Article
Cardiac & Cardiovascular Systems
Arman Kilic, Jennie H. Kwon, Kathleen L. Grady, Brandon A. Singletary, Ahmet Kilic, Melanie Everitt, Joseph Cleveland, Ryan S. Cantor, Shanda Blackmon, Khadijah Breathett, Stephen McKellar, Mary Keebler, James K. Kirklin, Josef Stehlik
Summary: This study aimed to quantify the impact of pre- and postoperative variables on health-related quality of life (HRQOL) after left ventricular assist device (LVAD) implantation. The results showed that postimplant adverse events (AEs) had a significant negative impact on HRQOL, which could assist shared decision-making regarding LVAD eligibility.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Oncology
Thomas U. Schulz, Sarah Zierold, Michael M. Sachse, Giulia Pesch, Dirk Tomsitz, Katharina Schilbach, Katharina C. Kaehler, Lars E. French, Lucie Heinzerling
Summary: Immune checkpoint inhibitors (ICIs) may induce persistent immune-related adverse events (irAEs) that significantly impact patients' lives. This study revealed that persistent irAEs lead to reduced health-related quality of life (HRQoL), increased burden of autoimmune symptoms, and respective therapies. These findings highlight the importance of careful evaluation of risk-benefit ratios in using ICIs for early-stage tumors and informing patients about potential long-term sequelae.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Neurosciences
Gurpreet Rekhi, Young Ern Saw, Keane Lim, Richard S. E. Keefe, Jimmy Lee
Summary: The aim of this study was to examine the association between cognitive impairments and health-related quality of life (HRQoL) in individuals with schizophrenia. The study found that cognitive factor g was significantly associated with EQ-5D-5L scores. Age, sex, and employment status were also significant predictors of EQ-5D-5L. These results are important for understanding the burden of cognitive impairments in individuals with schizophrenia.
Article
Gastroenterology & Hepatology
William W. L. Wong, Josephine Wong, Karen E. Bremner, Yasmin Saeed, Kate Mason, Arcturus Phoon, Valerie Martel-Laferriere, Julie Bruneau, Jordan J. Feld, Zeny Feng, Elizabeth Baguley, Samuel S. Lee, Jeff Powis, Murray D. Krahn
Summary: This study evaluated the impact of direct-acting antiviral agents (DAAs) on utilities for patients with chronic hepatitis C (CHC) in different clinical settings. The results showed that utilities improved after treatment, but community-based patients may face challenges related to comorbid health and social conditions that are not adequately addressed.
LIVER INTERNATIONAL
(2023)
Article
Immunology
Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu, Xin Lu
Summary: This study conducted a bibliometric analysis of immune-related adverse events (irAEs) research to map the basic knowledge structure including countries, institutions, authors, journals, and publications. The results showed that the United States, Japan, and China had the highest number of publications in this field, and immune checkpoint inhibitors, immunotherapy, and nivolumab were the most frequently used keywords.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Yanhui Li, Gurpreet Rekhi, Mei San Ang, Jimmy Lee
Summary: This study examines the association between Negative Symptoms (NS) dimensions and Health-related Quality of Life (HRQoL) in schizophrenia. The results show that lower severity of NS, specifically in the Motivation and Pleasure (MAP) dimension, and the asociality domain, is associated with higher HRQoL. Therefore, targeting NS, particularly MAP and asociality, is important for improving HRQoL in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Ratna Shree Sharma, Johannes Pallua, Michael Schirmer
Summary: This meta-analysis examines the occurrence of adverse events in the placebo arms of double-blind, randomized, placebo-controlled studies in rheumatoid arthritis. The results show that patients in the placebo arms reported adverse events such as nausea and hepatobiliary disorders at similar rates to those in the verum arms. It is important for patients to be aware that adverse events can still occur even with placebo medication.
Article
Medicine, General & Internal
Jose L. Valencia-Martin, Jorge Vicente-Guijarro, Diego San Jose-Saras, Paloma Moreno-Nunez, Alberto Pardo-Hernandez, Jesus Maria Aranaz-Andres
Summary: Adverse Events (AE) are a major issue in healthcare, and policies have been implemented globally to mitigate their impact. This study found that surgical patients, patients in intensive care units, and patients in hospitals of medium complexity are more prone to experiencing adverse events. Adverse events lead to longer hospital stays and can contribute to patient mortality, highlighting the need for a renewed focus on patient safety.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Editorial Material
Oncology
Douglas B. Johnson, Justin M. Balko
Summary: Immune-related adverse events (irAEs) are a common complication of immune checkpoint inhibitors (ICIs) and occur unpredictably. In a study published in Med, Nunez et al. analyzed peripheral blood markers in patients treated with ICIs and found that dynamic changes in proliferating T cells and upregulation of cytokines are associated with irAEs.
Article
Multidisciplinary Sciences
Satoshi Nishioka, Masaki Asano, Shuntaro Yada, Eiji Aramaki, Hiroshi Yajima, Yuki Yanagisawa, Kyoko Sayama, Hayato Kizaki, Satoko Hori
Summary: This study aimed to build deep-learning models for extracting signals of adverse events (AE) limiting activities of daily living (ADL) from patients' narratives. The T5 model showed the best performance in identifying articles describing AE limiting ADL or all AE.
SCIENTIFIC REPORTS
(2023)
Review
Nursing
Mohamed Faizal Asan, Renita Lorina Castelino, Subhas G. Babu, Kumuda Rao, Vaibhav Pandita
Summary: Recent introduction of immune checkpoint inhibitors has shown significant improvement in cancer treatment outcomes by targeting key immune checkpoints. However, these inhibitors can also lead to immune-related adverse events, including oral reactions, which require early recognition and intervention for improved patient quality of life. Further research is needed on oral irAEs as literature focusing on them is limited.
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
(2021)
Article
Education & Educational Research
Emma Davies, John Read, Mark Shevlin
Summary: The study investigated the relationship between adverse childhood experiences and anxiety in first-year university students in a diverse district in England with a high poverty rate. It found that life stressors and childhood adversities were significantly associated with higher levels of anxiety, and only childhood adversities predicted lower levels of quality of life. Additionally, the high rates of ACEs and anxiety may be partly influenced by poverty and racism in the student population at the University of East London.
Article
Family Studies
Nancy R. Downing, Marvellous Akinlotan, Carly W. Thornhill
Summary: Research shows that self-reported child sexual abuse (CSA) is associated with lower health-related quality of life (HRQoL), and the nature of the abuse affects HRQoL outcomes. Understanding the long-term impacts of CSA is crucial for informing treatment options and policies for preventing and addressing CSA in adults.
CHILD ABUSE & NEGLECT
(2021)
Article
Chemistry, Medicinal
Lina Keutzer, Laurynas Mockeliunas, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Onno W. Akkerman, Ulrika S. H. Simonsson
Summary: This study analyzed therapeutic drug monitoring data of linezolid in drug-resistant tuberculosis patients and found that long-term usage of linezolid can lead to adverse events such as peripheral neuropathy, anemia, and thrombocytopenia. The study identified exposure-response relationships between linezolid exposure and these adverse events. New safety targets for individualized linezolid dosing were proposed based on the study findings.
Review
Economics
Alison Scope, Arjun Bhadhuri, Becky Pennington
Summary: This systematic review examines the inclusion of family member health-related quality-adjusted life-years (QALYs) in cost-utility analyses (CUAs). The study finds that few economic evaluations have included family member QALYs and the methods for doing so are often inconsistent and data sources often limited. The estimation of family member QALYs in patient CUAs is frequently uncertain and substantial in magnitude. The findings highlight the need for greater consistency in methods for incorporating family member QALYs in patient CUAs.
Article
Endocrinology & Metabolism
Patrick Bidulka, Rohini Mathur, David G. Lugo-Palacios, Stephen O'Neill, Anirban Basu, Richard J. Silverwood, Paul Charlton, Andrew Briggs, Liam Smeeth, Amanda Adler, Ian J. Douglas, Kamlesh Khunti, Richard Grieve
Summary: This study assessed the disparities in the prescription of second-line antidiabetic treatments among people with type 2 diabetes in England based on ethnicity and social deprivation. The findings showed no significant differences in the percentage of different types of antidiabetic medications prescribed as second-line treatment based on ethnicity or deprivation level.
DIABETES OBESITY & METABOLISM
(2023)
Article
Health Care Sciences & Services
M. A. Chaudhary, M. Edmondson-Jones, G. Baio, E. Mackay, J. R. Penrod, D. J. Sharpe, G. Yates, S. Rafiq, K. Johannesen, M. K. Siddiqui, J. Vanderpuye-Orgle, A. Briggs
Summary: This study evaluated the effectiveness of flexible parametric models in predicting the survival benefits of immunooncology treatment for patients with non-small cell lung cancer. The results showed that flexible parametric models were more accurate than standard parametric models in estimating long-term observation results using early follow-up data.
MEDICAL DECISION MAKING
(2023)
Article
Economics
Nathan Green, Felicity Lamrock, Nichola Naylor, Jack Williams, Andrew Briggs
Summary: A health economic evaluation (HEE) is a comparative analysis of alternative courses of action considering both costs and consequences. Cost-effectiveness analysis, a type of HEE, is commonly performed using MS Excel. However, there is a growing interest in using other software, such as R, for more complex problems, methods, and data, as well as improved reproducibility and transparency. This tutorial provides a step-by-step guide on implementing a Markov model, a mainstay model of HEE, in R, aimed at bridging the gap between MS Excel and R for health economic modellers.
Article
Economics
Nichola R. Naylor, Jack Williams, Nathan Green, Felicity Lamrock, Andrew Briggs
Summary: This paper demonstrates how advanced health economic analysis techniques performed in Microsoft Excel can be transferred to R. It provides a step-by-step guide using a Markov model in R and compares the results with established analyses in Microsoft Excel, using a previously published case study of a hip replacement surgery cost-effectiveness model. The paper aims to facilitate the switch from Microsoft Excel to R for complex health economic analyses and provides open-access code and data for future adaptation.
Article
Economics
Francois-Xavier Chalet, Teodora Bujaroska, Evi Germeni, Nizar Ghandri, Emilio T. Maddalena, Kushal Modi, Abisola Olopoenia, Jeffrey Thompson, Matteo Togninalli, Andrew H. Briggs
Summary: This study aimed to map the Insomnia Severity Index (ISI) to the EQ-5D-3L utility values from a UK perspective. Various regression models were used to explore the relationship between ISI scores and EQ-5D utility. The study provides an updated mapping algorithm for estimating EQ-5D-3L utilities from the ISI summary total score.
PHARMACOECONOMICS-OPEN
(2023)
Article
Medicine, Research & Experimental
Bartholomeus J. A. Willigers, Mario Ouwens, Andrew Briggs, Hiddo J. L. Heerspink, Carol Pollock, Roberto Pecoits-Filho, Navdeep Tangri, Csaba P. P. Kovesdy, David C. C. Wheeler, Juan Jose Garcia Sanchez
Summary: To minimize uncertainty in projecting long-term outcomes in clinical trials, researchers developed a novel method that incorporates expert opinion in a Bayesian analysis. The results showed that using expert opinion in Bayesian analysis produced a smaller range of survival values compared to frequentist methods.
ADVANCES IN THERAPY
(2023)
Article
Economics
Penny R. Breeze, Hazel Squires, Kate Ennis, Petra Meier, Kate Hayes, Nik Lomax, Alan Shiell, Frank Kee, Frank de Vocht, Martin O'Flaherty, Nigel Gilbert, Robin Purshouse, Stewart Robinson, Peter J. Dodd, Mark Strong, Suzy Paisley, Richard Smith, Andrew Briggs, Lion Shahab, Jo-An Occhipinti, Kenny Lawson, Thomas Bayley, Robert Smith, Jennifer Boyd, Visakan Kadirkamanathan, Richard Cookson, Monica Hernandez-Alava, Christopher H. Jackson, Amanda Karapici, Franco Sassi, Peter Scarborough, Uwe Siebert, Eric Silverman, Luke Vale, Cathal Walsh, Alan Brennan
Summary: This paper aims to assist health economic modelers in responding to the increasing demand for complex systems models in public health. It proposes identifiable features of such models and provides guidance on how to plan public health modeling projects using these models.
Article
Economics
Marc d'Elbee, Fern Terris-Prestholt, Andrew Briggs, Ulla Kou Griffiths, Joseph Larmarange, Graham Francis Medley, Gabriella Beatriz Gomez
Summary: Appropriate costing and economic modeling are crucial for the successful scale-up of health interventions. However, different cost functions can lead to inconsistent cost projections. This study reviewed existing methods and proposed new mathematical notations and cost function frameworks to improve the analysis of healthcare costs in LMICs. These frameworks consider variable returns to scale, which are often neglected in current studies, and aim to balance simplicity and accuracy while increasing transparency in reporting methods.
Letter
Biochemistry & Molecular Biology
Aris Angelis, Ajay Aggarwal, Andrew Briggs
Correction
Economics
Hardik Goswami, Adnan Alsumali, Yiling Jiang, Matthias Schindler, Elizabeth R. Duke, Joshua Cohen, Andrew Briggs, Amy Puenpatom
Article
Economics
Aris Angelis, Martin Harker, John Cairns, Mikyung Kelly Seo, Rosa Legood, Alec Miners, Virginia Wiseman, Kalipso Chalkidou, Richard Grieve, Andrew Briggs
Summary: This study evaluates the health technology assessment methods of the National Institute for Health and Care Excellence (NICE) and analyzes key decisions.
Article
Medicine, General & Internal
Emily Herrett, Keith Tomlin, Liang-Yu Lin, Laurie A. Tomlinson, Mark Jit, Andrew Briggs, Michael Marks, Frank Sandmann, John Parry, Christopher Bates, Jessica Morley, Seb Bacon, Benjamin Butler-Cole, Viyaasan Mahalingasivam, Alan Dennison, Deb Smith, Ethan Gabriel, Amir Mehrkar, Ben Goldacre, Liam Smeeth, Rosalind M. M. Eggo
Summary: This study aims to understand the impact of long COVID on health-related quality of life and productivity in English primary care patients. Participants will be asked to complete questionnaires through a smartphone app, covering aspects such as HRQoL, productivity, and symptoms of long COVID. Analysis will be conducted using the OpenSAFELY data platform to estimate the impact on HRQoL, productivity, and cost to the NHS.
Article
Education, Special
C. A. Melville, C. Hatton, E. Beer, R. P. Hastings, S. -A. Cooper, N. McMeekin, D. Dagnan, K. Appleton, K. Scott, L. Fulton, R. S. P. Jones, A. McConnachie, R. Zhang, R. Knight, D. Knowles, C. Williams, A. Briggs, A. Jahoda
Summary: This study identified baseline variables, including anxiety, IQ, hearing impairment, depression severity, expectation of change, and therapy attendance, as predictors and moderators of outcome in psychological therapies for depression experienced by adults with IDs. These findings have important implications for tailoring therapeutic approaches in treating depression among adults with IDs.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2023)
Article
Respiratory System
Linzy Houchen-Wolloff, Charlotte Overton, Andrew Ibbetson, Archie Walters, Claire Hastie, Rhyan Gill, Natalie Armstrong, Sally Singh, Paul Little, Kirby Evans, John Pimm, Michael Marks, Krisnah Poinasamy, Sam Walker, Andrew Briggs, Rachael A. Evans
Summary: This study aims to describe a typology of UK healthcare pathways post-hospital discharge to understand the clinical effectiveness and cost-effectiveness of different pathways. The study found that over half of post-COVID-hospitalisation adults have persistent symptoms 2 years after discharge, posing challenges for individuals and healthcare systems. The results highlight the heterogeneity and vulnerability of healthcare services after COVID-19 hospitalisation.
Editorial Material
Medicine, General & Internal
Aris Angelis, Ajay Aggarwal, Alec Miners, Richard Grieve, John Cairns, Andrew Briggs
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2023)
