Article
Immunology
Rebekah W. Moehring, Michael E. Yarrington, Angelina E. Davis, April P. Dyer, Melissa D. Johnson, Travis M. Jones, S. Shaefer Spires, Deverick J. Anderson, Daniel J. Sexton, Elizabeth S. Dodds Ashley
Summary: The study established a collaborative, consultative network to support hospital Antimicrobial Stewardship Programs (ASP). Results showed that participating hospitals increased ASP activities over 42 months, leading to a decline in antimicrobial use. There was significant variation in antimicrobial use among different hospitals.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Federico Perez, Roberto Viau Colindres, Brigid M. Wilson, Elie Saade, Robin L. P. Jump, Ritu Banerjee, Robin Patel, Scott R. Evans, Robert A. Bonomo
Summary: The study used the DOOR MAT approach to evaluate antibiotic treatment of E. coli and K. pneumoniae bloodstream infections in VHA patients across a decade. Over the 10-year period, resistance to certain antibiotics increased in E. coli but remained stable in K. pneumoniae. Discrepancy between empiric and definitive treatment desirability narrowed, with no negative impact on patient survival.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Marion Elligsen, Ruxandra Pinto, Jerome A. Leis, Sandra A. N. Walker, Derek R. MacFadden, Nick Daneman
Summary: A hospital-wide intervention focusing on evaluating clinically significant discordance and providing alternative therapy recommendations improved prescribing practices, resulting in a higher proportion of patients receiving empiric therapy concordant with prior culture results and a shorter time to receiving concordant therapy. Unnecessary vancomycin therapy duration was also reduced.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Adam L. Hersh, Laura M. King, Daniel J. Shapiro, Lauri A. Hicks, Katherine E. Fleming-Dutra
Summary: The percentage of unnecessary antibiotic prescriptions in US physician offices and emergency departments decreased slightly from 30% in 2010-2011 to 28% in 2014-2015. However, there was a greater decrease in children from 32% to 19%, while unnecessary prescribing in adults remained unchanged.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Larissa May, Alejandro Martin Quiros, Jaap Ten Oever, Jacobien Hoogerwerf, Teske Schoffelen, Jeroen Schouten
Summary: Emergency departments serve as the entrance gates for patients with infectious diseases and are an important unit for targeted antimicrobial stewardship interventions. Most antimicrobial stewardship programmes are focused on inpatient management, overlooking the equally high rates of inappropriate antibiotic use in the ED setting. Therefore, there is a need to strengthen the focus and intervention on antimicrobial stewardship in the ED.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Rebekah W. Moehring, Elizabeth S. Dodds Ashley, Angelina E. Davis, April Pridgen Dyer, Alice Parish, Xinru Ren, Yuliya Lokhnygina, Lauri A. Hicks, Arjun Srinivasan, Deverick J. Anderson
Summary: An electronic definition of antibiotic de-escalation was derived and applied in a retrospective study among 5 hospitals, showing variation in de-escalation rates among hospitals, units, and diagnoses. Critical care units exhibited higher rates of both de-escalation and escalation compared to general wards. This electronic metric may be useful for assessing stewardship opportunities and impact.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Marcella Sibani, Lorenzo Maria Canziani, Chiara Tonolli, Maddalena Armellini, Elena Carrara, Fulvia Mazzaferri, Michela Conti, Annarita Mazzariol, Claudio Micheletto, Andrea Dalbeni, Domenico Girelli, Evelina Tacconelli
Summary: Since the emergence of the SARS-CoV-2 pandemic, antimicrobial stewardship (AS) activities have shifted towards COVID-19 management. This study analyzed changes in antibiotic consumption in moderate-to-severe COVID-19 patients to assess the impact of COVID-19 on AS activities. The implementation of calibrated AS activities significantly decreased antibiotic consumption in the intervention units for COVID-19 patients.
Article
Medicine, General & Internal
Hong Zhou, Lihong Liu, Xiao Sun, Huaguang Wang, Xiaojia Yu, Ye Su, Zhaoyuan You, Zhuoling An
Summary: The study showed that pharmacist-led intervention can reduce the utilization of cephalosporins skin tests and decrease the prescription of unnecessary high-cost antimicrobials.
Article
Immunology
Brigid M. Wilson, Yunyun Jiang, Robin L. P. Jump, Roberto A. Viau, Federico Perez, Robert A. Bonomo, Scott R. Evans
Summary: Antibiotic stewardship must consider effectiveness and spectrum of therapy, proposing the DOOR MAT approach for evaluating desirability of antibiotic selection. The principle is to effectively treat the patient while minimizing future resistance development.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Hakan Erdem, Esra Kocoglu, Handan Ankarali, Rehab El-Sokkary, Atousa Hakamifard, Ridvan Karaali, Sholpan Kulzhanova, Amani El-Kholy, Hamed Azhdari Tehrani, Reham Khedr, Ayse Kaya-Kalem, Nenad Pandak, Meliha Cagla-Sonmezer, Summiya Nizamuddin, Hande Berk-Cam, Rahmet Guner, Jehan Ali Elkholy, Ferran Llopis, Andrea Marino, Roman Stebel, Balint Gergely Szabo, Maya Belitova, Elias Fadel, Tarkan Yetisyigit, Yasemin Cag, Sevil Alkan, Bircan Kayaaslan, Serkan Oncu, Mehmet Ozdemir, Mesut Yilmaz, Arzu Cennet Isik, Dilsah Baskol, Gulden Sincan, Antonio Cascio, Safak Ozer-Balin, Nesibe Korkmaz, Rezaul Karim Ripon, Salma Abbas, Irina Magdalena Dumitru, Gulden Eser-Karlidag, Massimiliano Lanzafame, Abdur Rafey, Aun Raza, Oguz Resat Sipahi, Ilad Alavi Darazam, Umran Elbahr, Ilknur Erdem, Pinar Ergen, Cemil Bilir, Hulya Caskurlu, Aysegul Erdem, Mateja Jankovic Makek, Mustafa Altindis, Botond Lakatos, Catalina Mihaela Luca, Esmeray Mutlu Yilmaz, Emmanuel Nsutebu, Rumeysa Cakmak, Fatma Sirmatel
Summary: This study aimed to identify factors predicting mortality in febrile neutropenic patients with bacteremia. The results showed that pulse rate, quick SOFA score, inappropriate antimicrobial treatment, Gram-negative bacteremia, bacteremia of non-urinary origin, and advancing age were independent predictors of mortality. Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritized.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Daniel John Hearsey, Kathleen B. Bamford, Michael Hutton, Liam Wade, Henry Coates, Elizabeth Ramsay, Barbara Alberts, Neil Powell
Summary: Identifying excess antibiotic prescribing in General Surgery is important for reducing unwarranted antibiotic use. This study found comparable levels of excess antibiotic prescribing at all three decision time-points, with the majority of excess prescribing occurring at the initiation stage and a significant proportion being intravenous antibiotics.
Article
Infectious Diseases
Julie A. Chambers, Margaret Crumlish, David A. Comerford, Le-Hong Phuoc, Vo-Hong Phuong, Ronan E. O'Carroll
Summary: This study investigates Vietnamese farmers' attitudes and beliefs about antibiotic and vaccine usage, finding that farmers have concerns about antibiotic use, but are more positive towards vaccine usage.
Article
Infectious Diseases
Braden D. Knight, Jayson Shurgold, Glenys Smith, Derek R. MacFadden, Kevin L. Schwartz, Nick Daneman, Denise Gravel Tropper, James Brooks
Summary: During the COVID-19 pandemic, the dispensing of antibiotics in the community in Canada decreased by 26.5%, with the most significant decrease in prescription rates observed in children and older adults.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Caroline Emilie, Phebe de Nocker, Nadia Saidani, Mark Gilchrist, R. Andrew Seaton, Sanjay Patel, Guillaume Beraud, Diamantis Kofteridis, Jeroen Schouten, Nathalie Thilly, Marvin Berrevoets, Marlies Hulscher, Franky Buyle, Celine Pulcini
Summary: Delivery of parenteral antimicrobials in non-inpatient settings (DPANS) varies among European countries, with the availability and organization of DPANS being highly heterogeneous. Most countries provide DPANS through specialized outpatient parenteral antimicrobial therapy (OPAT) services or infusion services, but only a few have formal OPAT team structures with specifically trained staff. Some countries rely on ad hoc arrangements for DPANS. The majority of countries cover the costs of DPANS for patients managed by specialized OPAT/infusion services.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Peter Mallett, Danielle McMichael, Yingfen Hsia, Paul Moriarty
Summary: This study described the trends of antimicrobial consumption in paediatric and neonatal inpatient care in Northern Ireland between September 2015 and September 2020. The research created a baseline dataset for paediatric and neonatal units and found that paediatric consumption accounted for approximately 10% of total antimicrobial consumption in hospital care. Variation in consumption rates between units and an increasing proportion of Watch and Reserve antibiotic consumption in some areas were observed.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)