Article
Medicine, General & Internal
Sube Banerjee, Juliet High, Susan Stirling, Lee Shepstone, Ann Marie Swart, Tanya Telling, Catherine Henderson, Clive Ballard, Peter Bentham, Alistair Burns, Nicolas Farina, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O'Brien, Annabel Price, Alan J. Thomas, Naji Tabet
Summary: This study evaluated the efficacy and safety of mirtazapine, an antidepressant, for treating agitation in patients with dementia. The findings showed that mirtazapine did not reduce agitation symptoms compared to placebo, and there was a potentially higher mortality rate associated with mirtazapine use.
Article
Health Care Sciences & Services
Sube Banerjee, Nicolas Farina, Catherine Henderson, Juliet High, Susan Stirling, Lee Shepstone, Julia Fountain, Clive Ballard, Peter Bentham, Alistair Burns, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O'Brien, Annabel Price, Alan J. Thomas, Ann Marie Swart, Tanya Telling, Naji Tabet
Summary: This study aimed to assess the clinical and cost-effectiveness and safety of mirtazapine and carbamazepine in treating agitation in dementia. The results showed that mirtazapine is not clinically or cost-effective compared to placebo for agitation in dementia. Effective and cost-effective management strategies are needed for agitation in dementia when non-pharmacological approaches are unsuccessful.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Medicine, General & Internal
Andrew W. Horne, Stephen Tong, Catherine A. Moakes, Lee J. Middleton, W. Colin Duncan, Ben W. Mol, Lucy H. R. Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Ann M. Doust, Jane P. Daniels
Summary: This study evaluated whether oral gefitinib in combination with methotrexate is more effective than methotrexate alone in the treatment of tubal ectopic pregnancy. The results showed that oral gefitinib does not offer clinical benefit over methotrexate and increases minor adverse reactions.
Article
Oncology
Dean A. Fennell, Sean Ewings, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Kayleigh Hill, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Aarti Gaba, Liz Darlison, Peter Wells-Jordan, Cathy Richards, Charlotte Poile, Jason F. Lester, Gareth Griffiths
Summary: The study evaluated the efficacy and safety of nivolumab in patients with pleural or peritoneal malignant mesothelioma who had progressed following platinum-based chemotherapy. Nivolumab showed improved progression-free survival and overall survival compared to placebo in these patients, with manageable treatment-related adverse events. The results suggest that nivolumab might be a beneficial treatment for patients with malignant mesothelioma who have progressed on first-line therapy.
Article
Medical Informatics
Chantal M. den Bakker, Frederieke G. Schaafsma, Esther C. J. Consten, Steven E. Schraffordt Koops, Eva van der Meij, Peter M. van de Ven, Hendrik J. Bonjer, Judith A. F. Huirne, Johannes R. Anema
Summary: This study aimed to assess the impact of a personalised eHealth programme on patients' return to normal activities after major abdominal surgery. The results showed that patients who received the eHealth intervention had a 13-day earlier return to normal activities compared to those who received standard care.
LANCET DIGITAL HEALTH
(2023)
Article
Gastroenterology & Hepatology
Evan S. Dellon, Kathryn A. Peterson, Benjamin L. Mitlyng, Alina Iuga, Christine E. Bookhout, Lindsay M. Cortright, Kacie B. Walker, Timothy S. Gee, Sarah J. McGee, Brenderia A. Cameron, Joseph A. Galanko, John T. Woosley, Swathi Eluri, Susan E. Moist, Ikuo Hirano
Summary: This study aimed to determine the efficacy of mepolizumab in improving dysphagia symptoms and reducing esophageal eosinophil counts in EoE. The results showed that mepolizumab significantly decreased symptoms and eosinophil counts within 3 months, but longer treatment did not yield additional improvement.
Article
Medicine, General & Internal
Nilufar Mohebbi, Alexander Ritter, Anna Wiegand, Nicole Graf, Suzan Dahdal, Daniel Sidler, Spyridon Arampatzis, Karine Hadaya, Thomas F. Mueller, Carsten A. Wagner, Rudolf P. Wuethrich
Summary: This study examined the effects of sodium bicarbonate treatment on graft function in kidney transplant recipients. The results showed that treatment with sodium bicarbonate for two years did not affect the decline in estimated glomerular filtration rate (GFR). Therefore, sodium bicarbonate treatment is not generally recommended for preserving GFR in kidney transplant recipients with chronic kidney disease and metabolic acidosis.
Article
Medicine, General & Internal
Martina Schneider, Marivic Narciso-Abraham, Sandra Hadl, Robert Mcmahon, Sebastian Toepfer, Ulrike Fuchs, Romana Hochreiter, Annegret Bitzer, Karin Kosulin, Julian Larcher-Senn, Robert Mader, Katrin Dubischar, Oliver Zoihsl, Juan-Carlos Jaramillo, Susanne Eder-Lingelbach, Vera Buerger, Nina Wressnigg
Summary: This study investigated the safety and immunogenicity of the live-attenuated vaccine candidate VLA1553 for chikungunya virus. The results showed that a single dose of VLA1553 induced a strong immune response and generated seroprotective antibody levels in almost all vaccinated participants. The vaccine was well tolerated and had a favorable safety profile.
Article
Medicine, General & Internal
Thomas Gargadennec, Jean-Ferreol Oilleau, Bertrand Rozec, Nicolas Nesseler, Sigismond Lasocki, Emmanuel Futier, Julien Amour, Michel Durand, Adrien Bougle, Thomas Kerforne, Maelys Consigny, Dauphou Eddi, Olivier Huet
Summary: The study aims to demonstrate the effectiveness of sleep induction by overnight infusion of dexmedetomidine to prevent delirium after cardiac surgery, with the goal of validating the hypothesis that preserving circadian rhythm can lower the occurrence of delirium.
Article
Medicine, General & Internal
Mette H. Bakker, Jacqueline G. Hugtenburg, Annemieke van Straten, Henriette E. van der Horst, Pauline Slottje
Summary: The trial aims to assess the effectiveness of low-dose amitriptyline and mirtazapine in patients with insomnia disorder. The study will be conducted in about 50 general practices, with participants randomly assigned to three treatment groups for 16 weeks. The primary outcome is self-reported insomnia severity at 6 weeks, with additional assessments on sleep quality, daytime functioning, safety, and treatment evaluation.
Article
Oncology
Eric J. Sherman, Jonathan Harris, Keith C. Bible, Ping Xia, Ronald A. Ghossein, Christine H. Chung, Nadeem Riaz, G. Brandon Gunn, Robert L. Foote, Sue S. Yom, Stuart J. Wong, Shlomo A. Koyfman, Michael F. Dzeda, David A. Clump, Saad A. Khan, Manisha H. Shah, Kevin Redmond, Pedro A. Torres-Saavedra, Quynh-Thu Le, Nancy Y. Lee
Summary: This study is the largest randomized anaplastic thyroid cancer study that has been completed, showing the feasibility and safety of the treatment combination. Although no significant improvement in overall survival was observed in the pazopanib group, hypothesis-generating data were generated that may warrant further investigation.
Article
Medicine, General & Internal
Elsa Tavernier, Francois Barbier, Ferhat Meziani, Jean-Pierre Quenot, Jean-Etienne Herbrecht, Mickael Landais, Damien Roux, Philippe Seguin, David Schnell, Anne Veinstein, Benoit Veber, Sigismond Lasocki, Qin Lu, Gaetan Beduneau, Martine Ferrandiere, Claire Dahyot-Fizelier, Gaetan Plantefeve, Mai-Anh Nay, Hamid Merdji, Pascal Andreu, Laurent Vecellio, Gregoire Muller, Maria Cabrera, Deborah Le Pennec, Renaud Respaud, Philippe Lanotte, Nicolas Gregoire, Marie Leclerc, Julie Helms, Thierry Boulain, Jean-Claude Lacherade, Stephan Ehrmann
Summary: Pre-emptive inhaled antibiotics may reduce ventilator-associated pneumonia among critically ill patients, with potential benefits for those undergoing invasive mechanical ventilation for over 3 days. This randomized controlled trial aims to evaluate the effectiveness of a 3-day course of inhaled antibiotics in preventing ventilator-associated pneumonia.
Article
Medicine, General & Internal
Kenneth B. Gordon, Peter Foley, James G. Krueger, Andreas Pinter, Kristian Reich, Ronald Vender, Veerle Vanvoorden, Cynthia Madden, Katy White, Christopher Cioffi, Andrew Blauvelt
Summary: The study demonstrated that Bimekizumab showed high levels of response in patients with moderate to severe plaque psoriasis, with durable effects over 56 weeks under both maintenance dosing schedules (every 4 weeks and every 8 weeks). Additionally, Bimekizumab was well tolerated with no unexpected safety issues, further supporting its therapeutic value for this patient population.
Article
Medicine, General & Internal
Lulu Bravo, Igor Smolenov, Htay Htay Han, Ping Li, Ramona Hosain, Frank Rockhold, Sue Ann Costa Clemens, Camilo Roa, Charissa Borja-Tabora, Antoinette Quinsaat, Pio Lopez, Eduardo Lopez-Medina, Leonardo Brochado, Eder A. Hernandez, Humberto Reynales, Tatiana Medina, Hector Velasquez, Leonardo Bautista Toloza, Edith Johana Rodriguez, Dora Ines Molina de Salazar, Camilo A. Rodriguez, Eduardo Sprinz, Jose Cerbino-Neto, Kleber Giovanni Luz, Alexandre Vargas Schwarzbold, Maria Sanali Paiva, Josefina Carlos, May Emmeline B. Montellano, Mari Rose A. de Los Reyes, Charles Y. Yu, Edison R. Alberto, Mario M. Panaligan, Milagros Saivani-Bautista, Erik Buntinx, Maya Hites, Jean-Benoit Martinot, Qasim E. Bhorat, Aysha Badat, Carmen Baccarini, Branda Hu, Jaco Jurgens, Jan Engelbrecht, Donna Ambrosino, Peter Richmond, George Siber, Joshua Liang, Ralf Clemens
Summary: The SCB-2019 vaccine, supplemented with CpG and alum, provides significant protection against COVID-19 caused by different SAR-CoV-2 viruses, including the dominant Delta variant.
Article
Medicine, General & Internal
James O'Hara, Deborah D. Stocken, Gillian C. Watson, Tony Fouweather, Julian McGlashan, Kenneth MacKenzie, Paul Carding, Yakubu Karagama, Ruth Wood, Janet A. Wilson
Summary: This study aimed to assess the use of proton pump inhibitors (PPIs) in treating persistent throat symptoms. The results showed no significant difference between the lansoprazole treatment group and the placebo group at 16 weeks and 12 months.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Serena Sabatini, Obioha C. Ukoumunne, Clive Ballard, Rachel Collins, Sarang Kim, Anne Corbett, Dag Aarsland, Adam Hampshire, Helen Brooker, Linda Clare
Summary: This study explored the factors associated with subjective age, finding that it may result from the interaction between factors that increase or decrease age-related thoughts and mental processes. The results show that individuals reporting an older subjective age are more likely to experience significant negative changes and engage in negative age-related thoughts. Women experience a more negative subjective age and more age-related events than men.
PSYCHOLOGY & HEALTH
(2023)
Article
Clinical Neurology
Naaheed Mukadam, Louise Marston, Gemma Lewis, Rohini Mathur, Greta Rait, Gill Livingston
Summary: This study investigated the incidence of diagnosed dementia and its association with age at diagnosis and survival afterward among the three largest ethnic groups in the UK. The findings showed that Black people had a higher incidence of dementia, while South Asian and Black people were diagnosed and died at a younger age compared to White individuals. Therefore, targeted prevention and care strategies should be prioritized and tailored to these ethnic groups.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Claudia K. Suemoto, Naaheed Mukadam, Sonia M. D. Brucki, Paulo Caramelli, Ricardo Nitrini, Jerson Laks, Gill Livingston, Cleusa P. Ferri
Summary: This study estimated the impact of risk factors on dementia in different populations in Brazil and found that education, hypertension, and hearing loss should be the priority targets.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Daniel J. Tozer, Robin B. Brown, Jessica Walsh, Young T. Hong, Guy B. Williams, John T. O'Brien, Franklin I. Aigbirhio, Tim D. Fryer, Hugh S. Markus
Summary: Recent studies have found evidence of increased microglial activation, indicating inflammation, in cerebral small vessel disease. However, it is unclear whether these areas of neuroinflammation progress to tissue damage. This study showed that white matter destined to become white matter hyperintensities already exhibited signs of altered inflammation at baseline.
Article
Geriatrics & Gerontology
E. V. Gerritzen, O. McDermott, M. Orrell
Summary: This study investigates the use of online peer support platforms by people with Young-Onset Dementia (YOD), the reasons for using or not using online peer support, and how to optimize its benefits and accessibility. A total of 69 completed surveys were analyzed, and it was found that Zoom is the most popular platform for online peer support, followed by Facebook and Twitter. While online peer support facilitates social support and accessibility, there are challenges related to following conversations and understanding others. Many individuals were unaware of online peer support and felt uncomfortable talking to strangers. To improve access and benefits, organizations and healthcare professionals should increase awareness and provide clear descriptions of online support groups.
AGING & MENTAL HEALTH
(2023)
Article
Psychology, Clinical
Tiffeny James, Naaheed Mukadam, Andrew Sommerlad, Samara Barrera-Caballero, Gill Livingston
Summary: The study aimed to investigate the care and support received and desired by South Asian and White British individuals affected by dementia in the UK, as well as the equity of access to such services. The findings revealed that South Asian individuals expressed a greater need for care from someone who spoke their language, while language differences could also be a challenge for White British individuals. Personal resources, including financial means and English language proficiency, influenced individuals' choices and access to care. Consequently, individuals from South Asian backgrounds may face a double disadvantage of limited options for suitable care and fewer resources to seek alternative care.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Multidisciplinary Sciences
Chris Fox, Simon P. P. Hammond, Tamara Backhouse, Fiona Poland, Justin Waring, Bridget Penhale, Jane L. L. Cross
Summary: This study explored whether a flexible, multicomponent intervention could be implemented in acute hospital settings to adapt to the needs of patients with cognitive impairment(s). The successful implementation of the intervention requires change agents to recognize and engage with local values, and then to enable its fit with practice and wider contextual goals.
Article
Psychiatry
Nicolas Farina, Roxanne Jacobs, Yuda Turana, Fasihah Irfani Fitri, Marguerite Schneider, Imelda Theresia, Sumaiyah Docrat, Tara Puspitarini Sani, Lydia Augustina, Emiliano Albanese, Adelina Comas-Herrera, Petra Du Toit, Cleusa P. Ferri, Ishtar Govia, Aliaa Ibnidris, Martin Knapp, Sube Banerjee
Summary: This study used the 10/66 short schedule and diagnostic algorithm to estimate the dementia prevalence in older adults in Indonesia and South Africa. The results showed high prevalence rates of dementia in both countries, but a very low rate of formal diagnosis. This highlights the need for improved diagnosis and prioritization of dementia in national health and social care policies.
Article
Nursing
K. Hambridge, S. Banerjee, L. Winfield, J. Gripton
Summary: This study investigates the demographic characteristics, attrition, and career intentions of applicants and enrolled students in nursing and midwifery programs in England. The study finds an increase in the percentage of male applicants for nursing, a higher average age of enrolled students, and an increase in the level of deprivation among applicants. Most applicants and enrolled students come from the same region as the nursing school and continue working there after graduation.
Article
Gerontology
Linda Birt, Georgina Charlesworth, Esme Moniz-Cook, Phuong Leung, Paul Higgs, Martin Orrell, Fiona Poland
Summary: This study examines how people living with dementia maintain social interactions in their local communities through observations in community spaces. The findings indicate that individuals with dementia construct narratives and use strategies to assert their presence in social settings, drawing on personal attributes and familiar rituals.
Article
Gerontology
Carmen Colclough, Eleanor Miles, Jennifer Rusted, Rotem Perach, Ben Hicks, Josie Dixon, Margaret Dangoor, Kate Gridley, Yvonne Birks, Paul Donaghy, Riona Mcardle, Elen Moseley, Harsharon K. Sondh, Sube Banerjee
Summary: The emotional wellbeing of family carers and people with dementia during the COVID-19 pandemic is influenced by their coping styles and how they cope together. Five styles of emotion-focused dyadic coping were identified, including common, supportive, hostile, disengaged avoidance, and protective. The variation in carers' experiences and quality of life was associated with these coping styles and co-residency status. Tailored dyadic interventions could help dyads identify and communicate coping needs, reconnect following avoidance coping, and replenish coping resources through social support.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Article
Health Care Sciences & Services
Bryony Waters, Martin Orrell, Orii McDermott
Summary: This study aims to investigate the appropriateness of the adapted UK manual for UK care homes and to explore the effects on residents' music engagement, staff's dementia competence, residents' quality of life, and staff burden. This study is significant in improving the interaction quality between care home staff and residents with dementia.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Medicine, General & Internal
Sarah Griffiths, Emily Spencer, Jane Wilcock, Claire Bamford, Alison Wheatley, Greta Brunskill, Federica D'Andrea, Kate R. Walters, Natalia Lago, Aidan O'Keeffe, Rachael Hunter, Remco Tuijt, Karen Harrison Dening, Sube Banerjee, Jill Manthorpe, Louise Allan, Louise Robinson, Greta Rait, PriDem Study Team
Summary: This study aims to assess the feasibility and implementation of a person-centred intervention for dementia care led by Clinical Dementia Leads working in primary care. Data from patients, carers, and healthcare professionals will be collected and analyzed quantitatively and qualitatively to evaluate the acceptability and feasibility of the intervention.
Article
Psychiatry
Maria A. Mendez, Roberto Canitano, Bethany Oakley, Antonia San Jose-Caceres, Michela Tinelli, Martin Knapp, James Cusack, Mara Parellada, Pierre Violland, Jan Derk R. Plas, Declan G. M. Murphy, Vinciane Quoidbach, Celso Arango
Summary: This study analyzed the care pathway for autistic children with co-occurring epilepsy in Italy, Spain, and the United Kingdom. The findings showed a lack of systematic screening and treatment of epilepsy, as well as inappropriate use of antiepileptic drugs. The major challenge is the lack of evidence-based guidelines for autism with co-occurring epilepsy in these countries. The study calls for policy harmonization in Europe to improve the experiences and quality of life of autistic individuals and their families.
EUROPEAN PSYCHIATRY
(2023)
Article
Cell Biology
Andrew Sommerlad, Mika Kivimaki, Eric B. Larson, Susanne Roehr, Kokoro Shirai, Archana Singh-Manoux, Gill Livingston
Summary: The increasing number of people with dementia globally highlights the urgent need to reduce its scale and impact. Lifetime social participation may play a crucial role in reducing dementia risk and could have implications for individual behavior and public health policy. However, more research is needed to fully understand the causal relationship.