Article
Multidisciplinary Sciences
Samuel M. Law, Jie J. Zheng
Summary: Wnt signaling pathways play a significant role in various diseases. β-catenin is central to the canonical Wnt signaling pathway. CHIR-99021, a GSK-3β inhibitor, is widely used for studying this pathway. However, caution is needed when using CHIR-99021 at certain concentrations.
Article
Chemistry, Medicinal
Xueyang Jiang, Junting Zhou, Yang Wang, Xin Liu, Kaiying Xu, Jian Xu, Feng Feng, Haopeng Sun
Summary: A series of heterobifunctional small molecule PROTACs based on CRBN were designed and synthesized to effectively degrade GSK-3β protein and protect against cell death, showing potential for further investigation in the biological function of GSK-3β protein and its association with diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Esther Llorens-Alvarez, Jordi Alom, Teodoro del Ser, Jesus Avila, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: This study demonstrates that P-tau can modulate AChE expression, and suggests that AChE may increase in the initial phases of AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Immunology
Ricarda Cortes-Vieyra, Octavio Silva-Garcia, Anel Gomez-Garcia, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor M. Baizabal-Aguirre
Summary: Understanding the regulation of GSK3 beta activity in inflammatory responses caused by pathogenic microorganisms is crucial for controlling the intensity of inflammation. Recent studies have shown that regulating GSK3 beta activity can reduce the detrimental effects of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Matthew P. Davies, Rocio Benitez, Concepcion Perez, Sven Jakupovic, Philip Welsby, Klaudia Rzepecka, Jane Alder, Colin Davidson, Ana Martinez, Joseph M. Hayes
Summary: The study introduces the in silico design, screening, and in vitro validation of potent GSK-3 beta type-II inhibitors, leading to the identification of highly potent nanomolar inhibitors with potential neuroprotective effects. The designed inhibitors show promise as a potential route toward more clinically effective GSK-3 beta inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Summary: The combination of GSK3 inhibitors and PARP inhibitors shows a strong synergistic effect in colorectal cancer cells, enhancing cell sensitivity to treatment and improving therapeutic outcomes.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Lingjuan Wang, Sijin Ouyang, Bin Li, Hao Wu, Fengli Wang
Summary: Ferroptosis is a newly characterized form of non-apoptotic-programmed cell death that has implications in human diseases and potential therapeutic applications for cancer. GSK-3 beta acts as a positive modulator of ferroptosis by influencing cellular iron metabolism, indicating its potential as a target for cancer chemotherapy.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Medicinal
Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen
Summary: Meridianin C, a natural product derived from marine organisms, and its analogues B29 and B30 showed enhanced glucose uptake and GSK-3 beta inhibitory activities, indicating therapeutic potential for diabetes.
Review
Biochemistry & Molecular Biology
Chia-Ling Chen, Po-Chun Tseng, Rahmat Dani Satria, Thi Thuy Nguyen, Cheng-Chieh Tsai, Chiou-Feng Lin
Summary: GSK-3 is a vital regulator of glycogen synthesis that plays a crucial role in cellular bioregulation. Abnormal GSK-3 activation and inactivation can lead to liver damage. Targeting GSK-3 with drugs is a potential therapeutic approach for liver protection. Additionally, blocking GSK-3 has a protective effect in IFN-gamma-mediated immune hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Medicine, General & Internal
Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wang
Summary: This study revealed a vicious cycle between tau hyperphosphorylation and GSK-3R activation through tau-mediated acetylation of GSK-3R. Inhibiting GSK-3R acetylation competitively improved cognitive impairment and AD-like pathologies.
Article
Pharmacology & Pharmacy
Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yang
Summary: This study demonstrates that tanshinone IIA (tan IIA) can ameliorate cognitive decline and tau pathology in APP/PS1 mice by modulating the PI3K/Akt/GSK-3β signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Yun-Ru Liu, Huang Han-Chang, Feng-Xue Lao
Summary: The study found that Zeaxanthin (Zea) can protect against endoplasmic reticulum stress (ERS), glycogen synthase kinase 3 beta (GSK-3 beta) activity, and tau phosphorylation.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Acoustics
Lifei Yang, Lingzi Chen, Ye Fang, Suya Ma
Summary: The study demonstrates that downregulation of GSK-3 beta expression via UTMD effectively suppresses vulnerable plaque factors and inflammation in atherosclerosis, leading to increased plaque stability. Additionally, UTMD does not affect the viability of foam cells.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor
Summary: GSK-3 plays a crucial role in T cell function and tumor immunity, with the isoforms GSK-3α and GSK-3β having differential effects on immune responses and tumor infiltration, working together to control PD-1 expression and tumor growth.
Article
Gastroenterology & Hepatology
Tian-Ying Zhang, Xue-Ran Guo, Yang-Tao Wu, Xiao-Zhen Kang, Qing-Bing Zheng, Ruo-Yao Qi, Bin-Bing Chen, Ying Lan, Min Wei, Shao-Juan Wang, Hua-Long Xiong, Jia-Li Cao, Bao-Hui Zhang, Xiao-Yang Qiao, Xiao-Fen Huang, Ying-Bin Wang, Mu-Jin Fang, Ya-Li Zhang, Tong Cheng, Yi-Xin Chen, Qin-Jian Zhao, Shao-Wei Li, Sheng-Xiang Ge, Pei-Jer Chen, Jun Zhang, Quan Yuan, Ning-shao Xia
Article
Immunology
Tung-Hung Su, Cheng-Yuan Peng, Tai-Chung Tseng, Hung-Chih Yang, Chun-Jen Liu, Chen-Hua Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Gastroenterology & Hepatology
Chen-Hua Liu, Mei-Hsuan Lee, Jou-Wei Lin, Chun-Jen Liu, Tung-Hung Su, Tai-Chung Tseng, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
JOURNAL OF HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Chen-Hua Liu, Chun-Jen Liu, Chien-Ching Hung, Szu-Min Hsieh, Tung-Hung Su, Hsin-Yun Sun, Tai-Chung Tseng, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
LIVER INTERNATIONAL
(2020)
Article
Immunology
Chi-Chang Sung, Jau-Hau Horng, Shih-Hong Siao, I-Tsu Chyuan, Hwei-Fang Tsai, Pei-Jer Chen, Ping-Ning Hsu
Summary: This study identified ASGM1-positive liver-resident CD8 T cells as the major effector immune cells that mediate anti-HBV immunity, working in coordination with TRM cells and other immune cells to clear HBV.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tai-Chung Tseng, Chun-Jen Liu, Crystal T. Chang, Tung-Hung Su, Wan-Ting Yang, Cheng-Hsueh Tsai, Chi-Ling Chen, Hung-Chih Yang, Chen-Hua Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
JOURNAL OF HEPATOLOGY
(2020)
Article
Medicine, General & Internal
Chen-Hua Liu, Tung-Hung Su, Chun-Jen Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Hau-Jyun Su, Jia-Horng Kao, Tai-Chung Tseng, Hung-Chih Yang, Tung-Hung Su, Pei-Jer Chen, Chun-Jen Liu
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Ming-Lung Yu, Pei-Jer Chen, Chia-Yen Dai, Tsung-Hui Hu, Chung-Feng Huang, Yi-Hsiang Huang, Chao-Hung Hung, Chun-Yen Lin, Chen-Hua Liu, Chun-Jen Liu, Cheng-Yuan Peng, Han-Chieh Lin, Jia-Horng Kao, Wan-Long Chuang
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2020)
Article
Cell Biology
Tung Chao, Hsueh-Tzu Shih, Shih-Chin Hsu, Pei-Jer Chen, Yu-Shan Fan, Yung-Ming Jeng, Zhao-Qing Shen, Ting-Fen Tsai, Zee-Fen Chang
Summary: Genotoxic insult leads to damages in nuclear and mitochondrial DNA with autophagy induction. The study reveals that specific nuclear DNA damage alone does not require autophagy for repair, unless there is mitochondrial DNA damage present. Furthermore, autophagy suppression causes increased mitochondrial permeability, releasing mitochondrial ENDOG to the nuclei and sustaining nuclear DNA damage.
Article
Virology
Chun-Ming Hong, You-Yu Lin, Chun-Jen Liu, Ya-Yun Lai, Shiou-Hwei Yeh, Hung-Chih Yang, Jia-Horng Kao, Shih-Jer Hsu, Yi-Hsiang Huang, Sheng-Shun Yang, Hsing-Tao Kuo, Pin-Nan Cheng, Ming-Lung Yu, Pei-Jer Chen
Summary: About 4% of population in Taiwan are seropositive for anti-HCV Ab and 70% with HCV RNA. Taiwan National Health Insurance reimburses genotype-specific and pangenotype DAAs for chronic hepatitis C disease. Adherence is an important cause of failure clinically, while common resistance-associated substitutions include NS5A-L31, NS5A-Y93, NS5BC316 for genotype-specific DAAs and NS5A-L31, NS5A-A/Q/R30, NS5A-Y93 for pangenotype DAAs.
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Review
Oncology
Chiao-Ling Li, Shiou-Hwei Yeh, Pei-Jer Chen
Summary: Cell-free tumor DNA (ctDNA) is a promising tumor marker that can reflect tumor burden, behavior, and prognosis. However, there are still challenges to be addressed before ctDNA can be used as a tumor marker. We propose using exogenous viral DNA integration to generate virus-host chimera DNA (vh-DNA) as a potential new biomarker. vh-DNA may overcome detection problems and serve as a universal marker for monitoring tumor expansion or burden related to oncogenic viruses.
Article
Medicine, General & Internal
Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Shang-Chin Huang, Tai-Chung Tseng, Jo-Hsuan Wu, Pei-Jer Chen, Jia-Horng Kao
Summary: This study found a strong correlation between serum M2BPGi levels and the severity of hepatic fibrosis in patients with HCV infection, and identified specific cutoff values that can be used for accurate diagnosis.
Article
Gastroenterology & Hepatology
Tai-Chung Tseng, Chun-Jen Liu, Wan-Ting Yang, Chen-Yang Hsu, Chun-Ming Hong, Tung-Hung Su, Cheng-Hsueh Tsai, Chi-Ling Chen, Hung-Chih Yang, Chen-Hua Liu, Hsiu-Hsi Chen, Pei-Jer Chen, Jia-Horng Kao
Summary: In patients with chronic hepatitis B virus infection, higher levels of HBcrAg are associated with increased risk of cirrhosis. Among patients with intermediate viral load, HBcrAg <10 KU/mL defines a low-risk group for disease progression.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)