research has found that the loss of the deubiquitinase USP22 leads to severe systemic emergency hematopoiesis and increased phagocytosis by neutrophilic granulocytes, ultimately enhancing innate protection against infection.
SCIENCE IMMUNOLOGY
(2022)