期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 33, 期 5, 页码 734-742出版社
WILEY
DOI: 10.1002/hed.21535
关键词
arsenic trioxide; metastasis; nasopharyngeal carcinoma; apoptosis; cell cycle
资金
- Chang Gung Memorial Hospital, Keelung, Taiwan [CMRPG250271]
Background. Although arsenic trioxide (ATO) has displayed anticancer activity against primary nasopharyngeal carcinoma (NPC), its efficacy in metastatic NPC deserved further investigation because the biological/therapeutic difference in cancer cells probably exists between primary and distant sites. Methods. Two human metastatic NPC cell lines (NPC-BM1 and NPC-BM2) were investigated. We measured cellular proliferation, cell cycle, and apoptotic extent of BM1 and BM2 cells treated with ATO in vitro. Furthermore, we evaluated the tumor growth after ATO treatment in vivo. Results. Low-dose ATO treatment is sufficient to induce an antiproliferative effect, alter the cell cycle, and increase apoptosis in BM1 and BM2 cells. BM1 tumor growth in a xenograft model with low-dose and short-schedule (1 mg/kg/day, intraperitoneal injection for 5 consecutive days) of ATO treatment significantly slowed in vivo. Conclusion. ATO at low dose seems to be an encouraging schedule for palliative treatment of metastatic NPC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 734-742, 2011
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