Article
Biochemistry & Molecular Biology
Grant Cave, Rachel Kee, Martyn Harvey, Zimei Wu
Summary: This study explores the possibility of extracting protein bound amitriptyline using liposomes added to peritoneal dialysate. The results indicate that more amitriptyline can be extracted when liposomes are present in the dialysate, both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Julian Yaxley, Tahira Scott
Summary: This article provides a comprehensive overview of the application of extracorporeal therapy in poisoned patients, emphasizing the importance of understanding toxicokinetics and elimination techniques.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Review
Hematology
Jianting Ke, Yuting Wei, Binhuan Chen
Summary: The rescue of acute poisoning is a race against time, and it is crucial to remove toxic substances promptly. Hemoperfusion is a highly effective blood purification technique that can directly eliminate toxic substances, making it a valuable treatment option for acute poisoning.
BLOOD PURIFICATION
(2023)
Article
Emergency Medicine
Daisuke Kobashi, Yoshito Kamijo, Tomoki Hanazawa, Tomohiro Yoshizawa, Mitsunobu Nakamura
Summary: In recent years, there has been an increase in severe or fatal cases of caffeine poisoning in Japan due to the consumption of large doses of caffeinated tablets. This case report describes a 23-year-old male who ingested a high-dose of caffeine tablets in a suicide attempt. The patient showed symptoms such as vomiting and tremors, and his condition improved significantly after receiving high-flow continuous hemodialysis treatment.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Maral Ramezani, Babak Mostafazadeh, Mitra Rahimi, Peyman Erfan Talab Evini, Shahin Shadnia
Summary: This case report describes an improved approach to treating colchicine poisoning using hemoperfusion and hemodialysis.
CLINICAL CASE REPORTS
(2022)
Article
Medicine, General & Internal
Zixin Wen, Xiuqin Li, Yanxia Zhang, Jie Shi, Juan Zhang, Yingying Zheng, Ying Lin, Tianzi Jian, Xiangdong Jian, Baotian Kan, Xiaorong Luan
Summary: This study compared three commonly used risk assessment models for deep vein thrombosis in patients with acute toxic hemoperfusion. The results showed that none of the three models were suitable for these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Ting-Ting Wang, Bing Wen, Xiu-Nan Yu, Zhang-Ge Ji, Yi-Yong Sun, Ying Li, Shou-Lian Zhu, Yong-Liang Cao, Mei Wang, Xiang-Dong Jian, Tan Wang
Summary: This study evaluated the efficacy of treatments and outcomes of five patients with early diagnosis of acute thallium poisoning. Patients presented with symptoms of acute thallium poisoning, including hyperalgesia and abdominal pain, along with accompanying symptoms such as hepatic damage and alopecia. With early diagnosis and intervention, four patients had a good prognosis and no permanent sequelae.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Toxicology
De-Hui Zeng, Xia-Hua Chen, Yun Li, Xiang-Yang Zhu, Ba-Li Wang, Xu-Guo Ma, Ya-Li Cao
Summary: This paper presents three cases of deliberate diquat self-poisoning, with two cases undergoing kidney biopsy showing acute tubular necrosis. The main treatments given included gastric lavage, catharsis, early hemoperfusion combined with continuous kidney replacement therapy or hemodialysis, administration of glucocorticoids, and antioxidant therapy. All patients survived.
CLINICAL TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Minghao Zhang, Wei Zhang, Shunzhong Zhao, Xiaoxi Tian, Guoqiang Fu, Boliang Wang
Summary: Combined hemoperfusion and hemofiltration is a very safe and effective treatment protocol for acute severe organophosphorus pesticide poisoning (ASOPP), resulting in decreased mortality and reduced total atropine dosing, duration of mechanical ventilation, cholinesterase recovery time, and length of stay.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2022)
Article
Hematology
Adrian Dominik, Jan Stange
Summary: Compared to MARS, CytoSorb hemoperfusion leads to an initially fast removal of cytokines, TNF-alpha and IL-6, as well as reduction of albumin-bound toxins such as indirect bilirubin and bile acids in our model. The initial removal is also associated with removal of albumin.
BLOOD PURIFICATION
(2021)
Article
Oncology
Hao Guo, Yaying Yuan, Yanan Ma, Jianling Shi, Hua Gu
Summary: This study aimed to investigate the effect of early, repeated hemoperfusion in conjunction with hemodialysis on the health status, blood-gas indices, and prognosis of patients with paraquat poisoning. The results showed that early, repeated hemoperfusion coupled with hemodialysis significantly improved the blood-gas indices and liver and kidney function in patients with paraquat poisoning, while also extending their short-term survival.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Wenbin Ren, Yongqiang Chen, Yuantao Wang, Chunbao Wang, Mimi Tian, Xiaoxu Gu, Weiguo Lv
Summary: The study demonstrated that PFD is efficacious in treating patients with pulmonary fibrosis caused by acute paraquat poisoning. PFD can improve pulmonary function and arterial blood gas status, with high safety.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Urology & Nephrology
Marc Ghannoum, Darren M. Roberts
Summary: Poisoning can cause severe toxicity, including death, and nephrologists may be involved in cases that cause kidney disease. The overall approach to poisoned patients includes initial resuscitation, risk assessment, and administration of interventions such as decontamination and antidotes. Decision making for the use of extracorporeal treatments in poisoned patients is guided by clinical indications and characteristics of the poison.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Hematology
Zhuan'e Yao, Pengbo Wang, Qinjuan Fu, Qiong Song, Wei Wang, Ai Liu, Peng Zhang
Summary: The study evaluated the efficacy and safety of plasma exchange combined with hemoperfusion in treating organophosphorus poisoning. The meta-analysis of 14 randomized controlled trials showed that the combination treatment group had higher effectiveness, lower fatality rate, shortened coma time, recovery time of cholinesterase activity, and hospital stay, as well as reduced inflammation markers and complications compared to the control group.
BLOOD PURIFICATION
(2023)
Article
Medicine, Research & Experimental
Cece Sun, Tianzi Jian, Yaqian Li, Siqi Cui, Longke Shi, Guangcai Yu, Baotian Kan, Xiangdong Jian
Summary: This article reports two suicidal cases of acute methyl ethyl ketone peroxide (MEKP) poisoning. Patients experienced oral and esophageal mucosal erosion and multi-organ damage after oral administration of MEKP. Regular follow-up is necessary to observe the long-term effects of acute oral MEKP poisoning on digestive tract corrosion and stenosis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Urology & Nephrology
Matthew Murphy, Ann Ding, Justin Berk, Josiah Rich, George Bayliss
Summary: CKD affects 15% of US adults and disproportionately impacts certain populations, including racial and ethnic minorities and individuals from disadvantaged socioeconomic backgrounds. Incarceration presents an opportunity to connect marginalized individuals to CKD care.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lirong Liu, Feng Liu, Yingjie Guan, Jianan Zou, Chunyun Zhang, Chongxiang Xiong, Ting C. Zhao, George Bayliss, Xiaogang Li, Shougang Zhuang
Summary: The lysine methyltransferase SMYD2 is highly expressed in renal fibrosis and plays a critical role in converting epithelial cells to a profibrotic phenotype, activating renal interstitial fibroblasts, and promoting renal fibrogenesis. Inhibition of SMYD2 with AZ505 could potentially be a target for treating chronic fibrosis in kidney disease.
Article
Transplantation
Lorine Haeuser, Maya Marchese, Eugene B. Cone, Joachim Noldus, George Bayliss, Kerry Laing Kilbridge, Quoc-Dien Trinh
Summary: By utilizing a pharmacovigilance approach, increased odds of nephritis were found with ICI therapy. Pembrolizumab, nivolumab, and the combination of ipilimumab + nivolumab showed the highest odds of nephritis among the examined ICI drugs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Ethics
Sanjay Kulkarni, Andrew Flescher, Mahwish Ahmad, George Bayliss, David Bearl, Lynsey Biondi, Earnest Davis, Roshan George, Elisa Gordon, Tania Lyons, Aaron Wightman, Keren Ladin
Summary: During the COVID-19 pandemic, the transplant community has been challenged to balance the risks of performing living donor transplants with the harms of suspending these procedures. This manuscript explores prioritization of living donation and provides recommendations for the transplant community on how to approach living donation under contingency standards of care.
JOURNAL OF MEDICAL ETHICS
(2023)
Editorial Material
Medical Laboratory Technology
John G. Toffaletti, Cyril O. I. I. I. I. I. I. Burke, George Bayliss, Matthew Lynch
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Editorial Material
Urology & Nephrology
George Bayliss
Summary: With recent surgeries proving the concept of pig organs being transplanted into humans, the ethical question has been settled. However, before pig kidney xenotransplantation becomes an option to solve the organ shortage, other issues need to be addressed and resolved.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
John A. D'Elia, George P. Bayliss, Larry A. Weinrauch
Summary: Cardiorenal syndrome, the end-stage of heart failure and kidney disease combination, is a serious condition that is influenced by factors such as diabetes, hyperlipidemia, obesity, hypertension, and renal impairment. Current therapy focuses on improving hemodynamic factors destructive to both the heart and kidney, but there have been limited advances in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chao Yu, Tingting Li, Jialu Li, Binbin Cui, Na Liu, George Bayliss, Shougang Zhuang
Summary: In this study, the role and mechanism of PRC2 in acute kidney injury (AKI) were investigated. The results showed that inhibition of PRC2 activity by targeting EED could protect against cisplatin-induced AKI by promoting the survival and proliferation of renal tubular cells and inhibiting inflammatory response.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
George Bayliss
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jianan Zou, Chao Yu, Chunyun Zhang, Yingjie Guan, Yunhe Zhang, Evelyn Tolbert, Wei Zhang, Ting Zhao, George Bayliss, Xiaogang Li, Zhibin Ye, Shougang Zhuang
Summary: Inhibition of the MLL1-menin interaction attenuates renal fibrosis by inhibiting partial EMT and renal fibroblast activation.
Article
Transplantation
Fatima Warsame, Nadia M. Chu, Jingyao Hong, Aarti Mathur, Deidra C. Crews, George Bayliss, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Long sleep duration is associated with worse cognitive function only among persons with chronic kidney disease (CKD), specifically global cognition, delayed recall, and verbal fluency. Among participants without CKD, sleep was not associated with any measures of cognitive function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Urology & Nephrology
Eli Y. Adashi, George Bayliss
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Meeting Abstract
Surgery
K. Mecadon, A. Hardesty, K. Vieira, R. Rogers, B. Merhi, J. Osband, G. Bayliss, R. Gohh, P. Morrissey, D. Farmakiotis
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Meeting Abstract
Urology & Nephrology
Lorine Haeuser, Maya Marchese, Eugene B. Cone, Joachim Noldus, George Bayliss, Kerry Laing Kilbridge, Quoc-Dien Trinh
JOURNAL OF UROLOGY
(2021)
Review
Physiology
Jianni Huang, George Bayliss, Shougang Zhuang
Summary: This article discusses the advantages of using pigs as a model for medical research, including their similar physiological patterns to humans and their role in narrowing the gap between clinical and preclinical studies of acute kidney injury (AKI). It compares the pros and cons of large versus small animal models and provides an overview of the development and application of porcine AKI models induced by clinically relevant insults.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
