Article
Clinical Neurology
Wilhelm Wimmer, Luca Sclabas, Marco Caversaccio, Stefan Weder
Summary: This study aimed to investigate the postoperative course of residual acoustic hearing and clinical impedance in patients with long electrode arrays and to explore the applicability of impedance telemetry for monitoring residual hearing. The results showed that residual hearing may be lost within 6 months postoperatively, and clinical impedance gradually decreased over time. Basal electrodes were more likely to have higher impedance. Furthermore, the study found a significant association between clinical impedance and residual hearing.
FRONTIERS IN NEUROLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Peter A. Santi, Shane Johnson, Julian Wuester, Matthew Griesbach, Alexander Claussen, Jonathon Kirk
Summary: Postmortem examination of the cochlea with a cochlear implant presents challenges due to the presence of wires and metal components that make sectioning difficult. Plastic embedded implanted cochleas have been successfully sectioned using specialized methods. An alternative non-destructive method is optical sectioning of a chemically cleared cochlea, but the presence of metal components results in artifacts in the 2D optical sections. Removal of the implant prior to imaging yields the best image quality.
Article
Multidisciplinary Sciences
Sudanthi Wijewickrema, Christofer Bester, Jean-Marc Gerard, Aaron Collins, Stephen O'Leary
Summary: Cochlear implants (CIs) offer the hearing impaired a chance to perceive sound through electrical stimulation of the cochlear nerve. However, CI surgery carries a high risk of losing natural hearing, which can impact speech perception and music appreciation. Electrocochleography (ECochG) has been used to detect trauma during surgery and potentially save natural hearing. This study discusses an automated method for analyzing cochlear responses during CI surgeries, demonstrating high accuracy compared to human experts and the potential to improve ECochG scalability and patient safety.
Article
Audiology & Speech-Language Pathology
Susan R. S. Bissmeyer, Raymond L. Goldsworthy
Summary: This study examines frequency discrimination in cochlear implant users using different combinations of electrode position and stimulation rate. The results show that combining place and rate cues improves frequency discrimination compared to using either cue alone, providing insights for signal processing in cochlear implants.
Article
Engineering, Biomedical
Simone R. de Rijk, Alexander J. Boys, Iwan V. Roberts, Chen Jiang, Charlotte Garcia, Roisin M. Owens, Manohar Bance
Summary: Cochlear implants are revolutionary devices that partially restore hearing for those with severe sensorineural hearing loss. However, they can lead to fibrotic tissue formation in the cochlea, causing residual hearing loss and suboptimal outcomes. This study develops a tissue-engineered model to examine the electrical characteristics associated with fibrotic tissue formation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Clinical Neurology
Faizah Mushtaq, Andrew Soulby, Patrick Boyle, Terry Nunn, Douglas E. H. Hartley
Summary: Recent technological advances in CI telemetry have allowed CI users to assess their cochlear health (CH) through self-assessment. This study evaluated the feasibility of using a CI to assess CH and found that electrode impedances and eCAPs are promising measurements for objectively assessing CH.
FRONTIERS IN NEUROLOGY
(2022)
Article
Engineering, Biomedical
Philipp Aebischer, Stefan Meyer, Marco Caversaccio, Wilhelm Wimmer
Summary: An intuitive approach was proposed to estimate the insertion depth of cochlear implant electrodes by calculating tissue resistances from transimpedance recordings. The method showed promising results in estimating linear insertion depths of electrodes, providing potential for clinical applications.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Immunology
Hong-Ying Qiu, Na-Na Zhang, Qing-Qing Ma, Rui-Ting Li, Meng-Yue Guan, Li-Li Zhang, Jia Zhou, Rong-Rong Zhang, Xing-Yao Huang, Wen-Hui Yang, Yong-Qiang Deng, Cheng-Feng Qin, Dong-Sheng Zhou
Summary: This study demonstrates that Zika virus can be transmitted via aerosol routes, resulting in systemic infection and inducing immune responses.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Audiology & Speech-Language Pathology
Raymond L. Goldsworthy, Susan R. S. Bissmeyer
Summary: This study aimed to characterize cochlear implant users' pitch perception for different types of tones and test their reliance on stimulation place and rate cues for pitch discrimination. The results showed that CI users integrate place and rate cues across the ecologically essential pitch range. They had better pitch discrimination for low-pass filtered harmonic complexes and amplitude-modulated tones when provided a covarying place cue.
Article
Engineering, Biomedical
Leanne Sijgers, Alexander Huber, Sonia Tabibi, Julian Grosse, Christof Roeoesli, Patrick Boyle, Kanthaiah Koka, Norbert Dillier, Flurin Pfiffner, Adrian Dalbert
Summary: This study investigates the relationship between cochlear implant electrode positioning and electrical impedance measurements. The results show that three-point and four-point impedances are strongly correlated with electrode-modiolar distance, while monopolar impedances are minimally affected by changes in electrode positioning. The findings have significant implications for predicting electrode positioning during cochlear implant insertion in real-time using electrical impedance measurements.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Jeff Jia-Fu Wei, Tao-Hsin Tung, Lieber Po-Hung Li
Summary: Cochlear implantation is the most effective treatment modality for severe to profound sensorineural hearing loss. This study investigated the impedance evolution of different devices after early switch-on within 24 hours of implantation and its influencing factors, providing valuable insights for future research.
Article
Medicine, Research & Experimental
Lutz Gaertner, Andreas Buechner, Angelika Illg, Thomas Lenarz
Summary: This study presents a case where abnormal impedance of electrode contacts in a cochlear implant resulted in reduced speech comprehension and distorted sound perception, despite not being detected by conventional tests. Re-implantation significantly improved the patient's subjective sound perception and speech comprehension, indicating the importance of careful monitoring and consideration of technical measurements and hearing performance data in cochlear implant patients.
Article
Audiology & Speech-Language Pathology
Charlotte Amalie Navntoft, David M. Landsberger, Tania Rinaldi Barkat, Jeremy Marozeau
Summary: The study compared rectangular, rising ramped, and declining ramped pulse shapes in terms of charge efficiency and discriminability in seven CI listeners. It was found that ramped pulses required reduced charge but increased peak current amplitudes compared to rectangular pulses. There was no significant difference between rising and declining ramped pulses, and most participants could not perceive a difference between pulse shapes.
Article
Biochemistry & Molecular Biology
Josephine Skat-Rordam, David H. Ipsen, Stefan E. Seemann, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Summary: The study found key similarities between the guinea pig NASH model and human NASH, supporting increased predictability when translating research findings to human patients.
Article
Engineering, Biomedical
Trevor L. Bruns, Katherine E. Riojas, Robert F. Labadie, Robert J. Webster
Summary: This paper presents a non-invasive method to determine the positioning of a cochlear-implant electrode array (EA) in the inner ear. The study shows that bipolar access resistance is highly correlated with the proximity of the EA to the modiolus, and proposes a new prediction approach based on a recurrent neural network to improve the accuracy of estimating the EA's positioning.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)