Article
Critical Care Medicine
Nicole S. Benzoni, Kyle A. Carey, Alice F. Bewley, Jeff Klaus, Brian M. Fuller, Dana P. Edelson, Matthew M. Churpek, Sivasubramanium V. Bhavani, Patrick G. Lyons
Summary: In this study, temperature trajectory modeling identified distinct clinical subphenotypes among oncology patients with neutropenia and suspected infection, and these subphenotypes were independently associated with important outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hung Chang, Ming-Chung Kuo, Tzung-Chih Tang, Tung-Liang Lin, Jin-Hou Wu
Summary: This study investigated the incidence, clinical features, and outcomes of HSC among 292 AML patients. The results showed that HSC tends to occur more frequently during induction or reinduction chemotherapy, with prolonged neutropenia being the only prognostic factor. Lungs are commonly involved, and the clinical relevance of pleural effusion warrants further research.
BIOMEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Awol Mekonnen Ali, Haileyesus Adam, Daniel Hailu, Ephrem Engidawork, Rawleigh Howe, Teferra Abula, Marieke J. H. Coenen
Summary: This study evaluated the effect of genetic variants in ITPA, TPMT, NUDT15, XDH, and ABCB1 on 6-MP related toxicities. The results showed that genetic variants in XDH and ITPA were associated with grade 4 neutropenia and neutropenic fever, respectively.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Li-xia Zhu, Rong-rong Chen, Lu-lu Wang, Jia-nai Sun, De Zhou, Li Li, Jie-jing Qian, Yi Zhang, Hong-yan Tong, Wen-juan Yu, Hai-tao Meng, Wen-yuan Mai, Wan-zhuo Xie, Jie Jin, Xiu-jin Ye, Hong-hu Zhu
Summary: The study aimed to investigate the incidence, sites, main pathogens, and risk factors for infectious complications in adult acute myeloid leukemia (AML) patients receiving venetoclax combined with decitabine or azacitidine. The results showed that compared to conventional chemotherapy, venetoclax combined with decitabine or azacitidine significantly reduced the incidence of infectious complications. High leukemia burden and fever were identified as independent risk factors for infections.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Ostafin, Olga Ciepiela, Michal Pruchniak, Malgorzata Wachowska, Edyta Ulinska, Piotr Mrowka, Eliza Glodkowska-Mrowka, Urszula Demkow
Summary: Patients with acute leukemia exhibit significantly impaired release of NETs by neutrophils during both the course of the disease and treatment, with full restoration of neutrophil function achieved only after successful completion of treatment. This impairment may be attributed to disease- and treatment-related factors, contributing to the deficient innate immune response and secondary immunodeficiency observed in this population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Franziska Modemann, Steffen Haerterich, Julian Schulze zur Wiesch, Holger Rohde, Nick Benjamin Lindeman, Carsten Bokemeyer, Walter Fiedler, Susanne Ghandili
Summary: Tigecycline treatment is more effective in combating infections in leukemia patients compared to standard treatment, resulting in lower rates of sepsis and infection-associated mortality.
Article
Infectious Diseases
Agathe Metais, Jose Miguel Torregrosa Diaz, Maria Pilar Gallego Hernanz, Maxime Pichon, Deborah Desmier, France Roblot, Blandine Rammaert
Summary: This study compared the efficacy of short versus prolonged antibiotic treatment for bloodstream infection (BSI) in acute myeloid leukemia (AML) patients. The findings suggest that short-term antibiotic treatment is as effective as prolonged treatment, with very few relapses within 30 days of discontinuation.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Anitha Marllyin Mairuhu, Mia Ratwita Andarsini, Retno Asih Setyoningrum, Andi Cahyadi, Maria Christina Shanty Larasati, I. Dewa Gede Ugrasena, Bambang Permono, Satrio Budiman
Summary: After studying children with Acute Lymphoblastic Leukemia on chemotherapy, it was found that risk stratification, chemotherapy phase, and neutropenia significantly affect the incidence of Hospital-Acquired Pneumonia. Other factors such as age, gender, nutritional status, length of stay, anemia, and thrombocytopenia were not proven to be risk factors.
Article
Biochemistry & Molecular Biology
Karolina Bukowska-Strakova, Joanna Wlodek, Ewelina Pitera, Magdalena Kozakowska, Anna Konturek-Ciesla, Maciej Ciesla, Monika Gonka, Witold Nowak, Aleksandra Wieczorek, Katarzyna Pawinska-Wasikowska, Alicja Jozkowicz, Maciej Siedlar
Summary: While survival rates for childhood acute lymphoblastic leukemia (ALL) have improved over recent decades, the overexpression of heme oxygenase-1 (HO-1) and specific polymorphisms in the HO-1 gene have been linked to chemoresistance and treatment failure in ALL patients. Targeting HO-1 may be a potential strategy to overcome treatment failure in ALL patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Nora J. Reibel, Christof Dame, Christoph Buehrer, Tobias Muehlbacher
Summary: IUGR-ELGANs have elevated nucleated red blood cells and lower neutrophil and platelet counts at birth. They receive more transfusions and antibiotics during the first week of life and have higher rates of infections, severe bronchopulmonary dysplasia or death, and mortality. The high rate of transfusions in these infants requires further investigation.
FRONTIERS IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Soo Jin Na, Dong Kyu Oh, Sunghoon Park, Yeon Joo Lee, Sang-Bum Hong, Mi-Hyun Park, Ryoung-Eun Ko, Chae-Man Lim, Kyeongman Jeon
Summary: Neutropenic sepsis is associated with distinct clinical characteristics and outcomes compared to non-neutropenic sepsis. Patients with neutropenia have higher-grade organ dysfunction at the time of sepsis diagnosis and a higher mortality rate.
Article
Oncology
Julia E. E. Szymczak, Kelly D. D. Getz, Rachel Madding, Sydney Shuster, Catherine Aftandilian, Staci D. D. Arnold, Anderson B. B. Collier, Maria M. M. Gramatges, Meret Henry, Nobuko Hijiya, Amir Mian, Elizabeth Raetz, Brian T. T. Fisher, Richard Aplenc
Summary: This study aims to investigate the impact of inpatient management strategies on children with AML and their parents during chemotherapy. The results showed that the majority of respondents in both inpatient and outpatient groups expressed satisfaction with the discharge management strategy, which was associated with safety and psychosocial concerns.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Osman Sutcuoglu, Orhun Akdogan, Bediz Kurt Inci, Fatih Gurler, Nuriye ozdemir, Ozan Yazici
Summary: The study aimed to evaluate the impact of uric acid (UA) on 30-day mortality in patients with febrile neutropenia (FEN). Results showed that combining serum UA levels with MASCC risk score could effectively predict 30-day mortality in FEN patients, with a significant increase in mortality rate in patients with high UA levels and MASCC risk scores.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Critical Care Medicine
Patrick G. Lyons, Colleen A. Mcevoy, Brandon Hayes-Lattin
Summary: The care and outcomes of critically ill cancer patients have improved over the past decade. This review focuses on recent updates in sepsis and acute respiratory failure among these patients, with an emphasis on opportunities for further improvement through phenotyping, predictive analytics, and improved outcome measures. Recent research has shown variation in outcomes for oncologic sepsis based on the type of cancer and sepsis definition used. Uncertainty remains regarding the value of diagnostic bronchoscopy and the optimal respiratory support strategy in acute respiratory failure in oncology patients. Improved outcomes in oncologic critical care require attention to the heterogeneity of cancer diagnoses, timely recognition and management of critical illness, and defining appropriate ICU outcomes.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Pharmacology & Pharmacy
Robert Crawford, Nicholson B. Perkins, Diana A. Hobbs, Athena L. Hobbs
Summary: The study found that for febrile neutropenia, extended infusions (EI) of cefepime resulted in faster defervescence and shorter duration of therapy compared to standard infusions (SI). There were no significant differences in other secondary outcomes between the two groups.