Formulation and evaluation of castor oil containing self-emulsifying pellets by using design of experiment

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作者

Shubhangi Shekade¹ , Satish Shirolkar¹ , Sanjeevani Deshkar¹

1. Dr. DY Patil Institute of Pharmaceutical Sciences and Research

会议/活动

25th Annual National Convention APTICON 2022, September 2022 (Mysuru, India)

海报摘要

The objective of the study was to examine the feasibility of extrusion/spheronization techniques for converting liquid castor oil into solid self-emulsifying pellets. A D-optimal mixture design was used for formulating self emulsifying pellets using castor oil, surfactant, cosurfactant, lactose, MCC, corn starch and HPMC by extrusion spheronization technique. The effect of composition of oil, surfactant and cosurfactant blend on dispersion time, resultant globule size and polydispersibility index was studied. Additionally, pellet flow properties, hardness, size distribution and disintegration time was also evaluated. The morphology of castor oil pellets was observed by scanning electron microscopy (SEM). Free flowing pellets were obtained with 30% of oil loading. SEM revealed sphericity and smooth surface of the oil loaded pellets. This developed system can serve as a carrier system for any activity as well as can also be used for delivery of castor oil.

关键词

Solid self-emulsifying drug delivery system, Extrusion spheronisation, Dispersion time, Castor oil, Pellets

研究领域

Agriculture, Chemistry, Immunology, Pharmacy and Pharmacology, Nanoengineering

参考文献

1. Scarpa A, Guerci A. Various Uses of the Castor Oil Plant (Ricinus Communis L.) A Review. Journal of Ethnopharmacology. 1982 Mar 1; 5(2):117-37.
2. Nagarjun Rangaraj, et al ,” Quality by Design Approach for the Development of Self-Emulsifying Systems for Oral Delivery of Febuxostat: Pharmacokinetic and Pharmacodynamic Evaluation”,AAPS Pharm Sci Tech (2019) Page No: 20:267.
3. Yeom DW, Song YS, Kim SR, Lee SG, Kang MH, Lee S, Choi YW. Development and optimization of a self-microemulsifying drug delivery system for atorvastatin calcium by using D-optimal mixture design. International Journal of nanomedicine. 2015;10:3865.
4. www//http://pharmamedicinalchemistry.blogspot.com/
5. https://pharmastuff.blogspot.com/2018/08/review-on-self-emulsifying-drug-delivery.html

基金

暂无数据

补充材料

1. DOI of article:10.5530/ijper.57.1s.9   Download

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Shekade et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.