Review
Oncology
Ana Julia Aguiar de Freitas, Rhafaela Lima Causin, Muriele Bertagna Varuzza, Cassio Murilo Trovo Hidalgo Filho, Vinicius Duval da Silva, Cristiano de Padua Souza, Marcia Maria Chiquitelli Marques
Summary: Breast cancer is the most common cancer in women worldwide, and personalized medicine requires a combination of clinical and molecular characterization for more effective treatment. Current studies aim to develop more personalized therapies to decrease the adverse effects of chemotherapy.
Review
Biochemistry & Molecular Biology
Dongchan Kim, Bhavya Gupta, Geoffrey Yuet Mun Wong
Summary: The liver is the most common site of metastasis in colorectal cancer. Multimodal treatment, including liver resection, is potentially curative and prolongs survival for selected patients with colorectal liver metastases (CRLM). However, the treatment of CRLM remains challenging because recurrence is common, and prognosis varies widely between patients despite curative-intent treatment. Clinicopathological features and tissue-based molecular biomarkers, either alone or in combination, are insufficient for accurate prognostication. As most of the functional information in cells resides in the proteome, circulating proteomic biomarkers may be useful for rationalising the molecular complexities of CRLM and identifying potentially prognostic molecular subtypes. High-throughput proteomics has accelerated a range of applications including protein profiling of liquid biopsies for biomarker discovery. Moreover, these proteomic biomarkers may provide non-invasive prognostic information even before CRLM resection. This review evaluates recently discovered circulating proteomic biomarkers in CRLM. We also highlight some of the challenges and opportunities with translating these discoveries into clinical applications. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Laura A. Lucaciu, Radu Seicean, Alina Uifalean, Maria Iacobescu, Cristina A. Iuga, Andrada Seicean
Summary: This study identified a unique serum biomarker panel for predicting the progression of Crohn's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Angela Davey, Marcel van Herk, Corinne Faivre-Finn, Alan McWilliam
Summary: The study found that tumor density and incidental dose in lung stereotactic radiotherapy are associated with the risk of distant metastasis, and imaging biomarkers may help predict which patients require dose escalation outside the gross tumor volume. Understanding the interaction between imaging biomarkers and dose is crucial for identifying patients who can benefit from dose-escalation, potentially influencing the clinical implementation of imaging biomarkers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiang-Yu Wang, Rui Zhang, Jia-Hao Han, Shi-Qing Chen, Fei-Long Zhao, Hui Chen, Jing Lin, Jie Fan, Wen-Wei Zhu, Lu Lu, Jin-Hong Chen
Summary: This study aims to investigate the potential of early circulating tumor DNA (ctDNA) dynamics as a precise predictor of treatment response and recurrence in patients with colorectal liver metastases (CRLM) receiving neoadjuvant therapy (NAT). Through deep targeted panel sequencing and analysis of blood samples from 34 patients, it was found that the dynamic changes in ctDNA could accurately predict treatment response and were superior to conventional tumor markers in predicting radiologic response and pathologic tumor regression. Early changes in ctDNA were also found to be an independent indicator of recurrence-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, Ian Geh, Joao D. Barros-Silva, Andrew D. Beggs
Summary: The phenomenon of pathCR in rectal cancer may be related to immunovisibility caused by a high tumor mutational burden phenotype. Potential therapy resistance mechanisms involve the PI3K/AKT/mTOR signaling pathway, but tumor heterogeneity does not seem to play a role in resistance.
RADIATION ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Geoffrey Yuet Mun Wong, Connie Diakos, Thomas J. Hugh, Mark P. Molloy
Summary: Colorectal liver metastases (CRLM) are a major cause of death in patients with metastatic colorectal cancer (CRC). Liver resection is the main treatment for select patients with CRLM, but effective treatment remains challenging due to high rates of recurrence. Genomic profiling has improved our understanding of CRC, but the functional context at the protein level is not well-established. Proteomic biomarkers are being explored for predicting CRLM and recurrence. This review aims to rationalize the proteomic complexity of CRC and explore the potential applications of proteomic biomarkers in CRLM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tiuri E. Kroese, Willemieke P. M. Dijksterhuis, Peter S. N. van Rossum, Rob H. A. Verhoeven, Stella Mook, Nadia Haj Mohammad, Maarten C. C. M. Hulshof, Mark I. van Berge Henegouwen, Martijn G. H. van Oijen, Jelle P. Ruurda, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: This study evaluated the management, overall survival, and prognostic factors of esophageal cancer patients with interval distant metastases. The findings suggest that the survival outcomes of these patients are influenced by treatment strategies and prognostic factors, and are comparable to those of synchronous metastatic patients.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Sumit Sahni, Christopher Nahm, Mahsa S. S. Ahadi, Loretta Sioson, Sooin Byeon, Angela Chou, Sarah Maloney, Elizabeth Moon, Nick Pavlakis, Anthony J. J. Gill, Jaswinder Samra, Anubhav Mittal
Summary: This study aimed to identify key differences in gene expression profile in tumors from chemoresponsive and chemoresistant patients. The results showed a distinct gene expression profile between good- and poor-chemotherapy responders, and a biomarker panel was selected with high diagnostic ability for good-responding PDAC patients.
Article
Oncology
Katia Ramos Moreira Leite, Leonardo Lima Borges, Leopoldo Ribeiro Filho, Daher Chade, Rafael Ferreira Coelho, Mauricio Cordeiro, Miguel Srougi, Willian Carlos Nahas
Summary: This study found that the presence of divergent histological differentiation and the immunexpression of CAIX in muscle invasive urothelial carcinoma predict no response to cisplatin based neoadjuvant chemotherapy. These findings can be easily used in clinical practice to select patients for upfront surgery.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Biochemical Research Methods
Emily R. Penick, Nicholas W. Bateman, Christine Rojas, Cuauhtemoc Magana, Kelly Conrads, Ming Zhou, Brian L. Hood, Guisong Wang, Niyati Parikh, Ying Huang, Kathleen M. Darcy, Yovanni Casablanca, Paulette Mhawech-Fauceglia, Thomas P. Conrads, G. Larry Maxwell
Summary: This study compared the proteomic profiles of HGSOC tumors before and after neoadjuvant chemotherapy, revealing significant alterations in proteins associated with cell survival and metabolic signaling. Additionally, analysis of pre-NACT tumors from R1 and R0 patients identified proteins related to tumor cell viability and invasion signaling enriched in R1 patients.
CLINICAL PROTEOMICS
(2022)
Article
Immunology
Jin Wu, Yuan Tian, Wei Liu, Hong Zheng, Yuanyin Xi, Yuzhao Yan, Ying Hu, Bin Liao, Minghao Wang, Peng Tang
Summary: A novel 12 gene-signature has been identified in this study to predict the response to neoadjuvant chemotherapy and prognosis in breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Simone Famularo, Flavio Milana, Matteo Cimino, Eloisa Franchi, Mario Giuffrida, Guido Costa, Fabio Procopio, Matteo Donadon, Guido Torzilli
Summary: This study aims to develop a machine-learning model to determine whether upfront surgery (UPS) or neoadjuvant chemotherapy followed by liver resection (NEOS) is a better treatment option for colorectal liver metastases (CLM). By conducting an inverse probability weighting analysis, baseline differences among 448 patients were leveled out. A mortality risk model was built using random-forest to identify the best potential treatment (BPT) for each patient. The BPT-upfront and BPT-neoadjuvant candidates were automatically selected using a classification-and-regression tree (CART).
Article
Medicine, General & Internal
Eftychia Chatziioannou, Jana Rossner, Thazin New Aung, David L. Rimm, Heike Niessner, Ulrike Keim, Lina Maria Serna-Higuita, Irina Bonzheim, Luis Kuhn Cuellar, Dana Westphal, Julian Steininger, Friedegund Meier, Oltin Tiberiu Pop, Stephan Forchhammer, Lukas Flatz, Thomas Eigentler, Claus Garbe, Martin Roecken, Teresa Amaral, Tobias Sinnberga
Summary: This study aims to evaluate the prognostic and predictive value of tumor-infiltrating lymphocytes (TILs) in cutaneous melanoma. The analysis of 321 primary tumors and 191 metastatic samples showed that low eTILs were closely associated with unfavorable prognosis. In therapy-naive metastases, high eTILs were associated with better survival outcomes in patients receiving anti-PD-1 immunotherapy.
Article
Oncology
Oran Zlotnik, Tal Goshen-Lago, Riad Haddad, Baruch Brenner, Yulia Kundel, Irit Ben-Aharon, Hanoch Kashtan
Summary: This study identified differential enrichment of pathways related to oxidative phosphorylation and the RAS oncogene pathway in esophageal cancer patients with a favorable response to chemoradiation. These pathways may serve as potential surrogate biomarkers for predicting treatment response.
