Article
Oncology
Jana Mekis, Primoz Strojan, Dusan Mekis, Irena Hocevar Boltezar
Summary: The study aimed to track the changes in voice quality for two years after radiotherapy (RT) for early glottic cancer. The results showed that only a minority of patients had a normal voice two years post-RT, mainly due to post-RT changes in the larynx, such as fibrosis and scarring of the vocal folds.
Article
Otorhinolaryngology
Maarten C. Dorr, Aniel Sewnaik, Elrozy Andrinopoulou, Diako Berzenji, Emilie A. C. Dronkers, Simone E. Bernard, Arta Hoesseini, Lisa Tans, Dimitris Rizopoulos, Robert J. Baatenburg de Jong, Marinella P. J. Offerman
Summary: This study aimed to investigate the longitudinal trajectories for patient-reported voice quality after treatment for early-stage glottic cancer and identify associated risk factors. The results showed that different treatment modalities resulted in varying degrees of improvement in voice quality, but no significant differences were found in long-term outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Multidisciplinary Sciences
Yukinori Takenaka, Atsuhiko Uno, Hidenori Tanaka, Norihiko Takemoto, Kengo Nozaki, Hidenori Inohara
Summary: Similar prognoses were observed in patients with verrucous carcinoma (VC) treated with radiation and surgery. VC can be treated using radiation.
Article
Oncology
Sofiane Allali, Matthieu Carton, Thomas Sarrade, Ophelie Querel, Alexandra Jacquet, Sofia Rivera, Youssef Ghannam, Karine Peignaux, Philippe Guilbert, Claire Chara-Brunaud, Julien Blanchecotte, David Pasquier, Severine Racadot, Celine Bourgier, Alain Labib, Julien Geffrelot, Ahmed Benyoucef, Francois Paris, Paul Cottu, Fabrice Andre, Youlia Kirova
Summary: Skin damage is a common and important toxicity during and after radiation therapy. This study found associations between skin erythema and obesity, type of surgery, axillary dissection, taxane-based chemotherapy, and the irradiation technique. Risk factors for fibrosis included age at diagnosis, obesity, tobacco, and the use of a boost. The use of IMRT technique decreased the occurrence of skin erythema.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Otorhinolaryngology
Maarten C. C. Dorr, Eleni-Rosalina Andrinopoulou, Aniel Sewnaik, Diako Berzenji, Kira S. S. van Hof, Emilie A. C. Dronkers, Simone E. E. Bernard, Arta Hoesseini, Dimitirs Rizopoulos, Robert J. Baatenburg J. de Jong, Marinella P. J. Offerman
Summary: This study aims to develop an individualized dynamic prediction model for patient-reported voice quality. The study found that the model can provide individualized predictions at every time point and can be used throughout the follow-up period. Increasing the number of measurements during prediction improves predictive performance, while adding more clinical and demographic variables does not provide better predictions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Tae Oike, Yoshihito Sekiguchi, Yuya Yoshimoto, Takahiro Oike, Ken Ando, Wenchao Gu, Yasushi Sasaki, Takashi Tokino, Akira Iwase, Tatsuya Ohno
Summary: Simultaneous mutations in KRAS and SMAD4 may be associated with radioresistance in cervical cancer, and carbon ion radiotherapy could be a potential treatment option for these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Sanjush Dalmia, Florien Boele, Kate Absolom, Alessandro Brunelli, Kevin Franks, Hilary Louise Bekker, Cecilia Pompili
Summary: This systematic review critically evaluates studies on patient and clinician preferences for treating early-stage non-small cell lung cancer (NSCLC). The findings suggest that patients and clinicians both prefer a collaborative role in treatment decisions. Most patients do not recall having a choice between surgery and stereotactic ablative radiotherapy (SABR), resulting in minimal decisional conflict.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Nanda Horeweg, Remi A. Nout, Ina M. Jurgenliemk-Schulz, Ludy C. H. W. Lutgens, Jan J. Jobsen, Marie A. D. Haverkort, Jan Willem M. Mens, Annerie Slot, Bastiaan G. Wortman, Stephanie M. de Boer, Ellen Stelloo, Karen W. Verhoeven-Adema, Hein Putter, Vincent T. H. B. M. Smit, Tjalling Bosse, Carien L. Creutzberg
Summary: The molecular classification of endometrial cancer has predictive value for response to radiotherapy in early-stage endometrioid EC. Different molecular subtypes have different responses to adjuvant therapy, and radiotherapy may not be necessary for certain molecular subtypes.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Patrick Schlegel, Kirsten Wong, Mamdouh Aker, Yazeed Alhiyari, Jennifer Long
Summary: This study investigated the changes in voice quality of pigs before and after laryngeal surgery, identifying four parameters related to post-operative voice quality changes out of 17 acoustic parameters measured. Two parameters, 50% spectral energy quartile and Flux, were recommended for assessing post-surgical voice quality in pigs.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Thomas Mulliez, Geertje Miedema, Hilde Van Parijs, Nathalie Hottat, Maud Vassilieff, Evy Gillet, Luc Baeyens, Mia Voordeckers, Jolien Coelmont, Tatiana Besse-Hammer, Thierry Gevaert, Andre Nazac, Mark De Ridder
Summary: Pre-operative 5-fraction breast radiotherapy followed by immediate breast-sparing surgery and sentinel node procedure was found to be feasible in early-stage breast cancer patients. However, wound problems were frequent and required intervention. Performing the sentinel node procedure before pre-operative radiotherapy is important for accurate staging.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Mohamed Shelan, Lukas Anschuetz, Adrian Schubert, Beat Bojaxhiu, Daniel M. Aebersold, Olgun Elicin, Roland Giger
Summary: This retrospective study aimed to define the optimal strategy for treating loco-regionally advanced squamous cell carcinoma of the larynx (LSCC). The results showed that primary surgery had superior locoregional control compared to primary radiotherapy with cisplatin, but there was no significant difference in progression-free survival or overall survival. The ideal patient selection criteria for the treatment of loco-regionally advanced LSCC still need to be defined.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Leonie Bruine de Bruin, Martijn J. A. M. Clausen, Lorian Slagter-Menkema, Gertruida H. de Bock, Johannes A. Langendijk, Bert van der Vegt, Bernard F. A. M. van der Laan, Ed Schuuring
Summary: This study investigated the association between DNA methyltransferase 1 (DNMT1) expression and local control in early-stage laryngeal squamous cell carcinoma (LSCC) patients treated with radiotherapy. The results showed that high expression of DNMT1 was associated with worse local control. Patients with higher T-stage and positive N-status also had worse local control.
Article
Medicine, General & Internal
David Winston Hamilton, James O'Hara, Amarkumar Rajgor, Gerald Selby, Mhairi Anderson, Kim Keltie, Rosalyn Parker, Dawn Teare, Joanne Patterson, Terry M. Jones, Linda Sharp
Summary: This study aims to compare the impact of surgery and (chemo)radiotherapy on survival and quality of life in patients with early and advanced laryngeal cancer, and explore the influence of clinical features on oncological, functional, and quality of life outcomes. The study plans to recruit 150 patients from 8 centers over a 3-year period and collect data at baseline, 6, 12, and 24 months. Multiple logistic regression analysis will be used for data analysis. The results will be published in high-impact international peer-reviewed journals and presented at scientific meetings.
Article
Cardiac & Cardiovascular Systems
Marcelo Cerullo, Hui-Jie Lee, Christopher Kelsey, Norma E. Farrow, Charles D. Scales, Betty C. Tong
Summary: This study investigated the clinical characteristics of patients with stage I NSCLC undergoing SBRT and found that only a minority of patients underwent TSUe. Patients undergoing TSUe had longer time to treatment, more invasive diagnostic procedures, and higher healthcare costs.
ANNALS OF THORACIC SURGERY
(2023)
Article
Oncology
Thomas Held, Henrik Franke, Kristin Lang, Tanja Eichkorn, Sebastian Regnery, Katharina Weusthof, Lukas Bauer, Karim Plath, Gerhard Dyckhoff, Peter K. K. Plinkert, Semi B. B. Harrabi, Klaus Herfarth, Juergen Debus, Sebastian Adeberg
Summary: The study evaluated intensity-modulated proton therapy as a novel treatment option for early-stage glottic cancer. The results showed that it had excellent treatment tolerability, preserved high rates of laryngeal function, and promising oncological outcomes.
RADIATION ONCOLOGY
(2022)
