Article
Biochemistry & Molecular Biology
Michal Mielnik, Aneta Szudy-Szczyrek, Iwona Homa-Mlak, Radoslaw Mlak, Martyna Podgajna-Mielnik, Aneta Goracy, Teresa Malecka-Massalska, Marek Hus
Summary: This study assessed the correlation between pretreatment serum concentrations of IL-6, IL-8, MCP-1, and VEGF and the clinical outcomes of MM patients. Results showed that IL-8 was significantly correlated with age, staging, performance status, anemia, kidney disease, and VEGF. Chemotherapy responders had lower IL-8, IL-6, and VEGF concentrations compared to non-responders. High levels of IL-6 were associated with a higher risk of disease progression and reduced overall survival.
Article
Biochemistry & Molecular Biology
Aurelia Lamanuzzi, Ilaria Saltarella, Antonia Reale, Assunta Melaccio, Antonio Giovanni Solimando, Concetta Altamura, Grazia Tamma, Clelia Tiziana Storlazzi, Doron Tolomeo, Vanessa Desantis, Maria Addolorata Mariggio, Jean-Francois Desaphy, Andrew Spencer, Angelo Vacca, Benedetta Apollonio, Maria Antonia Frassanito
Summary: Extracellular vesicles (EVs) derived from fibroblasts play an important role in promoting angiogenesis in the bone marrow of multiple myeloma patients. The cargo of these EVs contains angiogenic cytokines that mediate this process. The uptake-independent and uptake-dependent mechanisms of FBEVs contribute to different stages of angiogenesis.
Review
Biochemistry & Molecular Biology
Dominika Bebnowska, Rafal Hrynkiewicz, Ewelina Grywalska, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Iwona Smarz-Widelska, Stanislaw Gozdz, Jacek Rolinski, Paulina Niedzwiedzka-Rystwej
Summary: The article discusses the prognostic value of immune system components in patients with multiple myeloma to aid in the development of new diagnostic and therapeutic directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Alessandro Allegra, Francesca Paladin, Fabrizio Calapai, Caterina Musolino, Sebastiano Gangemi
Summary: This study examines the role of molecules such as high-mobility group box-1, heat shock proteins, and S100 proteins in the induction of neoangiogenesis in multiple myeloma, highlighting their significance in disease progression. The modulation of the host immune system and inhibition of neoangiogenesis may serve as potential therapeutic targets for MM treatment, aiming to improve survival outcomes and reduce the risk of relapsed/refractory disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Danfeng Zhang, Jingcao Huang, Fangfang Wang, Hong Ding, Yushan Cui, Yan Yang, Juan Xu, Hongmei Luo, Yuhan Gao, Ling Pan, Yu Wu, Yuping Gong, Liping Xie, Zhigang Liu, Ying Qu, Li Zhang, Weiping Liu, Wenyan Zhang, Sha Zhao, Qing Yi, Ting Niu, Yuhuan Zheng
Summary: Multiple myeloma is a malignancy characterized by plasma cell accumulation in the bone marrow. Within the tumor microenvironment, macrophages in multiple myeloma exhibit pro-myeloma functions, which are modulated by the polycomb-group protein BMI1. Knockout of BMI1 in MM-associated macrophages leads to reduced proliferation, decreased expression of angiogenic factors, and loss of protection against chemotherapy-induced cell death, ultimately negating the pro-myeloma effects of these cells.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Ilaria Saltarella, Concetta Altamura, Carmen Campanale, Paola Laghetti, Angelo Vacca, Maria Antonia Frassanito, Jean-Francois Desaphy
Summary: Angiogenesis is a critical factor in multiple myeloma, affecting patients' prognosis, survival, and drug resistance. Various anti-angiogenic drugs targeting angiogenic cytokines and their receptors have been developed, along with standard antimyeloma drugs that also exhibit anti-angiogenic effects. This review examines the pharmacological profile and in vitro and in vivo anti-angiogenic effects of these therapies. Although direct targeting of angiogenic cytokines/receptors has shown limited efficacy, there is a need for a deeper understanding of the bone marrow angiogenic niche to develop novel multi-targeting anti-angiogenic therapies.
Article
Pathology
Aurelia Lamanuzzi, Ilaria Saltarella, Maria A. Frassanito, Domenico Ribatti, Assunta Melaccio, Vanessa Desantis, Antonio G. Solimando, Roberto Ria, Angelo Vacca
Summary: The study revealed that thrombopoietin (TPO) in bone marrow plays a significant role in supporting angiogenesis and disease progression in multiple myeloma (MM). It suggests that TPO may serve as a new angiogenic and prognostic factor in MM patients.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Review
Hematology
Eline Menu, Karin Vanderkerken
Summary: This review summarizes the role of exosomes in multiple myeloma (MM), including their involvement in osteolysis, angiogenesis, immune suppression, and drug resistance. Targeting exosome secretion could potentially block these processes. The review also discusses current treatment strategies to counter these processes and explores how exosomes can be harnessed to deliver toxic payloads. Additionally, the review provides an overview of clinical studies investigating exosome cargo as potential MM biomarkers in liquid biopsies.
Article
Oncology
Roberto Ronca, Sara Taranto, Michela Corsini, Chiara Tobia, Cosetta Ravelli, Sara Rezzola, Mirella Belleri, Floriana De Cillis, Annamaria Cattaneo, Marco Presta, Arianna Giacomini
Summary: This study demonstrates the anti-angiogenic role of PTX3 produced by multiple myeloma cells, showing that induced expression of PTX3 can impede MM neovascularization, prevent the formation of a proficient BM vascular niche, and ultimately reduce tumor growth and dissemination. PTX3 overexpression leads to a significant reduction in tumor burden in both subcutaneously grafted and systemic MM models, paving the way for potential anti-angiogenic strategies in MM treatment.
Review
Medicine, General & Internal
Niels W. C. J. van de Donk, Charlotte Pawlyn, Kwee L. Yong
Summary: Multiple myeloma is the second most common haematological malignancy in high-income countries. Current treatment strategies have extended patient survival, but the majority will ultimately die from the disease. Diagnostics and risk stratification are crucial for prognosis and treatment strategies.
Article
Immunology
Qianwen Cheng, Fei Zhao, Bo Zhang, Yuyang Zhang, Li Cai, Bing Qiao, Yu Hu, Chunyan Sun
Summary: This study aimed to explore the relationship between pretreatment cytokine status and overall survival in newly diagnosed multiple myeloma (NDMM) patients, and established a prognostic nomogram incorporating cytokines. Using multivariate Cox analysis, three key variables (lactate dehydrogenase, MIP-1 alpha, and creatinine) were included in the nomogram. The nomogram showed superior predictive power for overall survival compared to existing staging systems, accurately predicting 1-year, 2-year, and 3-year survival rates for NDMM patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Melania Carlisi, Salvatrice Mancuso, Rosalia Lo Presti, Sergio Siragusa, Gregorio Caimi
Summary: Multiple myeloma is an incurable hematological malignancy that is often associated with cardiovascular complications, including high output heart failure. Understanding the pathogenetic mechanisms of this condition is crucial for optimal patient management.
Article
Multidisciplinary Sciences
Miaomiao Sun, Xiaoqian Wang, Yuwei Shou, Chao Chen, Chenbo Yang, Yinghao LIang, Yichen Hong, Jiao Shu, Kuisheng Chen
Summary: Multiple myeloma (MM) is the second most common hematological malignancy, and angiogenesis determines its progression. Research on the relationship between tumor angiogenesis and miR-21 is rare. Our study found that miR-21 was abundant in cancer-associated fibroblasts (CAFs)-derived exosomes and could enter multiple myeloma endothelial cells (MMECs), regulating angiogenesis in MM.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Manya Yu, Jie Yu, Yanyu Zhang, Xiaoqi Sun, Runjie Sun, Mengting Xia, Sumei Li, Xing Cui
Summary: Exosomal circ-ATP10A has been identified as a valuable prognostic biomarker in multiple myeloma (MM), promoting MM angiogenesis by targeting multiple miRNAs and modulating their downstream mRNA expression.
Review
Oncology
Alessandro Allegra, Marco Casciaro, Paola Barone, Caterina Musolino, Sebastiano Gangemi
Summary: This review focuses on the role of epigenetic mechanisms in the development and growth of multiple myeloma, as well as the crosstalk between tumor microenvironment cells and neoplastic cells, introducing the impact of these epigenetic changes on reshaping the tumor microenvironment.
Review
Toxicology
Silvia Vivarelli, Chiara Costa, Michele Teodoro, Federica Giambo, Aristidis Michael Tsatsakis, Concettina Fenga
Summary: Non-communicable diseases (NCDs) are major global causes of mortality and morbidity. Unhealthy lifestyle habits are closely associated with NCDs, and improving these habits may help alleviate symptoms and prolong the life expectancy of affected individuals. Polyphenols (PPLs) derived from plants have shown positive results in preventing and treating NCDs and are considered safe.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
N. V. Tyshko, N. S. Nikitin, S. I. Shestakova, E. O. Sadykova, M. D. Trebukh, G. V. Guseva, N. V. Trusov, I. V. Aksenov, K. S. Golokhvast, A. Tsatsakis, V. A. Tutelyan
Summary: In a chronic model experiment on rats, the liver morphology, intensity of apoptosis, and activity of xenobiotic metabolism enzymes were studied after exposure to a mixture of 6 pesticides and lifelong diets with adequate and insufficient supply of water-soluble vitamins. The dose of each pesticide in the mixture did not exceed the acceptable daily intake (1 ADI). The findings suggest that chronic exposure to low doses of anthropogenic toxicants combined with permanent vitamin deficiency can cause various liver changes, including increased apoptosis activity, depletion of the cytochrome P450 system, steatosis, and inflammatory infiltration, posing a potential health risk.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Ismail Topal, Mustafa Yasar Ozdamar, Tulin Catakli, Ismail Malkoc, Ahmet Hacimuftuoglu, Charalampos Mamoulakis, Aristidis Tsatsakis, Konstantinos Tsarouhas, Christina Tsitsimpikou, Ali Taghizadehghalehjoughi
Summary: This study aimed to evaluate the renoprotective effects of taxifolin (TXF) in a paracetamol (PAR)-induced nephrotoxicity rat model. The results showed that the levels of blood urea nitrogen, creatinine and malondialdehyde were significantly increased in the PAR group, while the levels of glutathione peroxidase, glutathione reductase and total glutathione were significantly higher in the TXF group. Histopathological examination revealed severe tubular epithelium damage in the PAR group, while the TXF group showed mild dilated/congested blood vessels. These findings suggest that TXF has potential renoprotective effects against PAR-induced nephrotoxicity through its antioxidant activity and should be further investigated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sidika Genc, Ali Taghizadehghalehjoughi, Yesim Yeni, Abbas Jafarizad, Ahmet Hacimuftuoglu, Dragana Nikitovic, Anca Oana Docea, Yaroslav Mezhuev, Aristidis Tsatsakis
Summary: In this study, the combination of Fe3O4 NPs and 5-FU showed a synergistic cytotoxic effect on Caco-2 cells at concentrations below the active drug threshold levels.
Article
Public, Environmental & Occupational Health
Ourania Anesti, Nafsika Papaioannou, Catherine Gabriel, Achilleas Karakoltzidis, Vazha Dzhedzheia, Ioannis Petridis, Antonios Stratidakis, Mike Dickinson, Milena Horvat, Janja Snoj Tratnik, Aristidis Tsatsakis, Spyros Karakitsios, Dimosthenis A. A. Sarigiannis
Summary: This study presents an integrated approach to investigating the impact of perinatal exposure to metals on child neurodevelopment in two cohorts carried out in Slovenia and Greece. The study found that heavy metal exposure during the perinatal period is associated with impaired mitochondrial respiration and oxidative stress, leading to developmental disorders in children. Additionally, factors such as diet, proximity to pollution sources, and socioeconomic and demographic characteristics also play a role in child neurodevelopment.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Medicinal
Betul Cicek, Ahmet Hacimuftuoglu, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Serhat Hayme, Dimitris Matthaios, Dimitra P. P. Vageli, Sotirios G. G. Doukas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: According to population-based studies, lung cancer is the most common cause of cancer-related deaths worldwide in males, and its incidence among females is also increasing alarmingly. Sorafenib (SOR), a multitargeted protein kinase inhibitor used for the treatment of hepatocellular carcinoma and renal cell carcinoma, has been the subject of interest in preclinical and clinical trials for lung cancer. This study aimed to investigate the effects of SOR in diethylnitrosamine (DEN)-induced lung carcinogenesis and explore its mechanisms of action. The results showed that SOR reduced the levels of SOX-2, TNF-alpha, and IL-1 beta, and alleviated the histopathological damage caused by DEN-induced lung carcinogenesis. Immunohistochemical and immunofluorescence analysis also revealed that SOR treatment decreased the expression of COX-2 and JNK in DEN-intoxicated rats. These findings suggest that SOR inhibits lung precancerous lesions induced by DEN through reducing inflammation and SOX-2 levels.
Article
Biochemistry & Molecular Biology
Vasiliki Karzi, Eren Ozcagli, Manolis N. Tzatzarakis, Elena Vakonaki, Irene Fragkiadoulaki, Aikaterini Kalliantasi, Christina Chalkiadaki, Athanasios Alegakis, Polychronis Stivaktakis, Aikaterini Karzi, Antonios Makrigiannakis, Anca Oana Docea, Daniela Calina, Aristidis Tsatsakis
Summary: Exposure to combined endocrine disruptors can cause DNA damage, as observed in this study using comet and micronuclei assays. The highest level of damage was found in the group exposed to a high-dose mixture of substances, particularly glyphosate. The micronuclei assay results were moderately correlated with exposure period, and all exposure groups showed an increasing trend in micronuclei counts over time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aristidis Tsatsakis, Tatiana Oikonomopoulou, Taxiarchis Konstantinos Nikolouzakis, Elena Vakonaki, Manolis Tzatzarakis, Matthaios Flamourakis, Elisavet Renieri, Persefoni Fragkiadaki, Evaggelia Iliaki, Maria Bachlitzanaki, Vasiliki Karzi, Ioanna Katsikantami, Fotios Kakridonis, Eleftheria Hatzidaki, Maria Tolia, Andrey A. Svistunov, Demetrios A. Spandidos, Dragana Nikitovic, John Tsiaoussis, Aikaterini Berdiaki
Summary: Cancer is a major issue in clinical, social, and economic aspects, ranking highest in terms of cause-specific disability-adjusted life years among all human pathologies. The trigger of cancer involves various factors, including genetic predisposition and telomere status, which are DNA structures at the end of chromosomes. However, there is no universal trend in the association between telomere length and cancer, as both short and long telomeres have been linked to high cancer incidence risks. This review aims to present the complex relationship between telomere length and cancer comprehensively.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Toxicology
Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Summary: This paper provides a comprehensive summary of the toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals. In vivo studies have shown adverse effects of selenium NPs on laboratory animals, including reductions in body mass, changes in hepatotoxicity indices, and possible impairment of metabolic processes. However, no specific toxic action solely attributable to selenium has been identified. The LOAEL and NOAEL values are contradictory, and the relationship between the adverse effects of selenium NPs and exposure dose is controversial and diverse.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Oncology
Ozgur Celebi, Ali Taghizadehghalehjoughi, Demet Celebi, Robin Mesnage, Kirill Sergeevich Golokhvast, Andreea Letitia Arsene, Demetrios A. Spandidos, Aristidis Tsatsakis
Summary: The gut microbiota is important for maintaining health and regulating immune response. Probiotics and vitamins can improve microbial population and prevent tight junction protein breakdown. The study evaluated the effects of vitamins and probiotics on Escherichia coli and Staphylococcus aureus.
MOLECULAR MEDICINE REPORTS
(2023)
Editorial Material
Substance Abuse
Cornel Radu-Loghin, Karina Mocanu, Hani Al Gouhmani, Constantine Vardavas, Ioanna Lagou, Zinovia Plyta, Aikaterini Papathanasaki, Stella Vogiatzidaki, Alexander Vardavas, Manolis Tzatzarakis, Aristidis Tsatsakis, Filip-pos Filippidis, Christina Kyriakos, Esteve Fernandez, Olena Tigova, Cristina Martinez, Anna Mar Lopez Luque, Marius Eremia, Lucia Maria Lotrean, Antigona Trofor, Thomas Wenzl, Bill Simpson, Pippa Powell, Polina Starchenko, Angeliki Bakou, Eleni Asimaki, Victoria Vivilaki
TOBACCO PREVENTION & CESSATION
(2023)
Article
Chemistry, Medicinal
Sidika Genc, Tarik Yagci, Dimitra P. Vageli, Riza Dundar, Panagiotis G. Doukas, Sotirios G. Doukas, Maria Tolia, Nikolaos Chatzakis, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This study found that serum exosomal miR-223, miR-146, and PTEN expression were significantly decreased, while miR-21 expression was significantly increased in LSCC patients. In addition, CRP and vitamin B12 levels were also altered. These results suggest that the expression of serum exosomal miR-223, miR-146, miR-21, as well as the changes in CRP and vitamin B12 levels, may serve as potential indicators of LSCC.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Oncology
Aristidis Tsatsakis, Elisavet Renieri, Dimitris Tsoukalas, Ana Maria Buga, Evangelia Sarandi, Elena Vakonaki, Persefoni Fragkiadaki, Athanasios Alegakis, Dragana Nikitovic, Daniela Calina, Demetrios A. Spandidos, Anca Oana Docea
Summary: This study evaluated the effects of a novel telomerase activator on telomere length and telomerase activity in aged rats. The nutraceutical formulation was found to reduce telomere shortening rate at lower dose and increase telomere length at higher dose. Telomerase activity was also increased in the treated rats.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Environmental Sciences
Yuliya V. Ryabova, Ilzira A. Minigalieva, Marina P. Sutunkova, Svetlana V. Klinova, Alexandra K. Tsaplina, Irene E. Valamina, Ekaterina M. Petrunina, Aristides M. Tsatsakis, Charalampos Mamoulakis, Kostas Stylianou, Sergey V. Kuzmin, Larisa I. Privalova, Boris A. Katsnelson
Summary: This study found that chronic diseases of the urogenital tract can develop under the effects of chemical hazards in the working environment, particularly from nanosized particles generated in industrial processes. The researchers studied the nephrotoxicity of element oxide nanoparticles through animal experiments, and found that these nanoparticles had a toxic effect on the kidneys and caused changes in kidney function and histological structure. The results of this study are important for the early diagnosis of occupational and nonoccupational nephropathies.
Review
Medicine, Research & Experimental
Fotios Kakridonis, Spyros G. Pneumatikos, Elena Vakonaki, Aikaterini Berdiaki, Manolis N. Tzatzarakis, Persefoni Fragkiadaki, Demetrios A. Spandidos, Stella Baliou, Petros Ioannou, Eleftheria Hatzidaki, Dragana Nikitovic, Aristidis Tsatsakis, Elias Vasiliadis
Summary: This review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. It found a weak association between telomere length and osteoporosis in some studies, suggesting that telomere shortening may be used as a biomarker for tracking the development and progression of osteoporosis.
BIOMEDICAL REPORTS
(2023)
