Article
Medicine, General & Internal
Alberto Palazzuoli, Isabella Evangelista, Matteo Beltrami, Filippo Pirrotta, Maria Cristina Tavera, Luigi Gennari, Gaetano Ruocco
Summary: Congestion is a major cause of hospitalization in patients with acute heart failure. The recent introduction of lung ultrasound scan (LUS) and B-type natriuretic peptide (BNP) has enabled a more accurate assessment of pulmonary congestion. This study compared clinical congestion with LUS and BNP, and found that LUS and BNP were better predictors of prognosis compared to traditional clinical evaluation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Alberto Cordero, Elias Martinez Rey-Ranal, Maria J. Moreno, David Escribano, Jose Moreno-Arribas, Maria A. Quintanilla, Pilar Zuazola, Julio Nunez, Vicente Bertomeu-Gonzalez
Summary: NT-pro-BNP serves as an independent predictor of HF readmission after ACS, associated with increased risk of HF or death. Complete revascularization has a preventive effect on HF readmission, while several other variables are linked to higher risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Bo Pan, Di Hu, Huichao Sun, Tiewei Lv, Wangguo Xu, Jie Tian
Summary: This study summarized the differences between pediatric diastolic heart failure and systolic heart failure in terms of primary causes, clinical features, and short-term prognosis. B-type natriuretic peptide has limited diagnostic value in pediatric DHF. Diastolic function indicators significantly improved after treatment in DHF patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Pietro Scicchitano, Massimo Iacoviello, Andrea Passantino, Piero Guida, Micaela De Palo, Assunta Piscopo, Michele Gesualdo, Pasquale Caldarola, Francesco Massari
Summary: The Donadio formula for calculating eGFR was found to be an independent predictor of mortality in patients with HF, along with measurements derived from MDRD4 and CKD-EPI formulas, but less accurate than Cockroft-Gault.
Article
Cardiac & Cardiovascular Systems
Claire Tonry, Ken McDonald, Mark Ledwidge, Belinda Hernandez, Nadezhda Glezeva, Cathy Rooney, Brian Morrissey, Stephen R. Pennington, John A. Baugh, Chris J. Watson
Summary: This study aimed to design a mass spectrometry-based method to measure protein biomarkers of heart failure and found significant differences in some proteins between heart failure and non-heart failure patients. The combination of BNP measurement with a set of biomarkers was more accurate in predicting heart failure compared to BNP alone.
Review
Biochemistry & Molecular Biology
Riccardo Sarzani, Massimiliano Allevi, Chiara Di Pentima, Paola Schiavi, Francesco Spannella, Federico Giulietti
Summary: Cardiac natriuretic peptides are true hormones produced by cardiomyocytes, exerting systemic effects and contributing to cardiovascular health. They also have paracrine and autocrine activities on the heart, preventing cardiac dysfunction and promoting heart protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Mihai Marinescu, Violeta Diana Oprea, Aurel Nechita, Dana Tutunaru, Luiza-Camelia Nechita, Aurelia Romila
Summary: Heart failure is a major cause of morbidity and mortality, especially in elderly patients. The challenges in managing heart failure in the elderly include comorbidities, frailty, cognitive impairment, and polypharmacy. However, elderly patients are commonly excluded from clinical trials on heart failure. The use of biomarkers, such as natriuretic peptides like BNP and NTproBNP, has become increasingly important for screening, diagnosis, and treatment of heart failure.
Article
Cardiac & Cardiovascular Systems
Tetsuma Kawaji, Hiroki Shiomi, Bingyuan Bao, Shun Hojo, Yuji Tezuka, Hidenori Yaku, Kenji Nakatsuma, Shintaro Matsuda, Kazuhisa Kaneda, Masashi Kato, Takafumi Yokomatsu, Shinji Miki
Summary: The aim of this study was to evaluate the impact of intracardiac dynamics assessed by echo-vector flow mapping on atrial fibrillation (AF) complicated by heart failure (HF). The results showed that the average energy loss (EL) per stroke volume (SV) during AF rhythm was significantly higher in the high NT-proBNP group compared to the low NT-proBNP group. High levels of NT-proBNP were associated with large vortex formation and extreme EL during the diastolic phase. After sinus restoration, the average EL/SV significantly decreased in the high NT-proBNP group. There was no significant difference in average EL/SV during sinus rhythm between the high and low NT-proBNP groups.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Veterinary Sciences
Alice G. N. Morey, Kenneth E. E. Lamb, James J. J. Karnia, Kelly E. E. Wiggen, Bridget M. M. Lyons, Laura A. A. Nafe, Stacey B. B. Leach
Summary: This study compared NT-proBNP and cTnI concentrations as well as POCUS findings in dogs with cardiac and noncardiac nonhemorrhagic ascites. The results showed that NT-proBNP concentration was significantly higher in the cardiac non-pericardial disease group compared to the pericardial disease group. POCUS revealed a significantly higher number of dogs with hepatic venous and caudal vena cava distension in the cardiac non-pericardial disease group.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Jianjun Wu, Dawei Yang, Fan Yang
Summary: Cardiovascular diseases pose a significant global public health challenge, and emerging research highlights the correlation between sleep disorders and CVD. Sleep quality is closely related to cardiovascular disease risk, and exercise interventions play a crucial role in improving sleep quality and reducing the risk of CVD.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Emil Wolsk, Brian Claggett, Rafael Diaz, Kenneth Dickstein, Hertzel C. Gerstein, Lars Kober, Eldrin F. Lewis, Aldo P. Maggioni, John J. McMurray, Jeffrey L. Probstfield, Matthew C. Riddle, Scott D. Solomon, Jean-Claude Tardif, Marc A. Pfeffer
Summary: Serial NP measurements can improve the prediction of imminent cardiovascular death or heart failure hospitalization in patients with coronary artery disease and type 2 diabetes. The absolute risk estimates provided can aid clinicians in decision-making and help patients understand their short-term risk profile.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Pharmacology & Pharmacy
Xiaoyu Zhu, Lili Jiang, Xuejiao Wei, Mengtuan Long, Yujun Du
Summary: Roxadustat is a newly approved hypoxia-inducible factor prolyl hydroxylase inhibitor that has shown favorable safety and efficacy in treating renal anemia. Studies have also indicated its potential for treating other hypoxia-related diseases. Although no significant adverse or off-target effects have been found in clinical studies of roxadustat, clinicians should remain vigilant about these possibilities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Emergency Medicine
Lei Yin, Zhenzhen Han, Qing Zhang, Jiada Xie, Chunpeng Wang, Lianxing Zhao
Summary: This study systematically reviewed the influence of hemodialysis on NT-pro BNP concentration and found that NT-pro BNP may not be influenced by hemodialysis, and it could not be used to determine if heart failure is improving in patients with renal failure who are treated with hemodialysis.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alisse Hauspurg, Derek J. Marsh, Rebecca B. McNeil, C. Noel Bairey Merz, Philip Greenland, Adam C. Straub, Caroline E. Rouse, William A. Grobman, Victoria L. Pemberton, Robert M. Silver, Yii-Der Ida Chen, Brian M. Mercer, Lisa D. Levine, Afshan Hameed, Matthew K. Hoffman, Hyagriv N. Simhan, Janet M. Catov
Summary: Hypertensive disorders of pregnancy are linked to future cardiovascular disease, potentially due to pre-pregnancy subclinical cardiac dysfunction. This study examined the association between higher NT-proBNP concentrations in early pregnancy and hypertensive disorders of pregnancy and hypertension 2 to 7 years postpartum. The findings suggest that higher NT-proBNP concentrations are associated with a lower risk of these conditions.
Editorial Material
Oncology
Payton D. Stevens, Bart O. Williams
Summary: LGR4 is known for its role in regulating cell response to Wnt ligands and EGFR signaling. High levels of Lgr4 expression correlate strongly with EGFR signaling, challenging the understanding of the contributions of Wnt signaling and EGFR signaling in cancer.