Article
Endocrinology & Metabolism
Arthi Thirumalai, Bradley D. Anawalt
Summary: This narrative review discusses the controversy surrounding the cardiovascular effects of endogenous and exogenous testosterone in men. The evidence suggests that physiological dosages of testosterone have minimal to no effect on cardiovascular outcomes, but there is insufficient evidence to support testosterone therapy for high-risk patients. Clinicians should avoid prescribing supraphysiological testosterone therapy to hypogonadal men.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biology
K. Barbara Sahlin, Indira Pla, Jessica de Siqueira Guedes, Krzysztof Pawlowski, Roger Appelqvist, Gyorgy Marko-Varga, Gilberto Barbosa Domont, Fabio Cesar Sousa Nogueira, Aleksander Giwercman, Aniel Sanchez, Johan Malm
Summary: Long term testosterone deficiency has negative effects on metabolism, muscle degradation, and metabolic diseases, while short-term testosterone changes seem to impact amino acid levels, with an association between tyrosine and phenylalanine levels and testosterone changes. The study suggests that fasting amino acid levels can be used to monitor early metabolic changes induced by testosterone fluctuations.
Article
Cardiac & Cardiovascular Systems
Mengyuan Qu, Chenzhao Feng, Xiaotong Wang, Yiqun Gu, Xuejun Shang, Yuanzhong Zhou, Chengliang Xiong, Honggang Li
Summary: The study found that the decline in sex hormone levels due to aging may be an important factor in male aging and cardiovascular diseases. Testosterone levels were inversely associated with hypertension prevalence, but factors like age, weight, smoking, and family history can impact this association.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Peripheral Vascular Disease
Lauren C. Chasland, Louise H. Naylor, Bu B. Yeap, Andrew J. Maiorana, Daniel J. Green
Summary: Exercise training improves endothelium-dependent vasodilator function in middle-to-older-aged men with central adiposity and low/normal testosterone levels, while administration of testosterone at therapeutic doses does not directly impact vascular function and does not add to the benefits of exercise.
Article
Multidisciplinary Sciences
Yohwan Yeo, Seung Woo Park, Sang-Chol Lee, Yun-Mi Song
Summary: This study aimed to investigate the association between sex hormones and cardiac structure and function. The results showed a positive association between serum testosterone level and LV diastolic function independent of SHBG level.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Duke Appiah, Sujata Luitel, Chike C. Nwabuo, Imo Ebong, Stephen J. Winters
Summary: This study found that low levels of total E2 or FE2 were associated with an increased risk of CVD mortality in young and middle-aged men, particularly among non-Hispanic White men.
Article
Endocrinology & Metabolism
Thiberiu Banica, Charlotte Verroken, Tim Reyns, Ahmed Mahmoud, Guy T'Sjoen, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw
Summary: This study indicates that serum androgen levels start declining early in adult life, independently from changes in BMI and other lifestyle factors. The decline in androgen levels most likely arises from a primary decrease in testicular function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Yi X. Chan, Suchitra Raj, Girish Dwivedi, Christopher M. Reid, Bradley D. Anawalt, Shalender Bhasin, Adrian S. Dobs, Graeme J. Hankey, Alvin M. Matsumoto, Paul E. Norman, Terence W. O'Neill, Claes Ohlsson, Eric S. Orwoll, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: The study showed that lower serum testosterone levels were independently associated with higher all-cause and cancer-related mortality in middle-aged to older men, while lower SHBG levels were independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation of these associations and causality would require mechanistic studies and prospective trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Bhavya Varma, Oluseye Ogunmoroti, Chiadi E. Ndumele, Brigitte Kazzi, Carla P. Rodriquez, Olatokunbo Osibogun, Matthew A. Allison, Alain G. Bertoni, Erin D. Michos
Summary: Differences in sex hormone levels contribute to differences in cardiovascular disease risk. Adipokines, such as leptin, resistin, and adiponectin, play a role in cardiometabolic pathways and have differing associations with CVD. This study found that a more androgenic sex hormone profile was associated with higher leptin and resistin levels and lower adiponectin levels. These findings provide mechanistic insight into the interplay between sex hormones, adipokines, and CVD risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
Francesca Iannantuoni, Juan Diego Salazar, Aranzazu Martinez de Maranon, Celia Banuls, Sandra Lopez-Domenech, Milagros Rocha, Felipe Hurtado-Murillo, Carlos Morillas, Marcelino Gomez-Balaguer, Victor Manuel Victor
Summary: Testosterone treatment in transgender men increases leukocyte-endothelium interactions and levels of adhesion molecules and proinflammatory cytokines, indicating the necessity to monitor cardiovascular risk in these patients.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Fang Huang, Yongchao Li, Yu Cui, Zewu Zhu, Jinbo Chen, Feng Zeng, Yang Li, Zhiyong Chen, Hequn Chen
Summary: The study aimed to evaluate the relationship between serum testosterone levels and kidney stone prevalence in males. The results showed a significant inverse association between serum testosterone levels and the prevalence of kidney stones in men over 40 years of age, but no correlation was seen in the 20-40 age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Fernanda Cristina de Abreu Quintela-Castro, Taisa Sabrina Silva Pereira, Danubia Boy Alves, Leticia Chiepe, Laura Sperandio Nascimento, Kelly Cristina Mota Braga Chiepe, Rafael Mazioli Barcelos, Bruno Maia Costa, Oscar Geovanny Enriquez-Martinez, Joamyr Victor Rossoni Jr, Tatiani Bellettini-Santos
Summary: A recent US national survey has drawn attention to the little-studied relationship between testosterone hormone therapy in transgender men and cardiovascular outcomes. This systematic review aimed to assess the association between hormone therapy in transgender men and lipid profiles and cardiovascular risk. The findings suggest that hormone therapy may lead to a decrease in high-density lipoprotein cholesterol levels, but further studies are needed to establish cardiovascular risk.
Article
Nutrition & Dietetics
Gareth J. McKay, Natalie Lyner, Gerry J. Linden, Frank Kee, Marie Moitry, Katia Biasch, Philippe Amouyel, Jean Dallongeville, Vanina Bongard, Jean Ferrieres, K. Fred Gey, Chris C. Patterson, Jayne Woodside
Summary: This study examined the association between plasma antioxidant status and all-cause mortality and cardiovascular events, finding that higher levels of antioxidants were associated with lower risk of all-cause mortality, particularly retinol was significantly associated with decreased risk of cardiovascular events. Low antioxidant levels contribute to the gradient of all-cause mortality and cardiovascular incidence independent of lifestyle behaviours and traditional cardiovascular and socioeconomic risk factors.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Pai Zheng, Zhangjian Chen, Jiaqi Shi, Yuting Xue, Yi Bai, Yulin Kang, Huiyu Xu, Guang Jia, Tiancheng Wang
Summary: This study found that ambient air pollution in Beijing was associated with altered serum sex hormone levels in men, especially testosterone. Immediate and short-term exposure to PM2.5, PM10, and SO2 were related to a decrease in testosterone levels, with a cumulative effect observed within 30 days.
ENVIRONMENTAL RESEARCH
(2022)