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Prevention of HIV spread during the Ebola outbreak in Guinea

LANCET (2015)

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LANCET

卷 385, 期 9976, 页码 1393-1393

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ELSEVIER SCIENCE INC

DOI: 10.1016/S0140-6736(15)60713-9

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Medicine, General & Internal

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Mandei, Edmund Manning, Aldric Manuel, Ceila Maria Sant Ana Malaque, Flavio Marino, Carolline De Araujo Mariz, Charbel Maroun Eid, Ana Marques, Catherine Marquis, Brian Marsh, Laura Marsh, John Marshall, Celina Turchi Martelli, Guillaume Martin-Blondel, Ignacio Martin-Loeches, Alejandro Martin-Quiros, Dori-Ann Martin, Emily Martin, Martin Martinot, Caroline Martins Rego, Ana Martins, Joao Martins, Gennaro Martucci, Eva Miranda Marwali, Juan Fernado Masa Jimenez, David Maslove, Sabina Mason, Moshe Matan, Daniel Mathieu, Mathieu Mattei, Romans Matulevics, Laurence Maulin, Natalie Mc Evoy, Aine McCarthy, Anne McCarthy, Colin McCloskey, Rachael McConnochie, Sherry McDermott, Sarah McDonald, Samuel McElwee, Natalie McEvoy, Allison McGeer, Niki McGuinness, Kenneth A. McLean, Bairbre McNicholas, Edel Meaney, Cecile Mear-Passard, Maggie Mechlin, Ferruccio Mele, Kusum Menon, France Mentre, Alexander J. Mentzer, Noemie Mercier, Antoine Merckx, Blake Mergler, Laura Merson, Antonio Mesquita, Agnes Meybeck, Alison M. Meynert, Vanina Meyssonnier, Amina Meziane, Medhi Mezidi, Celine Michelanglei, Vladislav Mihnovits, Hugo Miranda Maldonado, Mary Mone, Asma Moin, David Molina, Elena Molinos, Agostinho Monteiro, Claudia Montes, Giorgia Montrucchio, Sarah Moore, Shona C. Moore, Lina Morales-Cely, Lucia Moro, Diego Rolando Morocho Tutillo, Ana Motos, Hugo Mouquet, Clara Mouton Perrot, Julien Moyet, Jimmy Mullaert, Daniel Munblit, Derek Murphy, Marlene Murris, Dimitra Melia Myrodia, Yohan N'guyen, Nadege Neant, Holger Neb, Nikita A. Nekliudov, Raul Neto, Emily Neumann, Bernardo Neves, Pauline Yeung Ng, Wing Yiu Ng, Orna Ni Choileain, Alistair Nichol, Stephanie Nonas, Marion Noret, Lisa Norman, Alessandra Notari, Mahdad Noursadeghi, Karolina Nowicka, Saad Nseir, Jose I. Nunez, Elsa Nyamankolly, Max O'Donnell, Katie O'Hearn, Conar O'Neil, Giovanna Occhipinti, Tawnya Ogston, Takayuki Ogura, Tak-Hyuk Oh, Shinichiro Ohshimo, Budha Charan Singh Oinam, Ana Pinho Oliveira, Joao Oliveira, Piero Olliaro, David S. Y. Ong, Wilna Oosthuyzen, Peter J. M. Openshaw, Claudia Milena Orozco-Chamorro, Andres Orquera, Javier Osatnik, Nadia Ouamara, Rachida Ouissa, Clark Owyang, Eric Oziol, Diana Povoas, Maider Pagadoy, Justine Pages, Mario Palacios, Massimo Palmarini, Giovanna Panarello, Prasan Kumar Panda, Mauro Panigada, Nathalie Pansu, Aurelie Papadopoulos, Briseida Parra, Jeremie Pasquier, Fabian Patauner, Luis Patrao, Christelle Paul, Mical Paul, Jorge Paulos, William A. Paxton, Jean-Francois Payen, India Pearse, Giles J. Peek, Florent Peelman, Nathan Peiffer-Smadja, Vincent Peigne, Mare Pejkovska, Ithan D. Peltan, Rui Pereira, Daniel Perez, Thomas Perpoint, Antonio Pesenti, Lenka Petrousova, Ventzislava Petrov-Sanchez, Gilles Peytavin, Scott Pharand, Michael Piagnerelli, Walter Picard, Olivier Picone, Marie Piel-Julian, Carola Pierobon, Carlos Pimentel, Lionel Piroth, Riinu Pius, Simone Piva, Laurent Plantier, Daniel Plotkin, Julien Poissy, Maria Pokorska-Spiewak, Sergio Poli, Georgios Pollakis, Jolanta Popielska, Douwe F. Postma, Pedro Povoa, Jeff Powis, Sofia Prapa, Christian Prebensen, Jean-Charles Preiser, Vincent Prestre, Nicholas Price, Anton Prinssen, Mark G. Pritchard, Lucia Proenca, Oriane Puechal, Gregory Purcell, Luisa Quesada, Else Quist-Paulsen, Mohammed Quraishi, Indrek Ratsep, Bernhard Rossler, Christian Rabaud, Marie Rafiq, Gabrielle Ragazzo, Fernando Rainieri, Nagarajan Ramakrishnan, Kollengode Ramanathan, Blandine Rammaert, Christophe Rapp, Menaldi Rasmin, Cornelius Rau, Stanislas Rebaudet, Sarah Redl, Brenda Reeve, Liadain Reid, Renato Reis, Jonathan Remppis, Martine Remy, Hanna Renk, Liliana Resende, Anne-Sophie Resseguier, Matthieu Revest, Oleksa Rewa, Luis Felipe Reyes, David Richardson, Denise Richardson, Laurent Richier, Jordi Riera, Ana Lucia Rios, Asgar Rishu, Patrick Rispal, Karine Risso, Maria Angelica Rivera Nunez, Nicholas Rizer, Andre Roberto, Stephanie Roberts, David L. Robertson, Olivier Robineau, Ferran Roche-Campo, Paola Rodari, Simao Rodeia, Julia Rodriguez Abreu, Emmanuel Roilides, Amanda Rojek, Juliette Romaru, Roberto Roncon-Albuquerque, Melanie Roriz, Manuel Rosa-Calatrava, Michael Rose, Dorothea Rosenberger, Andrea Rossanese, Benedicte Rossignol, Patrick Rossignol, Carine Roy, Benoit Roze, Clark D. Russell, Steffi Ryckaert, Aleksander Rygh Holten, Xavier Sanchez Choez, Isabela Saba, Musharaf Sadat, Nadia Saidani, Leonardo Salazar, Gabriele Sales, Stephane Sallaberry, Helene Salvator, Angel Sanchez-Miralles, Olivier Sanchez, Vanessa Sancho-Shimizu, Gyan Sandhu, Oana Sandulescu, Marlene Santos, Shirley Sarfo-Mensah, Benjamine Sarton, Egle Saviciute, Parthena Savvidou, Joshua Scarsbrook, Tjard Schermer, Arnaud Scherpereel, Marion Schneider, Stephan Schroll, Michael Schwameis, James Scott-Brown, Janet T. Scott, Nicholas Sedillot, Tamara Seitz, Caroline Semaille, Malcolm G. Semple, Eric Senneville, Filipa Sequeira, Tania Sequeira, Ellen Shadowitz, Mohammad Shamsah, Pratima Sharma, Catherine A. Shaw, Victoria Shaw, Nisreen Shiban, Nobuaki Shime, Hiroaki Shimizu, Keiki Shimizu, Sally Shrapnel, Hoi Ping Shum, Nassima Si Mohammed, Louise Sigfrid, Catarina Silva, Maria Joao Silva, Wai Ching Sin, Vegard Skogen, Sue Smith, Benjamin Smood, Michelle Smyth, Morgane Snacken, Dominic So, Monserrat Solis, Joshua Solomon, Tom Solomon, Emily Somers, Agnes Sommet, Myung Jin Song, Rima Song, Tae Song, Michael Sonntagbauer, Edouard Soum, Maria Sousa Uva, Marta Sousa, Vicente Souza-Dantas, Alexandra Sperry, Shiranee Sriskandan, Thomas Staudinger, Stephanie-Susanne Stecher, Ymkje Stienstra, Birgitte Stiksrud, Adrian Streinu-Cercel, Anca Streinu-Cercel, Samantha Strudwick, Ami Stuart, David Stuart, Asfia Sultana, Charlotte Summers, Magdalena Surovcova, Andrey A. Svistunov, Konstantinos Syrigos, Jaques Sztajnbok, Konstanty Szuldrzynski, Francois Teoule, Shirin Tabrizi, Lysa Tagherset, Ewa Talarek, Sara Taleb, Jelmer Talsma, Le Van Tan, Hiroyuki Tanaka, Taku Tanaka, Hayato Taniguchi, Coralie Tardivon, Pierre Tattevin, M. Azhari Taufik, Richard S. Tedder, Joao Teixeira, Marie-Capucine Tellier, Pleun Terpstra, Olivier Terrier, Nicolas Terzi, Hubert Tessier-Grenier, Vincent Thibault, Simon-Djamel Thiberville, Benoit Thill, A. A. Roger Thompson, Shaun Thompson, David Thomson, Emma C. Thomson, Duong Bich Thuy, Ryan S. Thwaites, Peter S. Timashev, Jean-Francois Timsit, Bharath Kumar Tirupakuzhi Vijayaraghavan, Maria Toki, Kristian Tonby, Rosario Maria Torres Santos-Olmo, Antoni Torres, Margarida Torres, Theo Trioux, Huynh Trung Trieu, Cecile Tromeur, Ioannis Trontzas, Jonathan Troost, Tiffany Trouillon, Christelle Tual, Sarah Tubiana, Helen Tuite, Lance C. W. Turtle, Pawel Twardowski, Makoto Uchiyama, Roman Ullrich, Alberto Uribe, Asad Usman, Luis Val-Flores, Stijn Van de Velde, Marcel Van den Berge, Machteld Van der Feltz, Nicky Van der Vekens, Peter Van der Voort, Sylvie Van der Werf, Marlice Van Dyk, Laura Van Gulik, Jarne Van Hattem, Steven Van Lelyveld, Carolien Van Netten, Noemie Vanel, Henk Vanoverschelde, Charline Vauchy, Aurelie Veislinger, Jorge Velazco, Sara Ventura, Annelies Verbon, Cesar Vieira, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyen Van Vinh Chau, Benoit Visseaux, Hannah Visser, Aapeli Vuorinen, Fanny Vuotto, Chih-Hsien Wang, Jia Wei, Katharina Weil, Sanne Wesselius, Murray Wham, Bryan Whelan, Nicole White, Aurelie Wiedemann, Keith Wille, Evert-Jan Wils, Ioannis Xynogalas, Jacky Y. Suen, Sophie Yacoub, Masaki Yamazaki, Yazdan Yazdanpanah, Cecile Yelnik, Stephanie Yerkovich, Toshiki Yokoyama, Hodane Yonis, Paul Young, Saptadi Yuliarto, Marion Zabbe, Kai Zacharowski, Maram Zahran, Maria Zambon, Alberto Zanella, Konrad Zawadka, Hiba Zayyad, Alexander Zoufaly, David Zucman

INFECTION (2021)

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Article Pharmacology & Pharmacy

Health crisis: what opportunities for clinical research on drugs?

Dominique Deplanque, Stanislas Cviklinski, Marc Bardou, Florence Ader, Herve Blanchard, Philippe Barthelemy, Isabelle David, Eric D'Ortenzio, Helene Esperou, Odile Launay, Milan Lazarevic, Philippe Lechat, Francoise Lethiec, Yves Levy, David Perol, Virginie Rage, Matthieu Roustit, Gabriel Thabut

Summary: The COVID-19 pandemic has sparked an unprecedented academic and industrial research effort, leading to adjustments in regulatory procedures and removal of certain obstacles in clinical research organization, ultimately accelerating the conduct of trials.

THERAPIE (2022)

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Article Pharmacology & Pharmacy

Health crisis: What opportunities for clinical drug research?

Dominique Deplanque, Stanislas Cviklinski, Marc Bardou, Florence Ader, Herve Blanchard, Philippe Barthelemy, Isabelle David, Eric D'Ortenzio, Helene Esperou, Odile Launay, Milan Lazarevic, Philippe Lechat, Francoise Lethiec, Yves Levy, David Perol, Virginie Rage, Matthieu Roustit, Gabriel Thabut

Summary: The COVID-19 pandemic led to an unprecedented deployment of academic and industrial research efforts globally, with the implementation of digitization and decentralization of certain processes. However, it also exposed the fragility of clinical research organizations, with France lacking coordination, funding, and data sharing.

THERAPIE (2022)

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Article Rheumatology

Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial

France X. Mariette, O. Hermine, P-L Tharaux, M. Resche-Rigon, R. Porcher, P. Ravaud

Summary: Treatment with sarilumab did not improve early outcomes in patients with moderate-to-severe COVID-19 pneumonia. Further studies are warranted to evaluate the effect of sarilumab on long-term survival.

LANCET RHEUMATOLOGY (2022)

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Article Multidisciplinary Sciences

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Esteban Garcia-Gallo, Laura Merson, Kalynn Kennon, Sadie Kelly, Barbara Wanjiru Citarella, Daniel Vidali Fryer, Sally Shrapnel, James Lee, Sara Duque, Yuli V. Fuentes, Valeria Balan, Sue Smith, Jia Wei, Bronner P. Goncalves, Clark D. Russell, Louise Sigfrid, Andrew Dagens, Piero L. Olliaro, Joaquin Baruch, Christiana Kartsonaki, Jake Dunning, Amanda Rojek, Aasiyah Rashan, Abi Beane, Srinivas Murthy, Luis Felipe Reyes

Summary: The ISARIC COVID-19 dataset is one of the largest international databases of clinical data on hospitalized COVID-19 patients. It includes data from hospitals worldwide and provides comprehensive information on patient characteristics and treatments.

SCIENTIFIC DATA (2022)

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Article Infectious Diseases

HIV stigma limits the effectiveness of PMTCT in Guinea: the ANRS 12344-DIAVINA study

Guillaume Breton, Oumou Hawa Diallo, Mohamed Cisse, Oumou Hawa Diallo, Nene Aissatou Diallo, Seny Agnes Soumaoro, Yalikhatou Camara, Alice Montoye, Christine Rouzioux, Youssouf Koita, Gilles Peytavin, Roland Tubiana, Pierre Prange

Summary: This study investigated the feasibility of reinforced antiretroviral prophylaxis and early infant diagnosis in high-risk infants. The study found that reinforced antiretroviral prophylaxis and early infant diagnosis at birth are widely feasible. However, the lack of maternal disclosure of HIV status and the stigma associated with it affect the assessment of mother-to-child transmission risk and follow-up.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Article Medicine, General & Internal

Randomized Trial of Vaccines for Zaire Ebola Virus Disease

Mark Kieh, Laura Richert, Abdoul H. Beavogui, Birgit Grund, Bailah Leigh, Eric D'Ortenzio, Seydou Doumbia, Edouard Lhomme, Samba Sow, Renaud Vatrinet, Celine Roy, Stephen B. Kennedy, Sylvain Faye, Shelley Lees, Niouma P. Millimouno, Alseny M. Camara, Mohamed Samai, Gibrilla F. Deen, Moussa Doumbia, Helene Esperou, Jerome Pierson, Deborah Watson-Jones, Alpha Diallo, Deborah Wentworth, Chelsea McLean, Jakub Simon, Aurelie Wiedemann, Bonnie Dighero-Kemp, Lisa Hensley, H. Clifford Lane, Yves Levy, Peter Piot, Brian Greenwood, Genevieve Chene, James Neaton, Yazdan Yazdanpanah

Summary: In the study of vaccines for preventing Zaire Ebola virus disease, the Ad26-MVA regimen showed good immune responses in both adults and children, and the other two regimens also provided protection. The trial results demonstrated the safety of these vaccines, and immune responses were observed from day 14 after vaccination until month 12.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Public, Environmental & Occupational Health

Characteristics and outcomes of an international cohort of 600000 hospitalized patients with COVID-19

Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas

Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2023)

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Article Public, Environmental & Occupational Health

Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active- controlled trial in Guinea and Sierra Leone

Edward Man-Lik Choi, Boris Lacarra, Muhammed Afolabi, Boni Maxime Ale, Frank Baiden, Christine Betard, Julie Foster, Benjamin Hamze, Christine Schwimmer, Daniela Manno, Eric D'Ortenzio, David Ishola, Cheick Mohamed Keita, Babajide Keshinro, Yusupha Njie, Wim van Dijck, Auguste Gaddah, Dickson Anumendem, Brett Lowe, Renaud Vatrinet, Bolarinde Joseph Lawal, Godfrey Otieno, Mohamed Samai, Gibrilla Fadlu Deen, Ibrahim Bob Swaray, Abu Bakarr Kamara, Michael Morlai Kamara, Mame Aminata Diagne, Dickens Kowuor, Chelsea McLean, Bailah Leigh, Abdoul Habib Beavogui, Maarten Leyssen, Kerstin Luhn, Cynthia Robinson, Macaya Douoguih, Brian Greenwood, Rodolphe Thiebaut, Deborah Watson-Jones

Summary: This study evaluated the safety and immunogenicity of the Ad26.ZEBOV and MVA-BN-Filo Ebola virus vaccine regimen in infants aged 4-11 months in Guinea and Sierra Leone. The results showed that the vaccine was well tolerated and induced strong humoral responses in infants younger than 1 year, with no safety concerns related to vaccination.

LANCET GLOBAL HEALTH (2023)

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Article Pediatrics

Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity

Eva Miranda Marwali, Aria Kekalih, Saptadi Yuliarto, Dyah Kanya Wati, Muhammad Rayhan, Ivy Cerelia Valerie, Hwa Jin Cho, Waasila Jassat, Lucille Blumberg, Maureen Masha, Calum Semple, Olivia Swann, Malte Kohns Vasconcelos, Jolanta Popielska, Srinivas Murthy, Robert A. Fowler, Anne-Marie Guerguerian, Anca Streinu-Cercel, Mohan Dass Pathmanathan, Amanda Rojek, Christiana Kartsonaki, Bronner P. Goncalves, Barbara Wanjiru Citarella, Laura Merson, Piero L. Olliaro, Heidi Jean Dalton

Summary: The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). The study found that mortality and morbidities were higher in LMICs than HICs, which may be attributable to differences in patient demographics, complications, and access to supportive and treatment modalities.

BMJ PAEDIATRICS OPEN (2022)

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Article Critical Care Medicine

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson, Elsa D. Ibanez-Prada, Jordi Rello, Yuli Fuentes, Ignacio Martin-Loeches, Fernando Bozza, Sara Duque, Fabio S. Taccone, Robert A. Fowler, Christiana Kartsonaki, Bronner P. Goncalves, Barbara Wanjiru Citarella, Diptesh Aryal, Erlina Burhan, Matthew J. Cummings, Christelle Delmas, Rodrigo Diaz, Claudia Figueiredo-Mello, Madiha Hashmi, Prasan Kumar Panda, Miguel Pedrera Jimenez, Diego Fernando Bautista Rincon, David Thomson, Alistair Nichol, John C. Marshall, Piero L. Olliaro

Summary: This study described the clinical characteristics, outcomes, and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 in high-income countries (HICs) and low middle-income countries (LMICs) during the first two years of the pandemic. The most frequently used advanced respiratory support was high-flow nasal cannulas (HFNC), although invasive mechanical ventilation (IMV) was more commonly used in LMICs. High leukocyte counts, tachypnoea, and treatment in LMICs were identified as risk factors for HFNC/NIV failure. HFNC/NIV failure was associated with worse clinical outcomes, such as 28-day mortality.

CRITICAL CARE (2022)

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Letter Infectious Diseases

Bridging the gap between scientific discovery and clinical application during the COVID-19 epocha

Boris Lacarra, Guillaume Mellon, Inmaculada Ortega Perez, Eric D'Ortenzio, Franois-Xavier Lescured

INFECTIOUS DISEASES NOW (2021)

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