Article
Cardiac & Cardiovascular Systems
Moris Topaz, Ehud Chorin, Arie Lorin Schwartz, Aviram Hochstadt, Avraham Shotan, Itamar Ashkenazi, Mark Kazatsker, Narin-Nard Carmel, Guy Topaz, Yoram Oron, Gilad Margolis, Eyal Nof, Roy Beinart, Michael Glikson, Anna Mazo, Anat Milman, Michal Dekel, Shmuel Banai, Raphael Rosso, Sami Viskin
Summary: This study evaluated the efficacy of delivering continuous, in situ-targeted, ultrahigh concentration of antibiotics (CITA) into the infected device pocket as an alternative to device extraction. It was found that CITA is a safe and effective treatment for patients with pocket infections who are unable or unwilling to undergo extraction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hui-Chen Han, Nathaniel M. Hawkins, Charles M. Pearman, David H. Birnie, Andrew D. Krahn
Summary: CIED infection is a serious complication with a 1% infection rate, influenced by technical, patient, and procedural factors. Considering these factors is essential for minimizing infection risk.
Review
Cardiac & Cardiovascular Systems
Maria Hee Jung Park Frausing, Mads Brix Kronborg, Jens Brock Johansen, Jens Cosedis Nielsen
Summary: Complications related to cardiac implantable electronic device (CIED) implantations are common, impacting both patients and the healthcare system. Future efforts should focus on research and guidelines for primary prevention measures.
Article
Cardiac & Cardiovascular Systems
Carina Blomstrom-Lundqvist, Bozena Ostrowska
Summary: CIED infections are a significant concern despite recommended prevention strategies, with infection rates continuing to rise and leading to increased healthcare costs. Recent trials aim to provide important steps for better prevention of device infections, emphasizing the importance of adherence to recommendations.
Article
Cardiac & Cardiovascular Systems
Fozia Z. Ahmed, Carina Blomstrom-Lundqvist, Heather Bloom, Christopher Cooper, Christopher Ellis, Andreas Goette, Arnold J. Greenspon, Charles J. Love, Jens Brock Johansen, Francois Philippon, Khaldoun G. Tarakji, Reece Holbrook, Lou Sherfesee, Ying Xia, Swathi Seshadri, Daniel R. Lexcen, Andrew D. Krahn
Summary: The PADIT infection risk score, developed from a large dataset, identified five independent predictors of CIED infection. A validation study using U.S. healthcare claims data confirmed the predictive value of the risk score, especially when combined with prior CIED infection history, in identifying high-risk patients for targeted interventions to reduce CIED infection risk.
Article
Infectious Diseases
Lucia Boix-Palop, Beatriz Dietl, Esther Calbo, Andrea Di Marco, Mariona Xercavins, Pedro Maria Martinez Perez-Crespo, Adrian Sousa, Miguel Montejo Baranda, Jesus Rodriguez-Bano, Luis Eduardo Lopez-Cortes
Summary: Cardiac device-related infection is common during late-onset bloodstream infection, with Gram-positive pathogens being the main cause.
JOURNAL OF INFECTION
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas F. Deering, John N. Catanzaro, David A. Woodard
Summary: This study found that the use of antibiotics, especially gentamicin, in biologic envelope hydration solution may reduce infection risk in CIED procedures. Additionally, utilizing antibacterial envelopes without adjunct IV ABX may not be sufficient to reduce infection rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Igor Diemberger, Luca Segreti, Christopher A. Rinaldi, Jesper Hastrup Svendsen, Andrzej Kutarski, Arwa Younis, Cecile Laroche, Christophe Leclercq, Barbara Malecka, Przemyslaw Mitkowski, Maria Grazia Bongiorni
Summary: According to the analysis of patients with infection of implantable pacemakers/defibrillators, about one-third of the cases showed systemic infection, which is associated with increased complications and mortality during hospitalization. Patients with systemic infection have different characteristics compared to those with local infection, suggesting that some infections may be systemic from the beginning. These findings have important implications for further research and treatment.
Article
Cardiac & Cardiovascular Systems
Khaldoun G. Tarakji, Panagiotis Korantzopoulos, Francois Philippon, Mauro Biffi, Suneet Mittal, Jeanne E. Poole, Charles Kennergren, Daniel R. Lexcen, Jeff D. Lande, Swathi Seshadri, Bruce L. Wilkoff
Summary: Among WRAP-IT patients, the risk of hematoma was 2.2%. Control patients with hematoma had a significantly higher risk of developing major CIED infection, which was effectively reduced by 82% with antibacterial envelope use compared to control patients.
Article
Cardiac & Cardiovascular Systems
Michele Malagu, Francesco Vitali, Alessandro Brieda, Paolo Cimaglia, Martina De Raffele, Enea Tazzari, Cristina Musolino, Cristina Balla, Matteo Serenelli, Rosario Cultrera, Claudio Rapezzi, Matteo Bertini
Summary: In a study involving patients undergoing CIED surgery, stratification of infective risk guided antibiotic prophylaxis with similar infection rates observed between high and low-risk groups after 250 days of follow-up. Active neoplasia, haematoma, and reintervention were identified as independent risk factors for CIED-related infection.
Article
Health Care Sciences & Services
Giuseppe Boriani, Marco Proietti, Matteo Bertini, Igor Diemberger, Pietro Palmisano, Stefano Baccarini, Francesco Biscione, Nicola Bottoni, Antonio Ciccaglioni, Alessandro Dal Monte, Franco Alberto Ferrari, Saverio Iacopino, Marcello Piacenti, Daniele Porcelli, Stefano Sangiorgio, Luca Santini, Michele Malagu, Giuseppe Stabile, Jacopo Francesco Imberti, Davide Caruso, Massimo Zoni-Berisso, Roberto De Ponti, Renato Pietro Ricci
Summary: In this nationwide cohort study in Italy, the incidence of CIEDs infection was low but the composite clinical outcome rate of infection or all-cause death was high and associated with several clinical factors.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Tuncay Guzel, Adem Aktan, Raif Kilic, Serhat Gunlu, Bayram Arslan, Abdulkadir Arpa, Hamdullah Guzel, Ismail Tatli, Saadet Aydin, Veysel Suzan, Muhammed Demir
Summary: This study investigated whether there is a higher incidence of complications in cardiac implantable electronic devices (CIED) procedures in patients aged ≥ 75 years compared to those aged < 75 years. The results showed no significant difference in the cumulative events defined as the primary outcome between the two age groups. However, the infection related to the device system was significantly higher in the ≥ 75 age group.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Simone Gulletta, Giulio Falasconi, Lorenzo Cianfanelli, Alice Centola, Gabriele Paglino, Manuela Cireddu, Andrea Radinovic, Giuseppe D'Angelo, Alessandra Marzi, Simone Sala, Nicolai Fierro, Caterina Bisceglia, Giovanni Peretto, Nadia Di Muzio, Paolo Della Bella, Pasquale Vergara, Italo Dell'Oca
Summary: This study reports the ten-year real-world experience of a tertiary multidisciplinary teaching hospital in managing patients with cardiac implantable electronic devices (CIEDs) undergoing radiotherapy (RT). The results show infrequent changes in device parameters and occurrence of arrhythmias, with no clinically significant adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ziad F. Issa, Tariq Z. Issa
Summary: This study assessed the management approach and outcome of subacute and delayed cardiac perforation by pacemaker or ICD leads. Percutaneous repositioning or replacement of the perforating lead was found to be a safe and effective management approach in this study.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Vincenzo Livio Malavasi, Jacopo Francesco Imberti, Alberto Tosetti, Giulio Francesco Romiti, Marco Vitolo, Massimo Zecchin, Ercole Mazzeo, De Marco Giuseppina, Frank Lohr, Teresa Lopez-Fernandez, Giuseppe Boriani
Summary: The prevalence of radiotherapy-induced CIEDs malfunctions ranges from 4% to 20%. The use of neutron-producing energies and more complex devices (ICD/CRT-D) are associated with a higher risk of device malfunction, while the radiation dose at CIED does not significantly impact the risk unless higher doses (>10 Gy) are used.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
John Rickard, Mohammed Bassiouny, Ryan J. Tedford, Bryan Baranowski, David Spragg, Daniel Cantillon, Niraj Varma, Bruce L. Wilkoff, W. H. Wilson Tang
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Editorial Material
Cardiac & Cardiovascular Systems
Bruce L. Wilkoff, Charles Kennergren, Charles J. Love, Steven P. Kutalek, Laurence M. Epstein, Roger Carrillo
Article
Cardiac & Cardiovascular Systems
Shady Nakhla, Ayman A. Hussein, Michael P. Brunner, Oussama Wazni, Bruce L. Wilkoff, Khaldoun G. Tarakji
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Divyang Patel, Kevin M. Trulock, Saleem Toro, Adam Grimaldi, Matthew Gonzalez, Laurie Ann Moennich, Eiran Z. Gorodeski, Emer Joyce, Mark Niebauer, Bruce L. Wilkoff, Niraj Varma, John W. Rickard
AMERICAN JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Bruce L. Wilkoff, Giuseppe Boriani, Suneet Mittal, Jeanne E. Poole, Charles Kennergren, G. Ralph Corey, John C. Love, Ralph Augostini, Svein Faerestrand, Sherman S. Wiggins, Jeff S. Healey, Reece Holbrook, Jeffrey D. Lande, Daniel R. Lexcen, Sarah Willey, Khaldoun G. Tarakji
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Bruce L. Wilkoff, Giuseppe Boriani, Suneet Mittal, Jeanne E. Poole, Charles Kennergren, G. Ralph Corey, Andrew D. Krahn, Edward J. Schloss, Jose L. Gallastegui, Robert A. Pickett, Rudolph F. Evonich, Steven F. Roark, Denise M. Sorrentino, Darius P. Sholevar, Edmond M. Cronin, Brett J. Berman, David W. Riggio, Hafiza H. Khan, Marc T. Silver, Jack Collier, Zayd Eldadah, Reece Holbrook, Jeff D. Lande, Daniel R. Lexcen, Swathi Seshadri, Khaldoun G. Tarakji
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Mohamed B. Elshazly, Bruce L. Wilkoff, Khaldoun Tarakji, Yuping Wu, Eoin Donnellan, Charbel Abi Khalil, Nidal Asaad, Wael Jaber, Oussama Wazni, Leslie Cho
Summary: In patients with HF and AF, higher resting ventricular rate and lower peak exercise ventricular rate are associated with worse exercise capacity, while lower exercise ventricular rate parameters are linked to higher mortality. Further studies are needed to determine if modulating exercise ventricular rate can improve exercise performance and outcomes.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas D. Callahan, Khaldoun G. Tarakji, Bruce L. Wilkoff
Summary: Cardiovascular implantable electronic devices (CIED) play a crucial role in modern cardiovascular care, but carry the risk of infections as a major complication. Recent studies have shown that using absorbable antibiotic eluting envelopes in high-risk CIED patients can significantly reduce infection rates.
Article
Cardiac & Cardiovascular Systems
Najmul Siddiqi, Patrick Tchou, Mark J. Niebauer, Bruce L. Wilkoff, Niraj Varma
Summary: Testing the impact of high defibrillation threshold (DFT) on patients' outcomes, it was found that patients with high DFT have higher mortality rates. While system modification can decrease DFT, it does not seem to improve survival, indicating that the electrical substrate underlying high DFT plays a critical role in determining patients' survival.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Arwa Younis, Bruce L. Wilkoff
Article
Cardiac & Cardiovascular Systems
Pierce J. Vatterott, Blandine Mondesert, Mark Marshall, Thomas Lulic, Bruce L. Wilkoff
Summary: This study evaluated the physical properties of Medtronic SelectSecure Model 3830 leads and described extraction techniques. The retained connector method provided better preservation of the extraction rail strength, while limiting traction force and avoiding poor lead preparation methods were crucial for consistent extraction. Femoral snaring did not affect the rail strength.
Article
Cardiac & Cardiovascular Systems
Katsuhide Hayashi, Haruhiko Abe, Brian Olshansky, Arjun D. Sharma, Paul W. Jones, Nicholas Wold, David Perschbacher, Ritsuko Kohno, Mark Richards, Bruce L. Wilkoff
Summary: Heart rate score (HRSc), a measure of atrial pacing and sensing events in the largest bin of a pacemaker's rate histogram, predicts survival in cardiac device patients, but not the development of atrial fibrillation (AF). This study examines the relationship between HRSc and the incidence of newly developed atrial tachyarrhythmias (ATAs) in patients with pacemakers.
Article
Cardiac & Cardiovascular Systems
Katsuhide Hayashi, Thomas Callahan, John Rickard, Arwa Younis, Bryan Baranowski, David Martin, Shady Nakhla, Chadi Tabaja, Bruce L. Wilkoff
Summary: This study assessed the safety and efficacy of transvenous lead extraction (TLE) of implantable cardioverter-defibrillator (ICD) leads, and investigated the impact of lead manufacturer and model on the outcomes. The study found that complete and safe TLE of ICD leads had a high success rate, but varied depending on the manufacturer and lead family.
Article
Cardiac & Cardiovascular Systems
Bruce L. Wilkoff, Laurence D. Sterns, Michael S. Katcher, Gaurav Upadhyay, Peter Seizer, Chaoyi Kang, Jennifer Rhude, Kevin J. Davis, Avi Fischer
Summary: This study developed a novel algorithm called VF Therapy Assurance (VFTA) to improve the detection and timely delivery of high-voltage therapy for ventricular tachyarrhythmias (VTA) with low and varying signal amplitudes and morphologies. The results showed that VFTA successfully identified undertreated VTA episodes missed by traditional detection algorithms, increasing the likelihood of delivering life-saving high-voltage therapy.
Article
Cardiac & Cardiovascular Systems
Arjun D. Sharma, Mark Richards, Brian Olshansky, Nicholas Wold, Paul Jones, David Perschbacher, Bruce L. Wilkoff
Summary: The study found that a heart rate score (HrSc) greater than or equal to 70% is related to chronotropic incompetence and clinical sick sinus syndrome in pacemaker subjects. This measurement can serve as a quantitative indicator of chronotropic incompetence in pacemaker subjects.