Review
Biochemistry & Molecular Biology
Kevin M. Casin, John W. Calvert
Summary: Cardiovascular disease is the leading cause of death in the U.S. Research has shown the beneficial impact of endogenous hydrogen sulfide production on heart health; modulating H2S enzyme sources is a promising research area.
Article
Immunology
Kobkaew Bumroongthai, Dean P. J. Kavanagh, Paul Genever, Neena Kalia
Summary: This study demonstrates that 3D culture of specific bone marrow-derived MSC sub-populations improves their homing and protective effects on coronary blood vessels in the injured heart. Compared to conventional 2D culture, 3D culture enhances the adhesive behavior of MSCs and reduces neutrophil events in the coronary capillaries. Additionally, the combination of dual therapy with heparin further enhances the vasculoprotective efficacy. The findings highlight the importance of 3D culture and specific MSC sub-populations in improving therapeutic outcomes for reperfusion injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Physiology
Jordan Hernandez-Martinez, Rodrigo Ramirez-Campillo, Tiago Vera-Assaoka, Maria Castillo-Cerda, Bastian Carter-Truillier, Tomas Herrera-Valenzuela, Antonio Lopez-Fuenzalida, Hadi Nobari, Pablo Valdes-Badilla
Summary: This study compares the effects of standard warm-up versus warm-up using stretching exercises on the physical performance of male youth soccer players. The results show that stretching-based warm-up has no effect on jump height, sprint speed, and ball kicking speed of male youth soccer players compared to standard warm-up.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Sport Sciences
Jose Afonso, Joao Brito, Eduardo Abade, Goncalo Rendeiro-Pinho, Ivan Baptista, Pedro Figueiredo, Fabio Yuzo Nakamura
Summary: Warm-up is beneficial for increasing body temperature and preparing athletes for training and competitions. It can also be used as a pedagogical and training moment. Individualized warm-ups can be beneficial and athletes should be educated about exploring different warm-up tasks.
Article
Cardiac & Cardiovascular Systems
Sashiananthan Ganesananthan, Christopher A. Rajkumar, Michael Foley, David Thompson, Alexandra N. Nowbar, Henry Seligman, Ricardo Petraco, Sayan Sen, Sukhjinder Nijjer, Simon A. Thom, Roland Wensel, John Davies, Darrel Francis, Matthew Shun-Shin, James Howard, Rasha Al-Lamee
Summary: This analysis examined the relationship between CPET parameters, myocardial ischemia, and anginal symptoms in patients with chronic coronary syndrome. The results showed that only an oxygen-pulse plateau was able to detect the severity of myocardial ischemia and predict the placebo-controlled response to PCI in patients with single-vessel CAD.
EUROPEAN HEART JOURNAL
(2022)
Article
Sport Sciences
Rohit K. Thapa, Filipe M. Clemente, Jason Moran, Felipe Garcia-Pinillos, Aaron T. Scanlan, Rodrigo Ramirez-Campillo
Summary: The aim of this study was to compare the effects of small-sided soccer games (SSSGs) and traditional warm-up (TWU) routines on physical fitness qualities in soccer players. The results showed that the SSSG warm-up group was more effective at improving CODS and CMJ performance, while the TWU group was more effective at improving linear speed. Soccer coaches can choose between SSSG or traditional warm-up activities according to player needs and preferences, but the superior effects of SSSG suggest it might offer greater benefits than TWU in preparing players for optimal physical output.
Article
Medical Laboratory Technology
Jacek Bil, Olga Mozenska, Agnieszka Segiet-Swiecicka, Robert J. Gil
Summary: This study aimed to evaluate the angiographic characteristics, feasibility, and safety of the provocative test with acetylcholine (AChT) in Middle European patients over a 5-year follow-up. The study found that AChT was safe in these patients, but those with microvascular spasm and a history of MINOCA had a higher risk of MI and recurrent chest pain requiring hospitalization in the follow-up period.
TRANSLATIONAL RESEARCH
(2021)
Article
Computer Science, Interdisciplinary Applications
Pablo Daniel Cruces, Mariano Llamedo Soria, Pedro David Arini
Summary: Coronary artery disease (CAD) is a major cause of death worldwide. Traditional indices show insufficient diagnostic performance. This study proposes the use of quaternion methods to evaluate abnormal alterations during ventricular depolarization and repolarization. The findings suggest that maximum linear velocity during ventricular depolarization and maximum angular velocity during the second half of the repolarization loop are significant markers for differentiating ischemic and non-ischemic patients.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Sport Sciences
Maria H. Gil, Henrique P. Neiva, Ana R. Alves, Antonio C. Sousa, Ricardo Ferraz, Mario C. Marques, Daniel A. Marinho
Summary: This study aimed to examine the impact of changing running techniques during warm-up on sprint performance, biomechanics, and physiological responses. The results showed that although there were no significant differences in 30-m sprint biomechanics and performance between warm-ups focusing on stride length or frequency, different running strategies and a more stable performance were observed with a warm-up focused on higher stride frequency.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Review
Medicine, General & Internal
Arduino A. Mangoni, Angelo Zinellu
Summary: This study conducted a systematic review and meta-analysis to explore the potential of ischaemia-modified albumin (IMA) as a biomarker for acute coronary syndrome (ACS). The findings suggest that IMA concentrations are significantly higher in ACS patients, indicating its potential usefulness in diagnosing ACS. Further research is needed to compare the diagnostic performance of IMA with established markers and to understand its potential in distinguishing between different types of ACS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Brooke M. Russell, Courtney R. Chang, Terry Hill, James D. Cotter, Monique E. Francois
Summary: The study found that substituting the final half of exercise with warm water immersion provides similar cardiometabolic health benefits to time-matched exercise, while substituting with cold water immersion does not.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Iwona Janczarek, Witold Kedzierski, Ewelina Tkaczyk, Beata Kaczmarek, Jaroslaw Luszczynski, Karolina Mucha
Summary: This study compared the impact of different warm-up regimes on the surface temperature of distal limbs in showjumping horses and leisure horses. The results showed that the surface temperature increase in jumping sport horses was greater than in leisure horses, indicating that the warming-up effect is achieved earlier and lasts longer in heavily trained horses than in non-performance horses.
Review
Cell Biology
Chenxia Hu, Lingfei Zhao, Fen Zhang, Lanjuan Li
Summary: The liver is the only organ with regenerative capacity, but various injury factors can lead to irreversible liver dysfunction. Liver resection and transplantation are effective treatments for liver failure. Melatonin has antioxidant properties and can attenuate liver ischemia/reperfusion injury. Understanding the mechanisms of melatonin's interactions with other cellular processes can improve its potential for treating liver diseases.
CELL PROLIFERATION
(2021)
Review
Sport Sciences
Francisco Cuenca-Fernandez, Daniel Boullosa, Oscar Lopez-Belmonte, Ana Gay, Jesus Juan Ruiz-Navarro, Raul Arellano
Summary: Warm-up is important for competitive swimming as it helps to improve performance by maintaining muscle activity and body temperature. The most common approach includes an in-water warm-up followed by dryland exercises. However, there is a lack of research on backstroke, butterfly, and individual medley, as well as warm-up effects over distances greater than 100m. Women are also under-represented in warm-up research.
SPORTS MEDICINE-OPEN
(2022)
Review
Biochemistry & Molecular Biology
Richi Nakatake, Mareike Schulz, Christina Kalvelage, Carina Benstoem, Rene H. Tolba
Summary: The study focused on inducible nitric oxide synthase (iNOS) as an early inflammatory response to hepatic ischaemia reperfusion injury (HIRI) and found that iNOS was upregulated in almost all HIRIs, with no direct associations of endothelial nitric oxide synthase (eNOS) or nitric oxide (NO) with iNOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Aung Myat, Simon R. Redwood, Satpal Arri, Bernard J. Gersh, Deepak L. Bhatt, Michael S. Marber
Summary: The study found that prolonged GLP-1R activation did not improve exercise tolerance or haemodynamics in chronic stable angina patients with established obstructive CAD. However, it significantly reduced weight and improved the lipid profile in these patients.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Nestelberger, Jasper Boeddinghaus, Pedro Lopez-Ayala, Thomas E. Kaier, Michael Marber, Vincent Gysin, Luca Koechlin, Ana Yufera Sanchez, Maria Rubini Gimenez, Desiree Wussler, Joan Elias Walter, Ivo Strebel, Tobias Zimmermann, Noemi Glarner, Oscar Miro, F. Javier Martin-Sanchez, Tatjana Zehnder, Raphael Twerenbold, Dagmar Keller, Christian Mueller
Summary: Novel cardiovascular biomarkers quantifying different pathophysiological pathways involved in T2MI and/or T1MI showed modest discrimination in early, noninvasive diagnosis of T2MI.
Review
Cardiac & Cardiovascular Systems
Sandrine Lecour, Bastiaan C. Du Pre, Hans Erik Botker, Bianca J. J. M. Brundel, Andreas Daiber, Sean M. Davidson, Peter Ferdinandy, Henrique Girao, Can Gollmann-Tepekoeylu, Mariann Gyoengyoesi, Derek J. Hausenloy, Rosalinda Madonna, Michael Marber, Cinzia Perrino, Maurizio Pesce, Rainer Schulz, Joost P. G. Sluijter, Sabine Steffens, Sophie Van Linthout, Martin E. Young, Linda W. Van Laake
Summary: Circadian rhythms play a crucial role in cardiovascular diseases and should be considered as a key research parameter to improve understanding of cardiac physiology/pathology and enhance the translation and efficacy of cardiac therapies. The aim is to highlight key aspects of circadian rhythms for the improvement of preclinical and translational studies related to ischemic heart disease and cardioprotection, which may lead to better clinical outcomes.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medical Laboratory Technology
Bashir Alaour, Torbjorn Omland, Janniche Torsvik, Thomas E. Kaier, Marit S. Sylte, Heidi Strand, Jasmine Quraishi, Sam McGrath, Luke Williams, Steven Meex, Simon Redwood, Michael Marber, Kristin M. Aakre
Summary: Research on weekly biological variation of cardiac myosin-binding protein C (cMyC) showed that it is suitable for disease monitoring, risk stratification, and prognostication, with analytical quality specifications comparable to cardiac troponin.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Heerajnarain Bulluck, Valeria Paradies, Emanuele Barbato, Andreas Baumbach, Hans Erik Botker, Davide Capodanno, Raffaele De Caterina, Claudio Cavallini, Sean M. Davidson, Dmitriy N. Feldman, Peter Ferdinandy, Sebastiano Gili, Mariann Gyongyosi, Vijay Kunadian, Sze-Yuan Ooi, Rosalinda Madonna, Michael Marber, Roxana Mehran, Gjin Ndrepepa, Cinzia Perrino, Stefanie Schupke, Johanne Silvain, Joost P. G. Sluijter, Giuseppe Tarantini, Gabor G. Toth, Linda W. Van Laake, Clemens von Birgelen, Michel Zeitouni, Allan S. Jaffe, Kristian Thygesen, Derek J. Hausenloy
Summary: The article recommends measuring baseline and post-PCI cTn values in all CCS patients undergoing PCI and confirms the prognostic relevance of post-PCI cTn elevation >5x 99th percentile URL for defining type 4a MI. In the absence of related complications, the same cTn cut-off threshold can be used to define major periprocedural myocardial injury, which are strong predictors of all-cause mortality post-PCI and can be used as quality metrics in clinical trials. Further research is needed to evaluate treatment strategies for reducing the risk of major periprocedural myocardial injury, type 4a MI, and MACE in CCS patients undergoing PCI.
EUROPEAN HEART JOURNAL
(2021)
Letter
Cardiac & Cardiovascular Systems
Vincent L. Aengevaeren, Roland R. J. van Kimmenade, Jordi Ordonez-Llanos, Alvaro Garcia-Osuna, Thomas E. Kaier, Michael Marber, Martijn Froeling, Sandra van den Berg-Faay, Melissa T. Hooijmans, Jithsa R. Monte, Maria T. E. Hopman, Gustav J. Strijkers, Aart J. Nederveen, Adrianus J. Bakermans, Thijs M. H. Eijsvogels
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medical Laboratory Technology
Kristin M. Aakre, Anett H. Ottesen, Heidi Strand, Arne L. Faaren, Bashir Alaour, Janniche Torsvik, Marit S. Sylte, Michael Marber, Geir Christensen, Helge Rosjo, Torbjorn Omland
Summary: In this study, secretoneurin was found to have low CVI, CVG, RCV, and II values, indicating its potential suitability as a diagnostic or prognostic biomarker. The findings suggest that delta values in serial samplings may be preferable for identifying clinical changes.
CLINICAL BIOCHEMISTRY
(2021)
Letter
Medical Laboratory Technology
Cindhya Sithiravel, Ragnhild Roysland, Bashir Alaour, Marit Sverresdotter Sylte, Janniche Torsvik, Heidi Strand, Michael Marber, Torbjorn Omland, Kristin Moberg Aakre
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Raphael Twerenbold, Pedro Lopez-Ayala, Thomas Nestelberger, Jasper Boeddinghaus, Bashir Alaour, Iris-Martina Huber, Yuan Zhi, Luca Koechlin, Desiree Wussler, Karin Wildi, Samyut Shrestha, Ivo Strebel, Oscar Miro, Javier F. Martin-Sanchez, Michael Christ, Damien Kawecki, Dagmar Keller, Maria Rubini Gimenez, Michael Marber, Christian Mueller
Summary: Cardiac myosin-binding protein C (cMyC) has shown high diagnostic accuracy in the early detection of non-ST-elevation myocardial infarction (NSTEMI). Its dynamic release kinetics may enable a more effective 0/1h-decision algorithm compared to current ESC hs-cTnT/I algorithm.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Michael S. Marber, Nicholas L. Mills, David A. Morrow, Christian Mueller
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Medical Laboratory Technology
Rasmus Bo Hasselbalch, Jonas Henrik Kristensen, Nicoline Jorgensen, Nina Strandkjaer, Bashir Alaour, Shoaib Afzal, Michael Marber, Henning Bundgaard, Kasper Karmark Iversen
Summary: The hs-cTnI assay showed comparable diagnostic accuracy to the cTnI-U assay for diagnosing myocardial infarction, but measured higher concentrations. This resulted in a higher frequency of acute myocardial injury. A subset of patients had significantly elevated hs-cTnI concentrations without any evidence of heterophilic antibodies.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew Ryan, Kalpa De Silva, Holly Morgan, Kevin O'Gallagher, Ozan M. Demir, Haseeb Rahman, Howard Ellis, Luke Dancy, Daniel Sado, Julian Strange, Narbeh Melikian, Michael Marber, Ajay M. Shah, Amedeo Chiribiri, Divaka Perera
Summary: Coronary wave intensity analysis shows similar accuracy to late-gadolinium-enhanced cardiac magnetic resonance imaging in predicting myocardial viability, indicating its potential to streamline the management of ischemic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Divaka Perera, Matthew Ryan, Holly P. Morgan, John P. Greenwood, Mark C. Petrie, Matthew Dodd, Roshan Weerackody, Peter D. O'Kane, Pier Giorgio Masci, Muhummad Sohaib Nazir, Alexandros Papachristidis, Navtej Chahal, Rajdeep Khattar, Saad M. Ezad, Stam Kapetanakis, Lana J. Dixon, Kalpa De Silva, Adam K. McDiarmid, Michael S. Marber, Theresa McDonagh, Gerry P. McCann, Tim C. Clayton, Roxy Senior, Amedeo Chiribiri
Summary: The study aimed to determine the effect of the extent of viable and nonviable myocardium on the effectiveness of PCI, prognosis, and improvement in left ventricular function in patients with ischemic left ventricular dysfunction.
Letter
Medical Laboratory Technology
Bashir Alaour, Thomas E. Kaier, Rasmus Bo Hasselbalch, William van Doorn, Steven Meex, Michael Marber
JOURNAL OF APPLIED LABORATORY MEDICINE
(2023)
Article
Physiology
Tiffany Patterson, Simone Rivolo, Daniel Burkhoff, Jan Schreuder, Natalia Briceno, Rupert Williams, Satpal Arri, Kaleab N. Asrress, Christopher Allen, Jubin Joseph, Hannah Z. R. McConkey, Howard Ellis, Antonis Pavlidis, Brian Clapp, Divaka Perera, Jack Lee, Michael S. Marber, Simon R. Redwood
Summary: The study demonstrates that in the presence of flow-limiting CAD, exercise to maximal effort can lead to impairment of LV contractile function and a deterioration in VA coupling compared to a control cohort.
PHYSIOLOGICAL REPORTS
(2021)