Article
Medicine, Research & Experimental
Ann-Jean C. C. Beck, Wim H. van Harten, Michiel W. M. van den Brekel, Arash Navran, Valesca P. Retel
Summary: Treatment decision-making for patients with laryngeal cancer involves a trade-off between survival, quality of life, and costs. A cost-effectiveness analysis comparing surgery with organ preservation in advanced laryngeal cancer patients showed that the surgical approach had higher QALYs but also higher costs. The study suggests that surgical treatment may be cost-effective compared to organ preservation within certain thresholds.
Article
Oncology
Patricia Garcia-Cabo, Fernando Lopez, Mario Sanchez-Canteli, Laura Fernandez-Vanes, Cesar Alvarez-Marcos, Jose Luis Llorente, Maria Angeles de la Rua, Pilar Blay, Juan P. Rodrigo
Summary: This study compared organ-preservation protocols with surgery followed by radiotherapy in locally advanced squamous cell carcinoma patients. The results showed no significant differences in overall survival, disease-specific survival, locoregional control, and metastasis-free survival between the two treatment approaches for patients with specific cancer stages.
Article
Oncology
Yifan Yang, Ling Feng, Qi Zhong, Yang Zhang, Zhigang Huang, Shurong Zhang, Shuling Li, Junmao Gao, Lizhen Hou, Hongzhi Ma, Shizhi He, Qian Shi, Meng Lian, Yanming Zhao, Xixi Shen, Jiaming Chen, Lingwa Wang, Haiyang Li, Shaoshi Chen, Jiaqi Xu, Ru Wang, Jugao Fang
Summary: This study compared the therapeutic effect of induction chemotherapy-based organ-preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients. The results showed no significant difference in progression-free survival and overall survival between the two groups. The organ-preservation approach allowed more than 70% of the survivors to retain their larynx function.
Review
Biochemistry & Molecular Biology
Karthik Nagaraja Rao, Prathamesh S. Pai, Prajwal Dange, Luiz P. Kowalski, Primoz Strojan, Antti A. Makitie, Orlando Guntinas-Lichius, K. Thomas Robbins, Juan P. Rodrigo, Avraham Eisbruch, Robert P. Takes, Remco de Bree, Andres Coca-Pelaz, Cesare Piazza, Carlos Chiesa-Estomba, Fernando Lopez, Nabil F. Saba, Alessandra Rinaldo, Alfio Ferlito
Summary: The management of cT3 laryngeal cancers remains controversial, and there is a lack of studies showing which treatment has better survival outcomes. This study compared total laryngectomy, concurrent chemoradiation, and radiation therapy alone in T3 laryngeal cancers and found that TL and CRT had similar overall survival outcomes, which were better than RT alone.
Article
Medicine, General & Internal
Shahin Tahan Shoushtari, Jocelyn Gal, Emmanuel Chamorey, Renaud Schiappa, Olivier Dassonville, Gilles Poissonnet, Deborah Aloi, Mederic Barret, Inga Safta, Esma Saada, Anne Sudaka, Dorian Culie, Alexandre Bozec
Summary: This study compared the survival outcomes of salvage vs. primary total laryngectomy in patients with locally advanced laryngeal or hypopharyngeal carcinoma and determined their predictive factors. The results showed that salvage TL had significantly worse survival rates than primary TL. The predictive factors identified here should be considered in the therapeutic decision-making, especially for salvage TL patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Elena Molina-Fernandez, Jose M. Palacios-Garcia, Ramon Moreno-Luna, Tomas Herrero-Salado, Julio Ventura-Diaz, Serafin Sanchez-Gomez, Angel Vilches-Arenas
Summary: The worldwide incidence rate of laryngeal cancer is decreasing, but the 5-year survival rate has decreased from 66% to 63% in recent years. The study evaluated the survival rate of patients with laryngeal cancer according to the disease stage and treatment method. The results showed that patients who underwent surgical treatment had a higher chance of survival than those treated with chemoradiotherapy.
Review
Medicine, Research & Experimental
Nille B. Wulff, Anna Hojager, Irene Wessel, Susanne O. Dalton, Preben Homoe
Summary: The study found that patients who received TL treatment have worse HRQoL compared to the male normative reference population. Although TL patients experience clinically important differences in many domains compared to normative data, their symptom burden is generally mild. Despite a large number of studies conducted, the strength of evidence remains weak.
Article
Otorhinolaryngology
Ashley J. Schlafstein, Subir Goyal, Arya Amini, Sana D. Karam, Nabil F. Saba, Azeem S. Kaka, Ashley H. Aiken, Jonathan J. Beitler, William A. Stokes
Summary: This study found that for T4 larynx cancer patients, larynx preservation (LP) surgery did not significantly reduce overall survival compared with laryngectomy (LGX) if operability was ensured.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Thomas K. Hoffmann
Summary: Complete removal of the larynx (total laryngectomy) offers a curative approach for advanced laryngeal and pharyngeal cancer, while resulting in the loss of voice can be compensated by functional rehabilitation with a significant quality of life improvement. The surgical procedure including neck dissection is highly standardised and safe.
Article
Oncology
Chineme Amechi, Lauren Ottenstein, Ayannah Lang, Tekiah McClary, Anna M. Avinger, Andre J. Burnham, Margie D. Dixon, Rebecca D. Pentz, Nicole C. Schmitt
Summary: This study assesses the quality of life and satisfaction with decision in patients after total glossectomy with laryngectomy, revealing the impact of the procedure on patients' quality of life. Although patients were satisfied with their decision and overall quality of life, the procedure had negative effects on mood, oral function, and activity.
Article
Oncology
Gerhard Dyckhoff, Rolf Warta, Christel Herold-Mende, Volker Winkler, Peter K. Plinkert, Heribert Ramroth
Summary: For T3 laryngeal cancers, there was no significant difference in survival between pCRT and TL + a(C)RT, but survival was significantly worse after pRT alone. The recommendation is to use pCRT rather than pRT alone for T3 laryngeal cancers.
Article
Health Care Sciences & Services
Mahmoud Abdelghany, Ayman Amin, Emilia Degni, Claudia Crescio, Asem Elsani M. A. Hassan, Tarek Ftohy, Francesco Bussu
Summary: The aim of this study is to review the outcomes of postirradiation salvage total laryngectomy (STL) and reconstruction with pectoralis major flap. The overall survival after STL and reconstruction with PMMF is low, but most deaths are due to comorbidities, not cancer progression or recurrence.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Otorhinolaryngology
Eugene Wong, Murray Smith, Malcolm A. A. Buchanan, Akshay Kudpaje, Andrew Williamson, Prasanna Suresh Hedge, Daniel Hazan, Jordan Idaire, Mark C. C. Smith, Niranjan Sritharan, Carsten Palme, Faruque Riffat
Summary: A total laryngectomy creates an alternate airway that bypasses the upper aerodigestive tract, leading to a reduction in nasal airflow and resulting in hyposmia or anosmia. This study aimed to assess the impact of anosmia on the quality of life of laryngectomy patients and identify any patient-related risk factors associated with poorer outcomes.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Ylenia Longobardi, Jacopo Galli, Tiziana Di Cesare, Lucia D'Alatri, Stefano Settimi, Dario Mele, Francesco Bussu, Claudio Parrilla
Summary: This study evaluated the effects of new devices (heat and moisture exchangers and adhesives) on post-laryngectomy patients. The results showed that using the new products significantly reduced expectoration and dry coughs, improved quality of life and pulmonary symptoms, increased patient adherence and satisfaction. Additionally, the use of these new devices also reduced shortness of breath and skin irritation, and improved emotional well-being. Therefore, using better-performing devices is crucial for improving quality of life and patient satisfaction.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Oncology
Luca Ghirotto, Gianluca Catania, Helena Camera, Concetta D'Adamo, Danilo Ignone, Antonio Rizzuto, Simone Stevanin, Elisabetta Losi, Cristina Pedroni, Giorgio Peretti, Annamaria Bagnasco, Loredana Sasso, Valentina Bressan
Summary: This study explored how laryngectomised patients perceived themselves as cancer survivors during the follow-up phase. Through interviews and analysis of 19 patients, it was found that they experienced changes and adaptations in their lives during the follow-up period. This study provides important insights for improving care models, patient education, and support systems.
SUPPORTIVE CARE IN CANCER
(2023)
