☆ 4.4 Article

Cellular (FLICE) like inhibitory protein (cFLIP) expression in diffuse large B-cell lymphoma identifies a poor prognostic subset, but fails to predict the molecular subtype

HEMATOLOGICAL ONCOLOGY (2012)

期刊

HEMATOLOGICAL ONCOLOGY

卷 30, 期 1, 页码 8-12

出版社

WILEY-BLACKWELL

DOI: 10.1002/hon.996

关键词

lymphoma; cFLIP; apoptosis

类别

Oncology Hematology

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Reagent

摘要

Immunohistochemistry can sub-classify diffuse large B-cell lymphoma (DLBCL) into germinal centre B-cell like (GCB) and non-GCB subtypes. The latter consists predominately of the activated B-cell like subgroup in which nuclear factor kappa-B activation is its characteristic. Expression of cellular caspase 8 (FLICE)-like inhibitory protein (cFLIP), a caspase 8 homologue, is regulated by nuclear factor kappa-B signalling, and it is the main inhibitor of Fas ligand activated apoptosis. To determine if cFLIP expression was confined to non-GCB subtype, we studied 66 cases of DLBCL. cFLIP expression showed no significant correlation to DLBCL subtypes (GCB or non-GCB) but was associated with a worse clinical outcome. For cFLIP positive and negative patients, the five-year event free survival was 20 and 31%, respectively (p?=?0.049), and the five-year overall survival was 20 and 57%, respectively (p?=?0.041). Copyright (c) 2011 John Wiley & Sons, Ltd.

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Solomon, Kostas Stamatopoulos, Christian Steidl, Stephan Stilgenbauer, Narittee Sukswai, Kengo Takeuchi, Giovanni Tallini, Junichi Tamaru, Soo-Yong Tan, Prashant Tembhare, Enrico Tiacci, Yoshiki Tokura, Olivier Tournilhac, Steven Treon, Lorenz Truemper, Kunihiro Tsukasaki, Frits van Rhee, Abraham Varghese, Maarten H. Vermeer, Philippe Vielh, Brian Walker, Michael Wang, Huan-You Wang, Zhe Wang, Takashi Watanabe, Oliver Weigert, David Wein-Stock, Sean J. Whittaker, Rein Willemze, Wilhelm Woessmann, Catherine J. Wu, Motoko Yamaguchi, Hidetaka Yamamoto, Daisuke Yamashita, Shenmiao Yang, David T. Yang, Takahiko Yasuda, Wei-Hua Yin, Yoh Zen, Sha Zhao, Wei-Li Zhao

LEUKEMIA (2023)

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Article Dermatology

CD5+ Gamma Delta T-Cell Lymphoproliferative Disorder/Lymphoma Without Cytotoxic Granules in the Skin

Jennifer Y. Ju, Eric P. Sorensen, John S. Walsh, Michi M. Shinohara, Kikkeri N. Naresh

Summary: We report a rare and aggressive case of gamma delta T-cell lymphoproliferative disorder/lymphoma that presented in the skin without the expected cytotoxic markers but with increased expression of CD5, CD20, CD79a, CD30, and PD-I. Monoclonal TCR-gamma gene rearrangement was identified. The clinical, morphologic, and immunophenotypic features of this case do not fit into the current classifications.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2022)

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