Review
Oncology
Simon Beyaert, Jean-Pascal Machiels, Sandra Schmitz
Summary: Therapeutic vaccines are administered to cancer patients to stimulate an immune T cell response against specific antigens, with the challenge of considering tumor heterogeneity. Current research in therapeutic vaccines focuses on viral or non-viral antigens, particularly in head and neck cancers, with advancements seen in clinical trials and FDA approvals for certain treatments.
Article
Oncology
Junjun Jia, Hongkai Guo, Jiabin Liu, Qi Sun, Guoqiang Cao, Shao Zhou, Mingqi Shuai, Feng Gao, Shusen Zheng, Min Zhang
Summary: The purpose of this study was to optimize the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma (LELC). By retrospectively analyzing 16 cases of LELC and using cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) as control groups, it was found that the diagnosis and treatment of LELC showed better results.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Binny Khandakar, Jun-Ru Liu, Swan Thung, Ying Li, Hyungjin Rhee, Alexander C. Kagen, Tommy Sun-Wing Tong, Young Nyun Park, Neil Theise, Irene Oi-Lin Ng
Summary: This study presented three rare cases of intrahepatic biliary EBV-associated LEL tumors, with a distinctly benign biliary epithelial component, low proliferation index, and good prognosis. These cases with unique features warrant further investigation and may require revision of the current nomenclature.
Article
Oncology
Liming Li, Wenpeng Huang, Ping Hou, Weiwei Li, Menyun Feng, Yiyang Liu, Jianbo Gao
Summary: This study aimed to develop a preoperative risk scoring model based on CT images to distinguish lymphoepithelioma-like gastric carcinoma (LELGC) from non-LELGC. The study found that enhancement pattern, CT-defined lymph node status, and attenuation in the venous phase were independent predictors of LELGC. The risk identification model showed high accuracy in both the training and validation cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante, Carla Petrella, Marco Fiore, Antonio Minni, Christian Barbato
Summary: The treatment of unresectable or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) traditionally relied on chemotherapy or radiotherapy, but with suboptimal outcomes. The introduction of immunotherapy has significantly improved HNSCC treatment, but long-term results are still uncertain. This review focuses on therapeutic vaccines for HNSCC treatment, gathering existing evidence and summarizing ongoing clinical trials. Encouraging results and ongoing experiments bring hope for potential paradigm shifts in HNSCC therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Oncology
Dauren Adilbay, Saudamini Lele, John Pang, Ameya Asarkar, Jason Calligas, Cherie-Ann Nathan
Summary: Circulating human papillomavirus (HPV) DNA is a promising tool in managing HPV-positive oropharyngeal cancer, enabling changes in treatment, diagnosis, and patient monitoring. With the increasing incidence of HPV-related head and neck cancers, the use of circulating HPV DNA can help identify patients suitable for de-escalation protocols and those at risk of treatment failure.
Article
Multidisciplinary Sciences
Huiying Hu, Huanyu Jiang, Zhenwen Zhu, Honglin Yin, Kai Liu, Lijuan Chen, Mengyuan Zhao, Zhenkun Yu
Summary: Squamous papillomas (SPs) of the head and neck are often benign lesions caused by HPV infection. The prevalence of HPV varies depending on the anatomical site, with higher rates in the larynx and external auditory canal. p16 immunohistochemistry shows promise as a surrogate marker for HPV infection in head and neck SPs. Further studies are needed to confirm this association.
Article
Oncology
Yu Dou, Chao Ma, Ketao Wang, Shaohua Liu, Jintang Sun, Wanye Tan, Markus Neckenig, Qingjie Wang, Zuoqing Dong, Wenjuan Gao, Anwei Chen, Dong Zhang, Bing Wang, Liang Shi, Zhaodi Nan, Dan Ai, Wenjie Yu, Jia Liu, Bingfeng Song, Lei Zhao, Qianqian Shao, Yong Zhu, Tao Wang, Jianing Wang, Wei Hu, Fengcai Wei, Xin Xu, Xun Qu
Summary: The study reveals an association between tumor microbiota and outcomes of HNSCC patients, with poor prognosis patients having lower microbial richness and specific genera enrichment, while good prognosis patients having richer and health-promoting microbial communities. The microbial dysbiosis index (MDI) shows significant association with overall survival (OS) and disease free survival (DFS), independently of other clinical factors.
Article
Virology
Yan-Xia Wu, Wen-Li Zhang, Tong-Min Wang, Ying Liao, Yi-Jun Zhang, Ruo-Wen Xiao, Yi-Jing Jia, Zi-Yi Wu, Chang-Mi Deng, Da-Wei Yang, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Ting Zhou, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Jiang-Bo Zhang, Wei-Hua Jia
Summary: This study provides the first comprehensive analysis of the genomic characteristics of Epstein-Barr virus (EBV) associated with pulmonary lymphoepithelioma-like carcinoma (PLELC). Through sequencing, the researchers identified 3,995 variations in EBV sequences from PLELC patients compared to a reference genome. They also discovered 32 significant variations associated with PLELC risk through a genome-wide association analysis. Additionally, they characterized the latent type-II infection of EBV in PLELC at both transcription and methylation levels.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Fei Liu, Qing Xu, Parbatraj Regmi, Fu-Yu Li, Yi-Xin Lin
Summary: This article reported a rare case of LEL-ICC in a Chinese female, which was discovered during a pancreatitis examination. MRI examination revealed a 1.1x1.3 cm tumor in the left lobe of the liver. The definitive diagnosis was confirmed through histopathological examination, and the patient achieved successful treatment through surgical resection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Qing-Qing Xu, Qing-Jie Li, Zhen Xu, Li-Long Lan, Zan Hou, Juan Liu, LiXia Lu, Yuan-Yuan Chen, Run-Zhe Chen, Xin Wen
Summary: By establishing an immunohistochemical (IHC) score model, we have developed a method for predicting the prognosis of head and neck squamous cell carcinoma (HNSCC). The results showed that the IHC score can independently predict the prognosis of HNSCC and is more accurate than the TNM system. Combining these two methods could enable individualized patient consultation and care.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Edyta M. Borkowska, Magda Baranska, Magdalena Kowalczyk, Wioletta Pietruszewska
Summary: Head and neck squamous cell carcinomas (HNSCC) are a significant cause of mortality with genetic factors playing a crucial role in their etiology. Detection of genetic mutations and HPV infection in tumor samples can provide important prognostic information.
Article
Otorhinolaryngology
Faiez K. Saiyed, Theresa Guo, Faye Johnson, Jeffrey N. Myers
Summary: The outcomes of OPSCC patients with distant metastases remain controversial in relation to HPV status. HPV-positive patients had higher 2-year survival after DM, but did not show greater episodes or sites of DM. Multiple sites of DM, early development of DM, and comorbidities were independently associated with worse survival after DM.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Yuki Adachi, Hideki Yokoo, Masahiro Hagiwara, Hiroyuki Takahashi, Hiroyoshi Iwata, Tomohiro Takeda, Tomohiro Yamamoto, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Naoto Matsuno
Summary: Lymphoepithelioma-like cholangiocarcinoma is a rare variant of primary liver tumor, which occurs more frequently in Asian women and is strongly associated with EBV and hepatitis viruses. This article describes a case of LEL-CC in a 76-year-old woman not associated with EBV or hepatitis virus.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Review
Oncology
Rebecca R. Pharaon, Yan Xing, Mark Agulnik, Victoria M. Villaflor
Summary: A subset of head and neck cancers in the oropharynx and nasopharynx associated with human papillomavirus or Epstein-Barr virus pose limited treatment options once patients develop recurrent or metastatic disease. Current studies are focusing on utilizing immunotherapy to overcome resistance to standard chemoradiation therapy and improve treatment response and outcomes in these viral-associated cancers.
FRONTIERS IN ONCOLOGY
(2021)