Review
Pharmacology & Pharmacy
Rohit Siddhartha, Minal Garg
Summary: MMPs are a group of enzymes that play a crucial role in degrading proteins in the extracellular matrix and regulating cell signaling. Dysregulation of MMPs can lead to serious pathological conditions such as inflammation, uncontrolled cell growth, and cancer metastasis. Understanding the functions of MMPs has potential implications for cancer diagnosis, prognosis, and therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stephan Niland, Andrea Ximena Riscanevo, Johannes Andreas Eble
Summary: This review examines the current knowledge of the interplay of various MMPs in the context of cancer on the protein, subcellular, and cellular level, with a focus on MMP-14. It highlights the importance of a deeper understanding of functional mechanisms for the development of new prognostic and predictive markers, as well as targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Kang Fu, Xueyao Zheng, Yuhan Chen, Liuying Wu, Zhiming Yang, Xu Chen, Wei Song
Summary: Diabetic foot ulcers (DFUs) are serious complications of diabetes mellitus, characterized by tissue destruction in the foot. Matrix metalloproteinases (MMPs) play crucial roles in the pathogenesis and wound healing process of DFUs. Overexpression of MMPs in DFUs can result in excessive tissue degradation and impaired wound healing. Regulation of MMP levels may facilitate wound healing in DFUs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Fisheries
Zhimeng Lv, Guanghui Han, Chenghua Li
Summary: The TIMP1 gene plays a crucial role in inflammatory diseases in vertebrates, responding to bacterial challenge and LPS exposure. AjTIMP1 is expressed in all tissues, with the highest levels in the body wall. Imbalance in AjMMP1/AjTIMP1 ratio was observed in skin ulceration syndrome patients, leading to an inflammatory response with ROS formation and collagen degradation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Article
Medicine, Research & Experimental
Craig N. Morrell, Doran Mix, Anu Aggarwal, Rohan Bhandari, Matthew Godwin, Phillip Owens, Sean P. Lyden, Adam Doyle, Krystin Krauel, Matthew T. Rondina, Amy Mohan, Charles J. Lowenstein, Sharon Shim, Shaun Stauffer, Vara Prasad Josyula, Sara K. Ture, David Yule, Larry E. Wagner, John M. Ashton, Ayman Elbadawi, Scott J. Cameron
Summary: Biomechanical platelet activation may be a potential mechanism behind resistance to antiplatelet medication. A study on patients with abdominal aortic aneurysms (AAA) found that activation of olfactory receptor pathway is associated with AAA progression. A molecule activating platelet olfactory receptor was identified and shown to inhibit platelet activation and AAA growth.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Aneta Choreziak-Michalak, Dawid Szpecht, Anna Chmielarz-Czarnocinska, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews, Grazyna Kurzawinska, Ewa Strauss, Anna Gotz-Wieckowska
Summary: This study investigates the relationship between genetic variations in matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) and the development of retinopathy of prematurity (ROP) in the Polish population. The results suggest that certain genetic variants, including the MMP-1 rs179975 1G deletion allele and TIMP-1 rs4898C allele, are associated with an increased risk of ROP. The study also identifies interactions between multiple genetic loci that impact the risk of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chun-Yan Wan, Lei Li, Ling-Shuang Liu, Chun-Miao Jiang, Hong-Zhe Zhang, Jian-Xun Wang
Summary: The study investigated the relationship between MMPs and TIMPs during the development of apical periodontitis in mice. Results showed that the expression levels of MMPs and TIMPs increased with periapical inflammation progression, with variations in expression levels during acute and chronic stages.
JOURNAL OF ENDODONTICS
(2021)
Article
Oncology
Dan-Dan Wang, Wen-Xiu Xu, Wen-Quan Chen, Lei Li, Su-Jin Yang, Jian Zhang, Jin-Hai Tang
Summary: This study comprehensively analyzed the prognostic and therapeutic value of TIMP2 in cancer patients using bioinformatics tools. The results showed that TIMP2 is a potential prognostic marker in various cancers and is associated with tumor microenvironment and immunity. High expression of TIMP2 is correlated with unfavorable survival outcomes in multiple cancers, and the mechanisms involved include ECM regulation, degradation, and other signaling pathways.
JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Venkatesh Sadananda Rao, Qianyu Gu, Sandra Tzschentke, Kuailu Lin, Nicole Ganig, May-Linn Thepkaysone, Fang Cheng Wong, Heike Polster, Lena Seifert, Adrian M. Seifert, Nathalie Buck, Carina Riediger, Jonas Weisse, Tony Gutschner, Susanne Michen, Achim Temme, Martin Schneider, Franziska Baenke, Juergen Weitz, Christoph Kahlert
Summary: This study reveals the important role of EV-mediated ECM remodeling in colorectal cancer liver microenvironment and identifies EV-associated TIMP1 as a potential therapeutic target and a circulating biomarker for preoperative risk stratification in patients with colorectal liver metastases.
Article
Immunology
Gokul Raj Kathamuthu, Kadar Moideen, Kannan Thiruvengadam, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu
Summary: This study investigated the levels of circulating MMPs and TIMPs in TBL individuals with and without helminth coinfection, revealing that MMPs and TIMPs were elevated in TBL-Hel+ coinfected individuals. Regression analysis showed that these changes were independent of age, sex, and culture status. The MMP-2 ratio with all TIMPs was significantly associated with TBL-helminth coinfection, indicating a profound effect of helminth infection on TBL pathogenesis and immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Oncology
Nadezhda V. Popova, Manfred Juecker
Summary: The extracellular matrix plays a critical role in cancer development and progression by influencing the behavior of cancer cells. Abnormal extracellular matrix directly promotes cancer cell proliferation, survival, migration, and differentiation, leading to the emergence of an oncogenic microenvironment.
Article
Immunology
Shipra Pant, Astha Dimri, Renu Arora, Fouzia Siraj, Sheikh Raisuddin, Sangita Rastogi
Summary: This study investigated the expression of MMP-2, -9, -14/TIMP-1, -2, -3 in C. trachomatis-positive tubal EP patients. The results showed upregulated expression of MMP-2, -9, and -14, as well as downregulated expression of TIMP-1, -2, and -3 in C. trachomatis-positive patients compared to controls. The fold-change in MMP expression was significantly higher in C. trachomatis-positive patients, with MMP-2 showing the greatest upregulation. These findings suggest that dysregulation of MMPs/TIMPs, particularly enhanced MMP-2 expression, may play a role in the development of tubal EP in C. trachomatis-positive women.
MICROBIAL PATHOGENESIS
(2022)
Article
Multidisciplinary Sciences
Hiroe Konishi, Shun-En Kanou, Rika Yukimatsu, Mizuki Inui, Motoya Sato, Naruto Yamamoto, Masayoshi Nakano, Masahiro Koshiba
Summary: This study investigated the mechanism of the abnormal MMP-3 concentration in patients with rheumatoid arthritis successfully treated with MTX and found that intervention through the A(2A) AdoR signaling pathway and cAMP can reduce TNFα-induced MMP-3 production.
SCIENTIFIC REPORTS
(2022)
Article
Otorhinolaryngology
Aleksander Zwierz, Krystyna Masna, Karol Zwierz, Maksymilian Bojkowski, Pawel Burduk
Summary: This study found that isolating preschool children for 3 months can stabilize the bacterial microbiome of the nose and nasopharynx, significantly affecting the number of recurrent upper respiratory tract infections and nasal patency. The only symptom related to adenoid hypertrophy was snoring, and there was a weak correlation between the prevalence of infections and the size of the adenoid. The adenoid size decreased by approximately 5.4% during the isolation period and was correlated with residual mucus in the nasopharynx.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Review
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Navid Ahmadi, Lukasz Szylberg
Summary: Currently, multiple myeloma is considered an incurable disease, but CDK9 inhibitors have emerged as a potential treatment option to overcome resistance and prolong survival. By downregulating gene expressions and restoring tumor-suppressive functions, CDK9 inhibitors have shown promising efficacy in preclinical trials and synergistic effects with other drugs.
Article
Medicine, General & Internal
Aleksander Zwierz, Krystyna Masna, Krzysztof Domagalski, Pawel Burduk
Summary: The purpose of this study was to analyze the long-term effects of a 12-week course of topical steroids on adenoid size, mucus, and middle ear effusion. The results indicated that there was no significant effect on adenoid size, mucus, and otitis media with effusion (OME) three to six months after finishing the treatment. Therefore, the decision of adenoidectomy and tympanostomy should not be procrastinated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Marek Zdrenka, Piotr Slupski, Paulina Antosik, Sylwia Kolodziejska, Marta Sekielska-Domanowska, Mariusz Dubiel, Magdalena Bodnar, Lukasz Szylberg
Summary: This article investigates the prognostic role of cyclin-dependent kinase 9 expression in urothelial carcinoma. The results show that high CDK9 expression is associated with a better prognosis, tumor grade, stage, and invasiveness, contradicting previous findings. CDK9 may play a crucial role in the early stages of urothelial carcinoma.
Article
Medicine, General & Internal
Aleksander Zwierz, Krzysztof Domagalski, Krystyna Masna, Pawel Burduk
Summary: The study aims to assess the effectiveness of endoscopic examination in evaluating the size of the pharyngeal tonsil and determine the minimum necessary frequency of tests. Results showed that flexible endoscopic examination has high sensitivity and specificity in assessing the size of the pharyngeal tonsil.
Review
Biochemistry & Molecular Biology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Adam Kowalewski, Marlena Janiczek-Polewska, Anna Szylberg, Andrzej Marszalek, Lukasz Szylberg
Summary: Inflammation plays a significant role in colon cancer development, with cytokine networks in the intestines being critical for tissue homeostasis and inflammation regulation. Recent studies suggest that inflammation is more important in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have received attention for their potential role in CRC pathogenesis and promising results in clinical trials. The balance between proinflammatory and anti-inflammatory factors is crucial for maintaining homeostasis, and immune cells in the tumor microenvironment modulate immune sensitivity and aid cancer immune evasion.
Review
Biochemistry & Molecular Biology
Marlena Janiczek-Polewska, Lukasz Szylberg, Julian Malicki, Andrzej Marszalek
Summary: Inflammatory cytokines play a significant role in the mechanisms of chemoresistance and may serve as potential biomarkers for evaluating chemoresistance and influencing the management of GC treatment.
Article
Biochemistry & Molecular Biology
Mateusz Szylberg, Pawel Sokal, Paulina Sledzinska, Marek Bebyn, Stanislaw Krajewski, Lukasz Szylberg, Aneta Szylberg, Tadeusz Szylberg, Kamil Krystkiewicz, Marcin Birski, Marek Harat, Robert Wlodarski, Jacek Furtak
Summary: This study evaluated the impact of MGMT promoter methylation on the survival rate of patients with primary glioblastoma and found that patients with methylation had a longer median survival, indicating that MGMT promoter methylation is an important prognostic marker.
Article
Virology
Pawel Solarz, Magdalena Bodnar, Joanna Czech, Hanna Mackiewicz-Nartowicz, Anna Sinkiewicz, Lukasz Szylberg, Jedrzej Borowczak, Paula Rutkiewicz, Aleksander Zwierz, Pawel Burduk
Summary: Recurrent respiratory papillomatosis is a disease closely related to human papillomavirus infection. The main treatment for lesions in the larynx or lower pharynx is microsurgical excision using a CO2 laser, but combined antiviral therapy can reduce the number of surgeries and prevent regrowth of the lesions.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Aleksandra Kwasniewska, Krzysztof Kwasniewski, Andrzej Skorek, Dmitry Tretiakow, Anna Jazwinska-Curyllo, Pawel Burduk
Summary: The aim of this study was to evaluate the correlation between ENT symptom occurrence and antibody titer in convalescent plasma, as well as the influence of age and gender on ENT manifestations of COVID-19. Antibody levels were measured in 346 blood donors with PCR-confirmed previous infection. ENT symptoms, antibody levels, age, and gender were statistically analyzed. The most common ENT symptoms were smell/taste disturbances, dry cough, sore throat, and dyspnea. Smell/taste disturbances were more common in younger patients and associated with lower antibody levels, while dry cough, dyspnea, and dizziness were associated with higher antibody levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Damian Jaworski, Bartosz Brzoszczyk, Lukasz Szylberg
Summary: This review provides a comprehensive overview of the critical roles of mismatch repair (MMR) and double-strand break (DSB) defects in prostate cancer, as well as their clinical implications. It discusses the promising potential of immune checkpoint inhibitors and PARP inhibitors as targeted therapies, particularly in personalized medicine. Recent clinical trials have shown the efficacy of these novel treatments, leading to FDA approvals, offering hope for improved outcomes for patients.
Article
Medicine, General & Internal
Malgorzata Wierzchowska, Paulina Kalinczak-Gorna, Magdalena Zwolinska, Joanna Ligmanowska, Justyna Durslewicz, Aleksander Zwierz, Bartosz Malinowski, Michal Wicinski, Pawel Burduk
Summary: We aimed to evaluate the effect of treatment with prednisone on nasal and systemic periostin and eotaxin expression, IgE in plasma and eosinophils in tissue. The results showed that treatment with prednisone significantly decreased the levels of periostin, eotaxin, and IgE in plasma, as well as reduced the number of eosinophils in tissue. These findings suggest the need for further research on inflammatory markers associated with chronic rhinosinusitis and the development of drugs that can selectively target inflammation.
Article
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Marek Zdrenka, Piotr Slupski, Hanna Andrusewicz, Joanna Lysik-Miskurka, Paula Rutkiewicz, Magdalena Bodnar, Lukasz Szylberg
Summary: This study found that high expression of p53 is associated with unfavorable clinical features in bladder cancer and is correlated with the expression of CDK9. CDK9 may influence p53 expression through interactions with p53 inhibitors. Confirming the crosstalk between p53 and CDK9 in bladder cancer may be an important step in explaining the mechanism of tumor progression in its early stages.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Aleksander Zwierz, Krystyna Masna, Marcin Perczak, Pawel Burduk
Summary: The reverse superior labial artery (rSLA) island flap is an effective technique for facial reconstruction after tumor excision, providing satisfactory functional and aesthetic outcomes.
MEDICINA-LITHUANIA
(2022)
