Review
Cardiac & Cardiovascular Systems
Lorenz H. Lehmann, Jennifer Cautela, Nicolas Palaskas, Alan H. Baik, Wouter C. Meijers, Yves Allenbach, Joachim Alexandre, Tienush Rassaf, Oliver J. Muller, Mandar Aras, Aarti H. Asnani, Anita Deswal, Michal Laufer-Perl, Franck Thuny, Mathieu Kerneis, Salim S. Hayek, Stephane Ederhy, Joe-Elie Salem, Javid J. Moslehi
Summary: ICIs have become an important treatment option for various cancer types, but their use is associated with the risk of myocarditis. The diagnosis of ICI-associated myocarditis can be challenging and relies on a combination of clinical suspicion, cardiac biomarkers, imaging, and endomyocardial biopsy. Combining different types of ICIs may increase the risk of developing myocarditis.
Article
Cardiac & Cardiovascular Systems
Yuka Shiheido-Watanabe, Yasuhiro Maejima, Takeshi Kasama, Natsuko Tamura, Shun Nakagama, Yusuke Ito, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano
Summary: The study demonstrated the mechanism of ameliorating experimental autoimmune myocarditis by linagliptin, showing that it reduces Th17 cells infiltration and oxidative stress in EAM hearts. It also found that the interaction between DPP-4 and cathepsin G plays a detrimental role by suppressing SerpinA3N activity.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Pawel Franczuk, Michal Tkaczyszyn, Maria Kulak, Esabel Domenico, Piotr Ponikowski, Ewa Anita Jankowska
Summary: Viral respiratory infections (VRI) are common and can worsen existing cardiovascular diseases and lead to new complications, especially in COVID-19.
Review
Virology
Kiruthiga Mone, Jay Reddy
Summary: Myocarditis can be caused by infectious and non-infectious factors, leading to dilated cardiomyopathy and heart failure. Viruses are often suspected as the infectious causes, but it is challenging to detect viral particles during clinical presentations. Viral nucleic acids and virus-reactive antibodies may provide clues to the potential viral triggers of myocarditis. Persistent inflammatory infiltrates and autoantibodies to cardiac antigens suggest the involvement of autoimmunity in chronic myocarditis, requiring immune therapies to suppress autoimmune responses.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Biology
Mahima T. Rasquinha, Ninaad Lasrado, Erika Petro-Turnquist, Eric Weaver, Thiagarajan Venkataraman, Daniel Anderson, Uri Laserson, H. Benjamin Larman, Jay Reddy
Summary: In this study, the researchers analyzed the production of heart antigen antibodies in a mouse model of CVB3 myocarditis using the PhIP-Seq technique. They identified several previously unreported protein antibodies that may be relevant to human disease.
Review
Cardiac & Cardiovascular Systems
Jukka Lehtonen, Valtteri Uusitalo, Pauli Poyhonen, Mikko Mayranpaa, Markku Kupari
Summary: Cardiac sarcoidosis (CS) is characterized by granulomas infiltrating the myocardium, leading to conduction disturbances, ventricular tachyarrhythmias, and heart failure. However, imaging studies have shown that cardiac involvement occurs much more frequently than clinically detectable cases. Definitive diagnosis of CS requires myocardial biopsy and histopathology, but a combination of extracardiac histology, clinical manifestations, and cardiac imaging findings can provide a high likelihood of diagnosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Rui-Sheng Wang, Joseph Loscalzo
Summary: COVID-19 is a global pandemic caused by SARS-CoV-2, leading to various respiratory and extrapulmonary complications. Comorbidities such as hypertension, diabetes, cardiovascular diseases, and chronic kidney diseases worsen the severity and mortality of COVID-19. SARS-CoV-2 infection also results in cardiovascular complications, including myocarditis, heart failure, and venous thromboembolism. This review summarizes recent advances in drug repositioning for COVID-19, focusing on treatments that consider cardiovascular manifestations. It discusses potential opportunities and methods for repurposing drugs to treat cardiovascular complications of COVID-19.
CIRCULATION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Bojana Popovic, Aleksandra Radovanovic Spurnic, Jelena Velickovic, Aleksandra Plavsic, Milica Jecmenica-Lukic, Tijana Glisic, Dusan Ilic, Danka Jeremic, Jelena Vratonjic, Vladimir Samardzic, Zoran Gluvic, Tatjana Adzic-Vukicevic
Summary: Patients with Cushing's syndrome are highly sensitive during the COVID-19 pandemic due to multiple comorbidities and immune system suppression. This case report suggests that immunomodulating therapies like IVIg might be an effective and safe treatment for COVID-19 in this particularly fragile group of patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Qian Xing, Zhongwei Zhang, Biao Zhu, Qionghua Lin, Lihua Shen, Fangfang Li, Zhili Xia, Zhiyong Zhao
Summary: This article reports a case of immune-related myocarditis in a patient with stage IV nasopharyngeal carcinoma during immune checkpoint inhibitor therapy. Tofacitinib, targeting the Janus kinase-signal transducer and activator of transcription signal pathway, was successfully used in the treatment of steroid-refractory immune-related myocarditis. The patient showed improvement without major adverse cardiac events.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Paolo Severino, Andrea D'Amato, Silvia Prosperi, Alessandra Dei Cas, Anna Vittoria Mattioli, Antonio Cevese, Giuseppina Novo, Maria Prat, Roberto Pedrinelli, Riccardo Raddino, Sabina Gallina, Federico Schena, Corrado Poggesi, Pasquale Pagliaro, Massimo Mancone, Francesco Fedele
Summary: Heart failure is a multisystemic disease that requires evaluation and treatment based on key parameters such as left ventricular ejection fraction (LVEF). The definition and therapy of HF need to be revised to move away from the old simplistic perspective.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Jin Zhou, Jing Xu, Peng Li, Shan Sun, Yimiti Kadier, Shiying Zhou, Aijuan Cheng
Summary: Programmed cell death, including necroptosis, plays an important role in cardiovascular diseases such as viral myocarditis. This review summarizes the evidence on the pathogenesis, molecule mechanism, diagnosis, and potential treatment strategies of viral myocarditis, with a special focus on the novel mechanism of necroptosis for cardiomyocytes death. Studies have shown that tumor necrosis factor-alpha (TNF-alpha) is involved in the activation of necroptosis and may have diagnostic implications for viral myocarditis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Emanuele Bobbio, Clara Hjalmarsson, Marie Bjorkenstam, Christian L. Polte, Anders Oldfors, Ulf Lindstrom, Pia Dahlberg, Sven-Erik Bartfay, Piotr Szamlewski, Amar Taha, Egidija Sakiniene, Kristjan Karason, Niklas Bergh, Entela Bollano
Summary: This study compared the demographics, clinical presentation, and outcome of patients diagnosed with cardiac sarcoidosis (CS) or giant cell myocarditis (GCM). The results showed that GCM has a more severe clinical course with higher levels of heart failure symptoms and a greater need for heart transplantation.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Medicine, General & Internal
Heinz-Peter Schultheiss, Christian Baumeier, Ganna Aleshcheva, C. -Thomas Bock, Felicitas Escher
Summary: Diagnosis of acute and chronic myocarditis is challenging due to diverse etiologies and clinical presentations. Most cases are caused by infectious agents, but the pathophysiology and treatment still require further research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Vigyan Bang, Sarju Ganatra, Sachin P. Shah, Sourbha S. Dani, Tomas G. Neilan, Paaladinesh Thavendiranathan, Frederic S. Resnic, Thomas C. Piemonte, Ana Barac, Rushin Patel, Ajay Sharma, Rohan Parikh, Ghulam M. Chaudhry, Mark Vesely, Salim S. Hayek, Monika Leja, David Venesy, Richard Patten, Daniel Lenihan, Anju Nohria, Leslie T. Cooper
Summary: Giant cell myocarditis is a rare and potentially fatal disease that often affects young and middle-aged adults, leading to symptoms such as acute heart failure. Early diagnosis and proper management can improve patient survival rates and reduce the risk of transplantation or death.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Immunology
Jingfeng Yu, Sihan Sheng, Xiaosu Zou, Zhengwu Shen
Summary: A novel artemisinin derivative (compound 4) showed strong immunosuppressive activity. Various methods were used to evaluate its immunosuppressive activity and mechanism of action. The results suggest that it has potential application as an anti-inflammatory bowel disease drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)