期刊
HEART RHYTHM
卷 9, 期 1, 页码 107-114出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2011.08.013
关键词
Spiral-wave reentry; Regional myocardial cooling; Unpinning; Optical mapping; Ventricular tachyarrhythmia
资金
- Japanese Society for Promotion of Sciences [19390210, 20590860]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [22136010]
- Grants-in-Aid for Scientific Research [22136010, 22136011, 19390210, 21790717, 20590860, 23390209] Funding Source: KAKEN
BACKGROUND Moderate global cooling of myocardial tissue was shown to destabilize 2-dimensional (2-D) reentry and facilitate its termination. OBJECTIVE This study sought to test the hypothesis that regional cooling destabilizes rotors and facilitates termination of spontaneous and DC shock-induced subepicardial reentry in isolated, endocardially ablated rabbit hearts. METHODS Fluorescent action potential signals were recorded from 2-D subepicardial ventricular myocardium of Langendorff-perfused rabbit hearts. Regional cooling (by 5.9 degrees C +/- 1.3 degrees C) was applied to the left ventricular anterior wall using a transparent cooling device (10 mm in diameter). RESULTS Regional cooling during constant stimulation (2.5 Hz) prolonged the action potential duration (by 36% +/- 9%) and slightly reduced conduction velocity (by 4% +/- 4%) in the cooled region. Ventricular tachycardias (VTs) induced during regional cooling terminated earlier than those without cooling (control): VTs lasting >30 seconds were reduced from 17 of 39 to 1 of 61. When regional cooling was applied during sustained VTs (>120 seconds), 16 of 33 (48%) sustained VTs self-terminated in 12.5 +/- 5.1 seconds. VT termination was the result of rotor destabilization, which was characterized by unpinning, drift toward the periphery of the cooled region, and subsequent collision with boundaries. The DC shock intensity required for cardioversion of the sustained VTs decreased significantly by regional cooling (22.8 +/- 4.1 V, n = 16, vs 40.5 +/- 17.6 V, n = 21). The major mode of reentry termination by DC shocks was phase resetting in the absence of cooling, whereas it was unpinning in the presence of cooling. CONCLUSION Regional cooling facilitates termination of 2-D reentry through unpinning of rotors.
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