Article
Biochemistry & Molecular Biology
Uiju Cho, Yeoun-Eun Sung, Min-Sik Kim, Youn-Soo Lee
Summary: This study indicates that pretreatment PLR is an independent predictor of disease-specific survival (DSS) and progression-free survival (PFS) in oral squamous cell carcinoma (OSCC) patients, with a stronger predictive effect in male patients, stage III/IV patients, and patients with lymph node metastasis.
Article
Oncology
Shigeo Ishikawa, Masahiro Sugimoto, Tsuneo Konta, Kenichiro Kitabatake, Shohei Ueda, Kaoru Edamatsu, Naoki Okuyama, Kazuyuki Yusa, Mitsuyoshi Iino
Summary: This study identified salivary 3-methylhistidine as a prognostic factor for overall survival in patients with oral squamous cell carcinoma through comprehensive metabolomic analyses.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Nada Binmadi, Maha Alsharif, Soulafa Almazrooa, Suad Aljohani, Sara Akeel, Samira Osailan, Muhammad Shahzad, Wael Elias, Yasmin Mair
Summary: This systematic review and meta-analysis summarize the current evidence regarding the prognostic role of perineural invasion (PNI) in patients with oral squamous cell carcinoma (OSCC). The findings suggest that PNI is associated with worse survival rates and recurrence, with Asian patients and peritumoral or peripheral PNI invasion having a poorer prognosis.
Article
Ecology
Manolito G. Torralba, Gajender Aleti, Weizhong Li, Kelvin Jens Moncera, Yi-Han Lin, Yanbao Yu, Michal M. Masternak, Wojciech Golusinski, Pawel Golusinski, Katarzyna Lamperska, Anna Edlund, Marcelo Freire, Karen E. Nelson
Summary: The study found a higher number of Fusobacteria, Bacteroidetes, and Firmicutes in oral squamous cell carcinoma (OSCC) tumor tissue, with an increase of Prevotella in saliva from OSCC patients and a prevalence of Corynebacterium in healthy subjects. Additionally, adhesion and virulence factors associated with Streptococcus gordonii and Fusobacterium genera were detected in OSCC tissues, suggesting potential biomarkers for disease progression.
Article
Endocrinology & Metabolism
X. F. Yu, Z. S. Li, K. M. Zhang, X. B. Chen
Summary: This study aimed to identify metabolic and prognostic molecular subtypes and corresponding molecular markers of OSCC based on TCGA data. Through various analysis methods, metabolic genes and clusters were identified, resulting in the discovery of metabolic and prognosis-related genes, divided into different clusters, and successfully verified the feasibility of some molecular markers.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Oncology
Wen-Lang Fan, Lan-Yan Yang, Jason Chia-Hsun Hsieh, Tsung-Chieh Lin, Mei-Yeh Jade Lu, Chun-Ta Liao
Summary: By analyzing mutational signatures and oncogenic signaling pathways in whole exome-sequencing data, a specific subgroup of patients with a significantly negative impact on disease-free and overall survival in OCSCC was identified, revealing potential target genes. The study showed that multiple genes drive the development of oral cavity squamous cell carcinoma in multiple pathways and identified candidate genes and pathways that may serve as prognostic genetic biomarkers or therapeutic targets.
Review
Medicine, General & Internal
Lara Nokovitch, Charles Maquet, Frederic Crampon, Ihsene Taihi, Lise-Marie Roussel, Rais Obongo, Francois Virard, Beatrice Fervers, Sophie Deneuve
Summary: Head and neck squamous cell carcinomas (HNSSCs) primarily originate from the mucosal linings of the upper aerodigestive tract and are mainly caused by the combination of alcohol drinking and tobacco use. Human papilloma virus is a risk factor for oropharyngeal SCC, while betel quid chewing is a known risk factor in southeast Asian countries. However, there are unidentified risk factors contributing to the increasing incidence of oral cavity SCC, particularly oral tongue cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tatjana Zejc, Jorg Piontek, Jorg-Dieter Schulzke, Michael Fromm, Jurgen Ervens, Rita Rosenthal
Summary: The study compares the expression of claudins in oral squamous cell carcinoma (OSCC) and healthy oral epithelium, and finds that the expression levels of claudin-2, -4, and -7 are associated with the diagnosis and prognosis of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Alhadi Almangush, Ilmo Leivo, Antti A. Makitie
Summary: The development trend of oral squamous cell carcinoma treatment is to improve survival rates through the use of immunotherapy, especially through the application of checkpoint inhibitors. The discovery of immune biomarkers is important for patient selection and evaluation of treatment response.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tomonori Sasahira, Miyako Kurihara-Shimomura, Hiroyuki Shimomura, Anja Katrin Bosserhoff, Tadaaki Kirita
Summary: TANGO downstream proteins MUC20 and SPRR1B may serve as useful molecular markers for oral squamous cell carcinoma (OSCC) due to their roles in tumor growth, invasion, and metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Silvia Pomella, Matteo Cassandri, Ombretta Melaiu, Francesco Marampon, Marco Gargari, Vincenzo Campanella, Rossella Rota, Giovanni Barillari
Summary: We analyzed the genomic and transcriptomic status of DNA damage response (DDR) genes in oral squamous cell carcinoma (OSCC) and identified a signature of eight DDR genes that could predict OSCC response to antitumor compounds. Our results also showed correlations between the expression of certain DDR genes and OSCC grading and human papilloma virus infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yong-Bin Di, Yang Bao, Jie Guo, Wei Liu, Su-Xin Zhang, Guan-Hua Zhang, Tian-Ke Li
Summary: This study suggests a significant correlation between CDSN and the prognosis and survival time of OSCC patients. Lower expression of CDSN is associated with poorer prognosis and shorter survival time.
Article
Oncology
Christian Doll, Carolin Bestendonk, Kilian Kreutzer, Konrad Neumann, Anne Pohrt, Irena Trzpis, Steffen Koerdt, Steffen Dommerich, Max Heiland, Jan-Dirk Raguse, Korinna Joehrens
Summary: Although ERa expression is rare in OSCC, it is associated with a dramatic decrease in overall survival in male patients. Further studies are needed to confirm these results and evaluate the exact mechanism underlying this observation. Therefore, ERa-positive OSCC patients might benefit from an ER-based therapeutic (adjuvant) approach in the future.
Article
Medicine, General & Internal
Yong-Bin Di, Yang Bao, Jie Guo, Wei Liu, Su-Xin Zhang, Guan-Hua Zhang, Tian-Ke Li
Summary: The high expression of COL11A1 is significantly associated with the occurrence, prognosis, and survival time of OSCC.
Review
Veterinary Sciences
Ines Sequeira, Maria Dos Anjos Pires, Jose Leitao, Joaquim Henriques, Carlos Viegas, Joao Requicha
Summary: Feline oral squamous cell carcinoma (FOSCC) is the most common oral neoplasia in cats. Its etiology is still unknown, but previous studies have suggested possible associations with viral infections and environmental factors such as tobacco smoke. However, the available evidence on the etiology of FOSCC is limited, indicating a need for further large-scale studies.
VETERINARY SCIENCES
(2022)
Article
Microbiology
Eunae Cho, YounJung Park, Ki-Yeol Kim, Dawool Han, Hyun Sil Kim, Jeong-Seung Kwon, Hyung-Joon Ahn
Summary: The study investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis, revealing significant differences in clinical factors among different hyphae groups. It suggested that low-grade hyphae infection might represent a subclinical state of OC, and identified a new subtype named MNSC.
Article
Dentistry, Oral Surgery & Medicine
Bora Lee, Jong-Eun Kim, Seung-Ho Shin, Jang-Hyun Kim, Ji-Man Park, Ki-Yeol Kim, Soo-Yoon Kim, June-Sung Shim
Summary: The study demonstrates the significance of simulated practice using patient-based customised models for dental students transitioning from preclinical to clinical curriculum. The feedback and suggestions from students indicate positive impacts on their skills and cognition through this simulation practice.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2022)
Article
Oncology
Xianglan Zhang, Mi Jang, Zhenlong Zheng, Aihua Gao, Zhenhua Lin, Ki-Yeol Kim
Summary: The study aimed to identify chemosensitive gene sets and compare the predictive accuracy of response to drug treatment based on both genomic features and cancer types through machine learning. The results showed that predictive models based on genomic information performed better than those based on cancer types, indicating that specific gene expression can help choose the most effective therapeutic drug for cancer patients with multiple primary cancers.
ANTICANCER RESEARCH
(2021)
Article
Otorhinolaryngology
Joongyo Lee, Jason Joon Bock Lee, In-Ho Cha, Kyung Ran Park, Chang Geol Lee
Summary: This study investigated dental implant outcomes in patients who had received radiotherapy for head and neck malignancies. The mean radiation dose at the implant site was identified as an independent prognostic factor for implant survival. Dental implants can be safely considered when the mean radiation dose is lower than 38 Gy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Multidisciplinary Sciences
Seoyeon Jung, Jaeyeon Kim, Jin Hoo Park, Ki-Yeol Kim, Hyung Jun Kim, Wonse Park
Summary: This study aimed to report cases of denosumab-induced MRONJ and investigate the factors affecting its occurrence. The study found that MRONJ can develop as chronic inflammation even without invasive dental treatment. Therefore, preventive dental treatment is necessary before initiating denosumab treatment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Taiqin Chen, Ki-Yeol Kim, Yeongjoo Oh, Hei Cheul Jeung, Kee Yang Chung, Mi Ryung Roh, Xianglan Zhang
Summary: The present study reveals that COPB2 may play a crucial role in the pathogenesis of cSCC and can serve as a novel predictive prognostic biomarker and immunotherapeutic target. The findings have significant implications for a better understanding of the molecular mechanisms underlying cSCC and the development of personalized treatment strategies.
Article
Oncology
Meiling Pei, Dawool Han, Ki-Yeol Kim, Dong Wook Kim, Woong Nam, Hyung Jun Kim, Eunae Sandra Cho, Hyun Sil Kim, In-Ho Cha, Xianglan Zhang
Summary: The width and dysplasia of surgical margins were not significantly associated with the outcome of OSCC patients. Higher age, Axin2, and Snail expression had independent impacts on worsened overall survival. Lesion site, extranodal extension, perineural invasion, and Snail expression had independent impacts on worsened recurrence-free survival. Axin2 and Snail are potential predictive biomarkers for the risk assessment of surgical margins in OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yeongjoo Oh, Zhenlong Zheng, Ki-Yeol Kim, Xiangshu Xu, Meiling Pei, Byungho Oh, Sang Kyem Kim, Kee Yang Chung, Mi Ryung Roh
Summary: A powerful risk prediction model for cSCC recurrence was constructed by combining clinical factors and biomarkers into a nomogram.
Editorial Material
Oncology
Hyounmin Kim, In-Ho Cha, Hyung Jun Kim, Woong Nam, Hyunwoo Yang, Sung-uk Cho, Yoon Woo Koh, Dongwook Kim
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hyounmin Kim, In-ho Cha, Hyung Jun Kim, Woong Nam, Hyunwoo Yang, Sung-uk Cho, Yoon Woo Koh, Dongwook Kim
Summary: This study aimed to investigate the feasibility and availability of free-flap reconstruction via the retroauricular approach in patients with advanced-stage oral cancer. The results showed a higher success rate and slightly longer total operation time in the retroauricular group compared to the transcervical group.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Hyounmin Kim, In-ho Cha, Hyung Jun Kim, Woong Nam, Hyunwoo Yang, Sung-uk Cho, Yoon Woo Koh, Dongwook Kim
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Hyounmin Kim, In-ho Cha, Hyung Jun Kim, Woong Nam, Hyunwoo Yang, Gibum Shin, Chena Lee, Dongwook Kim
Summary: This study suggests guidelines for predicting perforators of anterolateral thigh (ALT) free flaps using CTA imagery. The results show that CTA has a high positive predictive value and sensitivity for perforator detection. Although there may be some discrepancies between CTA and intraoperative findings in terms of the location of perforators, the addition of Doppler imaging can help improve accuracy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Seung-Woo Shin, Hyounmin Kim, Woong Nam, Hyung Jun Kim, In-Ho Cha, Yoon Woo Koh, Dongwook Kim
Summary: Although some surgeons prefer other methods, the radial forearm flap is still the most reliable option for soft tissue reconstruction in the head and neck area. To minimize donor site complications, the authors developed a new technique for harvesting the radial forearm flap using a robotic device. The study found no significant difference in flap outcome between the robot-assisted and conventional methods, but the robot-assisted method had a longer harvesting time.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Cell Biology
Zhenlong Zheng, Xianglan Zhang, Bong-Kyeong Oh, Ki-Yeol Kim
Summary: This study utilized machine learning methods to predict the risk of osteoporosis based on combined biomarkers, finding that predictive models based on two or three genes were superior to single genes, with the best predictive gene sets including PLA2G2A, WRAP73, LPN1, PFDN6, and DOHH.