Pathogenesis of Helicobacter pylori Infection

Helicobacter pylori relies on multiple colonization and virulence factors to persist in the human stomach for life. In addition, these factors can be modulated and vary to suit the ever-changing environment within the host individual. This article outlines the novel developments in this field of research during the past year, highlighting the cag pathogenicity island, VacA, gamma-glutamyl-transpeptidase as well as including recent advances in protein structure, bacteria host interaction, and the role of stomach microbiota.