Review
Cell Biology
Fangli Zhou, Xiaoli Sun
Summary: The role of cholesterol in HCC and its association with the pathogenesis of NAFLD-related HCC is complex, and conflicting research results suggest that further studies are needed to clarify their relationship.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bao-Jie Du, Rui Chen, Wen-Tao Tao, Hong-Liang Shi, Wen-Jun Bu, Ye Liu, Shuai Ma, Meng-Ya Ni, Fan-Li Kong, Jin-Hua Xiao, Da-Wei Huang
Summary: The discovery of a new nymph with exaggerated leaf-like antennae from the mid-Cretaceous suggests the presence of a sensitive sensory system and magnificent appearance in Hemiptera insects. These exaggerated antennae may play a role in sexual selection and could represent a new camouflage pattern. However, the oversized antennae also come with increased risks from predators.
Article
Oncology
Zixin Wu, Guishuai Lv, Fuxue Xing, Wei Xiang, Yue Ma, Qiyu Feng, Wen Yang, Hongyang Wang
Summary: Copper is a crucial cofactor that plays a dual role in promoting and inhibiting tumor development. Imbalanced copper homeostasis can have detrimental effects on the liver, especially in hepatocellular carcinoma (HCC), a highly aggressive and difficult-to-treat liver cancer. This review discusses the molecular mechanisms of copper in HCC pathogenesis, progression, and potential therapeutics, introducing the concepts of cuproplasia and cuproptosis.
Review
Immunology
Ying-Le Tang, Yan Tao, Lin Zhu, Jia-Lin Shen, Hong Cheng
Summary: In recent years, the study of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome has gained attention due to its role in various tumors. This review focuses on the relationship between NLRP3 and hepatocellular carcinoma (HCC), the predominant form of primary liver cancer. Studies have shown that NLRP3 inflammasome can both inhibit and promote tumor growth in HCC. Furthermore, the potential of NLRP3 as a therapeutic target for cancer therapy is explored by summarizing the effects and mechanisms of different NLRP3 inflammasome-targeting drugs on HCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Huijie Zhao, Yanting Zhang, Xiaodi Fu, Chaoren Chen, Saadullah Khattak, Honggang Wang
Summary: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, and it is also the leading cause of cancer-related death worldwide. Despite numerous studies conducted on HCC, the molecular mechanisms and effective treatment options are not fully understood. Hydrogen sulfide (H2S), previously considered a toxic gas, has been found to have multiple biological functions, but its role and mechanism in HCC remain unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiangyue Xu, Ke Ding, Lan Mu, Jiangsheng Huang, Fei Ye, Yu Peng, Can Guo, Chutong Ren
Summary: This study found that Hashimoto's thyroiditis (HT) is associated with thyroid carcinoma (TC), where HT is a risk factor for TC and papillary thyroid carcinoma (PTC), but acts as a protective factor against PTC progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Lu Zhang, Junyu Xiang, Fang Zhang, Limei Liu, Chongling Hu
Summary: This review discusses the use of mesenchymal stem cells (MSCs) in cancer immunotherapy and their immunomodulatory mechanisms in cancers, which are the primary factors influencing the different outcomes of MSCs therapies for tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zi-Jun Yan, Lei Chen, Hong-Yang Wang
Summary: Given the liver's regenerative capacity, researchers have focused on liver progenitor cells (LPCs) and liver cancer stem cells (LCSCs). LPCs can differentiate into hepatocytes and cholangiocytes, but the mechanisms underlying cell conversion and their roles in liver homeostasis and tumorigenesis are unclear. This review discusses the complex conversions involving LPCs and LCSCs, emphasizing their dual roles in liver regeneration and tumor formation. Understanding the sources and transformations of LPCs is crucial for harnessing their regenerative potential in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Agronomy
Bruno F. Flausino, Carolina F. M. Machado, Jose Hiago C. Silva, Claudio P. Ronchi, Marco Aurelio G. Pimentel, Lessando M. Gontijo
Summary: Intercropping maize with brachiaria can promote the abundance of pests and natural enemies in the maize agroecosystem. The intercropping treatment resulted in higher defoliation caused by caterpillars and increased populations of Dalbulus maidis, but reduced the populations of aphids and Diabrotica speciosa. Natural enemies were generally favored by intercropping. Maize productivity, however, was reduced in the intercropping treatment. The results and recommendations should be considered in the context of time and specific arthropod species.
PEST MANAGEMENT SCIENCE
(2022)
Review
Medicine, Research & Experimental
Xin-qiu Song, Qian Li, Jing Zhang
Summary: DLG5 is a scaffold molecule for signal transduction complexes, responsible for assembling receptors and adapters. It stabilizes adhesion and tight bonding complexes and is involved in maintaining epithelial polarity. It has been linked to the onset and development of several diseases, impacting cancer progression through interactions with various signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Adenuga
Summary: Neutrophils play an important role in malaria, both in the defense against the malaria parasite and in the pathogenesis of the disease. However, malaria parasites inhibit the antimicrobial function of neutrophils, which may make malaria patients more susceptible to bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Jannette M. Dufour
Summary: Sertoli cells serve a dual role in protecting germ cells from autoimmune destruction and activating immune responses against infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Fatemeh Tajik, Fatemeh Alian, Mohammad Yousefi, Ali Azadfallah, Aref Hoseini, Forogh Mohammadi, Maryam Karimi-Dehkordi, Shahin Alizadeh-Fanalou
Summary: miR-372 is a non-coding, single-stranded, endogenous RNA that regulates various biological processes by binding to 3'-UTR mRNAs and controlling gene expression at the post-transcriptional level. It has abnormal expression in many human malignancies, suggesting its role in carcinogenesis, where it can function both as an oncogene and a tumor suppressor.
Review
Oncology
Madison Ballman, Chen Zhao, Meredith J. McAdams, Arun Rajan
Summary: Immunotherapy has shown promise in treating various types of cancer, but the unique biology of thymic epithelial tumors (TETs) presents challenges for its use. This paper reviews the biology of TETs and discusses the potential benefits and risks of immunotherapy. It also explores the use of biomarkers to improve the safety and tolerability of immunotherapy for TETs.
Review
Pharmacology & Pharmacy
Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
