Article
Endocrinology & Metabolism
Matteo Franchi, Joel Gunnarsson, Emilio Gonzales-Parra, Anibal Ferreira, Oskar Stroem, Giovanni Corrao
Summary: This study compared the efficacy of ERC and PCT in treating non-dialysis CKD patients and found no significant differences in reducing PTH levels. PCT was associated with a significant increase in serum calcium compared to ERC. Therefore, ERC is an effective and well-tolerated treatment option for managing SHPT in patients with ND-CKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Matteo Bargagli, Maria Arena, Alessandro Naticchia, Giovanni Gambaro, Sandro Mazzaferro, Daniel Fuster, Pietro Manuel Ferraro
Summary: Diet plays a crucial role in the management and prevention of secondary hyperparathyroidism, with evidence supporting reduced phosphate intake, avoiding low calcium and vitamin D consumption, and considering individualized dietary modifications based on existing risk factors. Further studies are needed to assess the long-term outcomes of a balanced diet in at-risk patients.
Article
Medicine, General & Internal
Chen-Hsen Lee, Jui-Yu Chen, Po-Chung Kuo, Wei-Ting Chen
Summary: Calcimimetics is a new drug used to lower serum levels of parathyroid hormone, calcium, and phosphate in long-term dialysis patients with hyperparathyroidism. It can improve cardiac function by reducing PTH levels, but does not cure renal HPT. Heart failure is not a contraindication for surgery, and surgery should be performed before irreversible organ damage occurs.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Transplantation
Aarti Mathur, JiYoon B. Ahn, Whitney Sutton, Nadia M. Chu, Alden L. Gross, Dorry L. Segev, Mara McAdams-DeMarco
Summary: Receiving treatment for secondary hyperparathyroidism (SHPT) was associated with a lower risk of incident dementia among older patients with end-stage renal disease (ESRD). The beneficial effect of SHPT treatment differed by sex and race, with females and those of Asian or Black race experiencing the greatest reduction in dementia risk.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Gabrielle K. Steinl, Jennifer H. Kuo
Summary: Secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease, and those who fail medical treatment should be referred to a parathyroid surgeon. Surgical indications, preoperative planning, intraoperative strategies, and postoperative management are crucial.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Nutrition & Dietetics
Jacek Rysz, Beata Franczyk, Robert Rokicki, Anna Gluba-Brzozka
Summary: Chronic kidney disease (CKD) can lead to disturbances in bone metabolism and increase the risk of fractures. Nutritional treatment aims to prevent disease progression, avoid protein-energy wasting, delay mineral/bone disturbances, and postpone the need for dialysis.
Article
Endocrinology & Metabolism
Yosuke Nakagawa, Hirotaka Komaba, Naoto Hamano, Hisae Tanaka, Takehiko Wada, Hiroaki Ishida, Michio Nakamura, Hiroo Takahashi, Yuichiro Takahashi, Toru Hyodo, Miho Hida, Takao Suga, Takatoshi Kakuta, Masafumi Fukagawa
Summary: Elevated levels of sclerostin in hemodialysis patients are associated with increased bone density, decreased PTH levels, and decreased levels of bone turnover markers. However, the effects of PTH on bone turnover markers appear to be primarily direct rather than mediated by sclerostin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
M. N. Gynnild, R. Aakery, O. Spigset, T. Askim, M. K. Beyer, H. Ihle-Hansen, R. Munthe-Kaas, A. B. Knapskog, S. Lydersen, H. Nss, T. G. Rsstad, Y. M. Seljeseth, P. Thingstad, I Saltvedt, H. Ellekjaer
Summary: The study reported medication adherence and risk factor control following ischemic stroke. While medication persistence and adherence were high, risk factor control was suboptimal, indicating the need for a better understanding of the complex clinical setting to optimize secondary prevention strategies.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Urology & Nephrology
Hanne Skou Jorgensen, Geert Behets, Bert Bammens, Kathleen Claes, Bjorn Meijers, Maarten Naesens, Ben Sprangers, Dirk R. J. Kuypers, Etienne Cavalier, Patrick Dhaese, Pieter Evenepoel
Summary: This study aimed to characterize the evolution of bone disease in the first year after kidney transplantation. The results showed that changes in bone turnover, mineralization, and volume were related to steroid exposure and ongoing disturbances of mineral metabolism. Optimal control of mineral metabolism may be crucial for improving bone quality in kidney transplant recipients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Elena Chertok Shacham, Nimra Maman, Tatyana Lazareva, Refaat Masalha, Lila Mahagna, Gala Sela, Avraham Ishay
Summary: The study aims to compare the FGF-23 levels in patients with PHPT, NPHPT, and normal calcium and PTH levels. The findings suggest that NPHPT may be an early stage of PHPT and further research is needed to determine the role of FGF-23 in NPHPT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Li-Xi Zhang, Ben Zhang, Xu-Yao Liu, Zi-Ming Wang, Peng Qi, Tong-Yue Zhang, Qiang Zhang
Summary: Secondary and tertiary hyperparathyroidism are common and complicated endocrine diseases, and their hyperactivity disorder can cause structural alterations in multiple organs and systems. The current treatment for these diseases remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Mengjing Wang, Donghai Wen, Weichen Zhang, Weisheng Chen, Ye Tao, Chunyan Fan, Bihong Huang, Jing Chen, Hongying Wang, Minmin Zhang
Summary: This study observed the effects of different treatment modalities on blood pressure in MHD patients with secondary hyperparathyroidism. The results showed that parathyroidectomy significantly reduced blood pressure, while cinacalcet treatment significantly increased diastolic blood pressure.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Cell Biology
Francesca Marini, Francesca Giusti, Federica Cioppi, Davide Maraghelli, Tiziana Cavalli, Francesco Tonelli, Maria Luisa Brandi
Summary: This study evaluated the effect of parathyroidectomy on bone metabolism and bone mass in patients with MEN1 PHPT and sPHPT, confirming the efficacy of surgery in restoring normal hormone levels and improving bone mass. In MEN1 patients, surgery is strongly recommended to prevent early-onset bone mass loss in the presence of increased PTH and hypercalcemia.
Article
Urology & Nephrology
Alia Hassan, Yael E. E. Pollak, Rachel Kilav-Levin, Justin Silver, Nir London, Morris Nechama, Iddo Z. Z. Ben-Dov, Tally Naveh-Many
Summary: This study reveals that kidney failure leads to the loss of Pin1 activity in the parathyroid glands, resulting in increased production of PTH. Pin1 and KSRP phosphorylation, as well as the Pin1-KSRP-PTH mRNA axis, play important roles in secondary hyperparathyroidism.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Virginie Kreutzinger, Torsten Diekhoff, Lutz Liefeldt, Denis Poddubnyy, Kay Geert A. Hermann, Katharina Ziegeler
Summary: The study found that erosions in sacroiliac joints were significantly more prevalent in asymptomatic sHPT patients, mainly in the ventral and middle iliac portions. However, there were no significant differences in osteophytes or joint space alterations between the two groups, warranting further investigation into the clinical significance of these findings.
SCIENTIFIC REPORTS
(2021)