Article
Clinical Neurology
Oh Young Bang, Siin Kim, Young Keun On, Myung-Yong Lee, Sung-Won Jang, Seongwook Han, Jaeyun Ryu, Seongsik Kang, Hae Sun Suh, Young-Hoon Kim
Summary: NOACs have been proven to be alternative medications for preventing stroke in patients with non-valvular atrial fibrillation. However, the use of antiplatelet agents, warfarin, and NOACs in clinical practice is influenced by patient factors.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Monika Koziel, Christine Teutsch, Jonathan L. Halperin, Kenneth J. Rothman, Hans-Christoph Diener, Chang-Sheng Ma, Sabrina Marler, Shihai Lu, Venkatesh K. Gurusamy, Menno Huisman, Gregory Y. H. Lip
Summary: This study described the baseline characteristics, patterns of antithrombotic therapy, and factors associated with oral anticoagulant prescription in patients with atrial fibrillation and multi-comorbid conditions.
Article
Medicine, General & Internal
Valentin Mertz, Yves Cottin, Sid Ahmed Bentounes, Julie Pastier-Debeaumarche, Romain Didier, Julien Herbert, Marianne Zeller, Gregory Y. H. Lip, Laurent Fauchier
Summary: The study aims to assess the prognosis of AF patients and found that patients with cardiac or extra-cardiac concomitant conditions have worse outcomes compared to patients with Lone AF.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Physiology
Jordi Heijman, Dominik Linz, Ulrich Schotten
Summary: Atrial fibrillation leads to increased morbidity and mortality for millions of individuals, with complex pathophysiological mechanisms and a wide range of comorbidities contributing to atrial remodeling. Recent research suggests that AF risk is not constant, with temporal variations in concomitant conditions adding to the complexity of AF dynamics.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Medical Laboratory Technology
Rangrang Zhang, Weidong Jin, Minglei Han, Yonglan Hou
Summary: Atrial fibrillation (AF) is a common clinical arrhythmia associated with increased risk of death, stroke, and peripheral vascular embolism. Catheter ablation (CA) is an effective treatment, but a high recurrence rate remains a challenge. Identifying biomarkers for prediction of AF recurrence after CA is important for personalized treatment. Carbohydrate antigen 125 (CA-125) has been widely studied and may serve as a useful marker for AF.
CLINICA CHIMICA ACTA
(2023)
Review
Medicine, General & Internal
Marco Proietti, Marco Vitolo, Gregory Y. H. Lip
Summary: In high-risk atrial fibrillation patients with diabetes mellitus, chronic kidney disease, and metabolic syndrome, adherent management to the ABC pathway was associated with a lower risk of composite outcomes including cardiovascular events, cardiovascular death, and all-cause death.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Cardiac & Cardiovascular Systems
Mario Gaudino, Antonino Di Franco, Lisa Q. Rong, Jonathan Piccini, Michael Mack
Summary: Postoperative atrial fibrillation (POAF) is a common complication after various surgical procedures, especially cardiac surgery, and is associated with prolonged hospital stay, increased costs, and higher risk of recurrent AF and adverse cardiovascular events. Recent research has provided new insights into the pathophysiology of POAF and proposed novel preventive and therapeutic strategies. This review summarizes the current evidence on the incidence, prevention, and treatment of POAF, and highlights the future directions for clinical research.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Aditya Bhat, Gary C. H. Gan, Henry H. L. Chen, Shaun Khanna, Sumreen Nawaz, Maria Carmo P. Nunes, Timothy Dobbins, C. Raina MacIntyre, Timothy C. Tan
Summary: Left atrial enlargement and reduced LA mechanical function, reflected through LA volume index and LA emptying fraction, are associated with AF rehospitalization and long-term adverse cardiovascular outcomes in patients with nonvalvular AF following index hospitalization.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jihoon Kim, Sung-Ji Park, Dong Seop Jeong, Suryeun Chung, Kina Jeon, Minjung Bak, Darae Kim, Eun Kyoung Kim, Sung-A Chang, Sang-Chol Lee, Seung Woo Park
Summary: This study investigated the association between left atrial (LA) strain and LA fibrosis in patients undergoing totally thoracoscopic ablation (TTA) for atrial fibrillation (AF). The results showed that patients with mild LA fibrosis had a significantly lower rate of AF recurrence at 5 years after TTA compared to those with moderate or severe fibrosis. Peak LA strain was the only predictor of mild LA fibrosis, with a cutoff value of approximately 14.7%.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Hawa O. Abu, Weijia Wang, Edith M. Otabil, Jane S. Saczynski, Jordy Mehawej, Ajay Mishra, Mayra Tisminetzky, Gary Blanchard, Jerry H. Gurwitz, Robert J. Goldberg, David D. McManus
Summary: This study investigated the perception of atrial fibrillation (AF) symptoms and their impact on quality of life (QoL) in older adults, as well as the relationship between treatment strategies and symptoms. The study found that non-specific, non-cardiac symptoms were the most commonly reported among older adults with AF, and they had similar impact on QoL across all age groups. Cardiac-specific symptoms were less prevalent but had a significant impact on QoL in the youngest age group (65-74 years). Overall, patients who reported experiencing any AF symptoms during their clinic visit were more likely to receive rhythm control treatment, except for those aged >= 85 years.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Review
Cardiac & Cardiovascular Systems
Jason G. Andrade, Oussama M. Wazni, Malte Kuniss, Nathaniel M. Hawkins, Marc W. Deyell, Gian-Battista Chierchia, Steven Nissen, Atul Verma, George A. Wells, Ricky D. Turgeon
Summary: Cryoballoon catheter ablation has been shown to significantly improve arrhythmia outcomes, produce clinically meaningful improvements in patient-reported outcomes, reduce subsequent health care resource use, and not increase the risk of serious adverse events compared with initial antiarrhythmic drug therapy in patients with treatment-naive AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Meghan Reading Turchioe, Elsayed Z. Soliman, Parag Goyal, Alexander E. Merkler, Hooman Kamel, Mary Cushman, Orysya Soroka, Ruth Masterson Creber, Monika M. Safford
Summary: This study aimed to investigate the association between atrial fibrillation (AF) and stroke symptoms among adults without a clinical history of stroke or transient ischemic attack (TIA). The results showed that stroke symptoms in the absence of a stroke diagnosis may represent subclinical cardioembolic phenomena, implying the need for further research on stroke symptom screening.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Matthias D. Zink, Karl G. Mischke, Andras P. Keszei, Christian Rummey, Ben Freedman, Gabriele Neumann, Alina Tolksdorf, Friederike Frank, Jan Wienstroeer, Nicole Kuth, Joerg B. Schulz, Nikolaus Marx
Summary: Pharmacy-based, automated AF screening in elderly citizens identified subjects with unknown AF and an excess mortality risk over the next year. Participants with newly diagnosed or known AF had a significantly higher mortality risk compared with subjects without a history of AF at baseline and a normal ECG.
Article
Cardiac & Cardiovascular Systems
Evan L. O'Keefe, Jessica E. Sturgess, James H. O'Keefe, Sanjaya Gupta, Carl J. Lavie
Summary: The article identifies effective lifestyle-based strategies for reducing atrial fibrillation risk, such as controlling hypertension, treating obstructive sleep apnea, abstinence from alcohol, and moderate physical activity. Lifestyle changes and risk factor modification are highly effective for preventing atrial fibrillation.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Cardiac & Cardiovascular Systems
Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J. G. M. Crijns, Bastiaan Geelhoed, Hugo Ten Cate, Henri Spronk, Abraham Kroon, Ruben De With, Meelad Al-Jazairi, Alexander H. Maass, Yuri Blaauw, Robert G. Tieleman, Martin E. W. Hemels, Justin Luermans, Joris de Groot, Cornelis P. Allaart, Arif Elvan, Mirko De Melis, Coert Scheerder, Anton Jan van Zonneveld, Ulrich Schotten, Dominik Linz, Isabelle Van Gelder, Michiel Rienstra
Summary: This study aims to develop a new atrial fibrillation (AF) progression risk prediction model in patients with paroxysmal AF (PAF) to determine the risk and treatment targets for AF progression. The study found that markers for atrial remodeling, sex, mitral valve regurgitation, waist circumference, and biomarkers associated with coagulation, inflammation, cardiomyocyte stretch, and atherosclerosis were all associated with AF progression.
Article
Cardiac & Cardiovascular Systems
Rachel M. J. van der Velden, Nikki A. H. A. Pluymaekers, Elton A. M. P. Dudink, Justin G. L. M. Luermans, Joan G. Meeder, Wilfred F. Heesen, Timo Lenderink, Jos W. M. G. Widdershoven, Jeroen J. J. Bucx, Michiel Rienstra, Otto Kamp, Jurren M. van Opstal, Charles J. H. J. Kirchhof, Vincent F. van Dijk, Henk P. Swart, Marco Alings, Isabelle C. Van Gelder, Harry J. G. M. Crijns, Dominik Linz
Summary: This study aimed to evaluate the adherence to a 4-week mobile health prescription for monitoring atrial fibrillation (AF) recurrences after an emergency department visit for recent-onset AF. The results showed that approximately 85.7% of patients consistently used the device, with older patients being more adherent.
Article
Cardiac & Cardiovascular Systems
Martijn E. van de Lande, Rajiv S. Rama, Tim Koldenhof, Vicente Artola Arita, Bao-Oanh Nguyen, Colinda van Deutekom, Vanessa Weberndorfer, Harry J. G. M. Crijns, Martin E. W. Hemels, Robert G. Tieleman, Mirko de Melis, Ulrich Schotten, Dominik Linz, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aims to assess the association between the time of onset of atrial fibrillation (AF) episodes with the clinical phenotype and AF progression. The results suggest that patients with either predominant nocturnal or daytime onset of AF episodes have less associated comorbidities and less AF progression compared to patients with mixed onset of AF.
Article
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Martijn E. Van de Lande, Neda Khalilian Ekrami, Bao-Oanh Nguyen, Joost M. Van Melle, Bastiaan Geelhoed, Ruben R. De With, Vanessa Weberndorfer, Omer Erkuner, Hans Hillege, Dominik Linz, Hugo Ten Cate, Henri M. H. Spronk, Tim Koldenhof, Robert G. Tieleman, Ulrich Schotten, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. The study found that the 4S-AF scheme does not predict AF progression, but the 3S-AF scheme can predict progression. Therefore, the 3S-AF scheme may be more appropriate for predicting AF progression.
Article
Cardiac & Cardiovascular Systems
Maria Hee Jung Park Frausing, Martijn E. Van De Lande, Alexander H. Maass, Bao-Oanh Nguyen, Martin E. W. Hemels, Robert G. Tieleman, Tim Koldenhof, Mirko De Melis, Dominik Linz, Ulrich Schotten, Vanessa Weberndoerfer, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Jens Cosedis Nielsen, Michiel Rienstra
Summary: This study aimed to examine brady- and tachyarrhythmias using continuous rhythm monitoring in patients with paroxysmal self-terminating AF (PAF). The results showed that almost half of the PAF patients experienced severe bradyarrhythmias or rapid ventricular tachyarrhythmias during continuous rhythm monitoring.
Letter
Cardiac & Cardiovascular Systems
Isabelle C. Van Gelder, Neda Khalilian Ekrami, Katrin Borof, Thomas Fetsch, Christina Magnussen, A. Mulder, Renate Schnabel, Karl Wegscheider, Michiel Rienstra, Paulus Kirchhof
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jasper J. Brugts, Sumant P. Radhoe, Pascal R. D. Clephas, Dilan Aydin, Marco W. F. van Gent, Mariusz K. Szymanski, Michiel Rienstra, Mieke H. van den Heuvel, Carlos A. da Fonseca, Gerard C. M. Linssen, C. Jan Willem Borleffs, Eric Boersma, Folkert W. Asselbergs, Arend Mosterd, Hans-Peter Brunner-La Rocca, Rudolf A. de Boer
Summary: The MONITOR-HF trial conducted in the Netherlands examined the impact of haemodynamic monitoring on quality of life and heart failure hospitalization in patients with heart failure. The study found that haemodynamic monitoring significantly improved patients' quality of life and reduced heart failure hospitalizations.
Article
Medicine, General & Internal
Thomas M. Gorter, Dirk J. van Veldhuisen, Bart A. Mulder, Vicente A. Artola A. Arita, Vanessa P. M. van Empel, Olivier C. Manintveld, Robert G. Tieleman, Alexander H. Maass, Kevin Vernooy, Isabelle C. van Gelder, Michiel Rienstra
Summary: Atrial fibrillation is common in heart failure with HFmrEF/HFpEF and has a negative impact on outcome. Reliable data on prevalence, incidence, and detection of AF from contemporary, prospective HFmrEF/HFpEF studies are scarce. AF screening with an ILR had a much higher diagnostic yield than conventional modalities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ali A. A. Al-Mubarak, Niels Grote Beverborg, Victor Zwartkruis, Colinda van Deutekom, Martin H. H. de Borst, Ron T. T. Gansevoort, Stephan J. L. Bakker, Daan J. J. Touw, Rudolf A. A. de Boer, Peter van der Meer, Michiel Rienstra, Nils Bomer
Summary: This study aimed to investigate the association between micronutrient deficiencies and the development of atrial fibrillation (AFib). Selenium deficiency was found to be associated with new-onset AFib in non-smoking participants.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tim Koldenhof, Isabelle C. Van Gelder, Harry J. G. M. Crijns, Michiel Rienstra, Robert G. Tieleman
Summary: This study aimed to compare the effects of non-dihydropyridine calcium channel blockers and beta-blockers on heart rate in patients with non-permanent atrial fibrillation. The results showed that calcium channel blockers were associated with a lower incidence of bradycardia during sinus rhythm compared to beta-blockers.
Article
Endocrinology & Metabolism
Victor W. Zwartkruis, Navin Suthahar, Demy L. Idema, Belend Mahmoud, Colinda van Deutekom, Frans H. Rutten, Yvonne T. van der Schouw, Michiel Rienstra, Rudolf A. de Boer
Summary: The study found that relative fat mass (RFM) is an emerging marker of obesity that estimates body fat percentage. RFM was significantly associated with incident atrial fibrillation (AF), heart failure (HF), and coronary artery disease (CAD), and potential RFM cutoffs for cardiovascular disease (CVD) prediction were determined. This study provides useful information for future preventive strategies targeting obesity and cardiovascular risk.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medicine, General & Internal
Gijs E. de Maat, Bart A. Mulder, Martijn E. van de Lande, Rajiv S. Rama, Michiel Rienstra, Massimo A. Mariani, Alexander H. Maass, Theo J. Klinkenberg
Summary: This study compares the technical performance between epicardial left ventricular (LV) leads placed via video assisted thoracic surgery (VATS) and transvenously placed leads for cardiac resynchronization therapy (CRT). The results show that epicardial lead placement has lower failure rate and better long-term performance compared to transvenous leads. Therefore, epicardial lead placement should be considered when transvenous lead placement fails or in challenging cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alwin B. P. Noordman, Michiel Rienstra, Yuri Blaauw, Bart A. Mulder, Alexander H. Maass
Summary: This study investigates the occurrence of appropriate ICD therapies and inappropriate shocks in secondary prevention ICD recipients with ventricular arrhythmia of unclear cause and underlying heart disease. It found that ventricular arrhythmia of unclear cause was significantly associated with fewer appropriate ICD therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Colinda Van Deutekom, Bastiaan Geelhoed, Barbara C. Van Munster, Stephan J. L. Bakker, Ron T. Gansevoort, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study investigated the clustering of cardiovascular and renal comorbidities and their association with incident atrial fibrillation (AF) using the PREVEND cohort. Three clusters of comorbidities were identified, each carrying a different risk of incident AF. However, no specific combinations of comorbidities were observed within the clusters.