Article
Biochemistry & Molecular Biology
Megan Watts, Gopi K. Kolluru, Parinita Dherange, Sibile Pardue, Man Si, Xinggui Shen, Krystle Trosclair, John Glawe, Zaki Al-Yafeai, Mazen Iqbal, Brenna H. Pearson, Kathryn A. Hamilton, A. Wayne Orr, Edward Glasscock, Christopher G. Kevil, Paari Dominic
Summary: Oxidative stress is a driving factor in the pathogenesis of atrial fibrillation (AF), with hydrogen sulfide (H2S) playing an important role in regulating electrical remodeling and susceptibility to AF. Patients with AF had significantly lower plasma sulfide levels, and those with persistent AF had even lower levels compared to paroxysmal AF patients. Additionally, CSE knockout mice showed decreased atrial sulfide levels, increased atrial superoxide levels, and enhanced propensity for induced persistent AF compared to wild type mice.
Article
Oncology
Nicoline W. E. van den Berg, Makiri Kawasaki, Benedetta Fabrizi, Fransisca A. Nariswari, Arianne C. Verduijn, Jolien Neefs, Robin Wesselink, Rushd F. M. Al-Shama, Allard C. van der Wal, Onno J. de Boer, Jan Aten, Antoine H. G. Driessen, Aldo Jongejan, Joris R. de Groot
Summary: The study found that in atrial fibrillation (AF) patients, there was a decrease in epicardial cell gene expression, while an upregulation of epithelial-to-mesenchymal transition (EMT) and mesenchymal cell gene expression. Immunohistochemistry analysis showed thickening of the epicardium and an increase in (myo)fibroblast-like cells in the myocardium in AF patients. Additionally, endothelial cell proliferation, angiogenesis, and endothelial signaling were found to be upregulated in AF patients.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jieyun Bai, Yaosheng Lu, Yijie Zhu, Huijin Wang, Dechun Yin, Henggui Zhang, Diego Franco, Jichao Zhao
Summary: Atrial fibrillation (AF) is a common arrhythmia with genetic predispositions playing a major role in its development. Genetic variants near the PITX2 gene on chromosome 4q25 have been identified in association with AF populations. Computational models are useful for understanding the functional impacts of PITX2 and may lead to improved anti-AF therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Srikanth Perike, Francisco J. Gonzalez-Gonzalez, Issam Abu-Taha, Frederick W. Damen, Laurin M. Hanft, Ken S. Lizama, Anahita Aboonabi, Andrielle E. Capote, Yuriana Aguilar-Sanchez, Benjamin Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Jody Martin, Joseph G. Akar, Chad M. Warren, R. John Solaro, Sang-Ging Ong, Dawood Darbar, Kerry S. Mcdonald, Craig J. Goergen, Beata M. Wolska, Dobromir Dobrev, Xander H. T. Wehrens, Mark D. McCauley
Summary: The study revealed that patients with AF have increased expression of PPP1R12C protein, leading to decreased atrial contractility. Overexpression of PPP1R12C in mice increases PP1c targeting to MLC2a, causing MLC2a dephosphorylation, and subsequently increasing AF inducibility.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Joanna Zygadlo, Grzegorz Procyk, Pawel Balsam, Piotr Lodzinski, Marcin Grabowski, Aleksandra Gasecka
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and autoimmunity is believed to play a crucial role in its development. Autoantibodies are implicated in regulating heart rhythm and associated with AF. Identifying the autoantibody profile of different AF patient groups is essential for developing effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Yajun Yao, Mei Yang, Dishiwen Liu, Qingyan Zhao
Summary: Immune remodeling is a new direction for research and therapeutic strategies for atrial fibrillation (AF) as it has complex relationships with atrial electrical, structural, and neural remodeling. It may provide effective therapies for AF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Annejet Heida, Willemijn F. B. van der Does, Mathijs S. van Schie, Lianne N. van Staveren, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Natasja M. S. de Groot
Summary: This study compared conduction heterogeneity between the supervulnerable period after electrical cardioversion and long-term sinus rhythm in patients with atrial fibrillation (AF). The findings suggest that there might be no difference in biatrial conduction characteristics between these two periods.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Review
Medicine, General & Internal
Muath Alobaida, Abdullah Alrumayh
Summary: Atrial fibrillation (AF) is a major cardiac arrhythmia associated with higher risk of cardiovascular morbidity and mortality. Rate control is one of the strategies for managing AF, aiming to improve symptoms and quality of life, although its effectiveness in preventing disease progression and reducing symptoms in highly symptomatic patients is limited. Despite being widely used, there are still debates regarding the use of rate control as first line management for all patients with AF.
ANNALS OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Christoph Beyer, Lyudmyla Tokarska, Markus Stuhlinger, Gudrun Feuchtner, Florian Hintringer, Sarah Honold, Lukas Fiedler, Marie-Sophie Schonbauer, Robert Schonbauer, Fabian Plank
Summary: Atrial wall thickness, epicardial fat volume, and attenuation are associated with AF recurrence in patients undergoing ablation therapy.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao-Yan Qi, Faezeh Vahdati Hassani, Dennis Hoffmann, Jiening Xiao, Feng Xiong, Louis R. Villeneuve, Senka Ljubojevic-Holzer, Markus Kamler, Issam Abu-Taha, Jordi Heijman, Donald M. Bers, Dobromir Dobrev, Stanley Nattel
Summary: The study revealed that atrial fibrillation (AF) affects nucleoplasmic Ca2+ in atrial cardiomyocytes, leading to the upregulation of IP(3)R1 and enhanced CaMKII-HDAC4 signaling, resulting in the downregulation of L-type calcium current.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Guang Zhong Liu, Wei Xu, Yan Xiang Zang, Qi Lou, Peng Zhou Hang, Qiang Gao, Hang Shi, Qi Yun Liu, Hong Wang, Xin Sun, Cheng Liu, Peng Zhang, Hua Dong Liu, Shao Hong Dong
Summary: The study revealed that Sirt3 was significantly down-regulated in AF patients and models, but restored by HL treatment. Sirt3 could regulate the acetylated modification of key metabolic enzymes, and increasing Sirt3 levels rescued AF-induced atrial metabolic remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Christophe Simard, Virginie Ferchaud, Laurent Salle, Paul Milliez, Alain Manrique, Joachim Alexandre, Romain Guinamard
Summary: The study showed that hyperaldosteronemia and TRPM4 play a role in atrial electrical and structural remodeling, with Trpm4 knockout leading to an increase in atrial diameter. Hyperaldosteronemia-salt may increase the occurrence of atrial arrhythmias.
Article
Cardiac & Cardiovascular Systems
Lucile Fossier, Mathieu Panel, Laura Butruille, Sarah Colombani, Lan Azria, Eloise Woitrain, Raphael Decoin, Angelo G. Torrente, Jerome Thireau, Alain Lacampagne, David Montaigne, Jeremy Fauconnier
Summary: This study revealed that impaired mitochondrial Ca2+ handling and MCUC activity contribute to atrial fibrillation in metabolic cardiomyopathy. Increased expression of MICUs subunits of MCUC was associated with impaired mitochondrial Ca2+ uptake in patients with MetS and HFS mice. The MCUC agonist kaempferol restored MCUC activity and prevented AF in HFS mice.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Physiology
Mattias Karlsson, Frida Sandberg, Sara R. Ulimoen, Mikael Wallman
Summary: This study presents a method based on a network model and workflow for robust estimation of AV node properties from ECG data, demonstrating the feasibility of estimating refractory period and conduction delay in non-invasive data.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Brian Mac Grory, Sean R. Landman, Paul D. Ziegler, Chantal J. Boisvert, Shane P. Flood, Christoph Stretz, Tracy E. Madsen, Michael E. Reznik, Shawna Cutting, Elizabeth E. Moore, Hunter Hewitt, James B. Closser, Jose Torres, Patrick J. Lavin, Karen L. Furie, Ying Xian, Wayne Feng, Valerie Biousse, Matthew Schrag, Shadi Yaghi
Summary: The study found that the cumulative incidence of new atrial fibrillation (AF) after central retinal artery occlusion (CRAO) was approximately 49.6% at 2 years. Patients with CRAO had a higher risk of developing AF compared to controls and a similar risk to patients with stroke. CRAO was also associated with an increased incidence of new stroke.
