Four New Nortriterpenoids from Schisandra lancifolia

Four new highly oxygenated nortriterpenoids, lancifodilactones O-R (1-4), together with six known ones, i.e., 5-10, were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR experiments and mass spectrometry. Compounds 1-3 were evaluated for their cytotoxicity against NB4, A549, SHSY5Y, PC-3, and MCF-7 cell lines. No compounds exhibited significant cytotoxicity, the I(C5)0 values being above 50 mu M.