Article
Agriculture, Dairy & Animal Science
M. J. Kuhn, L. M. Sordillo
Summary: This study explored the antioxidant functions of various vitamin E analogs in bovine cells, finding that gamma-tocopherol and gamma-tocotrienol may have better abilities to reduce oxidative stress and protect cellular viability compared to alpha-tocopherol. Gamma-tocotrienol was shown to have significant cytotoxicity and reductions in viability at higher doses, suggesting a potential negative impact at supraphysiological levels. Further research is needed to fully understand the antioxidant properties of different vitamin E analogs in different cell types or animal models.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Joan M. Cook-Mills, Samantha H. Averill, Jacquelyn D. Lajiness
Summary: Asthma and allergic disease are the result of interactions between environmental exposures and genetics. Different isoforms of vitamin E have opposite functions in regulating allergic inflammation and development of allergic disease, which may explain the varying outcomes of vitamin E on allergies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Nutrition & Dietetics
Debora Gabriela Fernandes Assuncao, Lorena Thalia Pereira da Silva, Juliana Dantas de Araujo Santos Camargo, Ricardo Ney Cobucci, Karla Danielly da Silva Ribeiro
Summary: Vitamin E deficiency is not only associated with preterm newborns but also found in full-term newborns. This deficiency can compromise neurogenesis in children. Further studies are needed to assess the difference in vitamin E status among newborns of different gestational ages to support neonatal monitoring protocols.
Article
Biochemistry & Molecular Biology
Etsuo Niki, Noriko Noguchi
Summary: Vitamin E acts as an important physiological antioxidant, with alpha-TQ and 5-NgT serving as biomarkers for oxidative stress and nitrative stress respectively. The concentrations of these oxidation products in human plasma vary under different health conditions, indicating their potential role in disease diagnosis and treatment.
FREE RADICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maret G. Traber, Brian Head
Summary: This narrative review focuses on the structures, functions, biological determinants, and deficiency symptoms of vitamin E in humans, discussing the mechanisms for alpha-T tissue enrichment, potential new biomarkers, pharmacokinetic data, and approaches to evaluate alpha-T dietary requirements. The possible role of alpha-T supplements in delaying chronic diseases and the evaluation of vitamin E safety are also considered in this review.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Plant Sciences
Yue Niu, Qian Zhang, Jiaojiao Wang, Yanjie Li, Xinhua Wang, Yan Bao
Summary: Vitamin E is a lipid-soluble antioxidant that is essential for both humans and plants. The biosynthesis pathway of vitamin E has been extensively studied, but the chlorophyll-derived prenyl precursors for synthesizing vitamin E are still unknown. Recent research has made significant progress in understanding vitamin E and its role in plant stress response and signaling.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
Satoshi Haga, Hiroshi Ishizaki, Sanggun Roh
Summary: Hypovitaminosis E, caused by a decline in alpha-tocopherol levels around calving, is associated with peripartum diseases in high-yield cows. Studies have investigated the effects of alpha-tocopherol supplementation, but until recently, the physiological factors or pathways underlying hypovitaminosis E in the transition period have been poorly understood. Recent research suggests that factors such as decreased intake, changes in digestive and absorptive functions, and oxidative stress may contribute to alpha-tocopherol deficiency during the transition period. Further studies are needed to fully understand these mechanisms and their impact on dairy cow health.
Article
Biochemistry & Molecular Biology
Angelo Azzi, Jeffrey Atkinson, Nesrin Kartal Ozer, Danny Manor, Maria Wallert, Francesco Galli
Summary: This article proposes revising the nomenclature of vitamin E and argues that only RRR-alpha-tocopherol should be considered as vitamin E. Other tocochromanols have not been scientifically proven to function as vitamins. Prescribing molecules as vitamin E without proper testing could result in ineffective therapy and potential risks for patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Antonio Gazquez, Maria Sanchez-Campillo, Marino B. B. Arnao, Alejandro Barranco, Ricardo Rueda, Soren Krogh Jensen, Jia Pei Chan, Matthew J. Kuchan, Elvira Larque
Summary: The objective of this study was to evaluate the bioavailability and antioxidant activity of RRR-aT compared to S-aT in both mother and fetus. The results showed that RRR-aT supplementation increased the proportion of RRR-aT in maternal and fetal plasma, resulting in higher antioxidant activity in fetal plasma. Placental SR-B1 may play a role in the stereoselective transfer of RRR-aT and enhance aT bioactivity in the fetus.
ANNALS OF NUTRITION AND METABOLISM
(2023)
Article
Agriculture, Dairy & Animal Science
Vivian Vieira, Francielle O. Marx, Lucas S. Bassi, Marley C. Santos, Alexandre Oba, Simone Gisele de Oliveira, Alex Maiorka
Summary: This study showed that increasing vitamin E doses in the finishing period can enhance the brightness of broiler breast meat, while having minimal effects on other meat quality characteristics such as redness and water holding capacity. The age at slaughter had a quadratic effect on meat quality characteristics, with older birds having higher meat pH and shear force values.
Review
Food Science & Technology
Katieli Santos de Lima, Felipe Barreto Schuch, Natiele Camponogara Righi, Patricia Chagas, Mireli Hemann Lamberti, Gustavo Orione Puntel, Antonio Marcos Vargas da Silva, Luis Ulisses Signori
Summary: The combined supplementation of vitamins C and E can alleviate oxidative stress, inflammatory response, and muscle damage following exercise.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jeffrey Atkinson, Drew Marquardt, Mitchell DiPasquale, Thad Harroun
Summary: Vitamin E was one of the last fat-soluble vitamins discovered, and it plays important roles as an antioxidant and structural component in phospholipid bilayer membranes. Despite our detailed understanding of the orientation and dynamics of alpha-tocopherol in lipid bilayers, gaps still exist in our knowledge regarding its effects and potential receptors in controlling gene transcription.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Medicinal
Magdalina Melkonyan, Ashkhen Manukyan, Lilit Hunanyan, Artem Grigoryan, Hayk Harutyunyan, Lilit Sukiasyan, Lusine Danielyan, Konstantin Yenkoyan
Summary: Noise, a common stress factor in modern life, was found to cause dysfunction in the central nervous system and changes in hormone levels in a rat model. Chronic high-level noise exposure led to increased oxidative stress and altered behavior, with the involvement of the alpha(2)-adrenoceptor being a key factor in noise-induced stress pathology.
Article
Biochemistry & Molecular Biology
Brian Head, Jane La Du, Carrie Barton, Jie Zhang, Carmen Wong, Emily Ho, Robyn L. Tanguay, Maret G. Traber
Summary: The vitamin E regulatory protein, alpha-tocopherol transfer protein (Ttpa), is crucial for zebrafish embryo development. A fluorescent-tagged zebrafish transgenic line was created using CRISPR-Cas9 technology to study Ttpa function, showing fluorescence in various parts of RedEfish embryos at different developmental stages. This model provides valuable insights for studying Ttpa function during embryo development.
Article
Agriculture, Dairy & Animal Science
Erdem Danyer, Tanay Bilal, Aysen Altiner, Ismail Aytekin, Hasan Atalay
Summary: This study investigated the effects of vitamin E injection on ewes to prevent transport stress. The results showed that pre-transport vitamin E injection did not significantly affect stress and oxidative parameters in the ewes.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)