Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Review
Neurosciences
Robyn P. Thom, Michelle L. Palumbo, Claire Thompson, Christopher J. McDougle, Caitlin T. Ravichandran
Summary: The study found that the majority of adults with Down syndrome responded positively to a 12-week course of SSRI treatment for depression, with some experiencing adverse effects such as daytime sedation and anger. Controlled studies are needed to further evaluate the efficacy, tolerability, and safety of SSRIs in this population.
Review
Neurosciences
George M. Anderson, Isabella Bruno-Pacella
Summary: This article assesses the bioeffect of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and compares them using neuroimaging and in vitro measurements. The study finds that these drugs typically result in a 70-90% reduction in platelet serotonin (5-HT) content. The bioeffect is similar among different types of SSRIs and SNRIs and is consistent with other assessment methods.
PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Daniel Richter, Jeyanthan Charles James, Andreas Ebert, Aristeidis H. Katsanos, Lisa Mazul-Wach, Quirin Ruland, Ralf Gold, Georg Juckel, Christos Krogias
Summary: Early SSRI therapy is associated with a reduced risk of post-stroke depression, but increases the risk of bone fracture and nausea. Future research should focus on identifying high-risk individuals to improve the risk-benefit assessment of this therapy in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Izumi Kamo, Hiroshi Nagata, Gale O'Connell, Takuya Kato, Akio Imanishi, Masako Kuno, Satoshi Okanishi, Kyoko Yoshikawa, Yuya Nishiyama
Summary: The study demonstrated that a novel selective 5-hydroxytryptamine type 2C (5-HT2C) receptor agonist, TAK-233, enhances evoked momentary urethra-closing functions in female rats and humans. TAK-233 significantly increased urethral resistance and lowered the stimulus threshold of urethral contractile responses, indicating a positive impact of 5-HT2C receptor stimulation on urethral function.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: The exposure to antidepressants during pregnancy, especially SSRIs, is associated with a slightly increased risk of postpartum hemorrhage. However, the findings should be interpreted with caution, and precautionary measures are still recommended.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Oncology
Min-Jing Lee, Chien-Wei Huang, Yi-Lung Chen, Yao-Hsu Yang, Vincent Chin-Hung Chen
Summary: The study revealed an association between the use of SSRIs and decreased risk of kidney cancer, with citalopram and paroxetine showing protective effects in depressed patients with kidney cancer during a 2-year induction period.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Fiammetta Cosci, Sara Romanazzo, Giovanni Mansueto, Petra Rontani, Michelle N. Levitan, Roseane D. Halkjoer-Lassen, Laiana A. Quagliato, Tomoyuki Nakamura, Ken Uematsu, Antonio E. Nardi, Misari Oe, Virginie-Anne Chouinard, Guy Chouinard
Summary: The study evaluated the reliability and correlation of two measurement tools (DID-W1 and DESS) in withdrawal syndromes, showing excellent interrater reliability for both; DESS can serve as a useful tool for detecting SSRI/SNRI withdrawal symptoms with high sensitivity.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Soobeen Hwang, Jong-Hui Kim, Su-Hyun Jo
Summary: Paroxetine can acutely and directly modulate human Kv1.3 channels, inhibiting channel activity by accelerating steady-state inactivation, thus revealing a possible mechanism for acute immunosuppression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Rafael R. Domingues, Hannah P. Fricke, Celeste M. Sheftel, Autumn M. Bell, Luma C. Sartori, Robbie S. J. Manuel, Chandler J. Krajco, Milo C. Wiltbank, Laura L. Hernandez
Summary: The effects of SSRI drugs on pregnancy and neonatal outcomes in mice were investigated. The study found that the high dose of fluoxetine led to a decrease in pregnancy rate and maternal weight gain, while both high and low doses of sertraline led to a decrease in the number of pups born and weaned. The study suggests that the effects of SSRI on neonatal mortality may be mediated by SSRI-induced placental insufficiency.
Review
Public, Environmental & Occupational Health
Dena Firouzabadi, Fatemeh Kheshti, Saeed Abdollahifard, Erfan Taherifard, Mohammad Reza Kheshti
Summary: The study found that SSRI/SNRI may be effective in reducing mortality rate among COVID-19 patients, with fluvoxamine showing superiority over fluoxetine. Additionally, the safety profile and affordable cost of SSRI/SNRI for short-term use make them beneficial medications in preventing COVID-19 mortality.
HEALTH SCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Suresh Paudel, Eunae Kim, Anlin Zhu, Srijan Acharya, Xiao Min, Seung Hoon Cheon, Kyeong-Man Kim
Summary: This study identified the diverse effects of synthetic 4-benzylpiperidine carboxamides on serotonin, norepinephrine, and dopamine reuptake, as well as the critical structural features contributing to the selectivity of these molecules for each of the monoamine transporters. Additionally, the study found that specific residues on the compounds bound to the transporters and highlighted the functional role of a dopamine reuptake inhibitor in regulating dopamine D-2 receptor function.
BIOMOLECULES & THERAPEUTICS
(2021)
Editorial Material
Pediatrics
Leonora Hendson, Vibhuti Shah, Sandra Trkulja
Summary: This position statement provides guidance for the monitoring, care, and follow-up of newborns exposed to SSRIs or SNRIs in utero. While there are risks involved, the common neonatal adaptation syndrome is generally mild and treatable with nonpharmacological measures. The low levels of these drugs in breast milk make them compatible with breastfeeding, and serious adverse effects from exposure to SSRIs or SNRIs in utero are low.
PAEDIATRICS & CHILD HEALTH
(2021)