Review
Medicine, General & Internal
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Francesca Falangone, Davide Montanari, Federica Capuani, Giada Mastel, Vincenzo Stanghellini, Giovanni Barbara
Summary: Bile acid malabsorption (BAM) is a common cause of chronic diarrhea, but its prevalence is not well studied. Bile acid diarrhea (BAD) occurs due to dysregulation of the enterohepatic recirculation of bile acids. The gold standard for diagnosing and assessing the severity of BAD is currently the selenium homotaurocholic acid test, but other serum markers are being validated for clinical use. The first-line treatment for BAD is bile acid sequestrants, but further diagnostics are needed for patients who do not respond to this treatment. Early and accurate diagnosis of BAD can improve patients' quality of life and reduce the burden on healthcare systems. More research is needed to explore alternative therapeutic approaches for BAD, such as gut microbiota modulating therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Virginia Flores, Helena Martinez-Lozano, Federico Bighelli, Javier Orcajo, Javier Garcia-Lledo, Juan Carlos Alonso-Farto, Luis Menchen
Summary: Bile acid malabsorption is common in patients with chronic diarrhoea of functional characteristics, and systematic investigation should be included in the diagnostic algorithms for patients with chronic watery diarrhoea. Clinical response to cholestyramine varies among patients with bile acid diarrhoea, and there are no clear predictors of response to treatment.
BMC GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Smout, James Scuffham, Paul Hinton
Summary: The study evaluated the feasibility of replacing baseline images with a predictive model based on height and weight, which showed a strong correlation with measured counts. When using predicted baseline counts, almost all patients had no change in severity grading, indicating the potential practical application of the model.
NUCLEAR MEDICINE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
John T. Schousboe, Brian L. Sprague, Linn Abraham, Ellen S. O'Meara, Tracy Onega, Shailesh Advani, Louise M. Henderson, Karen J. Wernli, Dongyu Zhang, Diana L. Miglioretti, Dejana Braithwaite, Karla Kerlikowske
Summary: The study found that extending screening mammography to age 80 may have benefits for some women, but the absolute reduction in death rates is small for women with comorbidities. Therefore, women over 75 should weigh the risks and benefits when considering screening mammography.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
John T. Schousboe, Brian L. Sprague, Linn Abraham, Ellen S. O'Meara, Tracy Onega, Shailesh Advani, Louise M. Henderson, Karen J. Wernli, Dongyu Zhang, Diana L. Miglioretti, Dejana Braithwaite, Karla Kerlikowske
Summary: Extending mammography screening to age 80 appears to be cost-effective in certain scenarios, but the absolute number of deaths averted is small, especially for women with comorbidities. Women considering screening beyond age 75 should carefully weigh the potential harms of overdiagnosis against the potential benefits of averting breast cancer death.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Martin Storr, Manfred Gross, Ahmed Madisch, Ulrike von Arnim, Hubert Moennikes, Julian Walters, Heiner Krammer, Jutta Keller
Summary: Bile acid diarrhea is a commonly overlooked cause of chronic diarrhea, affecting up to 5% of individuals even after exclusion of other causes. Diagnosis of bile acid diarrhea follows a clear algorithm, with treatment typically involving medications and vitamin supplementation.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2021)
Article
Gastroenterology & Hepatology
Stefania Costa, Serena Gattoni, Maria Luisa Nicolardi, Martina Costetti, Stiliano Maimaris, Annalisa Schiepatti, Federico Biagi
Summary: This study aimed to evaluate the prevalence of bile acid diarrhea in patients with chronic diarrhea at an Outpatient Gastroenterology Clinic. The results confirmed that bile acid diarrhea is a common but often overlooked cause of chronic functional diarrhea, with a therapeutic trial of cholestyramine being a valid diagnostic strategy.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Oncology
Caroline Gee, Catherine Fleuret, Ana Wilson, Daniel Levine, Ramy Elhusseiny, Ann Muls, David Cunningham, Darina Kohoutova
Summary: Bile acid malabsorption is a common condition in cancer patients, but treatments are highly effective.
Article
Toxicology
Jingxuan Wang, Bas Sijs, Wouter Bakker, Laura de Haan, Hans Bouwmeester
Summary: The trichothecene toxin deoxynivalenol (DON) contaminates cereal-based food and inhibits protein translation. DON activates stress mitogen-activated protein kinases (MAPK), leading to pro-inflammatory cytokine production. DON also decreases bile acid reabsorption and apical sodium-dependent bile acid transporter (ASBT) expression. The study suggests that DON-induced bile acid malabsorption is regulated by MAPK activation-induced pro-inflammatory cytokine production and protein synthesis inhibition.
TOXICOLOGY LETTERS
(2023)
Review
Nutrition & Dietetics
Yvonne A. McKenzie, Jana Sremanakova, Chris Todd, Sorrel Burden
Summary: Currently, there is insufficient evidence to support the effectiveness of diet, psychological, or exercise therapies for diarrhea, abdominal pain, and flatulence in adults with BAD. High-quality randomized controlled trials are needed.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tamar Willson, Richard Meades
Summary: This study evaluated the uncertainty in SeHCAT retention studies performed in 'outer room' mode and found it to be within clinically acceptable limits. Adopting a wide central photopeak and downscatter window can significantly improve sensitivity.
NUCLEAR MEDICINE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
S. Coughlan, A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: The study conducted metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. It found significantly lower alpha diversity of viral clusters in IBS, identified core viromes in both IBS and control groups, and noted no significant covariation between the virome and the bacteriome, IBS clinical subtype, or Bile Acid Malabsorption status.
Review
Gastroenterology & Hepatology
Rachel A. Khaw, Edward J. Nevins, Alexander W. Phillips
Summary: This study evaluated the occurrence and management of malabsorption syndromes after esophagectomy, finding that these syndromes are often unrecognized and underreported. Patients may experience gastrointestinal symptoms that have a negative impact on post-operative quality of life. While treatment modalities exist to alleviate symptoms, further understanding of these conditions, their diagnosis, and management is necessary.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Health Care Sciences & Services
Marie Westwood, Isaac Corro Ramos, Nigel Armstrong, Edyta Ryczek, Hannah Penton, Marscha Holleman, Caro Noake, Maiwenn Al
Summary: This study evaluated the clinical effectiveness and cost-effectiveness of SeHCAT in investigating adults with chronic unexplained diarrhea. The results showed that SeHCAT testing had high sensitivity and specificity, and the SeHCAT 15% strategy was most likely to be cost-effective in the suspected primary bile acid diarrhea and Crohn's disease populations. However, there is still high uncertainty due to insufficient and poor-quality evidence.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Review
Medicine, Research & Experimental
Zhen-Ning Lu, Hong-Wei He, Na Zhang
Summary: This review discusses the expression characteristics, important roles in bile acid homeostasis, and regulatory mechanisms of OSTα-OSTβ. Studies show that multiple nuclear receptors and cytokines can be involved in regulating OSTα-OSTβ. Therapeutic strategies targeting OSTα-OSTβ are essential for correcting abnormal bile acid levels and intervening in the progression of diseases related to bile acid homeostasis disruption.
Review
Economics
Frederick W. Thielen, Nasuh C. Bueyuekkaramikli, Rob Riemsma, Debra Fayter, Nigel Armstrong, Ching-Yun Wei, Vanesa Huertas Carrera, Kate Misso, Gill Worthy, Jos Kleijnen, Isaac Corro Ramos
Article
Economics
Martine Hoogendoorn, Isaac Corro Ramos, Michael Baldwin, Nuria Gonzalez-Rojas Guix, Maureen P. M. H. Rutten-van Molken
Article
Respiratory System
Martine Hoogendoorn, Isaac Corro Ramos, Michael Baldwin, Laura Luciani, Cecile Fabron, Bruno Detournay, Maureen P. M. H. Rutten-van Molken
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2019)
Article
Economics
Matthijs M. Versteegh, Isaac Corro Ramos, Nasuh C. Buyukkaramikli, Amir Ansaripour, Vivian T. Reckers-Droog, Werner B. F. Brouwer
Article
Clinical Neurology
Valerie Wester, Saskia de Groot, Tim Kanters, Louis Wagner, Jacqueline Ardesch, Corro Isaac Ramos, Marie-Jose Enders-Slegers, Martine de Ruiter, Saskia le Cessie, Jeanine Los, Grigorios Papageorgiou, Job van Exel, Matthijs Versteegh, J. M. H. Mourits, J. A. G. M. van den Hurk-van Schadewijk, U. de Wit, H. M. G. Marell, H. Verhoeven
FRONTIERS IN NEUROLOGY
(2020)
Correction
Economics
Renee Else Michels, Maria De Francesco, Koshu Mahajan, Gerald J. D. Hengstman, Krijn M. H. Schiffers, Sangeeta Budhia, Gerard Harty, Marieke Krol
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2020)
Article
Health Care Sciences & Services
Isaac Corro Ramos, Martine Hoogendoorn, Maureen P. M. H. Rutten-van Molken
MEDICAL DECISION MAKING
(2020)
Article
Oncology
Casimir A. E. Kouwenberg, Marc A. M. Mureau, Leonieke W. Kranenburg, Hinne Rakhorst, Danielle de Leeuw, Taco M. A. L. Klem, Linetta B. Koppert, Isaac Corro Ramos, Jan J. Busschbach
Summary: The study evaluated the cost-utility of four common surgical treatment pathways for breast cancer, with breast-conserving therapy being the most cost-effective option and providing better quality of life compared to mastectomy. Implant breast reconstruction was found to be more cost-effective than autologous breast reconstruction, but the latter had a higher occurrence of complications.
Article
Medicine, General & Internal
Martine Hoogendoorn, Isaac Corro Ramos, Stephane Soulard, Jennifer Cook, Erkki Soini, Emma Paulsson, Maureen Rutten-van Molken
Summary: The study evaluated the cost-utility of the fixed dose combination of the bronchodilators tiotropium and olodaterol versus two comparators in three European countries. The results showed that tiotropium/olodaterol is a cost-effective treatment option versus tiotropium or LABA/ICS in all three countries, with more effectiveness and cost savings in Finland and Sweden compared to LABA/ICS.
Article
Economics
Talitha Feenstra, Isaac Corro-Ramos, Dominique Hamerlijnck, George van Voorn, Salah Ghabri
Summary: Health care decision makers in many jurisdictions rely on cost-effectiveness analysis based on health economic decision models for policy decisions regarding coverage and pricing of medicines and medical devices. Validation of these models is crucial, and the current opinion paper discusses the need for increased use of complex models, international cooperation, open-source modeling, and stakeholder involvement. These aspects are essential for ensuring model accuracy, transparency, and relevance in health economic decision-making.
Review
Health Care Sciences & Services
Marie Westwood, Isaac Corro Ramos, Nigel Armstrong, Edyta Ryczek, Hannah Penton, Marscha Holleman, Caro Noake, Maiwenn Al
Summary: This study evaluated the clinical effectiveness and cost-effectiveness of SeHCAT in investigating adults with chronic unexplained diarrhea. The results showed that SeHCAT testing had high sensitivity and specificity, and the SeHCAT 15% strategy was most likely to be cost-effective in the suspected primary bile acid diarrhea and Crohn's disease populations. However, there is still high uncertainty due to insufficient and poor-quality evidence.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Review
Economics
Marieke Krol, Nikkie Hosseinnia, Werner Brouwer, Leona Hakkaart van Roijen
Summary: This paper presents a systematic literature review on compensation mechanisms and multiplier effects in economic evaluations of health interventions. The review suggests that these mechanisms have a significant impact on productivity losses and costs, but more research is needed to clarify their features, measurement methods, and valuations.
Article
Economics
Fernando Albuquerque de Almeida, Isaac Corro Ramos, Maureen Rutten-van Molken, Maiwenn Al
Summary: The study developed and validated a patient-level simulation model to simulate the impact of different treatment scenarios on heart failure patients. The results showed that managing patients with an early warning system and adding a diagnostic algorithm could reduce healthcare resource utilization, improve patient quality of life, and increase life expectancy.
Review
Health Care Sciences & Services
Nigel Armstrong, Nasuh Buyukkaramikli, Hannah Penton, Rob Riemsma, Pim Wetzelaer, Vanesa Huertas Carrera, Stephanie Swift, Thea Drachen, Heike Raatz, Steve Ryder, Dhwani Shah, Titas Buksnys, Gill Worthy, Steven Duffy, Maiwenn Al, Jos Kleijnen
HEALTH TECHNOLOGY ASSESSMENT
(2020)
Article
Economics
Simone A. Huygens, Isaac Corro Ramos, Carlijn V. C. Bouten, Jolanda Kluin, Shih Ting Chiu, Gary L. Grunkemeier, Johanna J. M. Takkenberg, Maureen P. M. H. Rutten-van Molken
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2020)