Review
Medicine, General & Internal
Toni Valkovic, Marija Stanic Damic
Summary: Iron plays an important role in the survival and reproduction of fungal pathogens, and there is evidence linking invasive fungal infections to iron or iron overload. Understanding the association between iron and iron overload with susceptibility to invasive fungal infections is crucial, especially for patients with hematological malignancies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Felicitas Schulz, Ulrich Hauch, Sandra Ketzler-Henkel, Eyck von der Heyde, Michael Koenigsmann, Michael Lauseker, Nora Schulte, Ulrich Germing
Summary: Myelodysplastic syndromes and myeloproliferative neoplasms are hematologic diseases associated with bone marrow failure, and transfusion of red blood cells is necessary but leads to iron overload. Therefore, iron chelation therapy plays a crucial role in anemic patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jessica van Hattem, Philip Maes, Tonya Marianne Esterhuizen, Ann Devos, Martin Ruppert, Jaques van Heerden
Summary: Limited data on erythrocytapheresis in children, adolescents, and young adults have been published. This study aimed to evaluate the effectiveness of erythrocytapheresis, either alone or in combination with iron chelation therapy, in managing iron overload in patients with hemoglobinopathies. The results showed that erythrocytapheresis significantly reduced serum ferritin levels and had a better effect compared to iron chelation therapy alone. This study demonstrates that erythrocytapheresis is a promising therapy for treating transfusion-related iron overload.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mariarita Spampinato, Cesarina Giallongo, Alessandra Romano, Lucia Longhitano, Enrico La Spina, Roberto Avola, Grazia Scandura, Ilaria Dulcamare, Vincenzo Bramanti, Michelino Di Rosa, Nunzio Vicario, Rosalba Parenti, Giovanni Li Volti, Daniele Tibullo, Giuseppe A. Palumbo
Summary: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by clonal proliferation of hematopoietic stem cells leading to bone marrow fibrosis. The main consequences of PMF include neoangiogenesis, megakaryocytes hyperplasia, extensive bone marrow fibrosis, osteosclerosis, and bone damage. The involvement of cytokines, growth factors, and resident cells in the bone marrow microenvironment are linked to disease progression in PMF.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gerard M. Healy, Stephan A. R. Kannengiesser, Osvaldo Espin-Garcia, Richard Ward, Kevin H. M. Kuo, Kartik S. Jhaveri
Summary: Inline R-2*-LIC provides robust and comparable quantification of LIC compared to FerriScan, without the need for offline post-processing.
EUROPEAN RADIOLOGY
(2021)
Article
Hematology
John Chapin, Alan R. Cohen, Ellis J. Neufeld, Elliott Vichinsky, Patricia J. Giardina, Jeanne Boudreaux, Binh C. Le, Kristy Kenney, Sean Trimble, Alexis A. Thompson
Summary: Thalassaemia is a genetic disorder causing anaemia and dependence on transfusions, with recent clinical advancements leading to reduced mortality and potential future gene therapies. Research revealed older patients with more iron-related comorbidities and complications, while younger patients had excess liver and heart iron and were on combination chelation therapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, General & Internal
Reem Aldwaik, Tamara Abu Mohor, Israa Idyabi, Salam Warasna, Shatha Abdeen, Bashar Karmi, Rania Abu Seir
Summary: Management of beta-thalassemia in the West Bank presents challenges due to the lack of available therapies, leading to recurrent transfusions. Characteristics of patients include anemia, iron overload, and abnormal liver function tests. Iron chelation medication choice is associated with serum ferritin levels, highlighting the need for personalized assessment and follow-up protocols.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Christina Fragodimitri, Vasiliki Schiza, Anastasios Giakoumis, Kalliopi Drakaki, Anastasia Salichou, Fotis Karampatsos, Jacqueline Yousef, Markissia Karageorga, Vasili Berdoukas, Athanasios Aessopos
Summary: This study analyzed the benefits of the revolution in the management of beta-thalassemia major. The results showed that chelation therapy significantly optimized the indices and increased the proportion of patients with chelation success. Continuous magnetic resonance imaging and prolonged intensified chelation therapy can help patients achieve clearance of cardiac and liver iron load and reduce mortality.
Review
Chemistry, Analytical
Zahra Tariq, Muhammad Imran Qadeer, Iram Anjum, Christophe Hano, Sumaira Anjum
Summary: Thalassemia is a monogenic autosomal recessive disorder caused by mutations, which affect hemoglobin production. Conventional therapeutic methods such as transfusion and iron chelation therapy have limitations, leading to the demand for advanced therapies. Nanotechnology-based applications have emerged as simple, convenient, and cost-effective methods for theragnostics. This review summarizes the potential of nanotechnology in developing theragnostic approaches for diagnosing thalassemia-causing gene mutations and employing nano-based therapeutic procedures.
Review
Oncology
Helen T. Chifotides, Prithviraj Bose, Srdan Verstovsek
Summary: Momelotinib has shown consistent benefits in treating anemia in myelofibrosis patients by inhibiting the BMP6/ACVR1/SMAD and IL-6/JAK/STAT3 pathways, resulting in improved iron and hemoglobin levels, as well as restored erythropoiesis. Clinical data from phase 2 and phase 3 trials demonstrate high rates of sustained transfusion-independence with Momelotinib compared to other treatments.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Multidisciplinary Sciences
Yesim Aydinok
Summary: Combination chelation therapy is a viable option for transfusion-dependent thalassemia patients who have not achieved iron balance with monotherapy or need intensified treatment for rapid iron reduction. It allows for a more personalized approach, improving tolerability, adherence, and quality of life. Real-life data highlights the importance of compliance in achieving meaningful reduction in iron overload compared to monotherapy.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Shizhen Li, Xiangyu Zhang
Summary: Iron plays essential roles in cardiovascular diseases, with iron deficiency having detrimental effects in heart failure and pulmonary arterial hypertension patients. Ferroptosis, an iron-dependent cell death, has been reported in cardiomyopathy, atherosclerotic cardiovascular disease, and myocardial ischemia/reperfusion injury. Iron chelation therapy may be a potential strategy to address iron overload-related disorders in CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Toxicology
Ruiying Cheng, Rajitha Gadde, Yingfang Fan, Neha Kulkarni, Nachiket Shevale, Kai Bao, Hak Soo Choi, Swati Betharia, Jonghan Kim
Summary: N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a lipophilic metal chelator and antioxidant used for mercury poisoning. It has shown potential in binding to other metals like lead and iron. In this study, it was found that NBMI selectively binds to ferrous iron, protecting neuroblastoma cells from high iron-mediated cytotoxicity and reducing reactive oxygen species. Furthermore, NBMI effectively reduced iron accumulation in the brain and liver of iron-loaded mice, with a superior safety profile compared to the commonly used iron chelator, DFP. These findings highlight the neuroprotective and therapeutic potential of NBMI for neurodegenerative diseases associated with brain iron accumulation.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Hematology
Antonella Bruzzese, Enrica Antonia Martino, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Carlo Bova, Gianfranco Filippelli, Isabella Capodanno, Antonino Neri, Fortunato Morabito, Massimo Gentile, Ernesto Vigna
Summary: Iron overload can be caused by a congenital impairment of iron regulation, increased intestinal iron absorption, or chronic transfusions. Diagnosing iron overload is challenging, with liver biopsy being the gold standard despite its invasiveness. Noninvasive techniques have allowed for better understanding of iron overload in different organs. Serum ferritin estimation is the most commonly used diagnostic tool, although it may not be specific. Hematological conditions such as myelodysplastic syndromes, sickle cell disease, and thalassemia can cause iron overload, which can be treated with chelators like deferiprone, deferoxamine, and deferasirox.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Nutrition & Dietetics
William Kardasis, Ethan R. Naquin, Richa Garg, Tejas Arun, Jyotsna S. Gopianand, Eshani Karmakar, Jaya P. Gnana-Prakasam
Summary: Iron is a crucial micronutrient for athletes, but impaired iron levels can hinder athletic performance. Prolonged exercise can affect iron absorption, utilization, and storage, increasing the risk of iron deficiency. On the other hand, iron overload may initially enhance performance but can have detrimental health consequences in the long term. Proper management of iron intake is crucial for improving athletic performance and overall well-being.
Article
Hematology
S. Hindawi, S. A. El-Kafrawy, A. M. Hassan, M. A. Badawi, M. M. Bayoumi, A. A. Almalki, H. M. Zowawi, A. M. Tolah, T. A. Alandijany, Q. Abunada, M. Picard-Maureau, G. A. Damanhouri, E. Azhar
Summary: This study evaluated the efficacy of amotosalen/UVA pathogen reduction technology for SARS-CoV-2 in human platelet concentrates, demonstrating efficient inactivation of the virus. The treatment resulted in a mean log reduction of > 3.31, significantly reducing the viral load and inhibiting viral replication in subsequent passaging experiments.
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2022)
Editorial Material
Hematology
Laura Green, Simon Stanworth, Zoe McQuilten, Victor Lin, Harriet Tucker, Bryon Jackson, Maha Badawi, Salwa Hindawi, Rahul Chaurasia, Gopal Patidar, Hem Chandra Pandey, Foluke Fasola, Shigeki Miyata, Masanori Matsumoto, Tadashi Matsushita, Naomi Rahimi-Levene, Victoria Peer, Katerina Pavenski, Jeannie Callum, Troy Thompson, Michael Murphy, Julie Staves, Marc Maegele, Chathuri Abeyakoon, Kylie Rushford, Erica Wood, Maria Antonieta Nunez, Sandra Mellado, Edgardo Saa, Teguh Triyono, Bhirowo Pratomo, Torunn Oveland Apelseth, Nancy Dunbar
Editorial Material
Hematology
Laura Green, Simon Stanworth, Zoe McQuilten, Victor Lin, Harriet Tucker, Bryon Jackson, Maha Badawi, Salwa Hindawi, Rahul Chaurasia, Gopal Patidar, Hem Chandra Pandey, Foluke Fasola, Shigeki Miyata, Masanori Matsumoto, Tadashi Matsushita, Naomi Rahimi-Levene, Victoria Peer, Katerina Pavenski, Jeannie Callum, Troy Thompson, Michael Murphy, Julie Staves, Marc Maegele, Chathuri Abeyakoon, Kylie Rushford, Erica Wood, Maria Antonieta Nunez, Sandra Mellado, Edgardo Saa, Teguh Triyono, Bhirowo Pratomo, Torunn Oveland Apelseth, Nancy Dunbar
Article
Biotechnology & Applied Microbiology
Nora Y. Hakami, Afnan J. Al-Sulami, Wafaa A. Alhazmi, Talal H. Qadah, Waleed M. Bawazir, Abdullah Y. Hamadi, Amani Y. Owaidah, Razan A. Alhefzi, Fawaz Y. Hamdi, Amr Maqnas, Ghassab F. Alghassab, Maha A. Badawi, Salwa I. Hindawi
Summary: This study aimed to determine the impact of COVID-19 lockdown on blood donation services and supply in different regions of Saudi Arabia. The findings showed no major difference among the surveyed centers between 2020 and 2019, indicating effective management of blood supply and transfusion.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Hematology
Satyam Arora, Ruchika Goel, Arwa Z. Al-Riyami, Abdul Hakim Al-Rawas, Saif Al Hosni, Mauro Montanari, Benedetta Costantini, Christina Lee Lai Ling, Norliza Mustafa, Chan Kok Joo, Hari Krishan Dhawan, Sheetal Malhotra, Ratti Ram Sharma, Helen New, Rachel Moss, Jane Davis, Nancy Robitaille, Valerie Arsenault, Nabiha H. Saifee, Ann-Marie Taroc, Naomi Rahimi-Levene, Victoria Peer, Maha Badawi, Pauline M. Snijder, Elise J. Huisman, Josune Zubicaray Salegui, Julia Ruiz Pato, Julian Sevilla Navarro, Jose Mauro Kutner, Ana Paula Hitomi Yokoyama, Joyce Ching Mei Lam, Xin Ni Zhong, Mui Ling Heng, Oscar Walter Torres, Aggrey Dhabangi, Anel van Zyl, Nadia Mundey, Vernon Louw, Karin van den Berg, Nancy Dunbar
Article
Hematology
Satyam Arora, Ruchika Goel, Arwa Z. Al-Riyami, Abdul Hakim Al-Rawas, Saif Al Hosni, Mauro Montanari, Benedetta Costantini, Christina Lee Lai Ling, Norliza Mustafa, Chan Kok Joo, Hari Krishan Dhawan, Sheetal Malhotra, Ratti Ram Sharma, Helen New, Rachel Moss, Jane Davis, Nancy Robitaille, Valerie Arsenault, Nabiha H. Saifee, Ann-Marie Taroc, Naomi Rahimi-Levene, Victoria Peer, Maha Badawi, Pauline M. Snijder, Elise J. Huisman, Josune Zubicaray Salegui, Julia Ruiz Pato, Julian Sevilla Navarro, Jose Mauro Kutner, Ana Paula Hitomi Yokoyama, Joyce Ching Mei Lam, Xin Ni Zhong, Mui Ling Heng, Oscar Walter Torres, Aggrey Dhabangi, Anel van Zyl, Nadia Mundey, Vernon Louw, Karin van den Berg, Nancy Dunbar
Article
Hematology
Osman Radhwi, Maha A. Badawi, Adel Almarzouki, Fakhr Al-Ayoubi, Ghada ElGohary, Kazi Nur Asfina, Abdulrahim Mohammed Basendwah, Iman Ayed Alhazmi, Eiman A. Almahasnah, Ahmed AlBahrani, Abdulrahman Al Raizah, Ayel Yahya, Khadeja Alshahrani, Salwa Hindawi
Summary: This study assessed the care provided to TTP patients at a national level in Saudi Arabia and identified some deficiencies. The results showed a complete response in 78% of patients after treatment, with an overall mortality rate of 25%. This emphasizes the need for a national registry to facilitate proper diagnosis and management of this rare disorder.
JOURNAL OF CLINICAL APHERESIS
(2023)
Letter
Medicine, General & Internal
Nour Al-Mozain, Maha A. Badawi, Mohammad A. Alfhili
SAUDI MEDICAL JOURNAL
(2023)
Article
Hematology
Maha Abdulrazak Badawi, Hend Obad Hussain, Mazen Abdulrazak Badawi, Lana Adey Al Shawwa, Reda Abdullah Jamjoom, Yoon Soo Park, Ara Tekian
Summary: This study investigates the effectiveness of scoring OSCE as an educational method in undergraduate medical education. The results show that scoring OSCE can enhance learning of content discussed and evaluated in the stations. Watching and scoring videotaped OSCE stations can lead to significant improvement in students' knowledge test performance.
Article
Hematology
Lubna Al Zadjali, Khalid Batarfi, Maha Badawi, Ghada Elgohary, Mansour Aljabry, Omar Alsuhaibani, Hatoon Ezzat, Ghazala Radhwi, Hani AlHashmi
Summary: Maintaining a safe and adequate blood supply during a crisis is a major challenge. A study in Saudi Arabia found that although a majority of healthcare employees did not donate blood in the past two years, a significant percentage expressed their willingness to donate during the COVID-19 crisis. Concerns about the risk of infection and safety during the donation process were the main reasons for not donating.
Article
Hematology
Salwa Hindawi, Sundus Daghistani, Tarek Elgemmezi, Osman Radhwi, Maha Badawi, Wejdan Al-Tayeb, Sameera Felemban, Abdulelah Qadi, Reham Kaki, Mazen Badawi, Tariq Madani
Summary: This study aimed to assess the association between ABO/RhD blood types and COVID-19 susceptibility and severity, and compare the results with similar studies in Saudi Arabia. The results showed that individuals with blood group B had a higher proportion in the COVID-19 group compared to the control group (24.2% vs. 18%), while individuals with blood group O had a lower proportion (39.5% vs. 47.3%). The B blood group was associated with a higher risk of mortality, but neither ABO nor RhD was significantly associated with the severity of COVID-19.
Article
Hematology
Maha A. Badawi, Heidi Al-Wassia
Summary: This article describes a case of a newborn with hemolytic disease of the fetus and newborn (HDFN) due to a high-prevalence antigen of unknown specificity, requiring a blood transfusion. Antibody screening and identification in the mother showed pan reactivity, and the cord sample also showed positive results. Incompatible group O red blood cells were transfused to the newborn without complications.
Article
Hematology
Salwa Hindawi, Tarek Elgemmezi, Sherif A. El-Kafrawy, Hani Samadani, Mayasim Tilmisani, Omar Assiri, Mohammad Raml, Esam I. Azhar, Maha Badawi
Summary: COVID-19 convalescent plasma (CCP) has potential benefits for COVID-19 patients when administered in the early stages, but donors have similar risk profiles to first-time donors. Pathogen reduction treatment (PRT) can mitigate these risks without impacting CCP quality. This study investigated the impact of PRT technologies in Saudi Arabia on the neutralizing activity of CCP.
TRANSFUSION AND APHERESIS SCIENCE
(2023)
Article
Hematology
Maha A. A. Badawi, Ali Algiraigri, Afnan J. J. Al-Sulami, Anas A. A. Abunar, Rami Alharbi, Yoon Soo Park, Ara Tekian
Summary: Blood transfusion services face blood component wastage due to factors such as poor ordering and utilization practices by physicians. This study evaluates whether an educational intervention can reduce plasma ordering and improve wastage rates. The intervention included surveys, lectures, and periodic reports and reminders. While plasma transfusion rates decreased, wastage rates did not improve. There is a knowledge gap among physicians, and future interventions should include nurses and physicians from other departments.
Article
Medicine, General & Internal
Nora Y. Hakami, Afnan J. Al-Sulami, Wafaa A. Alhazmi, Mamdouh M. Sindi, Ohoud F. Alotaibi, Maha A. Badawi, Raed Felimban, Thoraia M. Shinawi, Talal Qadah
Summary: This study investigated the association between ABO, Rhesus (D), and P1 blood groups and COVID-19 susceptibility in Taif city, Western Saudi Arabia. The results showed a significant association between P1+ individuals and COVID-19 susceptibility, suggesting that P1 antigen can serve as a biological marker for identification of individuals at risk. Extra protective measures are recommended for P1+ individuals.
AFRICAN HEALTH SCIENCES
(2022)
