Article
Immunology
Ying Lu, Yarong Song, Xiangjun Zhai, Fengcai Zhu, Jianxun Liu, Zhanjun Chang, Yi Li, Yiwei Xiao, Lili Li, Minmin Liu, Jia Liu, Zhongping Duan, Huaibin Zou, Hui Zhuang, Jie Wang, Jie Li
Summary: This study demonstrated that maternal HBeAg can serve as a surrogate marker for monitoring HBV DNA and evaluating the necessity of antiviral prophylaxis in preventing perinatal HBV transmission.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Milan J. Sonneveld, Bettina E. Hansen, Willem P. Brouwer, Henry L-Y Chan, Teerha Piratvisuth, Ji-Dong Jia, Stefan Zeuzem, Rong-Nan Chien, Robert J. de Knegt, Cynthia Wat, Vedran Pavlovic, Anuj Gaggar, Qing Xie, Maria Buti, Robert A. de Man, Harry L. A. Janssen
Summary: This study investigated the relationship between HBsAg levels and hepatic fibrosis and cirrhosis in patients with chronic hepatitis B. The results showed that lower HBsAg levels were associated with higher rates of fibrosis and cirrhosis in HBeAg-positive patients, but not in HBeAg-negative patients. Additionally, genotype-specific HBsAg cutoffs could be used to rule out the presence of cirrhosis. These findings are important for the diagnosis and treatment of chronic hepatitis B patients.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Carola Hedberg-Oldfors, Ulrika Lindgren, Kittichate Visuttijai, Daniel Loof, Sara Roos, Christer Thomsen, Anders Oldfors
Summary: Patients with dermatomyositis (DM) have reduced aerobic metabolism and impaired muscle function due to mitochondrial respiratory chain dysfunction. This study found that the deficiency of complexes I and IV is a major cause of the disease, while complex II is unaffected. Depletion of mitochondrial RNA and a decrease in mtDNA copy number in affected muscle regions contribute to the muscle pathology and disturbed aerobic metabolism.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dimitri Loureiro, Issam Tout, Stephanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons-Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valerie Paradis, Abdellah Mansouri, Tarik Asselah
Summary: This study found that hepatitis B virus (HBV) infection can alter liver mitochondria and lead to changes in mitochondrial function and DNA damage associated with cirrhosis and fibrosis. In vitro experiments showed that HBV replication or expression of HBV X protein can induce the production of reactive oxygen species and nitric oxide, as well as mitochondrial DNA damage and impairment of mitochondrial function. These findings suggest that mitochondria may be a new target for drug development to prevent fibrosis progression.
Article
Physics, Multidisciplinary
Luca Lepori, Andrea Trombettoni, Domenico Giuliano, Johannes Kombe, Jorge Yago Malo, Andrew J. Daley, Augusto Smerzi, Maria Luisa Chiofalo
Summary: We discuss the conditions under which multipartite entanglement in mixed quantum states can be characterized using only two-point connected correlation functions, as is the case for pure states. However, these conditions are more severe compared to pure states. We were able to identify some interesting cases, such as when the one-point correlations in each possible decomposition of the density matrix have point-independence, or when the operators in the correlations are (semi-)positive/negative defined.
JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL
(2023)
Article
Clinical Neurology
Felix Kleefeld, Akinori Uruha, Anne Schanzer, Anna Nishimura, Andreas Roos, Udo Schneider, Hans H. Goebel, Markus Schuelke, Katrin Hahn, Corinna Preusse, Werner Stenzel
Summary: This study found similarities in molecular and histopathological characteristics between polymyositis with mitochondrial pathology (PM-Mito) and sporadic inclusion body myositis (IBM), while also identifying distinct differences in immune and cytokine expressions. PM-Mito may be considered an early form of IBM.
Article
Cell Biology
Caterina Vianello, Veronica Cocetta, Daniela Catanzaro, Gerald W. I. I. I. I. Dorn, Angelo De Milito, Flavio Rizzolio, Vincenzo Canzonieri, Erika Cecchin, Rossana Roncato, Giuseppe Toffoli, Vincenzo Quagliariello, Annabella Di Mauro, Simona Losito, Nicola Maurea, Scaffa Cono, Gabriele Sales, Luca Scorrano, Marta Giacomello, Monica Montopoli
Summary: This study found that mitochondrial morphology and autophagy are altered in cisplatin resistant cancer cell lines, and the levels of the mitophagy receptor BNIP3 are elevated. Inhibiting BNIP3-driven mitophagy may be a potential therapeutic strategy to counteract cisplatin resistance.
CELL DEATH & DISEASE
(2022)
Article
Toxicology
Tugce Boran, Aysenur Gunaydin Akyildiz, Ayse Tarbin Jannuzzi, Buket Alpertunga
Summary: Regorafenib (RGF) has shown great success in treating colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma, but it can also induce life-threatening cardiotoxicity such as hypertension and cardiac ischemia/infarction. The molecular mechanism of these adverse effects is not clear, but it may be associated with mitochondrial damage in cardiac cells.
TOXICOLOGY LETTERS
(2021)
Article
Chemistry, Physical
Mujaheed Abubakar, Salanee Kandandapani, Saharuddin B. Mohamed, Adyani Azizah Abd Halim, Saad Tayyab
Summary: The molecular interaction between clevudine and human serum albumin was investigated, revealing the formation of a complex. The static mode of protein fluorescence quenching was involved, supported by hydrophobic interactions, hydrogen bonds, and van der Waals forces. The binding site of clevudine in human serum albumin was identified in subdomain IIA (Site I).
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Neurosciences
Jinmo Kim, Jungmin Lee, Eunho Kim, Joon Ho Choi, Jong-Cheol Rah, Ji-Woong Choi
Summary: This study highlights the importance of aperiodic components as electrophysiological biomarkers in reflecting pathological activities in the basal ganglia of Parkinson's disease. The findings suggest that aperiodic parameters may provide a more sensitive measurement for early diagnosis and serve as a potential feedback parameter for adaptive deep brain stimulation.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Roberta Zerlotin, Marco Fornaro, Mariella Errede, Patrizia Pignataro, Clelia Suriano, Maddalena Ruggieri, Silvia Colucci, Florenzo Iannone, Maria Grano, Graziana Colaianni
Summary: In this cohort study, 41 patients with DM and IMNM were examined. The results showed lower expression of FNDC5 in the muscle biopsies of these patients compared to the control group, while serum irisin levels were higher. The authors hypothesize that increased expression of ADAM10 in the skeletal muscle of DM and IMNM patients may be responsible for the discrepancy between irisin levels and FNDC5 expression. Further research is needed to understand the mechanisms underlying exacerbated FNDC5 cleavage and muscle irisin resistance in these inflammatory myopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Caitlin R. Fong, Rachel L. Kennison, Peggy Fong
Summary: This study focuses on nitrogen concentration-frequencies in Southern California estuaries, revealing that these nutrients subsidies are often characterized as pulse-interpulse. High pulses of nitrogen, potentially driven by seasonal and rare rainfall, were observed. It is suggested that managers should target rainfall events in nutrient sampling protocols and monitor changes in biological indicators following these events to assess the impacts of these inputs. Future research on the timing, frequency, duration, and ecological consequences of nutrient subsidies in estuaries is necessary, especially in integrating pulse events into work on biological indicators.
ESTUARIES AND COASTS
(2021)
Article
Immunology
Xiuping Liang, Yanhong Li, Lu Cheng, Yinlan Wu, Tong Wu, Ji Wen, Deying Huang, Zehui Liao, Chunyu Tan, Yubin Luo, Yi Liu
Summary: This study investigated the alterations in gut microbiota communities in patients with immune-mediated necrotizing myopathy (IMNM) and found a dysbiosis in the gut microbiota of IMNM patients, which was correlated with certain clinical indicators.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ester Sara Di Filippo, Franco Checcaglini, Giorgio Fano-Illic, Stefania Fulle
Summary: In order to respond to changes in the environment and carry out necessary metabolic functions, cells require a functional control center. This review identifies the mitochondrion as such a control center, where messengers like H2O2, Ca2+, and Zn2+ collaborate to activate adaptive response mechanisms. By exchanging information, these messengers generate a holistic response of the cell.
Article
Pharmacology & Pharmacy
Kaori Ishikawa, Satoshi Yamamoto, Satoko Hattori, Naoya Nishimura, Hirokazu Matsumoto, Tsuyoshi Miyakawa, Kazuto Nakada
Summary: This study generated a novel mouse model expressing a dominant-negative form of MFN2 and found that continuous expression of the mutated MFN2 resulted in hyperactivity and cognitive impairments, while transient expression showed different phenotypes. Abnormal mitochondrial dynamics can lead to stress, triggering neuronal degeneration. Normalization of mitochondrial dynamics may prevent neurodegeneration. The mouse model created in this study can serve as a useful tool for investigating neuronal plasticity mechanisms and neurodegeneration.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yeoun Joo Lee, Eun Ha Hwang, Jae Hong Park, Jin-Hong Shin, Boram Kang, Sun-Young Kim
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Sun-Young Kim, Sung-Pa Park
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2016)
Article
Clinical Neurology
Hung Youl Seok, Ha Young Shin, Jong Kuk Kim, Byoung Joon Kim, Jeeyoung Oh, Bum Chun Suh, Sun-Young Kim, Sa-Yoon Kang, Suk-Won Ahn, Jong Seok Bae, Byung-Jo Kim
JOURNAL OF CLINICAL NEUROLOGY
(2017)
Article
Clinical Neurology
Sun-Young Kim, Jin-Hong Shin, Jin-Sung Park, Sa-Yoon Kang, Tai-Seung Nam, Jong Kuk Kim, Ki-Jong Park, So-Young Huh, Ji Seon Oh, Boram Kang, Dae-Seong Kim
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Jin Myoung Seok, Hye-Jin Cho, Suk-Won Ahn, Eun Bin Cho, Min Su Park, In-Soo Joo, Ha Young Shin, Sun-Young Kim, Byung-Jo Kim, Jong Kuk Kim, Joong-Yang Cho, So-Young Huh, Ohyun Kwon, Kwang-Ho Lee, Byoung Joon Kim, Ju-Hong Min
MULTIPLE SCLEROSIS JOURNAL
(2017)
Article
Clinical Neurology
Hyunjin Kim, Young-Min Lim, Joo Yea Jin, Dok Hyun Yoon, Cheolwon Suh, Sun-Young Kim, Jae-Cheol Jo, Kwang-Kuk Kim
Article
Clinical Neurology
Jin Myoung Seok, Hye-Jin Cho, Suk-Won Ahn, Eun Bin Cho, Min Su Park, In-Soo Joo, Ha Young Shin, Sun-Young Kim, Byung-Jo Kim, Jong Kuk Kim, Joong-Yang Cho, So-Young Huh, Ohyun Kwon, Kwang-Ho Lee, Byoung Joon Kim, Ju-Hong Min
MULTIPLE SCLEROSIS JOURNAL
(2017)
Article
Immunology
Eun-Jae Lee, Young-Min Lim, Sun-Young Kim, JooKyung Lee, Hyunjin Kim, Joo Yea Jin, Yeo Jin Oh, Kwang-Kuk Kim
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Article
Clinical Neurology
Jong-Geun Seo, Keun Tae Kim, Hye-Jin Moon, Jin Kuk Do, Sun-Young Kim, Sung-Pa Park
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Clinical Neurology
Sunyoung Kim, Yong-Hyun Lim, Kyunghun Kang, Donghwi Park, Ho-Won Lee, Jin-Sung Park
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Jae-Won Hyun, Hye Lim Lee, Woo Kyo Jeong, Hye Jung Lee, Jong Hwa Shin, Ju-Hong Min, Byoung Joon Kim, Seung Woo Kim, Ha Young Shin, Jeeyoung Oh, Woojun Kim, Hyun-June Shin, Sun-Young Oh, Hyunjin Kim, Young-Min Lim, So-Young Huh, Eun Bin Cho, Tai-Seung Nam, Seung-Han Lee, Sun-Young Kim, Sa-Yoon Kang, Suk Geun Han, Eun Hee Sohn, Seol-Hee Baek, Byung-Jo Kim, Sang-Soo Lee, Jin Myoung Seok, Yoon-Ho Hong, Seong-il Oh, Jong Kuk Kim, Kyong Jin Shin, Ohyun Kwon, Joong-Yang Cho, Jong Seok Bae, So Yeon Kim, Yeseul Kim, Min Young Lee, Su-Hyun Kim, Ho Jin Kim
Summary: In Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), the seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies was about five times lower than that of anti-aquaporin-4 (AQP4) antibodies.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Clinical Neurology
Young Nam Kwon, Mark Woodhall, Jung-Joon Sung, Kwang-Kuk Kim, Young-Min Lim, Hyunjin Kim, Jee-Eun Kim, Seol-Hee Baek, Byung-Jo Kim, Jin-Sung Park, Hung Youl Seok, Dae-Seong Kim, Ohyun Kwon, Kee Hong Park, Eunhee Sohn, Jong Seok Bae, Byung-Nam Yoon, Nam-Hee Kim, Suk-Won Ahn, Kyomin Choi, Jeeyoung Oh, Hyung Jun Park, Kyong Jin Shin, Sanggon Lee, Jinseok Park, Seung Hyun Kim, Jung Im Seok, Dae Woong Bae, Jae Young An, In Soo Joo, Seok-Jin Choi, Tai-Seung Nam, Sunyoung Kim, Ki-Jong Park, Ki-Han Kwon, Patrick Waters, Yoon-Ho Hong
Summary: This study aimed to evaluate the diagnostic accuracy of ELISA for anti-MuSK antibody in AChR antibody-negative generalized MG patients and investigate the clinical contexts for the diagnosis of MuSK MG. The results showed that the positive results of ELISA were mostly consistent with CBA and RIPA. The most common differential diagnosis was motor neuron disease. These findings are of great importance for the diagnosis of MuSK MG in clinical practice.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sunyoung Kim, Jin-Sung Park, Jae-Hyeok Lee, Ha-Young Shin, Hui-Jun Yang, Jin-Hong Shin
Summary: This study reports the clinical characteristics of six Korean CTX patients. The median age of onset was 22.5 years, with a median age at diagnosis of 42 years and an average diagnostic delay of 18.1 years. The most common symptoms observed were tendon xanthoma and spastic paraplegia. Four out of five patients showed latent central conduction dysfunction. All patients carried the same mutation in CYP27A1 (c.1214 G>A [p.R405Q]). These findings highlight the importance of early diagnosis and treatment for CTX patients in Korea.
Article
Medicine, General & Internal
Seung Won Ra, Soyeoun Lim, Hee Jeong Cha, Sunyoung Kim
Summary: In this article, we present a case of late-onset NMO with nonneoplastic, nonsarcoidosis, diffuse interstitial lung lesions, which is the finding of COP.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2022)
Letter
Clinical Neurology
Ji-Yun Park, Jee-Hyun Kwon, Wook-Joo Kim, Sun-Young Kim, Eun-Mi Lee, Hui-Jun Yang, Byeong-Su Park, Kwang-Dong Choi
JOURNAL OF CLINICAL NEUROLOGY
(2019)