期刊
HEART LUNG AND CIRCULATION
卷 23, 期 10, 页码 981-984出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hlc.2014.04.131
关键词
Blood brain barrier; Deep hypothermic circulatory arrest; Cardiopulmonary bypass; Cardiac surgery; Neurologic injury
资金
- NHLBI NIH HHS [R21 HL108280, R01 HL096978, R21 HL109971] Funding Source: Medline
Background Neurologic injury is common after cardiac surgery and disruption of the blood brain barrier (BBB) has been proposed as a contributing factor. We sought to study BBB characteristics in a rodent model of cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Methods Adult rats were subjected to CPB/DHCA or to sham surgery. Analysis included Western blotting of relevant BBB proteins in addition to in vivo brain magnetic resonance imaging (MRI) with a clinically used low-molecular contrast agent. Results While quantitative analysis of BBB proteins revealed similar expression levels, MRI showed evidence of BBB disruption after CPB/DHCA compared to sham surgery. Conclusions Combining molecular BBB analysis and MRI technology in a rodent model is a highly translatable approach to study adverse neurologic outcomes following CPB/DHCA.
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