Article
Oncology
Heng Li
Summary: By analyzing 1188 sets of in-vitro cell irradiation experiments, it was found that the biological effectiveness of ion beams is dependent on their fluence and linear energy transfer (LET). Consequently, a relationship between the relative biological effectiveness of ion beams to photon beams and LET was established. This relationship has important implications for proton and ion beam radiotherapy applications.
Article
Multidisciplinary Sciences
Rachel Delorme, Thongchai A. M. Masilela, Camille Etoh, Francois Smekens, Yolanda Prezado
Summary: This study compared the macroscopic and microscopic dosimetric properties of Very high energy electrons (VHEEs) with other types of beams, providing biologically relevant numerical information. From a macrodosimetric point of view, VHEEs showed potential improved biological efficacy over other beams, while the microdosimetric data did not show significantly increased biological efficacy.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jan Eulitz, Esther G. C. Troost, Lauritz Kluender, Felix Raschke, Christian Hahn, Erik Schulz, Annekatrin Seidlitz, Justus Thiem, Caroline Karpowitz, Patricia Hahlbohm, Arne Grey, Kay Engellandt, Steffen Loeck, Mechthild Krause, Armin Luehr
Summary: The purpose of this study was to investigate the variations in intra-cerebral radiosensitivity and relative biological effectiveness (RBE) in proton therapy of primary brain tumors. The results showed that 64 radiation-induced brain injuries (RIBI) appeared in 21 glioma patients who received proton radiotherapy. The study also found that dose, proton dose-averaged linear energy transfer (LET), and the periventricular region (PVR) were important predictors for RIBI.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juan Pardo-Montero, Miguel Pombar, Antonio Gomez-Caamano, Simona Giordanengo, Isabel Gonzalez-Crespo
Summary: This study presents a methodology for analyzing the variation of RBE with fractionation in proton therapy and applies it to study the response of prostate cancer. The results show a monotonically decreasing RBE with increasing dose per fraction, but the calculations should be carefully considered due to limitations in modeling assumptions and clinical data.
Article
Oncology
Stephen Joseph McMahon, Kevin M. Prise
Summary: Variations in intrinsic radiosensitivity of different cells to ionizing radiation play a significant role in response to radiotherapy. The Medras model provides a mechanistic framework to model different radiation responses and predict individual responses, by simulating repair of radiation-induced DNA damage and predicting a range of biological endpoints. Validation of the model against various exposure types, including different radiation qualities and dose-rates, supports its potential in informing mechanistic predictions of radiation sensitivity and supporting developments in treatment personalization.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Harald Paganetti
Summary: Proton therapy is increasingly used for radiation therapy, but there is uncertainty about its biological effectiveness compared to photon therapy. Despite a constant RBE value of 1.1 currently used in clinical radiation oncology, variations in RBE have been assessed and challenged, especially when considering normal tissue constraints. Evaluating the potential variations in RBE can provide guidance for treatment planning, personalized dose prescriptions, and outcome analysis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Business, Finance
Chi Zhang, Qiang Liu, Guoqing Ge, Ying Hao, Han Hao
Summary: This study examines the impact of government intervention on corporate environmental performance, focusing on the National Civilized City Award campaign. The results show that firms located in civilized cities have higher environmental performance during the event period, especially for state-owned enterprises, heavily polluted firms, and regions with officials having stronger promotion incentives. The study also finds that local officials who achieve the NCCA title are more likely to be promoted, and that the NCCA campaign may initially harm firms' financial performance but have long-term positive effects.
FINANCE RESEARCH LETTERS
(2021)
Article
Oncology
Liheng Tian, Christian Hahn, Armin Luehr
Summary: A linear RBE model using Q instead of LET was proposed and tested in this study, showing good predictive power for proton RBE when trained based on RBE data of other particles. Incorporating knowledge from carbon ion therapy can reduce biological uncertainty in proton therapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Biology
Laura C. Paterson, Andre Yonkeu, Fawaz Ali, Nicholas D. Priest, Douglas R. Boreham, Colin B. Seymour, Farrah Norton, Richard B. Richardson
Summary: The study investigated the characteristics of chromosome aberrations in lymphocytes exposed to low doses of Cf-252 spectrum neutrons, showing that even at low doses, chromosome aberration clustering can be observed. RBEM values for neutron-plus-photon and neutron-only dose components were found to be 15.0 +/- 2.2 and 25.7 +/- 3.8, respectively.
RADIATION RESEARCH
(2021)
Article
Polymer Science
M. Sayyed, Hanan Al-Ghamdi, Aljawhara H. Almuqrin, Sabina Yasmin, Mohamed Elsafi
Summary: In this study, the researchers investigated the potential of novel polymer composites for radiation protection applications. By incorporating different concentrations of micro- and nano-sized MgO into silicon rubber, the researchers found that the polymer composites with nano-MgO exhibited higher linear attenuation factors and lower mean free paths compared to those with micro-MgO. These findings highlight the importance of using high MgO content in silicon rubber for low-energy radiation protection applications.
Review
Oncology
Tracy S. A. Underwood, Aimee L. McNamara, Ane Appelt, Joanne S. Haviland, Brita Singers Sorensen, Esther G. C. Troost
Summary: This study provides a systematic review of clinical studies exploring the links between proton therapy and patient toxicities and image changes. The research suggests that current clinical evidence for variable proton RBE is statistically weak and recommends standardizing follow-up protocols and statistical analysis methods for larger studies.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Brita S. Sorensen, Joerg Pawelke, Julia Bauer, Neil G. Burnet, Alexandru Dasu, Morten Hoyer, Christian P. Karger, Mechthild Krause, Marco Schwarz, Tracy S. A. Underwood, Dirk Wagenaar, Gillian A. Whitfield, Armin Luehr
Summary: Proton therapy uses RBE to convert absorbed doses, however, RBE is not constant and can increase at the edge of the proton beam. Concerns about the clinical impact and emerging studies have prompted discussions on managing RBE uncertainties in patient care to develop safer and more effective treatment strategies.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Valdes-Cortez, Yury Niatsetski, Jose Perez-Calatayud, Facundo Ballester, Javier Vijande
Summary: This study aims to simulate clustered DNA damage caused by ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT) and electronic (eBT) surface brachytherapy. Realistic models of the sources and applicators were used in a hybrid Monte Carlo approach. The results show that the RBE values for rBT are almost constant, while for eBT, they depend on the system and patient geometry.
Article
Cardiac & Cardiovascular Systems
Victoria L. L. Cammann, Victor Schweiger, Maciej Cieslik, Burkhardt Seifert, Thomas Gilhofer, Iva Koleva, Michael Wuerdinger, Alessandro Candreva, Marko Gajic, Jonathan Michel, Philipp Jakob, Julia Stehli, Barbara Staehli, Christian Templin, Alexander Gotschy
Summary: This study compared the radiation protection effectiveness of suspended radiation protection systems (SRPS) and protective scatter radiation absorbing drapes (PAD) with conventional protection. The results showed that SRPS and PAD reduced the operator's radiation exposure by 93.9% and 66.4% respectively, compared to conventional shielding. The protective effect of SRPS was significantly higher than that of PAD. For the assistant, SRPS and PAD reduced the radiation exposure by 38.0% and 30.6% respectively, compared to conventional shielding, although the reduction was not statistically significant.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shane J. Foley, Ritva Bly, Adrian P. Brady, Steve Ebdon-Jackson, Alexandra Karoussou-Schreiner, Monika Hierath, Jacob Sosna, Boris Brkljacic
Summary: Published literature on CT justification in Europe is limited, with sub-optimal application. This study aimed to investigate CT justification practices in Europe and found variations across countries, with a minority having clinical decision support systems. The use of CT for health screening is not widespread in Europe.
INSIGHTS INTO IMAGING
(2022)