Article
Neurosciences
Xiaohui Lin, Sebastiaan W. F. Meenderink, Glenna Stomackin, Timothy T. Jung, Glen K. Martin, Wei Dong
Summary: Research shows that spontaneously healed tympanic membranes have abnormalities in structure and mechanical properties, leading to deterioration in middle ear sound transmission. Experiments in a controlled perforation gerbil model indicate frequency-dependent loss in forward ME transmission, with smaller variations in the reverse direction, offering insights into conductive hearing loss in patients with abnormal tympanic membranes. Moreover, changes in distortion product otoacoustic emissions (DPOAEs) reflect altered ME transmission, confirming their utility in assessing cochlear and middle ear health.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2021)
Article
Engineering, Biomedical
Pieter G. G. Muyshondt, Joris J. J. Dirckx
Summary: Experiments have shown that prestrain exists in the rabbit tympanic membrane (TM) even without external loads, but its influence on the vibration response of the middle ear (ME) is still unclear. In this study, a detailed 3D finite-element model of the rabbit ME was constructed to investigate this effect. The results demonstrated that even small levels of prestrain have a significant impact on the vibration response of the normal ME.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Otorhinolaryngology
Nicholas Bevis, Benjamin Sackmann, Thomas Effertz, Michael Lauxmann, Dirk Beutner
Summary: The study found that the size and location of tympanic membrane perforations have a characteristic influence on the middle ear transfer functions. Posterior tympanic membrane perforations affect the transmission properties to a larger degree than anterior perforations, and small perforations lead to a decrease in membrane rigidity and an increase in oscillation amplitude.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Chemistry, Analytical
Jungeun Won, Guillermo L. Monroy, Roshan I. Dsouza, Darold R. Spillman, Jonathan McJunkin, Ryan G. Porter, Jindou Shi, Edita Aksamitiene, MaryEllen Sherwood, Lindsay Stiger, Stephen A. Boppart
Summary: Middle ear infection is a common inflammatory disease, with subjective diagnostic methods currently in use. To improve diagnosis, researchers have integrated optical coherence tomography technology into a handheld imaging probe to non-invasively and quantitatively assess middle ear infections.
Article
Otorhinolaryngology
Mohammad Faramarzi, Ali Faramarzi, Sareh Roosta, Sajad Pishgar, Seyed Hossein Owji
Summary: The use of hyaluronic acid gel (HAG) in tympanoplasty can improve graft success rate, while audiometric outcomes are similar compared to the absorbable gelatin sponge packing group.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Multidisciplinary Sciences
Al-Rahim Habib, Yixi Xu, Kris Bock, Shrestha Mohanty, Tina Sederholm, William B. Weeks, Rahul Dodhia, Juan Lavista Ferres, Chris Perry, Raymond Sacks, Narinder Singh
Summary: This study evaluated the generalizability of AI algorithms using deep learning methods for identifying middle ear disease from otoscopic images. The study collected 1842 otoscopic images from three different sources and categorized them as normal or abnormal. The internal performance of the AI-otoscopy algorithms was high (mean AUC: 0.95), but the external performance on new test cohorts was lower (mean AUC: 0.76). Further efforts are needed to improve the external performance and develop a robust algorithm for real-world clinical applications.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona Elassal, Rania A. H. Ishak
Summary: This research aimed to design and optimize innovative nanovesicles called Glycerospanlastics for delivering triamcinolone acetonide (TA) for otitis media treatment. The optimized Glycerospanlastics showed good properties such as nanometer size, negative charges, high TA entrapment, and improved permeation across the tympanic membrane. They outperformed the marketed drug suspension in treating otitis media, as evidenced by the restoration of histopathological alterations and reduced levels of IL-1 beta and TNF-alpha.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona Elassal, Rania A. H. Ishak
Summary: This review focuses on the anatomy of the ear, barriers to effective delivery, and localized delivery methods. It specifically addresses middle and inner ear diseases and their targeted drug delivery systems, including the use of hydrogels and nanocarriers for local delivery to the middle ear.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Otorhinolaryngology
Francesco Dispenza, Angelo Immordino, Alessandro De Stefano, Federico Sireci, Francesco Lorusso, Pietro Salvago, Francesco Martines, Salvatore Gallina
Summary: Nasal functions are predictive of surgical outcomes in middle ear surgery. Nasal obstruction may cause Eustachian tube dysfunction, leading to negative prognostic factors such as nasal septal deviation, chronic rhinitis, and nasal polyps.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Acoustics
Lucas C. Lobato, Stephan Paul, Julio A. Cordioli
Summary: This study compiles and analyzes experimental data on the mechanical properties of the human middle ear. The results show that there is larger uncertainty in the stiffness properties of the tympanic membrane, ligaments, and tendons compared to the ossicles' mass. Additionally, the uncertainties of the middle ear response vary across frequency, and vibration measures are more uncertain than input impedance and reflectance. These findings provide the basis for the development of probabilistic models of the human middle ear.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Audiology & Speech-Language Pathology
Liam Gallagher, Mohamed Diop, Elizabeth S. Olson
Summary: The study investigated the acoustic effects of the tensor tympani muscle contraction on middle ear vibrations in young adult gerbils. The results showed that the muscle contraction produced both enhancement and attenuation effects on the velocity responses, with a narrow band of enhancement around 6 kHz.
Article
Otorhinolaryngology
Sheneen Meghji, Wahidah Wahid, Eyal Schechter, Codruta Neumann, Aaron Trinidade
Summary: This study compared two methods of ear packing following tympanoplasty for tympanic membrane perforation and found that BIPP-impregnated ribbon gauze and chloramphenicol/wick were comparable in terms of post-operative complications. Age and concurrent bony canaloplasty were identified as significant factors increasing complication rates. No significant difference was found in complication rates based on pre-operative ear status, indication, graft type, or gender.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona I. A. El-Assal, Rania A. H. Ishak
Summary: This study explores the use of glycerosomes for delivering triamcinolone acetonide (TA) to the middle ear, improving the treatment of otitis media (OM). The optimized formulation of TA glycerosomes showed superior tolerability and efficacy compared to the marketed drug in ex vivo and in vivo experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Audiology & Speech-Language Pathology
Nam Hyun Cho, Michael E. Ravicz, Sunil Puria
Summary: The flexible ossicular chain in mammals, consisting of the tensor tympani muscle and the stapedius muscle, allows independent alterations of middle-ear sound transmission. Pulling on these muscles can change the shape of the tympanic membrane and the motion of the ossicles, affecting sound-induced vibrations and transmission delay. These effects may play a role in aligning auditory and visual representations of the environment.
Article
Health Care Sciences & Services
Hayoung Byun, Seung Hwan Lee, Tae Hyun Kim, Jaehoon Oh, Jae Ho Chung
Summary: Teachable Machine (R) is a machine learning platform that can diagnose tympanic membrane lesions without coding knowledge. It achieved high accuracy in classifying normal and abnormal tympanic membranes, but the accuracy decreased with the complexity of pathology categorization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)