LSD, Afterglow and Hangover: Increased Episodic Memory and Verbal Fluency, Decreased Cognitive Flexibility

作者

Isabel Wießner¹ , Rodolfo Olivieri¹ , Marcelo Falchi¹ , Fernanda Palhano-Fontes² , Lucas Oliveira Maia¹ , Amanda Feilding³ , Draulio Araujo² , Sidarta Ribeiro² , Luís Fernando Tófoli¹

1. School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
2. Brain Institute, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
3. The Beckley Foundation, Beckley Park, Oxford, United Kingdom

会议/活动

Interdisciplinary Conference on Psychedelic Research, September 2022 (Haarlem, Netherlands)

海报摘要

Psychedelics acutely impair cognition and might sub-acutely improve it in ceremonial settings. In this light, we applied a randomized, double-blind, placebo-controlled, crossover study with 24 healthy volunteers receiving 50μg lysergic acid diethylamide (LSD) or inactive placebo. Cognition was measured 24 hours post-administration (Rey-Osterrieth Complex Figure; Object-Location Memory Task; Rey Auditory-Verbal Learning Test; verbal fluency; design fluency; Wisconsin Card Sorting Test; Trail Making Test; Stroop Task; Block Design Test). The results show that when compared to placebo and corrected for Body Mass Index and abstinence period from psychedelics, LSD sub-acutely improved visuospatial memory (ROCF, OLMT) and phonological verbal fluency and impaired cognitive flexibility (WCST). In conclusion, low-dose LSD moderately induced both “afterglow” and “hangover”. The improvements in visuospatial memory and phonological fluency suggest that LSD-assisted therapy should be explored as a novel treatment perspective in conditions involving memory and language declines such as brain injury, stroke or dementia.

关键词

Sub-acute LSD effects, Psycholytic dose, Visuospatial memory, Phonological verbal fluency, Cognitive flexibility, Executive functions

研究领域

Neuroscience, Psychology and Behavioral Sciences

参考文献

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基金

1. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (No. Finance Code 001)
2. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (No. grants 308775/2015-5 and 408145/2016-1)
3. Sao Paulo Research Foundation (No. grants 2013/07699-0 (Neuromathematics) and 2014/10068-4)

补充材料

暂无数据

附加信息

利益冲突

SR declares the following patent application as a competing interest: a) Patent applicants (The Beckley Foundation, Universidade Federal do Rio Grande do Norte); b) Name of inventors: Not yet listed; c) Application number: 1 911 024.6; d) Status of application: pending.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2022 Wießner et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.