Article
Cardiac & Cardiovascular Systems
Catalina A. Parasca, Andreea Calin, Deniz Cadil, Anca Mateescu, Monica Rosca, Simona Beatrice Botezatu, Roxana Enache, Carmen Beladan, Carmen Ginghina, Dan Deleanu, Ovidiu Chioncel, Serban Bubenek-Turconi, Vlad A. Iliescu, Bogdan A. Popescu
Summary: This study aimed to evaluate the determinant factors and prognostic value of right ventricle-pulmonary artery (RV-PA) coupling in patients undergoing transcatheter aortic valve implantation (TAVI). The results showed a significant improvement in RV-PA coupling early after TAVI, but some patients still had impaired coupling, which was associated with persistent pulmonary hypertension and adverse outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Dionysios Adamopoulos, Stamatia Pagoulatou, Georgios Rovas, Vasiliki Bikia, Hajo Mueller, Georgios Giannakopoulos, Sarah Mauler-Wittwer, Marc-Joseph Licker, Nikolaos Stergiopulos, Frederic Lador, Stephane Noble
Summary: This study aimed to investigate the impact of the novel definition of pulmonary hypertension (PH) on the prognosis of patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). The results showed that pre-interventional PH according to the novel hemodynamic criteria is associated with poor outcomes, but this is mainly driven by patients with a mean pulmonary artery pressure (PAP) >= 25 mmHg. Patients with a pre-capillary PH component have an even worse prognosis compared to patients with isolated post-capillary or no PH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Elke Boxhammer, Alexander E. Berezin, Vera Paar, Nina Bacher, Albert Topf, Sergii Pavlov, Uta C. Hoppe, Michael Lichtenauer
Summary: The current scientific data situation regarding cardiovascular biomarkers as non-invasive diagnostic tools for the determination of pulmonary hypertension in patients with severe aortic valve stenosis is poor. There is a great potential to combine different biomarkers in a non-invasive way to determine the presence or absence of pulmonary hypertension.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Garima Dahiya, Andreas Kyvernitakis, Adee Elhamdani, Andrew Begg, Mark Doyle, Mahmoud Elsayed, Stephen Bailey, Amresh Raina, Manreet Kanwar, Robert W. W. Biederman, Raymond L. Benza
Summary: This study aimed to investigate the implications of invasive pulmonary hemodynamics after transcatheter aortic valve replacement (TAVR) on major adverse cardiac events (MACE), biventricular function and NYHA functional class. The results showed that patients with pre-existing pulmonary hypertension had a higher risk of MACE after TAVR. Parameters such as mean PA pressure (mPAP), diastolic pulmonary gradient (DPG) and pulmonary vascular resistance (PVR) were predictive of MACE occurrence.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Samir R. R. Kapadia, Raj Makkar, Martin Leon, Mohamed Abdel-Wahab, Thomas Waggoner, Steffen Massberg, Wolfgang Rottbauer, Samuel Horr, Lars Sondergaard, Juhana Karha, Robert Gooley, Lowell Satler, Robert C. Stoler, Steven R. Messe, Suzanne J. Baron, Julia Seeger, Susheel Kodali, Amar Krishnaswamy, Vinod H. Thourani, Katherine Harrington, Stuart Pocock, Rodrigo Modolo, Dominic J. Allocco, Ian T. Meredith, Axel Linke, PROTECTED TAVR Investigators
Summary: Among patients with aortic stenosis undergoing transfemoral TAVR, the use of CEP did not have a significant effect on the incidence of periprocedural stroke, but on the basis of the 95% confidence interval around this outcome, the results may not rule out a benefit of CEP during TAVR.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Cardaioli, Luca Nai Fovino, Tommaso Fabris, Giulia Masiero, Federico Arturi, Aurora Trevisanello, Vittorio Zuccarelli, Massimo Napodano, Chiara Fraccaro, Saverio Continisio, Giuseppe Tarantini
Summary: The European Society of Cardiology has defined new cut-offs for pulmonary hypertension (PH) and pulmonary vasculature resistance (PVR). The prognostic value of this updated classification after transcatheter aortic valve implantation (TAVI) is yet to be determined.
Article
Cardiac & Cardiovascular Systems
Micha T. Maeder, Lukas Weber, Hans Rickli
Summary: In patients with severe aortic stenosis, pulmonary hypertension is a sign of decompensated cardiac function and heart failure resulting from AS-related cardiac injury. This review article discusses the pathophysiology of AS-induced PH, its prognostic impact, and options for prevention and treatment. The study emphasizes the importance of invasive hemodynamics in evaluating AS patients for aortic valve replacement, particularly the relevance of combined pre-and post-capillary PH. Comprehensive assessment, including right heart catheterization and non-invasive imaging, is crucial for accurately evaluating AS-related cardiac injury and distinguishing PH forms unrelated to AS.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Elke Boxhammer, Lukas Schmidbauer, Moritz Mirna, Vera Paar, Matthias Hammerer, Uta C. Hoppe, Michael Lichtenauer
Summary: This study aimed to evaluate the role of cardiovascular biomarkers in patients with severe aortic valve stenosis. The results showed that certain cardiovascular biomarkers have potential in the detection of pulmonary hypertension using echocardiography.
APPLIED SCIENCES-BASEL
(2022)
Article
Cardiac & Cardiovascular Systems
Lakshay Chopra, Hiroki Ueyama, Ankur Dalsania, Francesca R. Prandi, Gilbert Tang, Sahil Khera, Parasuram Melarcode-Krishnamoorthy, Samin K. Sharma, Annapoorna Kini, Stamatios Lerakis
Summary: This study aimed to investigate the impact of baseline and changes in pulmonary hypertension (PH) on low-flow low-gradient aortic stenosis (AS) patients after transcatheter aortic valve replacement (TAVR). The results showed that moderate-to-severe PH at baseline was an independent predictor of worse clinical outcomes, while postoperative changes in PH were not associated with clinical outcomes.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Yi-Ming Li, Tian-Yuan Xiong, Kai Xu, Zhen-Fei Fang, Lei Jiang, Jun Jin, Sheng-Hu He, Yi-Ning Yang, Jing-Jing He, Yu-Heng Jia, Yi Zhang, Yong Peng, Yuan Feng, Mao Chen
Summary: This study delineated the clinical characteristics and outcomes of Chinese TAVR patients, finding that TAVR candidates in China had lower rates of complications and mortality compared to other international registries, and patients with BAV had lower mortality rates. These results suggest that the application of TAVR in low-risk patients will be further propelled.
CHINESE MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Lola Gutierrez, Mauro Boiago, Chiara De Biase, Omar Oliva, Pietro Laforgia, Souheib Feliachi, Alessandro Beneduce, Nicolas Dumonteil, Didier Tchetche
Summary: Bicuspid aortic valve disease is the most common congenital heart disease, associated with unique morphological features and lack of consensus in sizing measurement. Multi-slice computed tomography plays a crucial role in TAVI procedure planning, and advancements in devices and procedure planning have improved clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Habertheuer, Edgar Aranda-Michel, John Schindler, Thomas G. Gleason, Arman Kilic, Dustin Kliner, Valentino Bianco, Catalin Toma, Ibrahim Sultan
Summary: The study found that TAVR can be performed safely in nonagenarians, with comparable outcomes to younger patients approximating natural life expectancy. This age paradox should strengthen the role of TAVR in well-selected nonagenarians by the heart team.
ANNALS OF THORACIC SURGERY
(2021)
Article
Surgery
Michael P. Rogers, Haroon Janjua, Emanuel Eguia, Lucian Lozonschi, Paul C. Kuo
Summary: This study evaluated the adoption of transcatheter aortic valve replacement technology in surgical aortic valve procedures in Florida. The findings showed that the introduction of transcatheter aortic valve replacement significantly increased the overall surgical volume and may be associated with lower hospital charges.
Article
Geriatrics & Gerontology
Wieneke Vlastra, Astrid C. van Nieuwkerk, Anne-Sophie G. T. Bronzwaer, Adriaan Versteeg, Esther E. Bron, Wiro J. Niessen, Henk J. M. M. Mutsaerts, Bjorn J. P. van Der Ster, Charles B. L. M. Majoie, Geert J. Biessels, Aart J. Nederveen, Mat J. A. P. Daemen, Matthias J. P. van Osch, Jan Baan, Jan J. Piek, Johannes J. Van Lieshout, Ronak Delewi
Summary: Following TAVI, an increase in cardiac output was associated with an increase in cerebral blood flow, but the extent of increase in cerebral blood flow varied among patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Edgar Aranda-Michel, Derek Serna-Gallegos, James Brown, Yisi Wang, Valentino Bianco, Sarah Yousef, Carlos E. Diaz-Castrillon, Ibrahim Sultan
Summary: This study aimed to assess the impact of a hospital's teaching status on the survival and outcomes of patients with type A aortic dissections. The results showed that the majority of patients were treated at teaching hospitals, which had a higher in-hospital mortality rate compared to non-teaching hospitals. Teaching hospitals also had higher hospital charges and a higher rate of 30-day readmissions. However, hospital teaching status was found to be a significant protective factor for mortality.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah Yousef, James A. Brown, Derek Serna-Gallegos, Forozan Navid, Nav Warraich, Pyongsoo Yoon, David Kaczorowski, Johannes Bonatti, Yisi Wang, Ibrahim Sultan
Summary: This study compared outcomes of aortic valve replacement (AVR) with or without aortic root enlargement (ARE). It found that patients who underwent AVR+ARE were more likely to be women, younger, and had longer hospital stays, higher rates of acute kidney injury, blood transfusions, and prolonged ventilation. However, survival rates and complication rates were similar between the two groups. In conclusion, for patients with small aortic annulus, AVR+ARE can be safely performed to avoid prosthesis-patient mismatch.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Edgar Aranda-Michel, Lena E. Trager, Jason J. Han, Rishav Aggarwal, Marisa Cevasco, Rosemary F. Kelly, Ibrahim Sultan
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Medicine, Research & Experimental
Andrew D. Althouse, Kaleab Z. Abebe, Michael K. Paasche-Orlow, Christina M. Lalama, Danielle Ferry, Michelle Lancet, Gretchen Swabe, Timothy Bickmore, Jared W. Magnani
Summary: This article introduces a mobile health application for individuals with AF, aiming to improve self-care. The application utilizes a relational agent to provide health education, counseling, and monitoring. It is an ongoing randomized controlled trial to evaluate the effectiveness of the application on anticoagulation adherence, patient-centered outcomes, and healthcare utilization.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Health Care Sciences & Services
Wagahta Semere, Andrew D. Althouse, Robert Arnold, Douglas White, Thomas J. Smith, Edward Chu, Margaret Q. Rosenzweig, Yael Schenker
Summary: This study found that a palliative care intervention did not improve burden or mood among caregivers of patients with advanced cancer, but they reported higher self-efficacy compared to caregivers receiving standard care. It highlights the need for strategies to optimize caregiver outcomes in palliative care interventions.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Chandler. J. J. Mitchell, Andrew Althouse, Robert Feldman, Robert M. Arnold, Margaret Rosenzweig, Kenneth Smith, Edward Chu, Doug White, Tom Smith, Yael Schenker
Summary: This study found that the most common and severe symptoms reported by patients with advanced cancer were fatigue, low sense of well-being, and poor appetite. However, these symptoms were addressed less frequently than expected in shared care plans developed by oncology nurses. Further research is needed to understand how primary palliative care interventions can effectively improve bothersome symptoms for patients with advanced cancer.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Health Care Sciences & Services
Mehak Dhande, Larissa Myaskovsky, Andrew Althouse, Madhurmeet Singh, Raul Weiss, Alaa Shalaby, Sana M. Al-Khatib, Alicia Topoll, Sandeep Jain, Samir Saba
Summary: This study examined the impact of CRT-P versus CRT-D on the quality of life (QOL) of older heart failure (HF) patients. The results showed that there were no significant differences in QOL outcomes between CRT-P and CRT-D recipients at six months post-implantation.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Talya F. F. Mandelkern, Ibrahim Sultan, Joshua E. E. Levenson
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marc A. Simon, John M. Cormack, Danial Sharifi Kia
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah Yousef, James A. Brown, Edgar Aranda-Michel, Derek Serna-Gallegos, Yisi Wang, Takuya Ogami, Ibrahim Sultan
Summary: This study evaluated the influence of sex on outcomes after TEVAR and found that women are more likely to undergo TEVAR for aneurysms, while men are more likely to undergo TEVAR for type B aortic dissection. There is no significant difference in in-hospital mortality between men and women after TEVAR, but female sex is associated with a reduced odds of 30-day readmission.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Irsa S. Hasan, James A. Brown, Derek Serna-Gallegos, Edgar Aranda-Michel, Sarah Yousef, Yisi Wang, Ibrahim Sultan
Summary: This observational study compared outcomes of patients undergoing thoracic endovascular aortic repair (TEVAR) for complicated type B aortic dissection (TBAD) or descending thoracic aortic (DTA) aneurysm using a nationwide readmissions database from 2010 to 2018. The results showed that patients with TBAD had higher rates of in-hospital mortality, postoperative complications, and readmissions compared to patients with DTA. TBAD was independently associated with mortality after adjusting for other variables.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Panagiotis Tasoudis, Xander Jacquemyn, Jef Van den Eynde, Thomas G. Caranasos, John S. Ikonomidis, Danny Chu, Derek Serna-Gallegos, Ibrahim Sultan
Summary: By comparing the use of different types of valves (bioprosthetic versus mechanical) in composite aortic valve graft replacement (CAVGR), it was found that patients with mechanical valves had a significantly lower risk of all-cause mortality after 30 days post-procedure, and a lower risk of reintervention.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Salil V. Deo, Andrew Althouse, Sadeer Al-Kindi, David A. Mcallister, Ariela Orkaby, Yakov E. Elgudin, Stephen Fremes, Danny Chu, Frank L. J. Visseren, Jill P. Pell, Naveed Sattar
Summary: The SMART2 risk score performs well in coronary artery bypass grafting patients, with better predictive capabilities in patients with chronic kidney disease. However, it underestimates the incidence of major adverse cardiovascular events and shows differences in predictive ability between White and Black patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Xander Jacquemyn, Jef van den Eynde, Derek Serna-Gallegos, Danny Chu, Marie-Annick Clavel, Philippe Pibarot, Ibrahim Sultan
Summary: A meta-analysis of reconstructed time-to-event data from randomized controlled trials and propensity-score matched studies showed that, in low-risk patients, surgical aortic valve replacement (SAVR) appeared to be associated with improved survival beyond 2 years compared to transcatheter aortic valve replacement (TAVR).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Urology & Nephrology
Cassandra L. Formeck, Robert Feldman, Andrew D. Althouse, John A. Kellum
Summary: Critically ill children with AKI have a higher risk of developing hospital-acquired sepsis compared to children without AKI. Children with stage 3 AKI remain at increased sepsis risk for at least 2 weeks after AKI onset. Medical providers should monitor for sepsis signs after AKI and minimize infection risk.
