Article
Pharmacology & Pharmacy
Hongyang Shu, Weijian Hang, Yizhong Peng, Jiali Nie, Lujin Wu, Wenjun Zhang, Dao Wen Wang, Ning Zhou
Summary: Trimetazidine attenuates pressure overload-induced heart failure by improving myocardial mitochondrial function and glucose uptake via AMPK, providing significant cardioprotective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hongyang Shu, Yizhong Peng, Weijian Hang, Ning Zhou, Dao Wen Wang
Summary: Heart failure is a complex syndrome caused by various pathological factors, and trimetazidine has been shown to protect the heart through multiple mechanisms. Clinical studies have demonstrated that trimetazidine as an adjunct therapy can improve symptoms of heart failure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Julia Ritterhoff, Timothy S. McMillen, Outi Villet, Sara Young, Stephen C. Kolwicz, Taurence Senn, Arianne Caudal, Rong Tian
Summary: The study revealed a sex-dependent regulation of PPAR alpha signaling pathway in heart failure, which accounted for the differential response to ACC2 deletion. Male mice showed downregulation in mitochondrial oxidative function under pressure overload, and the improvement in cardiac function with ACC2 deletion was limited. In contrast, mitochondrial oxidative capacity was sustained in female mice under pressure overload, and ACC2 deletion improved myocardial energetics.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Reem M. Hazem, Rasha F. Aboslema, Eman T. Mehanna, Safaa M. Kishk, Mohammed Elsayed, Norhan M. El-Sayed
Summary: This study aimed to examine the cytotoxic effect of trimetazidine (TMZ) on breast cancer cells and its impact on glycolytic enzymes and AKT signaling. The study found that TMZ can inhibit fatty acid β-oxidation, leading to enhanced glucose oxidation and metabolic respiration. TMZ has a cytotoxic effect on breast cancer cells, reduces tumor weight, and suppresses AKT signaling.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Gastroenterology & Hepatology
Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, Maria J. Gonzalez-Rellan, Eva Novoa, Begona Porteiro, Cristina Alonso, Rebeca Mayo, Natalia da Silva Lima, Cristina Iglesias, Aveline A. Filliol, Ana Senra, Teresa C. Delgado, Ashwin Woodhoo, Laura Herrero, Dolors Serra, Vincent Prevot, Markus Schwaninger, Miguel Lopez, Carlos Dieguez, Oscar Millet, Jose M. Mato, Francisco J. Cubero, Marta Varela-Rey, Paula Iruzubieta, Javier Crespo, Maria L. Martinez-Chantar, Robert F. Schwabe, Ruben Nogueiras
Summary: We found that the expression of CPT1A is elevated in HSCs of patients with fibrosis, and that CPT1A induces the activation of these cells. Inhibition of CPT1A can ameliorate fibrosis by preventing the activation of HSCs.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chuting Li, Xuting Zhang, Jie Li, Liyin Liang, Jingran Zeng, Min Wen, Linjie Pan, Dongxin Lv, Min Liu, Yuanyuan Cheng, Heqing Huang
Summary: The purpose of this study was to investigate the effects of GRb1 on heart failure (HF) and cardiac energy metabolism. The results showed that GRb1 could improve cardiac function by protecting mitochondrial function, inhibiting oxidative stress, and promoting ATP synthesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Kim L. Ho, Qutuba G. Karwi, David Connolly, Simran Pherwani, Ezra B. Ketema, John R. Ussher, Gary D. Lopaschuk
Summary: Diabetes increases the risk for heart failure through various mechanisms, including disrupted energy metabolism, cardiac fibrosis, vascular dysfunction, and changes in gene and protein activity.
Article
Cardiac & Cardiovascular Systems
Jean Issa, Pierre Lodewyckx, Helene Blasco, Isabelle Benz-de-Bretagne, Francois Labarthe, Bruno Lefort
Summary: Heart failure in children is characterized by reduced fatty acid oxidation and accumulation of lipid toxic derivatives, similar to adults. This metabolic alteration may worsen cardiac function and suggests the potential for metabolic treatment in pediatric heart failure.
Article
Cardiac & Cardiovascular Systems
Arno A. van de Bovenkamp, Kiki T. J. Geurkink, Frank T. P. Oosterveer, Frances S. de Man, Wouter E. M. Kok, Patrick N. A. Bronzwaer, Cor P. Allaart, Aart J. Nederveen, Albert C. van Rossum, Adrianus J. Bakermans, M. Louis Handoko
Summary: This study investigated whether trimetazidine could improve myocardial energy homeostasis and exercise haemodynamics in patients with HFpEF. The results showed that there was no improvement in the primary outcome and myocardial energy status in the trimetazidine group compared to the placebo group.
Article
Medicine, General & Internal
M. A. ap Pfeffer, B. Claggett, E. F. Lewis, C. B. Granger, L. Kober, A. P. Maggioni, D. L. Mann, J. J. V. McMurray, J. -L. Rouleau, S. D. Solomon, P. G. Steg, O. Berwanger, M. Cikes, C. G. De Pasquale, C. East, A. Fernandez, K. Jering, U. Landmesser, R. Mehran, B. Merkely, F. Vaghaiwalla Mody, M. C. Petrie, I. Petrov, M. Schou, M. Senni, D. Sim, P. van der Meer, M. Lefkowitz, Y. Zhou, J. Gong, E. Braunwald
Summary: Among patients with acute myocardial infarction, the use of Sacubitril-Valsartan did not significantly reduce the incidence of death from cardiovascular causes or incident heart failure compared to ramipril.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew N. Carley, Santosh K. Maurya, Matthew Fasano, Yang Wang, Craig H. Selzman, Stavros G. Drakos, E. Douglas Lewandowski
Summary: The study revealed that short-chain fatty acids (SCFAs) are oxidized more readily than ketones in failing hearts, serving as a potential unexplored carbon source for energy production. Despite both SCFAs and ketones bypassing reduced CPT1 activity, SCFAs show higher oxidation rates and may represent a promising alternative energy substrate for failing hearts.
Review
Cardiac & Cardiovascular Systems
Krishnega Murugasamy, Aastha Munjal, Nagalingam Ravi Sundaresan
Summary: The heart, as a highly metabolically active organ, primarily uses fatty acids as an energy source. SIRT3, a deacetylase, plays a crucial role in regulating cardiac metabolism. Increasing SIRT3 levels or activity can alleviate cardiac pathologies, as SIRT3 targets mitochondrial proteins involved in energy metabolism. This review emphasizes the importance of SIRT3 as a master regulator of cardiac metabolism and discusses potential therapeutic strategies for improving cardiac health.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell & Tissue Engineering
Nadeera M. Wickramasinghe, David Sachs, Bhavana Shewale, David M. Gonzalez, Priyanka Dhanan-Krishnan, Denis Torre, Elizabeth LaMarca, Serena Raimo, Rafael Dariolli, Madhavika N. Serasinghe, Joshua Mayourian, Robert Sebra, Kristin Beaumont, Srinivas Iyengar, Deborah L. French, Arne Hansen, Thomas Eschenhagen, Jerry E. Chipuk, Eric A. Sobie, Adam Jacobs, Schahram Akbarian, Harry Ischiropoulos, Avi Ma'ayan, Sander M. Houten, Kevin Costa, Nicole C. Dubois
Summary: By modulating metabolic pathways, we have successfully facilitated the maturation of human pluripotent stem-cell-derived cardiomyocytes. Activation of PPARd signaling enhances fatty acid oxidation and improves mitochondrial cristae formation and myofibril organization, ultimately enhancing the function of cardiomyocytes.
Review
Cell Biology
Baigalmaa Lkhagva, Ting-Wei Lee, Yung-Kuo Lin, Yao-Chang Chen, Cheng-Chih Chung, Satoshi Higa, Yi-Jen Chen
Summary: The article discusses the high prevalence and mortality rates of atrial fibrillation in diabetes, emphasizing the importance of understanding the pathophysiological mechanisms of atrial fibrillation and the development of new therapeutic approaches.
Article
Medicine, Research & Experimental
Lin Ma, Mingyan Shao, Wenkun Cheng, Jinchi Jiang, Xu Chen, Nannan Tan, Guanjing Ling, Ye Yang, Qian Wang, Ran Yang, Chun Li, Yong Wang
Summary: This study explored the pharmacological effects of NCTS on energy metabolism to protect against heart failure post-acute myocardial infarction (AMI) via RXRa. The results showed that NCTS protects the heart against ischaemic damage by activating RXRa and improving cardiac dysfunction and cellular hypoxic injury. NCTS also enhances fatty acid metabolism and mitochondrial biogenesis, promoting myocardial energy production.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Stefano Ciardullo, Alice Oltolini, Rosa Cannistraci, Emanuele Muraca, Gianluca Perseghin
Summary: This study found that an android fat deposition pattern is associated with an increased prevalence of NAFLD in both sexes, independently of BMI. Furthermore, the effect on fibrosis was only evident in females.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Federico Rea, Laura Savare, Gabriella Morabito, Gianluca Perseghin, Giovanni Corrao
Summary: This study investigated the relationship between prolonged use of proton pump inhibitors (PPIs) and the risk of developing diabetes. The results showed that compared to short-term use, long-term use of PPIs was associated with a higher risk of diabetes. This association held true across different age groups, genders, and clinical profiles.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
S. Ciardullo, E. Bianconi, R. Cannistraci, P. Parmeggiani, E. M. Marone, G. Perseghin
Summary: This study aimed to assess the prevalence of peripheral arterial disease (PAD) in patients with non-alcoholic fatty liver disease (NAFLD) and its association with all-cause and cardiovascular disease (CVD) mortality. The results showed that PAD was associated with a higher risk of all-cause and cardiovascular mortality, supporting the current guidelines recommending CVD screening in NAFLD patients.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Eleonora Bianconi, Rosa Cannistraci, Silvia Perra, Francesca Zerbini, Gianluca Perseghin
Summary: This study investigated the distribution of sNfL levels and its association with diabetes in the general US population. The results showed that patients with diabetes had higher sNfL levels, and higher sNfL levels were associated with worse cognitive function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Stefano Ciardullo, Gianluca Perseghin
Summary: Using data from the National Health and Nutrition Examination Survey, the authors applied the Fibrotic NASH Index (FNI) to estimate the prevalence of fibrotic non-alcoholic steatohepatitis (NASH) in the US population. They found that the prevalence of probable fibrotic NASH was 8.4%, with higher rates in males and Hispanic participants. The study also revealed an increasing trend in NASH prevalence, which is associated with rising rates of obesity and type 2 diabetes.
LIVER INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin
Summary: This study aims to report the prevalence of fibrotic NASH in the general US population and evaluate the performance of the Fibrotic NASH Index (FNI). The study found that FNI had good accuracy in predicting probable fibrotic NASH in the overall population and in individuals with diabetes. This suggests that FNI is a simple and reliable test for screening NASH.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Rosa Cannistraci, Silvia Perra, Guido Lattuada, Gianluca Perseghin
Summary: This study analyzes data from a national survey and finds an association between 25(OH)D levels and NAFLD and liver fibrosis, suggesting a potential role of vitamin D in the occurrence and progression of NAFLD.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Giovanna Castoldi, Raffaella Carletti, Silvia Ippolito, Massimiliano Colzani, Sara Pelucchi, Gianpaolo Zerbini, Gianluca Perseghin, Giovanni Zatti, Cira R. T. di Gioia
Summary: This study investigates the potential mechanisms underlying the cardioprotective effects of the SGLT2 inhibitor empagliflozin, independent of glycemic control. The results suggest that the protective effects may be associated with a reduction in myocardial sympathetic activity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Gastroenterology & Hepatology
Stefano Ciardullo, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Gianluca Perseghin
Summary: This systematic review and meta-analysis found an association between liver stiffness measurement (LSM) obtained through vibration-controlled transient elastography (VCTE) and all-cause mortality in patients with nonalcoholic fatty liver disease (NAFLD). The analysis showed that higher LSM, indicating liver fibrosis, is independently associated with a higher mortality risk in NAFLD patients.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Stefano Ciardullo, Francesca Zerbini, Rosa Cannistraci, Emanuele Muraca, Silvia Perra, Alice Oltolini, Gianluca Perseghin
Summary: Sex hormones have different impacts on body composition in men and women. This study aimed to evaluate the association between testosterone, estradiol, and body fat distribution in the general population. The results showed that testosterone was positively associated with lean body mass and negatively associated with fat mass and the android/gynoid ratio in men, while estradiol showed the opposite trend. Among women, testosterone did not have an impact on body composition, but estradiol was positively associated with lean mass and negatively associated with fat mass. These findings highlight the varying effects of sex hormones on specific fat depots between men and women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Stefano Ciardullo, Michela Vergani, Gianluca Perseghin
Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic dysfunction-associated steatotic liver disease (MASLD), is common in patients with type 2 diabetes (T2D) and can lead to advanced liver fibrosis. Patients with T2D have an increased risk of liver-related complications and mortality. Screening for NAFLD/MASLD and advanced liver fibrosis is recommended in T2D patients. While there are no approved drugs for NAFLD/MASLD, certain antidiabetic drugs have shown positive effects on liver health. Diabetologists have the opportunity to actively treat NAFLD/MASLD and potentially change its natural course.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Alessandro Roberto Dodesini, Giuseppe Lepore, Anna Corsi, Cristiana Scaranna, Gianluca Perseghin, Roberto Trevisan
Summary: A model of insulin sensitivity was developed using clinical and laboratory parameters in patients with type 2 diabetes, and it was found to be associated with all-cause and cardiovascular mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Stefano Ciardullo, Marco Carbone, Pietro Invernizzi, Gianluca Perseghin
Summary: This study aimed to evaluate the prevalence of MAFLD among US adolescents and investigate whether the new MAFLD definition can identify individuals with more advanced liver disease. The study found that most US adolescents with elastographic evidence of steatosis meet the criteria for MAFLD, but these criteria do not appear to improve the detection of subjects with more advanced liver disease.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Gianluca Perseghin
Summary: This study found that the levels of s-Klotho in patients with type 2 diabetes are associated with kidney function and glycemic control. These findings highlight the importance of studying the mechanisms linking glycemic control and s-Klotho levels, as well as their predictive ability for clinical outcomes in patients with diabetes.
ACTA DIABETOLOGICA
(2022)