Article
Chemistry, Multidisciplinary
Yang Xu, Liangliang Xiong, Yushu Yan, Dejuan Sun, Yanwei Duan, Hua Li, Lixia Chen
Summary: Stemona tuberosa, a traditional medicine widely used in China and South Asian regions, was found to contain 29 alkaloids, including eight newly discovered compounds. These compounds showed inhibitory effects on NO production in experimental cells.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Applied
Hong-Mei Li, Tian-Tian He, Miao Zhang, Jia-Ning Liu, Xue Zhao, Jie Liu, Lei Fang
Summary: Two new stilbenoids, named stemobenoids A (1) and B (2), were obtained from the roots of Stemona tuberosa, along with three known compounds. The structures of the new compounds were determined through extensive spectroscopic analysis. Compounds 1 and 2 exhibited potent quinone reductase inducing activity in Hepa 1c1c7 cells.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Wesley J. Olivier, Nigel T. Lucas, Alex C. Bissember, Jason A. Smith
Summary: The first total syntheses of the Stemona alkaloid dehydrostenine A and dehydrostenine B have been completed. Two independent Bronsted-acid-mediated intramolecular Michael additions were used to construct the tetracyclic dehydrostenine core. Revisions of the structures originally assigned to dehydrostenines A and B are proposed based on synthetic studies and literature analysis.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ru-Shang He, Shi-Wei Li, Tian-Tian Yang, Jia-Xin Lai, Xiao-Jie Liu, Bian-Xia Xue, Li-Hua Zhang, Hong-Hua Wu
Summary: A chemical investigation on Stemona tuberosa Lour. resulted in the isolation of a previously undescribed furfural derivative and twenty-five known compounds. Their structures were determined by extensive spectroscopic analysis. This study uncovers diverse constituents in the water decoction of S. tuberosa, which can be used for quality control and discrimination of Stemona plants.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Plant Sciences
Lixia Wang, Hongwei Wu, Cong Liu, Tong Jiang, Xiaoyun Yang, Xiaoxu Chen, Liying Tang, Zhuju Wang
Summary: Stemonae Radix, a widely used traditional Chinese medicine, has a wide range of pharmacological effects and contains over 170 compounds isolated from its three official species. However, pharmacological studies often focus on extracts rather than specific compounds, making it difficult to identify the major active ingredients and establish a connection between chemical constituents and pharmacological activities. Further experiments are needed to deepen the understanding of the development and clinical use of Stemonae Radix.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Genetics & Heredity
Pan-Hua Liao, Dong-Ling Li, Hai-Ying Tong
Summary: The study focused on the assembly and annotation of the complete chloroplast genome of Stemona tuberosa, a perennial herb commonly used in traditional Chinese medicine. The genome was characterized by a quadripartite structure, with specific lengths and regions identified. Phylogenetic analysis revealed the close relationship between S. tuberosa and other related species in the Stemonaceae family.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Chemistry, Organic
Yu Zheng, Hong-Dou Yang, Kun Wei, Yu-Rong Yang
Summary: A new strategy was used to construct the common, key tricyclic core of stemona alkaloids parvistemonine and parvistemoline, setting three contiguous stereogenic centers using Carreira's asymmetric Ir/amine-catalyzed allylation and Ellman's sulfinamide chiral auxiliary. The designed furan ring acted as a precursor of the butyrolactone while establishing significant chirality.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Wesley J. Olivier, Jackson S. Henneveld, Jason A. Smith, Bill C. Hawkins, Alex C. Bissember
Summary: This review presents the key strategies and overall progress made in the synthesis of Stemona alkaloids and related compounds since 2009. Case studies are grouped by alkaloid class, showcasing the advancements in this field. Structural reassignments reported during this period are also identified.
NATURAL PRODUCT REPORTS
(2022)
Article
Chemistry, Applied
Sirinrat Chalom, Jukreera Panyakaew, Manlika Phaya, Stephen G. Pyne, Pitchaya Mungkornasawakul
Summary: A new Stemona alkaloid glycoside derivative was isolated and identified from the ethanolic extract of Stemona curtisii Hook.f., with the structure elucidated using NMR and MS experiments. One alkaloid showed strong larvicidal activity against Aedes aegypti, while another exhibited cytotoxicity against MCF-7 and KB cells. The quantitative analysis of the active compounds in the crude extracts was also conducted using HPLC.
NATURAL PRODUCT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Aurapa Sakulpanich, Siriluck Attrapadung, Wandee Gritsanapan
Summary: The ethanolic root extract of S. collinsiae has larvicidal activity against M. domestica and C. megacephala, causing irregular development and preventing the emergence of adult flies. This study suggests the potential use of S. collinsiae root extract as a natural fly control biopesticide.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Yun-Lai Liu, Yong Wang, Xiao-Ru He, Li-She Gan, Fan Xu, Yun-Jing Xu, Xiao-Ning Wang, Tao Shen, Zhi-Wang Zhou
Summary: Two new isoquinoline alkaloids and one known pavine alkaloid were isolated from the twigs of Cryptocarya wrayi. The structures of the new compounds were determined through spectral analysis and ECD calculations, and both compounds showed moderate quinone reductase inducing activity in Hepa 1c1c7 cells.
Article
Chemistry, Multidisciplinary
Martina Oberhofer, Judith Wackerlig, Martin Zehl, Havva Buyuk, Jia Jian Cao, Alexander Prado-Roller, Ernst Urban, Sergey B. Zotchev
Summary: The study identified new antibiotic compounds from endophytic fungi in Edelweiss, including two new alkaloids and a novel compound. It was found that the antibiotic activity observed was primarily due to emestrin, a previously unknown epidithiodioxopiperazine. This highlights the potential for drug discovery from endophytic fungi.
Article
Chemistry, Organic
Giovanni Bernardi Rosso, Bruno Matos Paz, Ronaldo Aloise Pilli
Summary: The proposed structure for the putative Stemona alkaloid named parvistemoamide has been questioned. The study also reports on the intramolecular Friedel-Crafts alkylation of a furan molecule, leading to the synthesis of related compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Xiao-Yang Wang, Hui Gao, Zhao-Chao Ma, Guan-Yuan Wang, Xu Ma, Jing-Tao Liu, Long-Tao Huangfu, Hua Ning, Hai-Feng Tang, Yan-Hua Zhang
Summary: Phytochemical investigation of Pachysandra terminalis led to the discovery of a novel alkaloid, a new pregnane-type alkaloid, and four known pregnane-type alkaloids. The compounds were tested for antibacterial activities, with compound 2 showing good antibacterial activity against methicillin-resistant bacteria.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Applied
Zhuo-Bin Guan, Yong-Qian Liang, Jia-Li Lin, Xiao-Jian Liao, Shi-Hai Xu, Bing-Xin Zhao
Summary: Two new pyrrolidine alkaloids were isolated from the red alga Acanthophora spicifera, along with five known ones. Their structures were determined through spectroscopic methods and X-ray diffraction analysis. The antibacterial activities of these alkaloids were evaluated.
NATURAL PRODUCT RESEARCH
(2021)
