Review
Integrative & Complementary Medicine
Xiang Li, Ziqi Liu, Jie Liao, Qian Chen, Xiaoyan Lu, Xiaohui Fan
Summary: Network pharmacology provides a novel paradigm to understand the complex interactions between Traditional Chinese medicines and diseases, promoting their safety, efficacy, and mechanism investigations. Shifting from phenotype and symptom to endotype and cause is crucial for understanding and redefining current diseases.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Review
Pharmacology & Pharmacy
Yun-kai Dai, Hai-na Fan, Yong-hong Hu, Zhi-min Zhao, Chenghai Liu
Summary: This study compared and ranked different traditional Chinese medicine therapies for treating liver fibrosis caused by chronic hepatitis B. The results showed that Fuzheng Huayu therapy and combined with entecavir, as well as Ziyin Shugan therapy and combined with ETV, had preferable effects on improving clinical efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
Yi Zhang, Da Luo, Shi-Kang Zhou, Lin Yang, Wei-Feng Yao, Fang-Fang Cheng, Jun-Jie Zhu, Li Zhang
Summary: Chinese herbal medicines (CHMs) have been widely used in China for disease treatment, but their unstable quality and ambiguous effects have raised suspicions among people. The application of nanomaterials combined with analytical and imaging techniques provides new solutions to ensure the quality, discover active compounds, monitor in-vivo processes, and improve efficacy in the field of CHMs. This review highlights the applications of nanomaterials in CHMs, including hazardous substances detection, active compound screening and quantification, toxicity and pharmacological evaluation, therapeutic efficacy optimization, and component enrichment.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Peiliang Shen, Yuanyuan Jia, Silin Shi, Jia Sun, Xin Han
Summary: Traditional Chinese medicine (TCM) plays a significant role in disease prevention and treatment, but there are unresolved issues regarding active compounds and mechanisms of action. Therefore, innovative strategies and advanced technologies are promising for TCM research. Microfluidic chips provide controllable platforms for TCM research, enabling analysis and biomedical applications in quality control, delivery, pharmacological activity evaluation, and disease diagnosis of Chinese herbal medicines (CHMs).
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Immunology
Md. Arifur Rahman, Keiji Ueda, Tomoyuki Honda
Summary: The study found that maoto has the potential to suppress hepatitis B virus production by interfering with the viral nucleocapsid incorporation. Additionally, the reduction of host gene TPM2 expression by maoto also leads to inhibition of virus production, suggesting TPM2 as a novel molecular target for anti-HBV drug development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jie Chen, Xiaohong Wei, Qian Zhang, Yuzhuo Wu, Guiyang Xia, Huan Xia, Lingyan Wang, Hongcai Shang, Sheng Lin
Summary: Traditional Chinese medicine (TCM) has multiple targets for the treatment of chronic heart failure (CHF) and can regulate molecular mechanisms to combat different pathological processes of CHF. This review analyzes the application of TCM in different stages of CHF and summarizes the bioactive ingredients in Chinese medicinal herbs and their multiple molecular mechanisms for treating CHF.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Plant Sciences
Zhi Chen, Si-yong Ye
Summary: This study investigates the antiviral active ingredients and mechanisms of traditional Chinese medicines (TCM) against viral diseases. The findings provide analytical evidence supporting the effectiveness of TCM in treating virus infections and offer reference for the development of innovative TCMs with multiple components, multiple targets, and low toxicity.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Ying-lan Xie, Fei Han, Ying-hui Jin, Yan-bing Ding, Jing Guo, Dong-xiao Ji, Teng Zhang, Xiao-min Chen, Hong-cai Shang
Summary: The transformation and implementation of clinical practice guidelines for integrated traditional Chinese medicine (TCM) and Western medicine (WM) is crucial for the adoption and international availability of medical science and technological findings. This study analyzed the current situation and problems in existing guidelines of TCM and WM integration, and explored the degree and methods of integration in Chinese and Western medicine guidelines. The findings will contribute to the establishment of Chinese characteristic, repeatable, and calculable clinical practice guidelines for TCM and WM integration.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yuzhou Liu, Congying Li, Xiaofei Shen, Yue Liu
Summary: This review aims to summarize the biological processes of exercise-induced fatigue, types of traditional Chinese medicines (TCMs) used to relieve fatigue, their active components, and possible molecular mechanisms. Various TCMs have been found to have significant effects in relieving exercise-induced fatigue, primarily through improvements in energy metabolism, elimination of metabolites, inhibition of oxidative stress and inflammation, and regulation of HPA axis and neurotransmitters.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Infectious Diseases
Manal Buabeid, Munazza Ijaz, Saba Shamim, Xianju Huang, Ghulam Murtaza
Summary: COVID-19 is a severe respiratory disorder caused by coronavirus, and there is currently no specific antiviral drug. 85% of patients in China are treated with traditional Chinese medicine, which has shown advantages in treating SARS-CoV.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Medicine, Research & Experimental
Mengru Yang, Yi Wang, Yimin Yue, Lanyuan Liang, Mingming Peng, Mantong Zhao, Ying Chen, Xia Cao, Wei Li, Chuanqiu Li, Han Zhang, Jieyong Du, Renxing Zhong, Tianyi Xia, Zunpeng Shu
Summary: Influenza virus-induced pneumonia (IVP) is a highly morbid and contagious pulmonary infectious disease caused by invasion of the influenza virus into the lower respiratory tract. While the current treatment options are limited due to virus variability and drug resistance, Traditional Chinese Medicines (TCMs) offer unique advantages and have been widely used in clinical practice in China. This review provides a comprehensive analysis of TCMs used for IVP prevention and treatment, offering a theoretical basis for future drug development and suggesting the potential for new, low-toxicity drugs with multi-target effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Liyao Xiang, Zaoyu Chen, Shaobin Wei, Haiyan Zhou
Summary: This article analyzes the trade data of traditional Chinese medicine (TCM) products from 2001 to 2020 to examine the evolution of global trade patterns. The findings show that the total trade volume of TCM products is increasing, and the trade network is controlled by a few countries. China's position in the global trade network has improved, and there is a trend of increasing trade volume with various countries.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Yinghong Zhou, Juan Yang, Yingchun He, Yinghua Lv, Chunli Wang, Hongyong Deng, Jihan Huang
Summary: This study reviewed the registration and approval of clinical trials of traditional Chinese medicines (TCMs) in mainland China from 2013 to 2021, based on the data from the platform for the registry and publicity of clinical drug trials. The results showed a low number of registered clinical trials and low approval rate for new TCMs, but significant improvements were observed in clinical trial design.
FRONTIERS IN MEDICINE
(2022)
Article
Plant Sciences
Jiaxu Li, Chenyue Li, Xin Peng, Shaoping Li, Bingrui Liu, Chu Chu
Summary: This paper provides an overview of the application of tyrosinase inhibitors in skin senescence and pigmented skin diseases, as well as the potential of traditional Chinese medicines as natural tyrosinase inhibitors. It also discusses the screening methods for tyrosinase inhibitors and compares the advantages and disadvantages of different methods, and predicts their future applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Nan Yang, Huihui Zhang, Taoyi Deng, Jeff Jianfei Guo, Ming Hu
Summary: This study identified 431 published pharmacoeconomic articles on Traditional Chinese Medicine, with major concerns regarding study design, inappropriate pharmacoeconomic evaluation, insufficient sample size, or non-scientific assessment. Enhanced methodological training and cooperation, development of a targeted pharmacoeconomic evaluation guideline, and proposal of a reasonable health outcome index are needed for improving quality of future studies.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Gastroenterology & Hepatology
Behnam Saberi, Hetanshi Naik, Jessica R. Overbey, Angelika L. Erwin, Karl E. Anderson, D. Montgomery Bissell, Herbert L. Bonkovsky, John D. Phillips, Bruce Wang, Ashwani K. Singal, Brendan M. McGuire, Robert J. Desnick, Manisha Balwani
Summary: In this U.S. study, 1.5% of patients with AHP had HCC, which occurred without cirrhosis. Patients with AHP should be screened for HCC starting at age 50, regardless of clinical attacks.
Editorial Material
Gastroenterology & Hepatology
M. Balwani, E. Sardh, P. Ventura, P. A. Peiro, D. C. Rees, U. Stoelzel, D. M. Bissell, H. L. Bonkovsky, J. Windyga, K. E. Anderson, C. Parker, S. M. Silver, S. B. Keel, J. -D. Wang, P. E. Stein
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2020)
Article
Genetics & Heredity
Amy K. Dickey, Corbin Quick, Sarah Ducamp, Zhaozhong Zhu, Yen-Chen A. Feng, Hetanshi Naik, Manisha Balwani, Karl E. Anderson, Xihong Lin, John E. Phillips, Lina Rebeiz, Herbert L. Bonkovsky, Brendan M. McGuire, Bruce Wang, Daniel I. Chasman, Jordan W. Smoller, Mark D. Fleming, David C. Christiani
Summary: The prevalence of EPP has been underestimated due to underdiagnosis. The common c.315-48T>C allele is associated with both MCV and hemoglobin, indicating a potential importance for individuals with and without EPP.
GENETICS IN MEDICINE
(2021)
Article
Economics
Samira Massachi, Josh Epstein, Julie Hurd, Herbert L. Bonkovsky
JOURNAL OF MEDICAL ECONOMICS
(2020)
Letter
Hematology
Pei Li, Dhiman Maitra, Ning Kuo, Herbert L. Bonkovsky, M. Bishr Omary
Article
Pharmacology & Pharmacy
Christopher D. Ma, Cynthia G. Van Horn, Meimei Wan, Colin Bishop, Herbert L. Bonkovsky
Summary: It was found that using LMH cell culture model, a simple and reliable fluorescence-based assay can be developed to assess and predict the porphyrogenicity of drugs and chemicals that may exacerbate acute hepatic porphyrias.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Endocrinology & Metabolism
David Cassiman, Raili Kauppinen, Susana Monroy, Ming-Jen Lee, Herbert L. Bonkovsky, Manish Thapar, Encarna Guillen-Navarro, Anna-Elisabeth Minder, Cecilia Hale, Marianne T. Sweetser, Aneta Ivanova
Summary: Data from EXPLORE Part B showed that patients with acute hepatic porphyria (AHP) experienced high disease burden and impaired quality of life. Patients with more frequent attacks or on prophylaxis treatment and patients with fewer attacks and no prophylaxis treatment both reported chronic symptoms between attacks and diminished QOL compared to population norms.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Gastroenterology & Hepatology
Herbert L. Bonkovsky, Sean P. Rudnick, Christopher D. D. Ma, Jessica R. Overbey, Kelly Wang, Denise Faust, Csilla Hallberg, Karli Hedstrom, Hetanshi Naik, Akshata Moghe, Karl E. Anderson
Summary: Ledipasvir/sofosbuvir is effective for treating both chronic hepatitis C (CHC) and porphyria cutanea tarda (PCT) without the need for additional treatment methods.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
David J. Kuter, Herbert L. Bonkovsky, Susana Monroy, Gayle Ross, Encarna Guillen-Navarro, Maria Domenica Cappellini, Anna-Elisabeth Minder, Ole Hother-Nielsen, Paolo Ventura, Gang Jia, Marianne T. Sweetser, Manish Thapar
Summary: Long-term monthly givosiran treatment provides sustained improvement in clinical manifestations of acute hepatic porphyria (AHP) with a positive risk/benefit profile.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manish Thapar, Sean Rudnick, Herbert L. Bonkovsky
Summary: Acute hepatic porphyrias are rare genetic disorders affecting the heme biosynthetic pathway enzymes, with severe abdominal pain as a cardinal feature. The novel siRNA therapeutic agent givosiran has shown efficacy in decreasing levels of key enzymes and neurotoxins, but may cause side effects. Insurances are likely to restrict access to expensive treatments for patients with well-documented AHP and frequent severe attacks.
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
(2021)
Meeting Abstract
Hematology
Manisha Balwani, Herbert L. Bonkovsky, Kirstine J. Belongie, Karl E. Anderson, Fumihiro Takahashi, Antonio Irizarry, Mark Amster, D. Montgomery Bissell, Bruce Wang, Lydie Hazan, Charles J. Parker, Edward Cordasco, Cynthia Levy, Robert J. Desnick
Meeting Abstract
Gastroenterology & Hepatology
Eliane Sardh, Manisha Balwani, David C. Rees, Penelope Stein, Ulrich St, Paula Aguilera Peiro, D. Montgomery Bissell, Herbert L. Bonkovsky, Sioban Keel, Charles Parker, John D. Phillips, Samuel Silver, Jerzy Windyga, Delia D'Avola, Gayle Ross, Peter Stewart, Bruce Ritchie, Pauline Harper, Jiaan-Der Wang, Janneke Langendonk, Aneta Ivanova, Yutaka Horie, Karl E. Anderson, Paolo Ventura, Maria D. Cappellini, Daphne Vassiliou, Susana Monroy, Petro E. Petrides, Tomohide Adachi, David Kuter, Sushama Scalera, Craig Penz, Shangbin Liu, John J. Ko, Amy Simon, Laurent Gouya
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Herbert L. Bonkovsky, Manisha Balwani, Eliane Sardh, Laurent Gouya, David C. Rees, Penelope Stein, Ulrich Stoelzel, Paula Aguilera Peiro, D. Montgomery Bissell, Sioban Keel, Charles Parker, Samuel Silver, Jerzy Windyga, Delia D'Avola, Gayle Ross, Peter Stewart, Bruce Ritchie, Jeeyoung Oh, Pauline Harper, Jiaan-Der Wang, Janneke Langendonk, Aneta Ivanova, Yutaka Horie, Karl E. Anderson, Elisabeth Minder, Daphne Vassiliou, Ilja Kubisch, Encarna Guillen-Navarro, David Coman, Yoshie Goto, Hung-Chou Kuo, Zoe Hua, Amy Simon, John J. Ko, Paolo Ventura
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Paola Nicoletti, Yi-Ju Li, Elizabeth J. Phillips, Andrew Dellinger, Huiman Barnhart, Robert J. Fontana, Herbert L. Bonkovsky, Naga P. Chalasani
Meeting Abstract
Gastroenterology & Hepatology
Harshad Devarbhavi, Marwan S. Ghabril, Mallikarjun Patil, Sujata Raj, Naga P. Chalasani, Herbert L. Bonkovsky