期刊
HELVETICA CHIMICA ACTA
卷 94, 期 4, 页码 578-591出版社
WILEY-BLACKWELL
DOI: 10.1002/hlca.201000296
关键词
-
资金
- Japan Society for the Promotion of Science (JSPS) [20590002]
- Grants-in-Aid for Scientific Research [20590002] Funding Source: KAKEN
Towards total synthesis of a series of kinamycin and related antibiotics via common synthetic intermediates, total synthesis of prekinamycin was achieved via Suzuki coupling of naphthaleneboronic acid and bromobenzene derivative, intramolecular Friedel-Crafts reaction of 2-(naphthalen-2-yl) benzoic acid, and diazotization in ten steps from 3,5-dimethylphenol. Synthetic studies towards kinamycin antibiotics was also examined, and the tetracyclic quinone core for kinamycins was synthesized. Palladium-catalyzed site-selective hydroxylation of a benzoic acid derivative with the AB-D ring part was successfully applied to the selective D-ring functionalizations.
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