Article
Psychology, Multidisciplinary
Liwei Yang
Summary: This study explores the relationship between financial stressor events and emotional exhaustion, finding that financial stress has a direct impact on both organizations and employees, leading to emotional exhaustion and a decline in individual mental well-being. Additionally, financial stress and emotional exhaustion also directly affect individuals' physical health.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Yuji Kuroda
Summary: This study examines whether vulnerable and resilient interpersonal behaviors uniquely and differentially predict negative and positive peer events among young adolescents, filling an important gap in the literature. The study also explores potential sex differences in these relationships.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Rheumatology
Jennifer L. Beaumont, Elizabeth S. Davis, Jeffrey R. Curtis, David Cella, Huifeng Yun
Summary: The study estimated meaningful change thresholds for fatigue and pain interference in rheumatoid arthritis patients, finding the MCT range to be 1-2 points and showing low correlations between change scores and retrospective ratings.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Lotte van Ouwerkerk, Patrick Verschueren, Maarten Boers, Paul Emery, Pascal Hendrik Pieter de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: In patients with rheumatoid arthritis (RA), the use of glucocorticoids (GC) as bridging therapy resulted in a more rapid clinical improvement and fewer changes in medication, but similar long-term GC use compared with patients who did not receive bridging therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
Summary: This study identified nine novel autoantibodies in ACPA-negative RA, with anti-PTX3 and anti-DUSP11 showing the highest sensitivity. The combination of these two autoantibodies significantly increased the diagnostic sensitivity in ACPA-negative RA. The novel biomarkers provide potential diagnostic value for ACPA-negative RA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Ludovico De Stefano, Bernardo D'Onofrio, Antonio Manzo, Carlomaurizio Montecucco, Serena Bugatti
Summary: Research suggests that there are significant differences between autoantibody-positive and -negative rheumatoid arthritis, with the latter still holding many unknowns that require further investigation to improve clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maisa S. Ziadni, Dokyoung S. You, Eric M. Cramer, Steven R. Anderson, Gabrielle Hettie, Beth D. Darnall, Sean C. Mackey
Summary: Empirical data on the health impacts of the COVID-19 pandemic are lacking among patients with chronic pain. This study found that pain ratings remained unchanged, but pain catastrophizing scores increased when COVID-19 cases peaked. Pain interference, physical function, sleep impairment, and emotional support improved in the post-COVID-19 cohort. Depression, anxiety, anger, and social isolation remained unchanged.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Anna M. P. Boeren, Marloes Verstappen, Agnes E. M. Looijen, Pascal H. P. de Jong, Annette H. M. van der Helm-van Mil
Summary: The study found that RA patients with mono- or oligo-arthritis and high Patient Global Assessment (PGA) (VAS >= 50) at diagnosis are more likely to experience persistent fatigue. This understanding helps enable early intervention with non-pharmacological approaches in specific patient groups.
Article
Rheumatology
Onosi Sylvia Ifesemen, Daniel Frederick McWilliams, Sam Norton, Patrick D. W. Kiely, Adam Young, David Andrew Walsh
Summary: The study aims to describe the prevalence, risk factors, and longitudinal course of fatigue in early rheumatoid arthritis (RA) patients. The findings suggest that fatigue is common and persistent in early RA, and diverse characteristics indicative of central mechanisms are associated with persistent fatigue.
Article
Biochemical Research Methods
Xiangjie Luo, Hui Xiong, Yuhang Jiang, Yifan Fan, Cuicui Zuo, Dongxia Chen, Limin Chen, Hongyu Lin, Jinhao Gao
Summary: We propose a new strategy for alleviating inflammation by reprogramming macrophages through targeted reactive oxygen species scavenging and cyclooxygenase-2 downregulation. Our multifunctional compound MCI successfully attenuates COX-2 expression and reduces the level of ROS, leading to macrophage reprogramming and decreased inflammation. In vivo experiments demonstrate the promising therapeutic effects of MCI on rheumatoid arthritis. This study presents the successful targeted macrophage reprogramming for inflammation alleviation and provides insights for the development of new anti-inflammatory drugs.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Rheumatology
Anthony James Ocon, George Reed, Dimitrios A. Pappas, Jeffrey R. Curtis, Joel M. Kremer
Summary: The study found that initiating glucocorticoids in steroid-naive RA patients is associated with an increased risk of cardiovascular events, especially at daily doses of >= 5mg, cumulative doses exceeding 1100mg, and durations longer than 81 days. No increased risk was found at lower doses or shorter durations.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Joyce Aarts, Debbie M. Roeleveld, Monique M. Helsen, Birgitte Walgreen, Elly L. Vitters, Jay Kolls, Fons A. van de Loo, Peter L. van Lent, Peter M. van der Kraan, Marije Koenders
Summary: The study revealed that systemic overexpression of IL-22 has clear anti-inflammatory effects during collagen-induced arthritis, with reduced disease severity and incidence. Additionally, the protective effect of systemic IL-22 is likely mediated through upregulation of the negative immune regulator SOCS3.
Review
Medicine, General & Internal
Ketian Li, Min Wang, Lidan Zhao, Yudong Liu, Xuan Zhang
Summary: This review summarizes the current knowledge about the primary drivers of ACPA(-) RA, focusing on the serological, cellular, and molecular aspects of immune mechanisms. A better understanding of the etiology of ACPA(-) RA will aid in personalized treatment design and improve early treatment and outcomes.
Article
Biochemistry & Molecular Biology
Agnieszka Paradowska-Gorycka, Anna Wajda, Ewa Rzeszotarska, Tomasz Kmiolek, Barbara Stypinska, Ewa Dudek, Katarzyna Romanowska-Prochnicka, Piotr Syrowka
Summary: Circulating free-cell miRNAs have become increasingly important as potential non-invasive biomarkers, particularly in the field of oncology. This research aimed to investigate the association between selected miRNAs in serum and the expression of Th17/Treg transcription factors, as well as clinical features, in rheumatoid arthritis (RA) patients. The study found that miR-10 was only detected in RA patients and its expression was correlated with IL-35 serum concentration and STAT5a mRNA level. Additionally, miR-326 was significantly upregulated in RA patients with rheumatoid factor presence. The differential association of transcription factor expression with serum miRNA levels may have implications for the diagnosis and progression of RA and osteoarthritis (OA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Shujing Chen, Yuan Wang, Lei Zhang, Yuli Han, Chunxiao Liang, Shuangqi Wang, Lina Qi, Xiaoli Pang, Jin Li, Yanxu Chang
Summary: In this study, the therapeutic effects of Angelicae pubescentis radix (APR) on rheumatoid arthritis (RA) were evaluated using a comprehensive strategy. The results showed that APR effectively improved symptoms of RA in CIA mice, regulated inflammation and oxidative stress, and normalized gut microbiota and metabolites. The potential mechanisms involve the JAK1/STAT3, NF-κB, and Keap1/Nrf2 pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Shirin O. Hiatt, S. Albert Camacho, James O. Mudd, Jonathan Q. Purnell, Mary Davis, Kerri Winters-Stone, Christopher S. Lee
JOURNAL OF CARDIAC FAILURE
(2019)
Article
Nursing
Hiroko Kiyoshi-Teo, Kathlynn Northrup-Snyder, Mary Robert Davis, Ellen Garcia, Amy Leatherwood, Shigeko (Seiko) Izumi
JOURNAL OF CLINICAL NURSING
(2020)
Review
Cardiac & Cardiovascular Systems
Mary Roberts Davis, Christopher S. Lee, Amy Corcoran, Nandita Gupta, Izabella Uchmanowicz, Quin E. Denfeld
Summary: This study found that in heart failure, women are more likely to be frail compared to men, with frailty affecting women significantly more than men. Future research should focus on elucidating potential causes of gender differences in frailty in heart failure.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Beth A. Habecker, S. Albert Camacho, Mary Roberts Davis, Nandita Gupta, Shirin O. Hiatt, Mary E. Medysky, Jonathan Q. Purnell, Kerri Winters-Stone, Christopher S. Lee
Summary: In heart failure (HF), women are significantly more likely to be physically frail compared with men, with both genders exhibiting more comorbidities and worse symptoms; in men, physical frailty is characterized by worse physiological characteristics.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Kenneth M. Faulkner, Mary Roberts Davis, Beth A. Habecker, Christopher Chien, Jill M. Gelow, James O. Mudd, Shirin O. Hiatt, Kathleen L. Grady, Christopher S. Lee
Summary: The study found that there were differences in clinical markers between women and men after left ventricular assist device implantation, but their symptoms trajectories were similar.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Albert S. Camacho, Nathan Dieckmann, Shirin O. Hiatt, Mary Roberts Davis, Daniela V. Cramer, Allissah Rupert, Beth A. Habecker, Christopher S. Lee
Summary: This study aims to examine the changes and associations of symptom clusters, biomarkers, and physical frailty during the transition period of heart failure, providing personalized treatment options to improve symptom burden.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Nursing
MinKyoung Song, Hannah C. Bessette, Laura L. Hayman, Karen S. Lyons, Kerri M. Winters-Stone, Mary C. Roberts Davis, Carol M. Musil
Summary: This article describes the methodological challenges encountered and strategies developed when conducting virtual research with grandparent-grandchild dyads. The primary focus is on finger-stick blood sample collection procedures, while secondary focus is on virtual-based research with older adults and across multiple generations. The research team provides recommendations for strategies to overcome these challenges.
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Jonathan Q. Purnell, Christopher S. Lee, Eric S. Orwoll, S. Albert Camacho, Shirin O. Hiatt, Mary Roberts Davis, Kerri Winters-Stone, William R. Woodward, Beth A. Habecker
Summary: This study aimed to identify candidate biomarkers associated with physical frailty in heart failure (HF) using a multimarker strategy. The results showed that adiponectin, IGF-1, and myostatin were significantly associated with physical frailty in HF.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Sarah Goodlin, Rand Abedalweli, Mary Roberts Davis, Shirin O. Hiatt, Christopher S. Lee, Kerri Winters-Stone
Summary: The objective of this study was to quantify the frequency and predictors of falls over 1 year among adults with heart failure (HF). The results showed that nearly 40% of HF patients experienced a fall within 1 year. Screening for comorbidities, slowness, and exhaustion may help identify those at risk for a fall.
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mary Roberts Davis, Shirin O. Hiatt, Nathan Dieckmann, Lissi Hansen, Nandita C. Gupta, Christopher S. Lee, Quin E. Denfeld
Meeting Abstract
Geriatrics & Gerontology
MinKyoung Song, Laura Hayman, Karen Lyons, Hannah Bessette, Mary Roberts Davis, Kerri Winters-Stone, Carol Musil
INNOVATION IN AGING
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Jonathan Q. Purnell, Christopher S. Lee, Samuel A. Camacho, Mary Roberts Davis, Shirin O. Hiatt, Kerri Winters-Stone, William R. Woodward, Beth A. Habecker
Meeting Abstract
Cardiac & Cardiovascular Systems
Mary C. Davis, Christopher S. Lee, Amy Corcoran, Nandita Gupta, Izabella Uchmanowicz, Quin E. Denfeld
Meeting Abstract
Public, Environmental & Occupational Health
Mary Roberts Davis, Quin E. Denfeld
JOURNAL OF WOMENS HEALTH
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mary Christine Roberts Davis, Shirin O. Hiatt, Nandita Gupta, Albert Camacho, Kerri Winters-Stone, Christopher S. Lee, Quin E. Denfeld
JOURNAL OF CARDIAC FAILURE
(2020)