Editorial Material
Immunology
Luigi D. Notarangelo, Marita Bosticardo
Summary: The article reveals that individuals with Down syndrome have a lower risk of viral infections but suffer more severe infectious episodes. Dysregulated IFN-I responses in individuals with DS lead to increased initial signaling, resulting in a refractory state that reduces their immune system's ability to control viral infections.
Editorial Material
Hematology
Victoria da Silva-Diz, Daniel Herranz
Summary: Li et al. comprehensively analyzed the role of sphingosine kinases in regulating hematopoietic stem cell function using mouse models, and found that specific loss of Sphk2 can expand and rejuvenate HSCs.
Editorial Material
Biochemistry & Molecular Biology
Davide Pisani, Maria Eleonora Rossi, Ferdinand Marletaz, Roberto Feuda
Summary: Phylogenetic studies have traditionally placed the simple Xenoacoelomorph worms as the sister group of all other animals with bilateral body symmetry. A new study suggests that misidentification of orthologous genes might have contributed to this placement.
Article
Computer Science, Hardware & Architecture
Marcelo Bagnulo, Alberto Garcia-Martinez
Summary: This study examines the interaction between the LEDBAT++ and BBR congestion control algorithms. While LEDBAT++ fails to yield to BBR in some common conditions, the behavior varies for different versions of BBR.
Article
Microbiology
Maarten J. Sarink, Lonneke G. M. Bode, Peter Croughs, Jurriaan E. M. de Steenwinkel, Nelianne J. Verkaik, Mireille van Westreenen, Marius Vogel, Erlangga Yusuf
Summary: This study examined the frequency of antimicrobial susceptibility pattern changes in the same isolate of bacteria from the same patient under different situations. Laboratory data from a tertiary hospital's clinical microbiology laboratory over 8 years were analyzed for Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Pseudomonas aeruginosa, and Staphylococcus aureus. The study found that the longer the follow-up period, the higher the risk of phenotypic resistance and that certain drug-bug combinations were more likely to develop resistance. The findings suggest that omitting follow-up antimicrobial susceptibility tests within 7 days may be feasible for the microorganisms examined, resulting in cost and time savings.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Monalisha Ghosh Dastidar, Krishnan Murugappan, Adam M. Damry, David R. Nisbet, Christopher J. Nolan, Antonio Tricoli
Summary: The development of biosensors is crucial for controlling the spread of potential pandemics and decentralizing healthcare services. This study presents an efficient material platform for detecting biomarkers at extremely low concentrations with excellent selection and a wide linear response range, showcasing its potential for clinical utility and versatility in detecting other biomarkers.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Editorial Material
Geriatrics & Gerontology
Iliana C. Lega, Paula A. Rochon
Summary: The editorial provides comments on two articles.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Business
Paul Richard Steffens, Ted Baker, Per Davidsson, Julienne Marie Senyard
Summary: Entrepreneurial bricolage is often useful as a coping mechanism for resource-constrained new ventures, but it may also have detrimental effects. This study examines the conditions for effective bricolage and finds that it has a positive influence through resource replacement, but can be harmful through intertwined second-best solutions and tinkering trap. The intensity of these mechanisms depends on the venture's stage of development and growth expectations.
JOURNAL OF MANAGEMENT
(2023)
Article
Chemistry, Physical
G. C. Q. da Silva, J. M. Simon, J. Marcos Salazar
Summary: Zeolites have unique properties that make them suitable for separation processes. The ability to tailor their characteristics, such as Si/Al ratio, allows for optimization in synthesis for specific tasks. Understanding the effect of cations on the adsorption of toluene by faujasites is crucial for developing new materials with high selectivity and sensitivity. Grand Canonical Monte Carlo simulations reveal the role of Na-cations in toluene adsorption, with cations at site II enhancing adsorption and cations at site III hindering organization of toluene molecules.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Oncology
Zining Liu, Yinkui Wang, Fei Shan, Xiangji Ying, Yan Zhang, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Ziyu Li, Jiafu Ji
Summary: This study aimed to explore the possibility of reducing the duration of perioperative chemotherapy (PEC) in the adjuvant chemotherapy (AC) phase for locally advanced gastric cancer (LAGC) patients. The results showed that the optimal PEC cycles for ypT0-2N0 patients are four to six cycles, while ypT3-4N0 patients may require a minimum of five PEC cycles.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Federico Lucantoni, Ana M. Benedicto, Aleksandra Gruevska, Angela B. Moragrega, Isabel Fuster-Martinez, Juan Esplugues, Ana Blas-Garcia, Nadezda Apostolova
Summary: This study evaluates the impact of Rilpivirine on autophagy in hepatic stellate cells, finding that Rilpivirine can enhance autophagy in mouse models of chronic liver injury and activated hepatic stellate cells. Autophagy is involved in the cytotoxic effect of Rilpivirine on hepatic stellate cells. Additionally, Rilpivirine also affects the viability of hepatic stellate cells through its antifibrogenic effect.
CELL DEATH & DISEASE
(2022)
Editorial Material
Parasitology
Jeremy Bouyer
Summary: Recent research by Evans et al. confirms compensation and overcompensation in Aedes mosquitoes under field conditions, where equal or increased densities of emerging adults may result from reduced larval densities. This article discusses the consequences of applying the sterile insect technique and provides recommendations to avoid counter-productive effects.
TRENDS IN PARASITOLOGY
(2023)
Article
Robotics
Mohamed S. Talamali, Arindam Saha, James A. R. Marshall, Andreagiovanni Reina
Summary: The study shows that in a robot swarm, the ability to adapt to dynamic environments is enhanced when the communication range between robots is shorter. Despite the common belief that more communication links can improve information exchange, in reality, fewer communication links can improve the swarm's adaptability.
Article
Paleontology
Pauline Guenser, Samuel Ginot, Gilles Escarguel, Nicolas Goudemand
Summary: Taxonomy is the first step in biodiversity studies, but the accuracy of taxa delineation can be influenced by sampling effort, especially in the presence of transitional forms. This study highlights the complexity of taxonomic work and emphasizes the importance of extensively illustrating, measuring, and comparing material to better understand morphological variability and delineate taxa.
Review
Agriculture, Multidisciplinary
Peter Kalds, Shiwei Zhou, Shuhong Huang, Yawei Gao, Xiaolong Wang, Yulin Chen
Summary: Increasing meat production is a major concern in animal breeding. Recent genomic advances have revealed naturally occurring variants responsible for controlling economically relevant phenotypes. The myostatin (MSTN) gene, a crucial gene in animal breeding, has been found to negatively regulate muscle mass. Genetic modification, specifically gene editing, offers the potential to induce or mimic these naturally occurring mutations, resulting in higher growth rates and increased muscle mass in livestock. This review discusses the targeting of the MSTN gene in livestock breeding to further explore its utilization opportunities. It is expected that MSTN gene-edited livestock will soon be commercialized, making MSTN-edited meat available to the general public.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)