Sympathetic Neural Contributions to Vascular Control: Role of KATP Channels

作者

Clark Holdsworth¹ , Scott Ferguson¹ , Richard Fels¹ , Shawnee Montgomery¹ , Michael Kenney¹ , David Poole¹ , Timothy Musch¹

1. Kansas State University

会议/活动

Experimental Biology, March 2015 (Boston, MA, United States)

海报摘要

The ATP-sensitive K+ (KATP) channel is a class of inward rectifier K+ channels that contributes to systemic basal vasomotor tone. In rats blockade of KATP channels via glibenclamide (GLI) promotes vasoconstriction thereby increasing mean arterial pressure (MAP) and decreasing renal and hindlimb skeletal muscle blood flow. We tested the hypothesis that the GLI-induced increase in vascular tone resulted, in part, from increased renal or lumbar sympathetic nerve discharge (SND). Heart rate (HR), MAP and lumbar and renal SND (direct nerve recordings) were measured in 8 male Sprague Dawley rats for 10 min following vehicle (VEH) and GLI (2.5 mg/kg i.v.). GLI-induced reductions in skeletal muscle and renal blood flow reflect peripheral KATP channel vascular control and decreased SND actually acts to constrain the full magnitude of the hyperemic response. Consequently, the hindlimb skeletal muscle blood flow reductions with KATP channel blockade may be underestimated in baroreflex-intact animals.

关键词

autonomic control, microvascular, microcirculation

研究领域

Anatomy and Physiology

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.