Article
Urology & Nephrology
Benedikt Marahrens, Arndt Schulze, Jan Wysocki, Meei-Hua Lin, Minghao Ye, Yashpal S. Kanwar, Michael Bader, Juan Carlos Q. Velez, Jeffrey H. Miner, Daniel Batlle
Summary: The study found that aminopeptidase A deficiency results in increased blood pressure and altered glomerular structure in mice, but without significant proteinuria. Additionally, the activity, protein, and mRNA levels of certain enzymes in the renin-angiotensin system in the kidney may be regulated compensatory in knockout mice.
KIDNEY INTERNATIONAL
(2021)
Review
Peripheral Vascular Disease
Shawna D. Nesbitt
Summary: firibastat is a novel antihypertension medication with a unique mechanism targeting the brain renin angiotensin system. Recent clinical trials have shown its effectiveness and safety in treating mild and resistant hypertension, with significant reduction in blood pressure and minimal side effects particularly in difficult-to-treat patients. This new therapeutic class offers new pathways to consider and enhances the current regimens available for hypertension treatment.
CURRENT HYPERTENSION REPORTS
(2021)
Article
Physiology
Xinjun Mao, Verena Tretter, Yi Zhu, Felix Kraft, Benjamin Vigl, Marko Poglitsch, Roman Ullrich, Dietmar Abraham, Katharina Krenn
Summary: This study investigated the effects of combined use of Angiotensin-converting enzyme (ACE) inhibitor and aminopeptidase inhibitor on ventilator-induced lung injury. The results showed that the combination could prevent hypotension, reduce lung injury, and the optimal approach was the combination of 10 mu g/kg/min lisinopril and ALT-00.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo, Yan Wang, Kate M. Denton, Mark Del Borgo, Ketav Kulkarni, Marie -Isabel Aguilar, Chengxue Helena Qin, Chrishan S. Samuel, Tracey A. Gaspari, Robert E. Widdop
Summary: This study aimed to investigate the effects of angiotensin II type 2 receptor (AT2R) stimulation in a model of hypertension with type 1 diabetes mellitus (T1DM). The results showed that the AT2R agonist attenuated cardiac fibrosis, inflammatory markers, and superoxide levels in diabetic spontaneously hypertensive rats (SHRs). However, the AT1R blocker did not show the same protective effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Hematology
Olga Mulas, Brunella Mola, Alessandro Costa, Francesca Pittau, Daniela Mantovani, Samuele Dessi, Antonella Fronteddu, Giorgio La Nasa, Giovanni Caocci
Summary: This study found that hypertension is a significant risk factor for thrombotic-adverse events in patients with myeloproliferative neoplasms. The use of renin-angiotensin system inhibitors has a protective effect against these events.
ANNALS OF HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Constanza E. Martinez-Olivares, Leonardo Del Valle-Mondragon, Fernando Cortes-Camacho, Oscar R. Zambrano-Vasquez, Rogelio Hernandez-Pando, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: In this study, we evaluated the effects of allicin on vascular remodeling, endothelial function, and oxidative stress in experimental pulmonary arterial hypertension (PAH). Allicin administration improved body weight, survival rate, and prevented wall thickness and right ventricle hypertrophy. Allicin also maintained normal levels of angiotensin II and its receptors, increased nitric oxide and other beneficial molecules, and prevented oxidative stress and hypoxia response. These effects of allicin contribute to preventing endothelial dysfunction, remodeling of the pulmonary arteries, and heart failure in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Felicitas E. Hengel, Jean-Pierre Benitah, Ulrich O. Wenzel
Summary: The mosaic theory proposes that hypertension is a result of interactions among various causes, and recent research highlights the role of inflammation and salt intake in this process. Inflammation plays a crucial role in the pathophysiology of hypertension, and high-salt intake can modulate inflammatory responses, ultimately affecting the development of hypertension.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Kucmierz, Weronika Frak, Ewelina Mlynarska, Beata Franczyk, Jacek Rysz
Summary: Arterial hypertension is a major risk factor for cardiovascular diseases, affecting 10-20% of the adult population and accounting for 5.8% of global deaths. Several pathophysiologic factors contribute to hypertension, leading to damage in organs such as the heart, kidneys, brain, retina, and arteries. Early treatment and control of hypertension are crucial to prevent organ failure and cardiovascular complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alex Cleber Improta-Caria, Marcela Gordilho Aras, Luca Nascimento, Ricardo Augusto Leoni De Sousa, Roque Aras-Junior, Bruno Solano de Freitas Souza
Summary: MicroRNAs are small non-coding RNAs that regulate gene and protein expression, playing important roles in various cellular processes. In diseases such as hypertension, microRNAs are involved in regulating physiological processes, but the specific mechanisms need further study.
Article
Medicine, General & Internal
Chon Kit Pun, Ching-Chih Chang, Chiao-Lin Chuang, Hui-Chun Huang, Shao-Jung Hsu, Yi-Hsiang Huang, Ming-Chih Hou, Fa-Yauh Lee
Summary: This study found that ARNI treatment reduces portal hypertension by peripheral vasodilatation and decreasing systemic arterial pressure in rats with liver cirrhosis and portal hypertension.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Loris Zamai
Summary: This study argues that the zinc chelating ability of some non-steroidal anti-inflammatory drugs can enhance their efficacy against COVID-19.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
M. J. Ramirez-Exposito, M. P. Carrera-Gonzalez, J. M. Martinez-Martos
Summary: The study showed that the renin angiotensin system plays a role in tumor growth in the rat model of glioma, with increased levels of aspartyl aminopeptidase and aminopeptidase B activities, as well as decreased levels of aminopeptidase N, aminopeptidase A, and insulin-regulated aminopeptidase activities. These findings suggest the predominant actions of angiotensin III against a decreased action of angiotensin II and IV in tumor growth.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biology
Bikash Thakuri, Jayanta Kumar Das, Amit Kumar Roy, Amit Chakraborty
Summary: The renin-angiotensin systems have a pivotal role in cardiovascular physiology by regulating blood pressure and electrolyte homeostasis. The traditional understanding that the circulating RAS can only have deleterious effects on the cardiovascular system has been challenged by the discovery of non-canonical components. This study highlights the importance of AT2R-mediated feedback effects in maintaining normal blood pressure.
JOURNAL OF THEORETICAL BIOLOGY
(2023)
Article
Peripheral Vascular Disease
Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation
Summary: Studies suggest that blood-brain barrier crossing renin-angiotensin drugs may be linked to less memory decline, while nonpenetrant medications may help improve attention.
Article
Biochemistry & Molecular Biology
Moudhi Almutlaq, Fatmah A. Mansour, Jahad Alghamdi, Yassen Alhendi, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Hassan S. Alamri, Fayhan Alroqi, Tlili Barhoumi
Summary: This study demonstrates that angiotensin II (Ang II) exacerbates the T-cell response to SARS-CoV-2 in recovered COVID-19 patients. The presence of Ang II increases the phosphorylation levels of proteins involved in cardiovascular diseases, inflammation, and viral infection. These findings suggest that Ang II may worsen the inflammatory response and alter the immune response to a more inflammatory profile against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pierre Couvineau, Catherine Llorens-cortes, Xavier Iturrioz
Article
Biochemistry & Molecular Biology
Pierre Couvineau, Hugo De Almeida, Vincent Leroux, Bernard Roques, Bernard Maigret, Catherine Llorens-Cortes, Xavier Iturrioz
BIOCHEMICAL JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Christian Straus, Marion Teulier, Sebastien Morel, Nicolas Wattiez, David Hajage, Caroline Giboin, Beny Charbit, Eric Dasque, Laurence Bodineau, Bruno Chenuel, Nicolas Straus, Valerie Attali, Thomas Similowski
Summary: The study found that baclofen did not stabilize breathing and instead increased respiratory variability. This suggests that baclofen may not be suitable for use in patients with or at risk of periodic breathing.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Conrad Fischer, Tess Lamer, Kleinberg Fernandez, Mahmoud Gheblawi, Wang Wang, Cameron Pascoe, Gareth Lambkin, Xavier Iturrioz, Catherine Llorens-Cortes, Gavin Y. Oudit, John C. Vederas
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, Jose Alain Sahel, Laurence Bodineau, Christophe Baudouin, William Rostene, Stephane Melik-Parsadaniantz, Annabelle Reaux-Le Goazigo
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Multidisciplinary Sciences
Adrien Flahault, Pierre-Emmanuel Girault-Sotias, Mathilde Keck, Rodrigo Alvear-Perez, Nadia De Mota, Lucie Esteoulle, Sridevi M. Ramanoudjame, Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortes
Summary: In this study, LIT01-196 was shown to be a promising treatment for AVP-induced hyponatremia by activating apelin-R, reducing the antidiuretic effect of AVP, and increasing aqueous diuresis.
NATURE COMMUNICATIONS
(2021)
Article
Transplantation
Peter Janssens, Jean-Paul Decuypere, Bert Bammens, Catherine Llorens-Cortes, Rudi Vennekens, Djalila Mekahli
Summary: The apelinergic system plays an important role in renal and cardiovascular physiology and disease, primarily by regulating water homeostasis and blood pressure. It interacts with vasopressin and the renin-angiotensin system and has implications for various pathological states. Metabolically stable apelin analogues have also been developed with potential therapeutic applications.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Solene E. Boitard, Mathilde Keck, Robin Deloux, Pierre-Emmanuel Girault-Sotias, Yannick Marc, Nadia De Mota, Delphine Compere, Onnik Agbulut, Fabrice Balavoine, Catherine Llorens-Cortes
Summary: QGC606 treatment improves cardiac function and reduces cardiac remodeling and fibrosis in mice post-MI, without lowering blood pressure.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Respiratory System
A. Casciato, F. Cayetanot, L. Bodineau
Summary: Central hypoventilation syndromes, such as Ondine's curse, are rare neurorespiratory diseases characterized by a defect in automatic ventilation control and reduced chemosensitivity. Lifelong mechanical ventilation is currently the only available treatment.
REVUE DES MALADIES RESPIRATOIRES
(2022)
Article
Physiology
Celine Caravagna, Alexis Casciato, Jacques-Olivier Coq, Sylvie Liabeuf, Cecile Brocard, Julie Peyronnet, Laurence Bodineau, Florence Cayetanot
Summary: Prenatal hypoxia disrupts the development of Cl- cotransporters KCC2 and NKCC1, leading to alterations in central respiratory drive. This disruption may have long-term effects on the functioning of GABA(A) and glycinergic systems.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Chemistry, Medicinal
Afaf Bajjig, Florence Cayetanot, J. Andrew Taylor, Laurence Bodineau, Isabelle Vivodtzev
Summary: Spinal cord injury results in sensory-motor function loss due to damage between the brain and spinal neurons. This leads to reduced locomotor function, respiratory impairments, and increased cardiovascular risk. Pharmacologic neuromodulators, such as 5-HT1A receptor agonists, show potential in inducing functional improvements by activating spared motoneurons. Additionally, combining 5-HT1A agonists with other therapies may be even more promising.
Article
Biology
Afaf Bajjig, Pauline Michel-Flutot, Tiffany Migevent, Florence Cayetanot, Laurence Bodineau, Stephane Vinit, Isabelle Vivodtzev
Summary: This study used spinal cord contusion in mice to mimic human tetraplegia and found that the C3 model was an appropriate model for interventions aimed at restoring breathing following tetraplegia.
Article
Respiratory System
Jessica Taytard, Marie-Cecile Nierat, Camille Gand, Sophie Lavault, Capucine Morelot-Panzini, Maxime Patout, Laure Serresse, Nicolas Wattiez, Laurence Bodineau, Christian Straus, Thomas Similowski
Summary: This study found that cognitive tasks induced hypoxia in adult CCHS patients during unassisted breathing, but not under ventilatory support. Therefore, considering the use of ventilatory support during mental tasks in CCHS patients is justified to avoid repeated episodes of hypoxia.
Article
Multidisciplinary Sciences
Masahiro Tsuji, Takeo Mukai, Yoshiaki Sato, Yasue Azuma, Saki Yamamoto, Florence Cayetanot, Laurence Bodineau, Atsuto Onoda, Tokiko Nagamura-Inoue, Jacques-Olivier Coq
Summary: Low birth weight (LBW) increases the risk of neurodevelopmental disorders (NDDs) such as attention-deficit/hyperactive disorder and autism spectrum disorder, and there are currently no prophylactic measures available. Neuroinflammation plays a major role in NDDs, and umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have immunomodulatory properties. This study found that systemic administration of UC-MSCs in the early postnatal period improved hyperexcitability in LBW pups, but the beneficial effects for NDDs were marginal.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Alexis Casciato, Lola Bianchi, Manon Reverdy, Fanny Joubert, Roman Delucenay-Clarke, Sandrine Parrot, Nelina Ramanantsoa, Eleonore Sizun, Boris Matrot, Christian Straus, Thomas Similowski, Florence Cayetanot, Laurence Bodineau
Summary: Congenital Central Hypoventilation Syndrome, a rare disease caused by PHOX2B mutation, is associated with absent or blunted CO2/H+ chemosensitivity due to the dysfunction of PHOX2B neurons. Clinical observations have reported non-systematic CO2/H+ chemosensitivity recovery under desogestrel. This study used a preclinical mouse model to investigate the restoration of chemosensitivity by etonogestrel acting on serotonin neurons or residual PHOX2B cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
