Article
Agriculture, Dairy & Animal Science
Linda F. Boeswald, Dana Matzek, Helen Mohr, Ellen Kienzle, Bastian Popper
Summary: Body conditions can serve as indicators of nutritional status and health in animals, highlighting the importance of monitoring these conditions. Obtaining morphometric data through measurements and standardized photographs can be useful for evaluating the body condition and well-being of animals.
Article
Oncology
Birgitte V. Offersen, Jan Alsner, Hanne M. Nielsen, Erik H. Jakobsen, Mette H. Nielsen, Lars Stenbygaard, Anders N. Pedersen, Mette S. Thomsen, Esben Yates, Martin Berg, Ebbe L. Lorenzen, Ingelise Jensen, Mirjana Josipovic, Maj-Britt Jensen, Jens Overgaard
Summary: External-beam PBI is noninferior to WBI in terms of breast induration for patients with low-risk breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Chirag Shah, Xuefei Jia, Brian P. Hobbs, Rahul D. Tendulkar, Sarah M. C. Sittenfeld, Zahraa Al-Hilli, Douglas W. Arthur, Martin E. Keisch, Atif J. Khan, Simona F. Shaitelman, John Boyages, David Wazer, Neilendu Kundu, Frank A. Vicini
Summary: The study found that at 5 years, there was no significant difference in ipsilateral breast tumor recurrence rate between partial breast irradiation (PBI) and whole breast irradiation (WBI), with PBI having lower acute toxicities. Different PBI techniques, such as external beam radiation and brachytherapy, showed varying rates of IBTR.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biology
Lue Sun, Yohei Inaba, Yu Sogo, Kumi Morikawa, Naoki Kunugita, Koichi Chida, Takashi Moritake
Summary: The study examined changes in whole-blood antioxidant capacity in mice after localized or chronic radiation exposure. Localized leg irradiation had limited effects on WBAC, while WBAC decreased in a dose rate-dependent manner after total body irradiation. Results suggest that WBAC changes may indicate radiation-induced biological damage at the systemic level.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Biology
Francis A. Cucinotta, Olga A. Smirnova
Summary: A mathematical model is developed to describe the level of surviving lymphocytes in the blood after partial-body irradiation at ultra-high and lower dose rates. The model uses simple analytic formulas and involves physiological, biophysical, and physical parameters. The model predicts that the level of surviving blood lymphocytes increases with dose rate and approaches a limiting level. The study also proposes a hypothesis explaining the mechanisms of the abscopal effect of FLASH radiation therapy.
RADIATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dylan Le, Ziad Sabry, Aarav Chandra, William B. Kristan, Eva-Maria S. Collins, William B. Kristan
Summary: The behavior responses of freshwater planarians to mechanical and near-UV stimulation were found to produce distinct actions, depending on the specific stimulation location. Cutting planarians into multiple pieces revealed that each severed piece exhibited behavior similar to an intact animal, indicating a fast functional reorganization of the planarian nervous system. This reorganization allows planarians to adapt their responses to signals from remaining tissue, providing necessary behavioral capabilities for survival during regeneration.
Article
Biology
Claude J. Rogers, Espoir M. Kyubwa, Agnes Lukaszewicz, Jason Yamada-Hanff, Mark A. Starbird, Thomas A. Miller, Asa A. Phelps, Seth Wallack, Saikanth Mahendra, Karla Thrall, Naresh Menon
Summary: Thoracic exposure to ionizing radiation can result in delayed injuries to the heart and lungs, which are difficult to predict. This study found that changes in the circulating miRNA profile within the first 30 days post-irradiation could predict survival outcomes. The research suggests that plasma miRNA profiles may be used as biomarkers to identify individuals at high risk of organ-specific late radiation injury.
RADIATION RESEARCH
(2021)
Review
Oncology
Chirag Shah, Erica Fleming-Hall, Wafa Asha
Summary: Adjuvant whole breast irradiation (WBI) is commonly delivered after breast conserving surgery (BCS) to reduce local recurrence. Data supports moderately hypofractionated WBI (15-16 fractions) as standard of care for most patients, while ultra-hypofractionated WBI (5 fractions) shows promising outcomes.
CLINICAL BREAST CANCER
(2023)
Article
Multidisciplinary Sciences
Yibo Xie, Beibei Guo, Rui Zhang
Summary: This study analyzed the cost-effectiveness of six advanced WBRT techniques compared to standard of care, using a Markov model to simulate health states of women with early-stage breast cancer. Results showed that FIF may be the most cost-effective option at a WTP threshold of 50,000 $/QALY, while hybrid IMRT and MA-VMAT may be the most cost-effective options at a WTP threshold of 100,000 $/QALY.
Article
Medicine, General & Internal
Annaig Bertho, Morgane Dos Santos, Sarah Braga-Cohen, Valerie Buard, Vincent Paget, Olivier Guipaud, Georges Tarlet, Fabien Milliat, Agnes Francois
Summary: By utilizing three-fraction schedules delivered over a period of 1 week with doses per fraction of 20, 28, 40, and 50 Gy, only 3 x 40 Gy or 3 x 50 Gy generated focal lung fibrosis after 6 months. The study suggests that a fractionation schedule using an arc-therapy-delivered three fractions/1 week regimen with 3 x 3 mm beam requires 40 Gy per fraction for lung fibrosis to develop within 6 months.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Tien T. Tang, Janice A. Zawaski, Shelli Kesler, Christine A. Beamish, Taeko Inoue, Emma C. Perez, Lawrence Bronk, Falk Poenisch, Tina M. Briere, Omaima M. Sabek, David R. Grosshans, M. Waleed Gaber
Summary: This study compares the potential benefits of proton cranial radiation therapy (P-CRT) with photon cranial radiation therapy (X-CRT) in the treatment of pediatric brain tumors. The researchers identified cognitive, functional imaging, and molecular differences between the two radiation modalities. Both P-CRT and X-CRT led to neurocognitive changes compared to sham, with differences observed in glucose metabolism and brain connectome. Further investigation is warranted to understand the differential effects.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Xiaoxu Ding, Xiangguo Cui, Xiao Cui, Sai Wang
Summary: This meta-analysis compared the efficacy and toxicities of upper-neck irradiation (UNI) and whole-neck irradiation (WNI) in patients with node-negative nasopharyngeal carcinoma. The results showed that UNI had similar efficacy and lower toxicities compared to WNI.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Kasra Kolahdouzan, Mohammadreza Chavoshi, Reyhaneh Bayani, Nima Mousavi Darzikolaee
Summary: For COVID-19 patients, whole lung irradiation (WLI) has shown a mild improvement in reducing intubation days but has no significant effect on overall survival. Routine use of WLI for moderate-to-severe COVID-19 patients cannot be recommended based on the current evidence.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Jennifer Vogel, Susanta Hui, Chia-Ho Hua, Kathryn Dusenbery, Premavarthy Rassiah, John Kalapurakal, Louis Constine, Natia Esiashvili
Summary: Total body irradiation is an effective conditioning regimen for high risk or relapsed/refractory leukemia patients undergoing allogeneic stem cell transplantation. Pulmonary toxicity, particularly idiopathic pneumonia syndrome (IPS), remains a common adverse effect, with factors such as TBI regimen, dose rate, and pulmonary shielding influencing the risk. Further study is recommended to better understand and define IPS, as well as explore differences in risk factors between pediatric and adult patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Bartlomiej Ptaszek, Aneta Teleglow, Justyna Adamiak, Jacek Glodzik, Szymon Podsiadlo, Dawid Mucha, Jakub Marchewka, Tomasz Halski, Dariusz Mucha
Summary: This study examined the impact of 20 whole-body cryotherapy treatments on the blood indices of people with multiple sclerosis. While the treatments did not significantly affect blood counts, rheology, and biochemistry in MS patients, they did have a positive effect on the blood rheological properties of healthy women.
JOURNAL OF CLINICAL MEDICINE
(2021)